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Optimal physical activity for secondary prevention in coronary heart disease: a multicenter prospective cohort study

Research Project

Project/Area Number 19K24311
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0909:Sports sciences, physical education, health sciences, and related fields
Research InstitutionNagoya University

Principal Investigator

Takuji Adachi  名古屋大学, 医学系研究科(保健), 助教 (10849946)

Project Period (FY) 2019-08-30 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords心臓リハビリテーション / 重症化予防 / ライフスタイル / 身体活動量 / 冠動脈疾患 / 再発予防
Outline of Research at the Start

冠動脈疾患は、経皮的冠動脈形成術(percutaneous coronary intervention: PCI)の進歩に伴う救命率の飛躍的な改善に反して、長期的予後の改善が乏しい。その原因は、治療部位以外の動脈硬化が進行することにあり、再発予防のためには、薬物療法とともに根本的原因である生活習慣の改善が不可欠である。身体活動促進はその中核を成すが、冠動脈再狭窄の予防に効果的な身体活動は十分検討されておらず、特に、加速度計による客観的指標に基づく検討は少ない。そこで本研究では、PCI後の身体活動量を加速度計で測定し、冠動脈再狭窄や冠危険因子のコントロール状況との関連を検討する。

Outline of Final Research Achievements

Lifestyle modification to lower the risk of atherosclerosis progression is a key for secondary prevention of coronary heart disease. In particular, increasing physical activity is positioned as a core component of lifestyle modification. This multicenter prospective cohort study aimed to explore the effective physical activity levels for improving coronary risk factors such as hypertension, dyslipidemia, and diabetes mellitus. Patients underwent percutaneous coronary intervention were enrolled and asked to wear an accelerometer for consecutive seven days. We examined the association between post-discharge objective physical activity and control status of risk factors. As a result, patients not involved in the guidelines-recommended physical activity level (at least 150 minutes of moderate-intensity physical activity per week) showed the high prevalence of poorly controlled blood glucose levels.

Academic Significance and Societal Importance of the Research Achievements

身体活動をどの程度の強さでどれだけ実施すれば冠動脈疾患の再発リスクの低下に寄与するかは検討の余地がある。本研究では、加速度計を用いて冠動脈治療後の患者の身体活動量を客観的に測定し、動脈硬化の原因である高血圧、脂質異常症、糖尿病の管理状況との関連を分析した。
その結果、中等強度(例:早歩き)以上の強さで実施した身体活動時間が推奨量(150分/週)に達していない場合、空腹時血糖の高い者の割合が多かったが、歩数を指標とした場合にはこのような結果は確認できなかった。ある一定の強度以上の身体活動を意識したライフスタイル指導が重要となることを示唆した点で、臨床的意義は大きいと考えられる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (22 results)

All 2022 2021 2020 2019

All Journal Article (9 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (13 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Prognostic Effects of Cardiac Rehabilitation in Patients with Heart Failure (From a Multicenter Prospective Cohort Study)2022

    • Author(s)
      Takuji Adachi, Naoki Iritani, Kuniyasu Kamiya, Kotaro Iwatsu, Kenta Kamisaka, Yuki Iida, Sumio Yamada
    • Journal Title

      American Journal of Cardiology

      Volume: 164 Pages: 79-85

    • DOI

      10.1016/j.amjcard.2021.10.038

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of the Japanese version of Rapid Dementia Screening Test for mild cognitive impairment in older patients with cardiovascular disease: a cross-sectional study2021

    • Author(s)
      Takuji Adachi, Yuki Tsunekawa, Akihito Matsuoka, Daisuke Tanimura
    • Journal Title

      Journal of Geriatric Cardiology

      Volume: 18 Pages: 245-251

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 心血管疾患におけるリハビリテーションに関するガイドライン2021

    • Author(s)
      日本循環器学会
    • Journal Title

      -

      Volume: -

    • Related Report
      2020 Research-status Report
    • Open Access
  • [Journal Article] Association between Redox State of Human Serum Albumin and Exercise Capacity in Elderly Women: A Cross-Sectional Study2020

    • Author(s)
      Ashikawa H,Adachi T, Ueyama J, Yamada S
    • Journal Title

      Geriatr Gerontol Int

      Volume: 20 Issue: 3 Pages: 256-260

    • DOI

      10.1111/ggi.13849

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preferences for health information in middle-aged Japanese workers based on health literacy levels: a descriptive study2019

    • Author(s)
      Adachi T, Hori M, Ishimaru Y, Fujii T, Kondo T, Yamada S
    • Journal Title

      Public Health

      Volume: 174 Pages: 18-21

    • DOI

      10.1016/j.puhe.2019.05.036

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combined effects of obesity and objectively-measured physical activity on the risk of hypertension in middle-aged Japanese men: a 4-year prospective cohort study2019

    • Author(s)
      Adachi T, Kamiya K, Takagi D, Ashikawa H, Hori M, Kondo T, Yamada S
    • Journal Title

      Obes Res Clin Pract

      Volume: 13 Issue: 4 Pages: 365-370

    • DOI

      10.1016/j.orcp.2019.04.002

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 心不全におけるサルコペニア・フレイル2019

    • Author(s)
      足立拓史、山田純生
    • Journal Title

      JOURNAL OF CLINICAL REHABILITATION

      Volume: 28 Pages: 1080-1087

    • Related Report
      2019 Research-status Report
  • [Journal Article] 心不全におけるフレイル発生機序2019

    • Author(s)
      山田純生、足立拓史
    • Journal Title

      日本臨床生理学会雑誌

      Volume: 49 Pages: 125-129

    • NAID

      130007761249

    • Related Report
      2019 Research-status Report
  • [Journal Article] Maximal calf circumference reflects calf muscle mass measured using magnetic resonance imaging2019

    • Author(s)
      Asai C, Akao K, Adachi T, Iwatsu K, Fukuyama A, Ikeda M, Yamada S
    • Journal Title

      Arch Gerontol Geriatr

      Volume: 83 Pages: 175-178

    • DOI

      10.1016/j.archger.2019.04.012

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] 就業年層におけるbody mass indexと高血圧症重症化リスクとの関連:8年間の縦断的調査2021

    • Author(s)
      足立拓史、芦川博信、平松愛望、根岸真也、舟木空也、近藤諒、 小野哲也、井出光昭、今井俊博、永田博巳、荻上隆、近藤高明、山田純生
    • Organizer
      第57回日本循環器病予防学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Effects of cardiac rehabilitation on the two-year prognosis of patients with heart failure: a multicentre prospective cohort study2021

    • Author(s)
      Takuji Adachi, Naoki Iritani, Kuniyasu Kamiya, Kotaro Iwatsu, Kenta Kamisaka, Yuki Iida, Sumio Yamada
    • Organizer
      ESC Congress 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 心臓リハビリテーションの予後改善効果2021

    • Author(s)
      足立拓史、入谷直樹、神谷訓康、岩津弘太郎、上坂建太、飯田有輝、山田純生
    • Organizer
      第58回日本臨床生理学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 経皮的冠動脈形成術後患者における生活習慣指導への希望に関連する因子の探索2021

    • Author(s)
      舟木空哉、足立拓史、亀島匡高、藤山裕晃、入谷直樹、浅井千香子、作井大介、原康貴、芦川博信、山田純生
    • Organizer
      第57回日本循環器病予防学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Usefulness of the Japanese version of Rapid Dementia Screening Test for mild cognitive impairment in older patients with cardiovascular disease2021

    • Author(s)
      Takuji Adachi, Yuki Tsunekawa, Akihito Matsuoka, Daisuke Tanimura
    • Organizer
      EuroHeartCare 2021
    • Related Report
      2020 Research-status Report
  • [Presentation] Association between Big Five personality traits and participation in cardiac rehabilitation in Japanese patients with cardiovascular disease: a longitudinal study2021

    • Author(s)
      Takuji Adachi, Yuki Tsunekawa, Akihito Matsuoka, Daisuke Tanimura
    • Organizer
      EuroHeartCare 2021
    • Related Report
      2020 Research-status Report
  • [Presentation] Weight loss early after discharge predicts the risk of rehospitalization in non-obese patients with heart failure preserved ejection fraction2020

    • Author(s)
      K Kamisaka, K Kamiya, K Iwatsu, N Iritani, Y Iida, T Adachi, S Yamada, on behalf of the FLAGSHIP collaborators
    • Organizer
      ESC Congress 2020
    • Related Report
      2020 Research-status Report
  • [Presentation] Predictors of physical activity at 3-month after discharge in patients underwent percutaneous coronary intervention : a multicenter prospective cohort study2020

    • Author(s)
      Kuya Funaki, Takuji Adachi, Masataka Kameshima, Hiroaki Fujiyama, Naoki Iritani, Chikako Asai, Daisuke Sakui, Yasutaka Hara, Sumio Yamada
    • Organizer
      ESC Congress 2020
    • Related Report
      2020 Research-status Report
  • [Presentation] 高 BMI と冠危険因子を併存する就業者の減量行動に対する教育教材の効果: 予備的ランダム化比較試験2020

    • Author(s)
      根岸 真也,足立 拓史,舟木 空哉,小野 哲也,井出 光昭,今井 俊博,永田 博巳,近藤 高明,山田 純生
    • Organizer
      第56回日本循環器病予防学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Objectively measured daily physical activity and mobility function in community-dwelling older women aged 75 or over2019

    • Author(s)
      Adachi T, Yamada S
    • Organizer
      International Geriatric Physical Therapy Conference
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of continuous neuromuscular electrical stimulation on low frequency fatigue: A descriptive study2019

    • Author(s)
      Funaki K, Adachi T, Yamada S
    • Organizer
      International Geriatric Physical Therapy Conference
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 心不全患者の外来心臓リハビリテーション不参加要因の検討:FLAGSHIP studyからの報告2019

    • Author(s)
      入谷直樹、岩津弘太郎、上坂健太、神谷訓康、飯田有輝、井本晶太、足立拓史、山田純生
    • Organizer
      日本心不全学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Salt sensitivity may be increased by high body mass index score and low level of physical activity2019

    • Author(s)
      足立拓史
    • Organizer
      日本臨床生理学会総会(第24回日本臨床生理学会優秀論文賞講演)
    • Related Report
      2019 Research-status Report

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Published: 2019-09-03   Modified: 2024-12-25  

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