T cell optimization for effective CAR-T cell therapy to refractory esophageal cancer

• Project/Area Number: 19K22655
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
• Research Institution: Mie University
• Principal Investigator: 影山 愼一 三重大学, 医学系研究科, 教授 (80194695)
• Co-Investigator(Kenkyū-buntansha): 宮原 慶裕 三重大学, 医学系研究科, 准教授 (10582083) ; 加藤 琢磨 三重大学, 医学系研究科, 准教授 (60224515)
• Project Period (FY): 2019-06-28 – 2021-03-31
• Project Status: Granted (Fiscal Year 2019)
• Budget Amount: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: CAR-T細胞 / MAGE-A4 / 食道癌

Outline of Research at the Start

固形腫瘍（食道癌）に有効なMAGE-A4新規CAR-T療法に用いるT細胞の最適な調製法、選択法、複合的治療（T細胞の代謝改善薬との併用）のためのrationale構築とin vivoモデルによるPOC取得をする。