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Designing Super-survival System by Studying Bacterial Biofilm Formation

Research Project

Project/Area Number 19KK0103
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 21:Electrical and electronic engineering and related fields
Research InstitutionTohoku University

Principal Investigator

Kano Takeshi  東北大学, 電気通信研究所, 准教授 (80513069)

Co-Investigator(Kenkyū-buntansha) 福原 洸  東北大学, 電気通信研究所, 助教 (10827611)
石黒 章夫  東北大学, 電気通信研究所, 教授 (90232280)
安井 浩太郎  東北大学, 学際科学フロンティア研究所, 助教 (70876739)
Project Period (FY) 2019-10-07 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2022: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2021: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2020: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords自律分散制御 / バイオフィルム / サバイバビリティ / イトミミズ / チスイコウモリ / COVID-19 / 蝋燭振動子 / バクテリア / 自律分散システム
Outline of Research at the Start

本研究では,環境への適応戦略を自律的に創出し,過酷な環境下でも機能する「サバイバビリティ」の高い人工物システムの革新的設計論構築を目指す.目的達成のため,複数のバクテリアの相互作用により自己組織的に形成された構造体であるバイオフィルムに着目する.バクテリアを用いた生物実験と数理モデリングによりサバイバル戦略を創発可能なシステムの設計論を構築し,さらにその設計論を用いて過酷な環境に耐え得る人工物を実世界実現する.

Outline of Final Research Achievements

The aim is to construct a design theory for artificial systems with high "survivability", which autonomously generates adaptive strategies to the environment and effectively functions even under harsh conditions. To achieve this goal, together with Dr. Asally from the UK, we explored the principles of environmental adaptation strategies demonstrated by bacterial biofilms. While the initially planned evolutionary experiments with bacteria were abandoned, we extracted the essence of altruistic strategies, where individual cells of the population coexist by temporarily restricting nutrient intake, through mathematical modeling, and successfully reproduced their behavior through simulation. Furthermore, we investigated the mechanisms of survivability in life and social systems such as water fleas, pipistrelle bats, and the COVID-19 pandemic, paving the way towards systematic design theory construction.

Academic Significance and Societal Importance of the Research Achievements

従来の人工物は想定環境下で優れた機能を発揮できるものの,予期せぬ事態が起こりうる環境下で機能し続けるのは困難であった.本研究は,環境への適応戦略を自律的に創出し,過酷な環境下でも機能する「サバイバビリティ」の高い人工物システムの構築につながるものである.バクテリアは原初的な生物であるにもかかわらず,飢餓状態にある他の細胞を助けるために自身の餌摂取を控えるという利他的な戦略をとっており,その枠組みを数理で抽出できたことは意義深い.また,バクテリア以外のシステムのサバイバビリティ実現戦略も明らかにしており,異なるシステムをつなぐ原理の抽出は今後の人工物の適応能力の飛躍的向上につながると期待される.

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (22 results)

All 2024 2023 2022 2021 2020 Other

All Int'l Joint Research (5 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (14 results) (of which Int'l Joint Research: 6 results,  Invited: 2 results)

  • [Int'l Joint Research] University of Warwick(英国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] University of Warwick(英国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] University of Warwick(英国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] University of Warwick(英国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] University of Warwick(英国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Designing Decentralized Systems with High Survivability Inspired by Altruistic Social Interactions of Vampire Bats2024

    • Author(s)
      Takeshi Kano, Shokichi Kawamura, Taishi Mikami, Daiki Wakita, Akio Ishiguro
    • Journal Title

      Journal of Robotics and Mechatronics (accepted)

      Volume: -

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elongating, entwining, and dragging: mechanism for adaptive locomotion of tubificine worm blobs in a confined environment2023

    • Author(s)
      Mikami Taishi、Wakita Daiki、Kobayashi Ryo、Ishiguro Akio、Kano Takeshi
    • Journal Title

      Frontiers in Neurorobotics

      Volume: 17 Pages: 1207374-1207374

    • DOI

      10.3389/fnbot.2023.1207374

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An agent-based model of the interrelation between the COVID-19 outbreak and economic activities2021

    • Author(s)
      T. Kano, K. Yasui, T. Mikami, M. Asally, and A. Ishiguro
    • Journal Title

      Proceedings of the Royal Society A

      Volume: 477 Issue: 2245 Pages: 20200604-20200604

    • DOI

      10.1098/rspa.2020.0604

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Decoding essential mechanism for adaptive locomotion of tubificine worm blobs on confined environment2023

    • Author(s)
      Takeshi Kano, Taishi Mikami, Daiki Wakita, Ryo Kobayashi, Akio Ishiguro
    • Organizer
      6th Yamada Symposium on "Diversity of Biological Patterns and Forms in Nature: toward a Comprehensive Understanding"
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] チスイコウモリのコミュニティ形成から学ぶサバイバビリティの高い自律分散システムの設計論2023

    • Author(s)
      川村松吉, 脇田大輝, 三上大志, 石黒章夫, 加納剛史
    • Organizer
      第35回自律分散システム・シンポジウム
    • Related Report
      2022 Research-status Report
  • [Presentation] イトミミズ塊が示す不整地を活用した集団移動に内在する自律分散制御則2023

    • Author(s)
      三上大志, 脇田大輝, 小林亮, 石黒章夫, 加納剛史
    • Organizer
      第35回自律分散システム・シンポジウム
    • Related Report
      2022 Research-status Report
  • [Presentation] Toward Realization of Highly Survivable Engineering Systems: A Simple Mathematical Model of Social Interactions among Vampire Bats2022

    • Author(s)
      T. Kano, S. Kawamura, T. Mikami, A. Ishiguro
    • Organizer
      The 2022 Conference on Artificial Life, ABMHuB 2022 workshop
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 「絡まり,ほどけ,そして動き回る」:イトミミズ塊に学ぶ 超不定形群ロボットの設計方策2022

    • Author(s)
      三上大志, 加納剛史, 小林亮, 石黒章夫
    • Organizer
      ロボティクス・メカトロニクス講演会2022
    • Related Report
      2022 Research-status Report
  • [Presentation] 新たな自律分散制御の枠組みの構築を目指して~理学・工学の垣根を超えたアプローチ~2022

    • Author(s)
      加納剛史
    • Organizer
      第2回 トータルバイオミメティクス研究グループ 合同シンポジウム,「バイオミメティクスと群知能」
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 自律分散制御のあり方を問う2022

    • Author(s)
      加納剛史
    • Organizer
      新学術領域研究「細胞社会ダイバーシティーの統合的解明と制御」第4回若手ワークショップ
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Simple mathematical model for COVID-19 outbreak considering economic activities2021

    • Author(s)
      T. Kano, K. Yasui, T. Mikami, M. Asally, A. Ishiguro
    • Organizer
      The 15th International Symposium on Distributed Autonomous Robotic Systems 2021 The 4th International Symposium on Swarm Behavior and Bio-Inspired Robotics 2021 (DARS-SWARM2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mitigation of COVID-19 outbreak while continuing economic activities2021

    • Author(s)
      T. Kano, K. Yasui, T. Mikami, M. Asally, A. Ishiguro
    • Organizer
      The 2021 conference on Artificial Life, ABMHuB 2021 workshop
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] How to Mitigate the COVID-19 Outbreak While Maintaining Economic Activities?2021

    • Author(s)
      T. Kano, K. Yasui, T. Mikami, M. Asally, A. Ishiguro
    • Organizer
      The Conference on Complex Systems 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] バイオフィルムの振動的拡大現象を再現するシンプルな反応拡散モデル2021

    • Author(s)
      三上大志,浅利宗弘,加納剛史,石黒章夫
    • Organizer
      数理生物学会年会・企画シンポジウム「生物学・数理科学・ロボット工学の融合」
    • Related Report
      2021 Research-status Report
  • [Presentation] One-dimensional reaction-diffusion model for intra- and inter- biofilm oscillatory dynamics2020

    • Author(s)
      T. Mikami, M. Asally, T. Kano, A. Ishiguro
    • Organizer
      The 2020 Conference on Artificial Life
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 経済活動を考慮したCOVID-19流行の数理モデル2020

    • Author(s)
      加納剛史,安井浩太郎,三上大志,浅利宗弘,石黒章夫
    • Organizer
      日本数理生物学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] バイオフィルムのパターン形成を予測する反応拡散モデル2020

    • Author(s)
      三上大志,浅利宗弘,加納剛史,石黒章夫
    • Organizer
      日本数理生物学会年会
    • Related Report
      2020 Research-status Report

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Published: 2019-10-10   Modified: 2025-01-30  

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