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Quantitative visualization of organ fibrosis using the acoustically stimulated electromagnetic method

Research Project

Project/Area Number 19K22956
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

Kenji Ikushima  東京農工大学, 工学(系)研究科(研究院), 教授 (20334302)

Project Period (FY) 2019-06-28 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords臓器線維化 / コラーゲン / 超音波 / 圧電性 / 音響誘起電磁法 / 線維化 / 圧電効果
Outline of Research at the Start

本研究の目的は、超音波を利用する新手法――音響誘起電磁(ASEM)法――を用いて、非侵襲に臓器の線維化を定量可視化する基盤技術を提供することである。安全で繰り返し検査を行うことができる線維化の診断技術の確立は、循環器系、泌尿器系、消化器系、呼吸器系等の治療判断に大きく貢献することが期待される。

Outline of Final Research Achievements

The acoustically stimulated electromagnetic method (ASEM method) is a novel measurement technique for detecting electric polarization (piezoelectric polarization) induced by ultrasonic waves (ultrasound pressure). This polarization is derived from the piezoelectricity of fibrous tissue such as collagen having uniaxial symmetry. Therefore, it is expected that excess collagen accumulation associated with chronic diseases of organs will be detected and imaged. In this study, we performed visualization verification of fibrosis using a rat model of chronic myocardial infarction and renal failure. As a result, (1) since polarization was hardly observed in a healthy heart, a fibrotic distribution was obtained with a clear contrast in the myocardial infarction model. (2) Regarding the kidney, since polarization was also observed in healthy kidneys, a clear significant difference was obtained when evaluated as the polarization occurrence area ratio.

Academic Significance and Societal Importance of the Research Achievements

臓器の線維化は、心臓、腎臓、肝臓および肺など、慢性疾患において普遍的に認められる組織変性である。通常、患者から組織の一部を摘出して分析する生体検査(生検)が行われている。生検は患者への負担が大きいため、非侵襲検査が強く求められている。本研究により、超音波を用いた新手法(音響誘起電磁法)を用いて心臓や腎臓等のコラーゲン蓄積を直接画像化できることが実証された。音響誘起電磁法による線維化診断の実現は、患者の負担を軽減し、予後予測が頻繁に検査できる診断技術として新たな価値をもたらすことが期待される。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (21 results)

All 2020 2019 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (12 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Flaw Detection for Thin Sheet Using Acoustic Stimulated Electromagnetic Wave Technique2020

    • Author(s)
      J. Yotsuji, K. Ikushima, and H. Yamada
    • Journal Title

      ISIJ International

      Volume: 60 Issue: 5 Pages: 948-953

    • DOI

      10.2355/isijinternational.ISIJINT-2019-481

    • NAID

      130007843543

    • ISSN
      0915-1559, 1347-5460
    • Year and Date
      2020-05-15
    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tensile-stress dependence of magnetic hysteresis properties measured by the acoustically stimulated electromagnetic response in steel2020

    • Author(s)
      Y. Suzuki, H. Yamada, and K. Ikushima
    • Journal Title

      IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

      Volume: 67 Issue: 4 Pages: 825-831

    • DOI

      10.1109/tuffc.2019.2956040

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electric Polarization of Soft Biological Tissues Induced by Ultrasound Waves2019

    • Author(s)
      K. Ikushima, T. Kumamoto, K. Ito, and Y. Anzai
    • Journal Title

      Physical Review Letters

      Volume: 123 Issue: 23 Pages: 238101-238101

    • DOI

      10.1103/physrevlett.123.238101

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nondestructive evaluation of residual stress through acoustically stimulated electromagnetic response in welded steel2019

    • Author(s)
      Y. Suzuki, Y. Ichikawa, H. Yamada, and K. Ikushima
    • Journal Title

      2019 IEEE International Ultrasonics Symposium Proceedings

      Volume: - Pages: 19242858-19242858

    • DOI

      10.1109/ultsym.2019.8926251

    • Related Report
      2019 Research-status Report
  • [Presentation] 超音波による電気・磁気センシング2020

    • Author(s)
      生嶋健司
    • Organizer
      日本磁気学会第228回研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 音響誘起電磁法を用いた溶接鋼材における残留応力分布の評価 Ⅱ2020

    • Author(s)
      細川大介、鈴木優平、市川裕一、山田尚人、生嶋健司
    • Organizer
      第67回応用物理学会春季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 音響誘起電磁法を用いた腎不全による線維化の検出Ⅱ2020

    • Author(s)
      井上智博、安齋也真人、熊本貴司、生嶋健司、谷口歩、今村亮一、野々村祝夫
    • Organizer
      第67回応用物理学会春季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 生体組織における超音波誘起電気分極の異方性2020

    • Author(s)
      安齋也真人、熊本貴司、生嶋健司、道本樹、松川真美
    • Organizer
      第81回応用物理学会秋季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 音響誘起電磁応答で観測される局所的保磁力の応力依存性2020

    • Author(s)
      細川大介、鈴木優平、山田尚人、生嶋健司
    • Organizer
      第81回応用物理学会秋季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 音響誘起電磁法を用いた服薬アドヒアランス測定の試み2020

    • Author(s)
      皆藤信人, 生嶋健司
    • Organizer
      第68回応用物理学会春季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Acoustically stimulated electric polarization in osteoporotic bone2019

    • Author(s)
      Y. Kojima, N. Niimi, K. Ikushima, Y. Yabe, and Y. Hagiwara
    • Organizer
      ASBMR 2019 (The American Society for Bone and Mineral Research Annual Meeting)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Nondestructive evaluation of residual stress through acoustically stimulated electromagnetic response in welded steel2019

    • Author(s)
      Y. Suzuki, Y. Ichikawa, H. Yamada, and K. Ikushima
    • Organizer
      IEEE International Ultrasonics Symposium (IEEE IUS)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 複素誘電率を利用した半解凍状態の検査方法の開発2019

    • Author(s)
      伊藤惇、前川貴浩、川端康之亮、村山文仁、生嶋健司
    • Organizer
      2019年日本水産工学会春季シンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] 音響誘起電磁法を用いた腎不全による線維化の検出2019

    • Author(s)
      熊本貴司、伊藤賢四郎、生嶋健司、今村亮一、野々村祝夫
    • Organizer
      第80回 応用物理学会 秋季学術講演会
    • Related Report
      2019 Research-status Report
  • [Presentation] 超音波によって誘起される生体組織の電気分極Ⅱ2019

    • Author(s)
      安齋也真人、熊本貴司、生嶋健司
    • Organizer
      第80回 応用物理学会 秋季学術講演会
    • Related Report
      2019 Research-status Report
  • [Presentation] Non-destructive inspection using acoustically stimulated electromagnetic method2019

    • Author(s)
      鈴木優平、山田尚人、生嶋健司
    • Organizer
      日本磁気学会第43回学術講演会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Remarks] IKUSHIMA GROUP

    • URL

      http://web.tuat.ac.jp/~ikushima/index_j.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] Soft Biological Tissues Can Be Piezoelectric

    • URL

      https://physics.aps.org/synopsis-for/10.1103/PhysRevLett.123.238101

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
  • [Remarks] The body electric

    • URL

      https://www.nature.com/articles/d41586-019-03806-8

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
  • [Remarks] IKUSHIMA GROUP

    • URL

      http://web.tuat.ac.jp/~ikushima/members_j.html

    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] 線維化測定装置、線維化測定方法および特性測定装置2019

    • Inventor(s)
      生嶋健司
    • Industrial Property Rights Holder
      国立研究開発法人科学技術振興機構(JST)
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report

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Published: 2019-07-04   Modified: 2022-01-27  

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