Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Outline of Final Research Achievements |
We conducted genome-wide association studies of body weight of 20 years old in 17,231 male subjects and 28,464 female subjects from Tohoku Medical Megabank project. We extracted subjects in Japanese cluster by principal component analysis with 1000 genome projects phase 3 data. We identified total 13 loci at genome-wide significance (p<5x10-9), 11 loci (SEC16B, TMEM18, POMC, HMGA1, GRID1, ZNF143, METTL15, FAIM2, FTO, and MC4R) reached genome-wide significance in gender-combined analyses and two loci (NSD1 and LEP) in female only analyses. Conditional analyses did not detect secondary signals in these regions. Fine-mapping analyses detected four signals (LEP, GRID1, ZNF143, and FAIM2) for which less than ten variants accounted for more than 99% of the posterior probability of driving the association.
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