• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Impact of a novel urate transporter on the regulation of the blood urate level.

Research Project

Project/Area Number 19K23793
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0801:Pharmaceutical sciences and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

MIYATA Hiroshi  東京大学, 医学部附属病院, 助教 (90844415)

Project Period (FY) 2019-08-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords尿酸 / トランスポーター / 遺伝子欠損マウス / CRISPR-Cas9 / 痛風 / 生活習慣病 / GLUT12/SLC2A12 / 新規薬効標的
Outline of Research at the Start

体内へ尿酸の蓄積は痛風の原因となるため、尿酸値を適切に保つことは疾患の予防の観点からも重要である。しかしながら、体内の尿酸値の制御メカニズムは十分に理解されていない。本研究では、着目する候補遺伝子が体内の尿酸値制御に関わるか否かを明らかにすることを目的とする。そのために、遺伝子改変技術を用いて当該候補遺伝子の遺伝子欠損マウスを作出する。候補遺伝子の有無で尿酸の体内での挙動を比較することで、体内の尿酸値制御において候補遺伝子が果たす役割を明らかにする。

Outline of Final Research Achievements

In this study, the physiological function of novel urate transporter GLUT12 was investigated. For this purpose, Glut12 knockout mice were developed and urate levels were compared with wild type mice. As a result, plasma urate levels of Glut12 knockout mice were higher than those in wild type mice. This study provides insights into the deeper understanding of the urate regulatory system in the body, which is also important for pathophysiology of gout/hyperuricemia.

Academic Significance and Societal Importance of the Research Achievements

高尿酸血症は痛風の危険因子となる一方、尿酸は抗酸化作用を有する化合物であり、適切な血中尿酸濃度を維持することは臨床上重要である。細胞膜を介した尿酸の輸送には輸送体の関与が必要であるものの、尿酸輸送体に関する理解は不十分であるのが現状である。本研究により生理的に重要な尿酸輸送体としてGLUT12が見出されたことは、尿酸の体内動態制御機構の理解という学術的興味のみならず、高尿酸血症や痛風の病態形成の理解といった臨床的観点での貢献も期待される。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (9 results)

All 2020 2019

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (7 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Journal Article] Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice.2020

    • Author(s)
      Toyoda Y, Takada T, Miyata H, Matsuo H, Kassai H, Nakao K, Nakatochi M, Kawamura Y, Shimizu S, Shinomiya N, Ichida K, Hosoyamada M, Aiba A, Suzuki H
    • Journal Title

      Proc. Natl.Acad. Sci. USA

      Volume: 117 Issue: 31 Pages: 18175-18177

    • DOI

      10.1073/pnas.2006958117

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber2020

    • Author(s)
      Saito Hiroki、Toyoda Yu、Takada Tappei、Hirata Hiroshi、Ota-Kontani Ami、Miyata Hiroshi、Kobayashi Naoyuki、Tsuchiya Youichi、Suzuki Hiroshi
    • Journal Title

      Nutrients

      Volume: 12 Issue: 6 Pages: 1601-1601

    • DOI

      10.3390/nu12061601

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] GLUT12/SLC2A12は血清尿酸値を制御する尿酸輸送体である2020

    • Author(s)
      宮田 大資、高田 龍平、豊田 優、鈴木 洋史
    • Organizer
      第5回トランスポーター研究会関東部会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Functional Cooperation of Physiological Urate Transporters and Their Modification by Food Components2020

    • Author(s)
      Takada Tappei, Toyoda Yu, Miyata Hiroshi, Satsu Hideo, Matsuo Hirotaka, Ichida Kimiyoshi, Suzuki Hiroshi
    • Organizer
      JAACT2020 Fuchu
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ABCG2 is a physiological exporter of indoxyl sulfate, and its dysfunction accelerates the progression of chronic kidney disease2020

    • Author(s)
      Yamamoto Takehito , Takada Tappei, Tan Jeng Kae, Miyata Hiroshi, Yamanashi Yoshihide, Toyoda Yu, Suzuki Hiroshi
    • Organizer
      FIP PSWC 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ゲノム解析により見出された尿酸トランスポーターと尿酸降下薬に関する研究2020

    • Author(s)
      高田龍平、宮田大資、豊田優、鈴木洋史
    • Organizer
      第30回日本医療薬学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ABCG2, a physiologically and pharmacologically important exporter in humans2020

    • Author(s)
      Tappei Takada, Yu Toyoda, Hiroshi Miyata, Hirotaka Matsuo, Kimiyoshi Ichida, Hiroshi Suzuki
    • Organizer
      8th FEBS Special Meeting: ABC Proteins : From Multidrug Resistance to Genetic Disease, Innsbruck, Austria.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 腸管・腎尿細管の尿酸輸送と高尿酸血症2019

    • Author(s)
      高田龍平、宮田大資、豊田優、山梨義英、山本武人、鈴木洋史
    • Organizer
      第50回日本消化吸収学会総会 羽田
    • Related Report
      2019 Research-status Report
  • [Presentation] 尿酸排出トランスポーターABCG2に関する生理学的・薬理学的研究2019

    • Author(s)
      高田龍平、宮田大資、豊田優、山梨義英、山本武人、鈴木洋史
    • Organizer
      生理研研究会『上皮膜・間質の機能連関と病態発現機構解明のためのストラテジー』 岡崎
    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-09-03   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi