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Brain vital response via the central nervous immune system

Research Project

Project/Area Number 19K22755
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 58:Society medicine, nursing, and related fields
Research InstitutionUniversity of Yamanashi

Principal Investigator

Shojo Hideki  山梨大学, 大学院総合研究部, 准教授 (60284626)

Co-Investigator(Kenkyū-buntansha) 林 敬人  鹿児島大学, 医歯学域医学系, 教授 (40512497)
葛西 宏威  山梨大学, 大学院総合研究部, 助教 (20324189)
Project Period (FY) 2019-06-28 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords脳の生活反応 / 中枢神経系リンパ管 / 脳内免疫細胞 / 免疫細胞 / 生活反応 / 中枢神経系免疫システム / リンパ管
Outline of Research at the Start

法医学において、生活反応(出血や細胞反応などの生体反応)は損傷が生前に生成したことを示す重要な証拠である。本研究では、中枢神経系免疫反応を介した新たな生活反応のマーカーを創出するために、脳の炎症や消炎などに関わる免疫細胞基盤を明らかにすることを目的とする。そこで、作業仮説として、ヒトの中枢神経系にもリンパ管が存在することを分子組織化学的に証明し、脳脊髄液を介して移動する免疫細胞を特定する。

Outline of Final Research Achievements

This research objectives were to prove that lymphatic vessels also exist in the human central nervous system by molecular histochemical analyses, and to identify immune cells that migrate into the brain parenchyma. During this research period, it was exceedingly difficult to collect human samples due to spread of novel coronavirus infectious disease. Although the numbers of sample were limited, we tried to construct the image of lymphatic vessels in human central nervous system using a high-resolution image analysis. Moreover, in human and animal samples, immune cells migrated into the brain parenchyma, indicated that contributed to brain inflammation. These results indicated that it was possible to reveal brain vital responses through the central nerve immune system and suggested that it will be expected to find out novel vital response markers that have been overlooked so far. Therefore, we are currently promoting basic research on the vital responses in the brain.

Academic Significance and Societal Importance of the Research Achievements

これまで中枢神経系は免疫特権領域であり、正常な状態ではリンパ球の様な免疫細胞の出入りはないと考えられてきた。しかし、マウスの硬膜静脈洞の内表面にリンパ管が発見され、正常な脳でも免疫細胞が脳とリンパ管を移動している可能性が示唆された。つまり、中枢神経系への免疫細胞の移入は病的条件下でのみ生じていると考えられてきたが、本研究は学術の現状を変革する可能性があり意義深い。一方、法医学ではこれまで見過ごされてきた免疫細胞を指標とした脳の生活反応のマーカーを見出す可能性があり重要である。また、脳の炎症・消炎に関わる免疫細胞基盤の解明は、頭部外傷などの後遺症軽減や治療法の開発において重要であると考えられる。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (11 results)

All 2022 2021 Other

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (3 results) Remarks (5 results)

  • [Journal Article] Three Autopsy Cases of Non-Meningococcal Waterhouse-Friderichsen Syndrome with Hypoplastic Spleen or Post-Splenectomy Status2022

    • Author(s)
      Horita T, Kosaka N, Takaoka S, Fujii G, Fujimoto K, Koshimizu Y, Kakuda T, Shojo H, Adachi N.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 258 Issue: 4 Pages: 287-301

    • DOI

      10.1620/tjem.2022.J085

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Highly sensitive sex determination method using the exon 1 region of the amelogenin gene2022

    • Author(s)
      Fujimoto Kana、Fujii Gento、Shojo Hideki、Nakanishi Hiroaki、Kanzawa-Kiriyama Hideaki、Saitoh Masao、Yoshizawa Kunio、Aono Tomoya、Horita Tetsuya、Takada Aya、Saito Kazuyuki、Ueki Koichiro、Adachi Noboru
    • Journal Title

      Legal Medicine

      Volume: 59 Pages: 102136-102136

    • DOI

      10.1016/j.legalmed.2022.102136

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detection of 4-FMC, 4-MeO-α-PVP, 4-F-α-PVP, and PV8 in blood in a forensic case using liquid chromatography-electrospray ionization linear ion trap mass spectrometry2021

    • Author(s)
      Mochizuki Akira, Adachi Noboru, Shojo Hideki
    • Journal Title

      Forensic Science International

      Volume: 325 Pages: 110888-110888

    • DOI

      10.1016/j.forsciint.2021.110888

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 脾臓低形成および脾摘後の,非髄膜炎菌性Waterhouse-Friderichsen症候群の3症例.2022

    • Author(s)
      堀田哲也,小阪実生,高岡慎弥,藤井元人,藤本佳那,輿水嘉仁,角田恒雄,猩々英紀,安達 登.
    • Organizer
      第106次日本法医学会学術全国集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 身元不明遺体から年齢がかなり正確に判るアミノ酸ラセミ化法について.2022

    • Author(s)
      大谷進,猩々英紀,安達登.
    • Organizer
      第106次日本法医学会学術全国集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 物理式により被害者の転倒速度を算出できた交通事故解剖の一例.2022

    • Author(s)
      堀田哲也,角田恒雄,猩々英紀,安達 登.
    • Organizer
      第44回日本法医学会学術中部地方会
    • Related Report
      2022 Annual Research Report
  • [Remarks] 山梨大学法医学講座 猩々英紀

    • URL

      https://www.med.yamanashi.ac.jp/social/legal0me/classroom_member/shohjoh.html

    • Related Report
      2022 Annual Research Report
  • [Remarks] リサーチマップ 猩々英紀

    • URL

      https://researchmap.jp/read0048413

    • Related Report
      2022 Annual Research Report
  • [Remarks] 山梨大学大学院総合研究部法医学講座 猩々英紀

    • URL

      https://www.med.yamanashi.ac.jp/social/legal0me/classroom_member/shohjoh.html

    • Related Report
      2021 Research-status Report
  • [Remarks] researchmap

    • URL

      https://researchmap.jp/read0048413

    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Remarks] 山梨大学大学院総合研究部法医学講座猩々英紀

    • URL

      https://www.med.yamanashi.ac.jp/social/legal0me/classroom_member/shohjoh.html

    • Related Report
      2020 Research-status Report 2019 Research-status Report

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Published: 2019-07-04   Modified: 2024-01-30  

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