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Brain-controlled neuroprosthetic for restoration of upper-limb function

Research Project

Project/Area Number 19K23606
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0403:Biomedical engineering and related fields
Research InstitutionOsaka University

Principal Investigator

MILOSEVIC MATIJA  大阪大学, 基礎工学研究科, 助教 (50840188)

Project Period (FY) 2019-08-30 – 2022-03-31
Project Status Granted (Fiscal Year 2020)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsbrain-computer interface / neuroprosthetics / upper-limb / rehabilitation / neuroplasticity / brain-machine interface / neurotechnology / neuromodulation
Outline of Research at the Start

This research program aims to develop an advanced neurotechnology that can use brain signals to control paralyzed hand muscles of individuals with motor impairments by applying electrical stimulation to induce long-term cortical re-organization (neuroplasticity).

Outline of Annual Research Achievements

The objectives of this research are to develop: (1) a brain-computer interface (BCI) system that can detect hand opening / closing movements using non-invasive cortical (brain) signals from human participants during motor imagery tasks, and (2) a neuroprosthetic technology that can activate the upper-limb muscles through functional electrical stimulation (FES). Finally, the research program aims to test the feasibility of this BCI-controlled FES neuroprosthetic and examine how it can contribute to restoration of upper-limb motor function. Based on these objectives, we have developed and implemented a BCI-controlled FES system and proposed the underlying mechanisms of recovery of upper-limb motor function that can be elicited through BCI-controlled FES. We showed that presynaptic cortical facilitation followed by postsynaptic FES (BCI-controlled FES) is required to elicit short-term corticospinal facilitation, while only postsynaptic FES (random FES) activation was ineffective. Moreover, we have been testing how FES can be used to activate different muscles and as such facilitate excitability of the central nervous system. Specifically, it was shown that long-term application of upper-limb FES can facilitate cortical excitability beyond the training period. In summary, a BCI-FES system with an accuracy of ~85% was developed, and it was shown to contribute to restoration of upper-limb motor function through facilitation of cortical and peripheral activations.

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

(1) In the research related to the development of the BCI system, we have implemented and tested the BCI-FES system proved the underlying mechanisms of BCI-controlled FES for recovery of upper-limb function [1]. Specifically, motor imagery was shown to affect cortical networks [2]. Moreover, threshold-based motor imagery BCI was shown to work with an accuracy of ~85% [3], while a machine learning classifier had a comparable detection [4]. Notably, using the BCI-controlled FES system was shown as effective in facilitating corticospinal excitability more than random application of FES [3], confirming our results indicating that cortical facilitation before FES is necessary to elicit neural plasticity [5].

(2) In the research related to the development of FES technology, we have been testing how FES can activate muscles and the central nervous system. Specifically, we showed that upper-limb FES can elicit considerable and long-lasting cortical re-organization [6]. A book chapter is currently in preparation based on these findings for a textbook titled Neurorehabilitation Technology edited by Dr. Volker Dietz.

References: [1] M. Milosevic, et al., BioMedical Engineering Online, vol. 19, 81, 2020; [2] Y. Suzuki, et al., Neuroscience Letters, vol. 755, 2021; [3] Y. Suzuki, et al., To be submitted to Neuromodulation; [4] Y. Yamanouchi, et al., To be submitted to Artificial Organs; [5] N. Cao, et al., To be submitted to Brain Stimulation; [6] M. Milosevic, et al., medRxiv, 2020.

Strategy for Future Research Activity

In the future, we will complete all analyses of data that was collected during experiments in Osaka and Tokyo. Moreover, we will continue preparing manuscripts for dissemination of research results in international peer-reviewed journals and work towards publishing all the research findings.

Report

(2 results)
  • 2020 Research-status Report
  • 2019 Research-status Report

Research Products

(22 results)

All 2021 2020 2019 Other

All Int'l Joint Research (3 results) Journal Article (11 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 9 results,  Open Access: 5 results) Presentation (8 results) (of which Int'l Joint Research: 4 results,  Invited: 4 results)

  • [Int'l Joint Research] University of Toronto/Toronto Rehabilitation Institute(カナダ)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] University of Toronto/Toronto Rehabilitation Institute(カナダ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Yeungnam University(韓国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Muscle-specific movement-phase-dependent modulation of corticospinal excitability during upper-limb motor execution and motor imagery combined with virtual action observation2021

    • Author(s)
      Yoshiyuki Suzuki, Naotsugu Kaneko, Atsushi Sasaki, FumiyaTanaka, Kimitaka Nakazawa, Taishin Nomura and Matija Milosevic
    • Journal Title

      Neuroscience Letters

      Volume: 755

    • DOI

      10.1016/j.neulet.2021.135907

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Long-lasting event-related beta synchronizations of electroencephalographic activity in response to support-surface perturbations during upright stance: A pilot study associating beta rebound and active monitoring in the intermittent postural control2021

    • Author(s)
      Akihiro Nakamura, Yasuyuki Suzuki, Matija Milosevic and Taishin Nomura
    • Journal Title

      Frontiers in Systems Neuroscience

      Volume: - Pages: 660434-660434

    • DOI

      10.3389/fnsys.2021.660434

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Contribution of Each Motor Point of Quadriceps Femoris to Knee Extension Torque During Neuromuscular Electrical Stimulation2021

    • Author(s)
      Derrick Lim, Mikael Del Castillo, Austin J Bergquist, Matija Milosevic and Kei Masani
    • Journal Title

      IEEE Transactions on Neural Systems and Rehabilitation Engineering

      Volume: 29 Pages: 389-396

    • DOI

      10.1109/tnsre.2021.3052853

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Why brain-controlled neuroprosthetics matter: Mechanisms underlying electrical stimulations of muscles and nerves in rehabilitation2020

    • Author(s)
      Matija Milosevic, Cesar Marquez-Chin, Kei Masani, Masayuki Hirata, Taishin Nomura, Milos R. Popovic and Kimitaka Nakazawa
    • Journal Title

      Biomed Eng Online

      Volume: 19 (81) Pages: 81-81

    • DOI

      10.1186/s12938-020-00824-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Postural instability via a loss of intermittent control in elderly and patients with Parkinson’s disease: A model-based and data-driven approach2020

    • Author(s)
      Suzuki Yasuyuki、Nakamura Akihiro、Milosevic Matija、Nomura Kunihiko、Tanahashi Takao、Endo Takuyuki、Sakoda Saburo、Morasso Pietro、Nomura Taishin
    • Journal Title

      Chaos: Interdisciplinary Journal of Nonlinear Science

      Volume: 30 Pages: 113140-113140

    • DOI

      10.1063/5.0022319

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cortical and subcortical neural interactions between trunk and upper-limb muscles in humans2020

    • Author(s)
      Atsushi Sasaki, Matija Milosevic and Kimitaka Nakazawa
    • Journal Title

      Neuroscience

      Volume: 451 Pages: 126-136

    • DOI

      10.1016/j.neuroscience.2020.10.011

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Interlimb neural interactions in corticospinal and spinal reflex circuits during preparation and execution of isometric elbow flexion2020

    • Author(s)
      Atsushi Sasaki, Naotsugu Kaneko, Yohei Masugi, Matija Milosevic and Kimitaka Nakazawa
    • Journal Title

      Journal of Neurophysiology

      Volume: 124(3) Pages: 652-667

    • DOI

      10.1152/jn.00705.2019

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Changes in corticospinal excitability during bilateral and unilateral lower-limb force control tasks2020

    • Author(s)
      Akiko Yamaguchi, Atsushi Sasaki, Yohei Masugi, Matija Milosevic and Kimitaka Nakazawa
    • Journal Title

      Experimental Brain Research

      Volume: 238(9) Pages: 1977-1987

    • DOI

      10.1007/s00221-020-05857-0

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cortical re-organization after traumatic brain injury elicited using functional electrical stimulation therapy: A case report2020

    • Author(s)
      Matija Milosevic, Tomoya Nakanishi, Atsushi Sasaki, Akiko Yamaguchi, Taishin Nomura, Milos R. Popovic and Kimitaka Nakazawa
    • Journal Title

      medRxiv

      Volume: -

    • DOI

      10.1101/2020.05.31.20118323

    • Related Report
      2020 Research-status Report
    • Open Access / Int'l Joint Research
  • [Journal Article] Effects of neuromuscular electrical stimulation and voluntary commands on the spinal reflex excitability of remote limb muscles2019

    • Author(s)
      Kato Tatsuya、Sasaki Atsushi、Yokoyama Hikaru、Milosevic Matija、Nakazawa Kimitaka
    • Journal Title

      Experimental Brain Research

      Volume: 237 Pages: 3195-3205

    • DOI

      10.1007/s00221-019-05660-6

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Contractile properties of superficial skeletal muscle affect postural control in healthy young adults: A test of the rambling and trembling hypothesis2019

    • Author(s)
      Shin Sunghoon、Milosevic Matija、Chung Chul-min、Lee Yungon
    • Journal Title

      PLOS ONE

      Volume: 14 Pages: 0223850-0223850

    • DOI

      10.1371/journal.pone.0223850

    • Related Report
      2019 Research-status Report
  • [Presentation] Mechanisms of brain-controlled functional electrical stimulation of muscles in neurorehabilitation2021

    • Author(s)
      Matija Milosevic
    • Organizer
      Webinar - International Functional Electrical Stimulation Society (IFESS)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] How brain-controlled electrical stimulation of muscles can be used to elicit neural plasticity2020

    • Author(s)
      Matija Milosevic
    • Organizer
      Invited presentations at the Center for Information and Neural Networks (CiNet) - Osaka University
    • Related Report
      2020 Research-status Report
  • [Presentation] Development of an upper-limb virtual reality system for brain-computer interface2020

    • Author(s)
      Yoshiyuki Suzuki, Fumiya Tanaka, Matija Milosevic and Taishin Nomura
    • Organizer
      ME and Bio Cybernetics Virtual Forum
    • Related Report
      2020 Research-status Report
  • [Presentation] Validation of the effectiveness of functional electric stimulation (FES) therapy by using fMRI and TMS: Interventional study on a traumatic brain injury patient2020

    • Author(s)
      Tomoya Nakanishi, Matija Milosevic, Atsushi Sasaki, Akiko Yamaguchi and Kimitaka Nakazawa
    • Organizer
      Japanese Society for Brain Function and Rehabilitation
    • Related Report
      2020 Research-status Report
  • [Presentation] Neurophysiology of brain-machine interface rehabilitation2020

    • Author(s)
      Matija Milosevic
    • Organizer
      42nd International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Neural interactions between the trunk and the upper-limb muscles in humans: Effects of cortical and subcortical contributions2020

    • Author(s)
      Atsushi Sasaki, Matija Milosevic and Kimitaka Nakazawa
    • Organizer
      13th FENS Forum
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Neuroplasticity after electrical stimulation of muscles and nerves2020

    • Author(s)
      Milosevic Matija
    • Organizer
      NYC Neuromodulation Online 2020 Conference
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neuromodulation technologies for restoration of upper-limb motor function2019

    • Author(s)
      Milosevic Matija
    • Organizer
      Kakunodate General Hospital, Akita, Japan
    • Related Report
      2019 Research-status Report
    • Invited

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Published: 2019-09-03   Modified: 2021-12-27  

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