| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2023: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2022: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Based on the structural analysis of Cu/Zn superoxide dismutase (SOD1), we synthesized a candidate compound that stabilizes SOD1 by expanding the structure of ebselen, a small molecule compound that binds to SOD1. We synthesized a candidate compound that stabilizes SOD1. Through screening ebselen analogues, we demonstrated that these compounds have neuroprotective effects against toxicity induced by mutant proteins in cultured neurons and amyotrophic lateral sclerosis (ALS) mice. Through this project, researchers in structural biology and neuroscience from the U.K. and Japan exchanged academic ideas and published the results in an international joint research paper.
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