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Prediction and diagnosis of health effects of essential elements from miRNAs in urine and blood

Research Project

Project/Area Number 19K22907
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 63:Environmental analyses and evaluation and related fields
Research InstitutionShibaura Institute of Technology

Principal Investigator

Yajima Ichiro  芝浦工業大学, システム理工学部, 教授 (80469022)

Project Period (FY) 2019-06-28 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords元素 / miRNA / 皮膚 / 重金属 / 疾患
Outline of Research at the Start

「元素」「健康」「miRNA」を組み合わせた研究は極めて少なく、今後重要な研究分野となると考えられている。「世界の構成成分である《元素》が影響を与えるヒトの健康状態・疾患を、miRNAか ら予知・診断すること」を目的とし、元素が与える健康影響をmiRNAの発現解析によって明らかにするとともに、 実験動物や培養細胞への曝露試験及び分子細胞生物学的な解析を行う。本研究により、miRNA パターンによって元素が関連する健康状態・病態との関連性が明らかとなれば、予知診断する手法の開発に繋がると考えられる。将来的にはmiRNAをターゲットとした治療法開発も視野に入れ、研究を実施する。

Outline of Final Research Achievements

The exposure study was conducted to clarify the possible health effects of the elements through the function of miRNAs. In particular, since the skin is the frontline of exposure to various environmental factors, we conducted the study using human skin keratinocytes and melanocytes. We prepared inhibitor and mimic type miRNAs for the identified element-related miRNAs, and performed functional analysis by transfection. The results revealed that there are miRNAs that affect proliferative activity, melanogenesis, and apoptosis.
These results suggest that artificial regulation of miRNA functions may contribute to the development of preventive and therapeutic methods for element-induced diseases.

Academic Significance and Societal Importance of the Research Achievements

元素はヒトが地球上で生きる上で決して避けて通れない物質であり、自身もまた元素で構成されている。一方でmiRNAはヒトの健康や疾病を予防・治療するための最先端のツールである。この「元素」と「miRNA」の関連性を機能的に解析した研究は皆無であり、新たな学術的意味を見出す研究と言える。
また、今回明らかとなった「元素」と「miRNA」の関連性は、様々な疾患、特に元素に起因する疾患の予防や治療に大きく寄与する可能性を示しており、今後のより詳細な研究と予防法・治療法の開発が期待される。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (9 results)

All 2022 2020 2019

All Journal Article (5 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (4 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Calcitriol inhibits arsenic-promoted tumorigenesis through regulation of arsenic-uptake in a human keratinocyte cell line.2022

    • Author(s)
      Yajima I, Tazaki A , Ohgami N, Kato M.
    • Journal Title

      American Journal of Cancer Research

      Volume: 11 Pages: 5019-5028

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased levels of renal damage biomarkers caused by excess exposure to trivalent chromium in workers in tanneries2020

    • Author(s)
      Tsuchiyama Tomoyuki、Tazaki Akira、Al Hossain MM Aeorangajeb、Yajima Ichiro、Ahsan Nazmul、Akhand Anwarul Azim、Hashimoto Kazunori、Ohgami Nobutaka、Kato Masashi
    • Journal Title

      Environmental Research

      Volume: 188 Pages: 109770-109770

    • DOI

      10.1016/j.envres.2020.109770

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water2020

    • Author(s)
      Kato Masashi、Ohgami Nobutaka、Ohnuma Shoko、Hashimoto Kazunori、Tazaki Akira、Xu Huadong、Kondo-Ida Lisa、Yuan Tian、Tsuchiyama Tomoyuki、He Tingchao、Kurniasari Fitri、Gu Yishuo、Chen Wei、Deng Yuqi、Komuro Kanako、Tong Keming、Yajima Ichiro
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 25 Issue: 1 Pages: 16-16

    • DOI

      10.1186/s12199-020-00855-8

    • NAID

      210000158248

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chromium-mediated hyperpigmentation of skin in male tannery workers in Bangladesh2019

    • Author(s)
      Al Hossain M.M. Aeorangajeb、Yajima Ichiro、Tazaki Akira、Xu Huadong、Saheduzzaman Md、Ohgami Nobutaka、Ahsan Nazmul、Akhand Anwarul Azim、Kato Masashi
    • Journal Title

      Chemosphere

      Volume: 229 Pages: 611-617

    • DOI

      10.1016/j.chemosphere.2019.04.112

    • NAID

      120006718410

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hearing loss in humans drinking tube well water with high levels of iron in arsenic?polluted area2019

    • Author(s)
      He Tingchao、Ohgami Nobutaka、Li Xiang、Yajima Ichiro、Negishi-Oshino Reina、Kato Yoko、Ohgami Kyoko、Xu Huadong、Ahsan Nazmul、Akhand Anwarul Azim、Kato Masashi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 9028-9028

    • DOI

      10.1038/s41598-019-45524-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] MOLECULAR MECHANISMS OF NOVEL COMPOUNDS-MEDIATES ANTICANCER EFFECTS ON HEPATOCELLULAR CARCINOMA.2022

    • Author(s)
      Kohta Tonegawa , Kazuma Mizuno, Ryota Shigefuku, Yoshimoto Suhara, Ichiro Yajima
    • Organizer
      SEATUC (Malaysia)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] EFFECTS OF LOW MOLECULAR WEIGHT PEPTIDES ON UV-INDUCED SKIN CELL DAMAGE.2022

    • Author(s)
      Moeka Sogo, Rio Rio, Yoshitomo Suhara, Ichiro Yajima.
    • Organizer
      SEATUC (Malaysia)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Effect of Low Molecular Weight Peptides on UV-Induced Melanin Production.2022

    • Author(s)
      Rio Oki, Moeka Sogo, Yoshitomo Suhara, Ichiro Yajima.
    • Organizer
      SEATUC (Malaysia)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Anticancer effects of the retinoid on lung cancer cells.2022

    • Author(s)
      Ryota Shigefuku, Kohta Tonegawa, Kazuma Mizuno, Yoshitomo Suhara, Ichiro Yajima.
    • Organizer
      SEATUC (Malaysia)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research

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Published: 2019-07-04   Modified: 2024-01-30  

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