Biological effects of radioactive MnO2 particles

• Project/Area Number: 19KK0266
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 63:Environmental analyses and evaluation and related fields
• Research Institution: Hiroshima University
• Principal Investigator: 藤本 成明 広島大学, 原爆放射線医科学研究所, 准教授 (40243612)
• Co-Investigator(Kenkyū-buntansha): ムサジャノワ ジャンナ 長崎大学, 原爆後障害医療研究所, 助教 (30770432) ; 佐藤 斉 茨城県立医療大学, 保健医療学部, 教授 (90285057) ; 星 正治 広島大学, 平和センター, 名誉教授 (50099090)
• Project Period (FY): 2019-10-07 – 2024-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2022: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2021: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2020: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 放射性微粒子被曝影響 / 放射性マンガン / 内部被曝 / 放射線微粒子被曝影響 / 放射線マンガン / 放射性マンガン微粒子内部被ばく / 放射性微粒子曝露影響 / マウス / 放射性微粒子 / 内部被曝影響 / 二酸化マンガン

Outline of Research at the Start

放射線の影響を理解するためには、外部被曝ばかりでなく内部被曝の影響評価が重要であるが、現在のところ、防護上で両者の影響は同等とされている。最近、我々は放射性微粒子による内部被曝が強い生物学的影響を示す場合があることを報告した。本研究では、この内部被曝実験を展開し、分子生物学的解析によりその障害作用とメカニズムの詳細を解明することを目的とする。本研究は放射線被曝の防護と安全に関わる極めて重要な国際共同研究である。

Outline of Annual Research Achievements

放射線被曝影響評価では、放射性微粒子による内部被曝影響は外部被曝と同じとされている。しかし、原爆被曝者の疫学データやカザフスタン核実験場周辺の健康調査は、残留放射性物質の内部被曝の健康リスクが大きいことを示している。よって、ヒト被曝影響の正確な評価と被曝防護のためには、その影響を確定する必要がある。本研究は、原爆爆発時に土埃で多量に生成した放射性二酸化マンガン（56MnO2）をモデルとし、放射性微粒子の曝露影響を動物試験によって明らかにすることを目的とする。曝露試験が可能な施設を持つカザフスタンとの国際共同研究により実施する。
2022年度は、カザフスタンではCOVID-19のパンデミックは終結したが、日本政府はカザフスタンの感染危険レベルを２として維持し、日本人も含めた日本への入国制限も継続したため人的研究交流が難しい状況が続いた。しかし本研究課題のマウスを用いた56Mn曝露試験について最初の解析を完了した。
カザフスタン国立核研究センターの原子炉の中性子線によりMnO2微粒子を放射化し、雄C57BLマウスへ曝露した。主要臓器の放射活性を基に、臓器ごとの吸収線量を推計した。曝露後3日、14日、70日後の肺および精巣への生物学的影響について検索した。1) 臓器別の吸収線量の分布は、これまでのラットと同様に消化管で高く、続いて肺・皮膚の順であった。2) 肺での56Mn曝露線量は250mGy以下であったが、病理生理指標であるアクアポリン１発現が上昇しており影響が示された。2Gyの外部被曝ではこの変化は見られず、MnO2微粒子内部被曝のより高い生物影響が示唆された。3) 精巣への影響は、病理学的/遺伝子発現解析では見いだされなかった。Wistarラットでは、56Mn曝露のステロイドホルモン産生酵素への影響が顕著であったが、C57BLは「耐性」であった。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

COVID-19パンデミックの影響で、予定していたマウスへの放射性マンガン微粒子曝露実験の解析が遅れているため。しかし第一回目の曝露試験については、解析が完了し成果を得て発表した。

Strategy for Future Research Activity

マウスをモデルとした56MnO2微粒子内部被曝による生物影響解析をさらに進めるため、「放射線高感受性」の系統であるBalb/cマウスへの曝露実験により、C57BLとの比較解析を行う。これまでと同様に、臓器毎の線量推定、組織での放射線応答性遺伝子発現解析を行い、56MnO2微粒子内部被曝影響およびマウス系統差を解明する予定である。

Research Products

• [Int'l Joint Research] Semey Medical University/Eurasian University/Kazakhstan National Nuclear Center(カザフスタン)
• [Int'l Joint Research] Semey Medical University/Eurasian University/Kazkhstan National Nuclear Center(カザフスタン)
• [Int'l Joint Research] Semey Medical University/Eurasian University/Kazakhstan National Nuclear Center(カザフスタン)
• [Int'l Joint Research] National Med Res Center of Radiology(ロシア連邦)
• [Int'l Joint Research] Semey Medical University/Eurasian University/Kazakhstan National Nuclear Center(カザフスタン)
• [Int'l Joint Research] Medical Radiological Research Center(ロシア連邦)
• [Journal Article] Changes in the characteristics of suicide in Japan in the third year of the COVID-19 pandemic and the importance of continued suicide prevention measures. (2023)
  • Author(s): Inoue K, et al.
  • Journal Title: Med Sci Law Volume: in press Issue: 1 Pages: 1-2
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• [Journal Article] External dose estimates of laboratory rats and mice during exposure to dispersed neutron-activated 56Mn powder. (2022)
  • Author(s): Stepanenko V, Sato H, Fujimoto N, Shichijo K, Toyoda S, Kawano N, Endo S, Kaprin A, Ivanov S, Shegay P, Petukhov A
  • Journal Title: Journal of Radiation Research Volume: 63(S1) Issue: Supplement_1 Pages: i16-i20
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• [Journal Article] Microdistribution of internal radiation dose in biological tissues exposed to 56Mn dioxide microparticles. (2022)
  • Author(s): Stepanenko V, Kaprin A, Ivanov S, Shegay P, Viktoria B, Sato H, Shichijo K, Toyoda S, Kawano N, Ohtaki M, Fujimoto N, Endo S, Chaizhunusova N, Shabdarbaeva D, Zhumadilov K, Hoshi M
  • Journal Title: Journal of Radiation Research Volume: 63(S1) Issue: Supplement_1 Pages: i21-i25
  • DOI: 10.1093/jrr/rrac023
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of internal exposure to neutron-activated 56MnO2 powder on locomotor activity in rats (2022)
  • Author(s): Otani Keiko、Ohtaki Megu、Fujimoto Nariaki、Uzbekov Darkhan、Kairkhanova Ynkar、Saimova Aisulu、Chaizhunusova Nailya、Habdarbaeva Dariya、Azhimkhanov Almas、Zhumadilov Kassym、Stepanenko Valeriy、Hoshi Masaharu
  • Journal Title: Journal of Radiation Research Volume: 63 Issue: Supplement_1 Pages: i38-i44
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• [Journal Article] Estimation of ‘dose-depth’ profile in the surface layers of a quartz-containing tile from the former Hiroshima University building indicates the possible presence of beta-irradiation from residual radioactivity after A-bombing (2022)
  • Author(s): Stepanenko Valeriy、Kaprin Andrey、Ivanov Sergey、Shegay Peter、Sato Hitoshi、Toyoda Shin、Kawano Noriyuki、Fujimoto Nariaki、Endo Satoru、Bogacheva Viktoria、Kolyzhenkov Timofey、Khailov Artem、Zhumadilov Kassym、Zhumalina Aidana、Yerimbetova Dana、Hoshi Masaharu
  • Journal Title: Journal of Radiation Research Volume: 63 Issue: Supplement_1 Pages: i54-i60
  • DOI: 10.1093/jrr/rrac029
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Molecular Pathological Characteristics of Thyroid Follicular-Patterned Tumors Showing Nodule-in-Nodule Appearance with Poorly Differentiated Component (2022)
  • Author(s): Ueda Mayu、Matsuda Katsuya、Kurohama Hirokazu、Mussazhanova Zhanna、Sailaubekova Yerkezhan、Kondo Hisayoshi、Shimizu Tomoki、Takada Nami、Matsuoka Yuki、Otsubo Chieko、Sato Shinya、Yamashita Hiroyuki、Kawakami Atsushi、Nakashima Masahiro
  • Journal Title: Cancers Volume: 14 Issue: 15 Pages: 3577-3577
  • DOI: 10.3390/cancers14153577
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Overview and analysis of internal radiation dose estimates in experimental animals in a framework of international studies of the sprayed neutron-induced 56Mn radioactive microparticles effects (2022)
  • Author(s): Stepanenko Valeriy、Kaprin Andrey、Ivanov Sergey、Shegay Peter、Bogacheva Viktoria、Hoshi Masaharu
  • Journal Title: Journal of Radiation Research Volume: 63 Issue: Supplement_1 Pages: i8-i15
  • DOI: 10.1093/jrr/rrac043
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The overview of neutron-induced 56Mn radioactive microparticle effects in experimental animals and related studies (2022)
  • Author(s): Hoshi Masaharu
  • Journal Title: Journal of Radiation Research Volume: 63 Issue: Supplement_1 Pages: i1-i7
  • DOI: 10.1093/jrr/rrac020
  • Peer Reviewed / Open Access
• [Journal Article] Tooth enamel ESR dosimetry for Hiroshima ‘black rain’ zone residents (2022)
  • Author(s): Zhumadilov Kassym、Ivannikov Alexander、Stepanenko Valeriy、Toyoda Shin、Kazymbet Polat、Kaprin Andrey、Ivanov Sergey、Shegay Peter、Endo Satoru、Hoshi Masaharu
  • Journal Title: Journal of Radiation Research Volume: 63 Issue: Supplement_1 Pages: i61-i65
  • DOI: 10.1093/jrr/rrac024
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Studies on Gamma Dose Rates in Outdoor Environment and Assessment of External Exposure to Public in Stepnogorsk Area, Northern Kazakhstan (2022)
  • Author(s): Ibrayeva Danara、Ilbekova Kuralay、Aumalikova Moldir、Kazymbet Polat、Zhumadilov Kassym、Bakhtin Meirat、Hoshi Masaharu
  • Journal Title: Radiation Protection Dosimetry Volume: 198 Pages: 1387-1398
  • DOI: 10.1093/rpd/ncac180
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationships Between Types of Protective Eyewear and Eye Lens Dose Within Endoscopic Retrograde Cholangiopancreatography (2022)
  • Author(s): Nakajima Erika、Sato Hitoshi
  • Journal Title: Radiation Protection Dosimetry Volume: 198 Pages: 1399-1408
  • DOI: 10.1093/rpd/ncac181
  • Peer Reviewed
• [Journal Article] Suicides following an earthquake: Japanese proposals arising from post-earthquake analyses. (2021)
  • Author(s): Inoue K, et al.
  • Journal Title: Med Sci Law. Volume: in press Issue: 2 Pages: 158-159
  • DOI: 10.1177/00258024211049598
  • Peer Reviewed / Open Access
• [Journal Article] Biological impacts on the lungs in rats internally exposed to radioactive 56MnO2 particle (2021)
  • Author(s): Fujimoto Nariaki、Ruslanova Bakhyt、Abishev Zhaslan、Chaizhunussova Nailya、Shabdarbayeva Dariya、Amantayeva Gaukhar、Farida Rakhimzhanova、Sandybayev Marat、Nagano Kasuke、Zhumadilov Kassym、Kaprin Andrey、Ivanov Sergey、Stepanenko Valeriy、Hoshi Masaharu
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 11055-11055
  • DOI: 10.1038/s41598-021-90443-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hepatic Gene Expression Changes in Rats Internally Exposed to Radioactive 56MnO2 Particles at Low Doses (2021)
  • Author(s): Ruslanova Bakhyt、Abishev Zhaslan、Chaizhunussova Nailya、Shabdarbayeva Dariya、Tokesheva Sholpan、Amantayeva Gaukhar、Kairkhanova Ynkar、Stepanenko Valeriy、Hoshi Masaharu、Fujimoto Nariaki
  • Journal Title: Current Issues in Molecular Biology Volume: 43 Issue: 2 Pages: 758-766
  • DOI: 10.3390/cimb43020055
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid (2021)
  • Author(s): Matsuyama M, Shichijo K, Matsuda K, Fujimoto N, Kondo H, Miura S, Kurashige T, Nagayama Y, Nakashima M.
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 19096-19096
  • DOI: 10.1038/s41598-021-98481-z
  • NAID: 120007175565
  • Peer Reviewed / Open Access
• [Journal Article] Single neonatal irradiation induces long-term gene expression changes in the thyroid gland, which may be involved in the tumorigenesis (2021)
  • Author(s): Fujimoto Nariaki、Matsuu-Matsuyama Mutsumi、Nakashima Masahiro
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 23620-23620
  • DOI: 10.1038/s41598-021-03012-5
  • Peer Reviewed / Open Access
• [Journal Article] 53BP1 expression as a biomarker to differentiate thyroid follicular tumors (2021)
  • Author(s): Sato Ayako、Matsuda Katsuya、Motoyama Takahiro、Mussazhanova Zhanna、Otsubo Ryota、Kondo Hisayoshi、Akazawa Yuko、Higuchi Miyoko、Suzuki Ayana、Hirokawa Mitsuyoshi、Miyauchi Akira、Nagayasu Takeshi、Nakashima Masahiro
  • Journal Title: Endocrine Connections Volume: 10 Issue: 3 Pages: 309-315
  • DOI: 10.1530/ec-20-0630
  • Peer Reviewed / Open Access
• [Journal Article] The Contribution of Genetic Variants to the Risk of Papillary Thyroid Carcinoma in the Kazakh Population: Study of Common Single Nucleotide Polymorphisms and Their Clinicopathological Correlations (2021)
  • Author(s): Mussazhanova Z, Rogounovitch TI, Saenko VA, Krykpayeva A, Espenbetova M, Azizov B, Kondo H, Matsuda K, Kalmatayeva Z, Issayeva R, Yeleubayeva Z, Madiyeva M, Mukanova A, Sandybayev M, Bolsynbekova S, Kozykenova Z, Yamashita S, Nakashima M.
  • Journal Title: Front Endocrinol (Lausanne) Volume: 11 Pages: 1-10
  • DOI: 10.3389/fendo.2020.543500
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An Exploration of the Labor, Financial, and Economic Factors Related to Suicide in the Republic of Kazakhstan. (2021)
  • Author(s): Inoue K, et al.
  • Journal Title: Int J Environ Res Public Health. Volume: 18 Issue: 13 Pages: 6992-6992
  • DOI: 10.3390/ijerph18136992
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Early detection of excessive stress in people due to the ongoing COVID-19 pandemic: studies including those using biological markers. (2021)
  • Author(s): Fujita Y, Inoue K, et al.
  • Journal Title: Int Marit Health. Volume: 72 Issue: 2 Pages: 143-144
  • DOI: 10.5603/imh.2021.0025
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A combined scientific and public health approach is needed to evaluate the health impacts of internal exposure to radiation (2021)
  • Author(s): Ken Inoue, Noriyuki Kawano, Nobuo Takeichi, Yoshihiro Noso, Masaharu Hoshi
  • Journal Title: The Lancet Regional Health - Western Pacific Volume: 15 Pages: 1-2
  • DOI: 10.1016/j.lanwpc.2021.100296
  • Peer Reviewed / Open Access
• [Journal Article] Characteristic evaluation of a simple hand-made semiconductor dosimeter for mammography (2021)
  • Author(s): Nakajima Erika、Yamashita Hiromi、Sato Hitoshi
  • Journal Title: Journal of Radiological Protection Volume: 41 Issue: 4 Pages: 1018-1033
  • DOI: 10.1088/1361-6498/ac20b2
  • Peer Reviewed
• [Journal Article] Occupational eye lens dose in endoscopic retrograde cholangiopancreatography using a dedicated eye lens dosimeter (2021)
  • Author(s): Imai Shinya、Akahane Manabu、Ogata Yuji、Tanki Nobuyoshi、Sato Hitoshi、Tameike Kazuma
  • Journal Title: Journal of Radiological Protection Volume: 41 Issue: 3 Pages: 579-589
  • DOI: 10.1088/1361-6498/ac091f
  • Peer Reviewed
• [Journal Article] ESR tooth enamel doses of rats and mice exposed to radioactive 56MnO2 dust (2021)
  • Author(s): Azumi Todaka, Shin Toyoda, Nariaki Fujimoto, Hitoshi Saito, Valeriy tepanenko, Noriyuki Kawano, Nailya Chaizhunusova, Darkhan Uzbekov, Ynkar Kairkhanova, Bakhyt Ruslanova,Zhaslan Abishev, Gaukhar Amantayeva, Dariya Shabdarbaeva, Kassym Zhumadilov,Almas Azhimkhanov, Masaharu Hoshi
  • Journal Title: Advances in ESR Applications Volume: 37 Pages: 13-18
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Low-Dose Radiation Exposure with 56MnO2 Powder Changes Gene Expressions in the Testes and the Prostate in Rats (2020)
  • Author(s): Fujimoto Nariaki、Amantayeva Gaukhar、Chaizhunussova Nailya、Shabdarbayeva Dariya、Abishev Zhaslan、Ruslanova Bakhyt、Zhunussov Yersin、Azhimkhanov Almas、Zhumadilov Kassym、Petukhov Aleksey、Stepanenko Valeriy、Hoshi Masaharu
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 14 Pages: 4989-4989
  • DOI: 10.3390/ijms21144989
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Internal doses in experimental mice and rats following various exposures to neutron-activated 56Mn02 powder: results of international multicenter study (2020)
  • Author(s): Stepanenko V, Zhumadilov K, Hoshi M, Zhunussov YT, Endo S, Ohtaki M, Otani M, Fujimoto N, Shichijo K, Kawano N, Sakaguchi A, Chaizhunusova N, Shabdarbaeva D, Gnyrya V, Аzimkhanov A, Kaprin A, Ivanov S, Yaskova E, Belukha I, Kolyzhenkov T, Petukhov A , Bogacheva V.
  • Journal Title: Radiation and Environmental Biophysics Volume: 59 Issue: 4 Pages: 683-692
  • DOI: 10.1007/s00411-020-00870-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantitative Analysis of Effects of a Single 60Co Gamma Ray Point Exposure on Time-Dependent Change in Locomotor Activity in Rats (2020)
  • Author(s): Otani Keiko、Ohtaki Megu、Fujimoto Nariaki、Saimova Aisulu、Chaizhunusova Nailya、Rakhypbekov Tolebay、Sato Hitoshi、Kawano Noriyuki、Hoshi Masaharu
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 17 Issue: 16 Pages: 5638-5638
  • DOI: 10.3390/ijerph17165638
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Causative role for defective expression of mitochondria-eating protein in accumulation of mitochondria in thyroid oncocytic cell tumors. (2020)
  • Author(s): Mussazhanova Z, Shimamura M, Kurashige T, Ito M, Nakashima M, Nagayama Y
  • Journal Title: Cancer Sci. Volume: 111 Issue: 8 Pages: 2814-2823
  • DOI: 10.1111/cas.14501
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cutaneous pilomatrical carcinosarcoma: a case report with molecular analysis and literature review (2020)
  • Author(s): Luong Thi My Hanh、Akazawa Yuko、Mussazhanova Zhanna、Matsuda Katsuya、Ueki Nozomi、Miura Shiro、Hara Toshihide、Yokoyama Hiroko、Nakashima Masahiro
  • Journal Title: Diagnostic Pathology Volume: 15 Issue: 1 Pages: 7-7
  • DOI: 10.1186/s13000-020-0925-y
  • Peer Reviewed / Open Access
• [Journal Article] Impact of local high doses of radiation by neutron activated Mn dioxide powder in rat lungs: Protracted pathologic damage initiated by internal exposure. (2020)
  • Author(s): Shichijo K, Takatsuji T, Abishev Z, Uzbekov D, Chaizhunusova N, Shabdarbaeva D, Niino D, Kurisu M, Takahashi Y, Stepanenko V, Azhimkhanov A, Hoshi M.
  • Journal Title: Biomedicines Volume: 8 Issue: 6 Pages: 171-171
  • DOI: 10.3390/biomedicines8060171
  • NAID: 120006988116
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of Internal Exposure to 56MnO2 Powder on Blood Parameters in Rats (2020)
  • Author(s): Fujimoto N, Baurzhan A, Chaizhunusova N, Amantayeva G, Kairkhanova Y, Shabdarbaeva D, Zhunussov Y, Zhumadilov K, Stepanenko V, Gnyrya V, Azhimkhanov A, Kolbayenkov A, Hoshi M.
  • Journal Title: The Eurasian Journal of Medicine Volume: 52 Issue: 1 Pages: 52-56
  • DOI: 10.5152/eurasianjmed.2020.19228
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Preliminary assessment of dose distribution on the spatial micro level for internal exposure of alveolar epithelium of rats by 56M (2019)
  • Author(s): Stepanenko V, Zhumadilov K, Hoshi M, Zhunussov YT, Endo S, Ohtaki M, Otani M, Fujimoto N, Shichijo K, Kawano N, Sakaguchi A, Chaizhunusova N, Shabdarbaeva D, Gnyrya V, Аzimkhanov A, Kaprin A, Ivanov S, Yaskova E, Belukha I, Kolyzhenkov T, Petukhov A , Bogacheva V.
  • Journal Title: Bulletin of the Karaganda University. "Physics" Series Volume: 95 Issue: 3 Pages: 59-63
  • DOI: 10.31489/2019ph3/59-63
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] ラット新生仔期被曝による甲状腺腫瘍化に関与する遺伝子発現変化II低ヨード腫瘍化モデルの解析 (2022)
  • Author(s): 藤本成明, 松山睦美, 中島正洋
  • Organizer: 第95回日本内分泌学会学術総会
• [Presentation] ラット新生仔期被曝による甲状腺の遺伝子発現変化と腫瘍化 (2022)
  • Author(s): 藤本成明, 松山睦美, 中島正洋
  • Organizer: 第6回放射線災害・医科学研究拠点カンファランス
• [Presentation] Single neonatal irradiation induces long-term morphological and gene expression changes in the thyroid of rats - a possible mechanism of thyroid carcinogenesis by childhood radiation (2022)
  • Author(s): Fujimoto N
  • Organizer: International Conference - Modern Perspectives for Biomedical Sciences
  • Int'l Joint Research / Invited
• [Presentation] 充実性成分を呈する結節内結節型甲状腺結節の分子病理学的特徴解析 (2022)
  • Author(s): 松田勝也, 上田真由, Mussazhanova Zhanna, Saiaubekova Yerkezhan, 黒濵大和, 松岡優毅,大坪智恵子, 佐藤伸也, 山下弘幸, 中島正洋
  • Organizer: 第111回日本病理学会総会
• [Presentation] 低分化成分を有する非浸潤性甲状腺結節の分子病理学的特徴解析 (2022)
  • Author(s): 上田真由, 松田勝也, 黒濵大和, Mussazhanova Zhanna, Yerkezhan Sailaubekova, 近藤久義, 松岡優毅, 大坪智恵子, 佐藤信也, 山下弘幸, 川上 純, 中島正洋
  • Organizer: 第9回日本甲状腺病理学会学術集会
• [Presentation] Molecular Pathological Characteristics of Benign Thyroid Nodules with Poorly Differentiated Component (2022)
  • Author(s): Ueda M, Matsuda K, Kurohama H, Mussazhanova Z, Sailaubekova Y, Kondo H, Matsuoka Y, Otsubo C, Sato S, Yamashita H, Kawakami A, Nakashima M
  • Organizer: 34th European Congress of Pathology
  • Int'l Joint Research
• [Presentation] 低分化成分を有する結節内結節型甲状腺良性結節の分子病理学的特徴解析 (2022)
  • Author(s): 上田真由, 松田勝也, 黒濵大和, Mussazhanova Zhanna, Yerkezhan Sailaubekova, 近藤久義, 松岡優毅, 大坪智恵子, 佐藤信也, 山下弘幸, 川上 純, 中島正洋
  • Organizer: 第65回日本甲状腺学会学術集会
• [Presentation] A new indicator to differentiate thyroid follicular inclusions in the cervical lymph nodes from patients with thyroid cancer (2022)
  • Author(s): Mussazhanova Z, Otsubo C, Kurohama H, Shalgimbayeva G, Ueki N, Matsuoka Y, Madiyeva M, Sato S, Yamashita H, Nakashima M
  • Organizer: Scientific and practical aspects of the treatment and diagnosis of oncological diseases
  • Int'l Joint Research
• [Presentation] The new effects of radioactive microparticles for rats and mice and our future plan (2022)
  • Author(s): Hoshi M
  • Organizer: International Conference - Modern Perspectives for Biomedical Sciences
  • Int'l Joint Research / Invited
• [Presentation] Animal studies of 56MnO2 exposure in 2018-19 (2022)
  • Author(s): Fujimoto N
  • Organizer: The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
  • Int'l Joint Research / Invited
• [Presentation] Overview of our studies of radiation effects in Kazakhstan (2022)
  • Author(s): Hoshi M
  • Organizer: The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
  • Int'l Joint Research / Invited
• [Presentation] Study of 7Be and 210Pb in atmosphere of Akmola region of Kazakhstan (2022)
  • Author(s): Kassym Zhumadilov, Aidana Zhumalina, Yernaz Sambayev, Yeldos Bekzhanov, Asel Bagramova, Tulegen Kusainov, Aya Sakaguchi, Satoru Endo, Shin Toyoda, Hitoshi Sato, Masaharu Hoshi,
  • Organizer: The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
  • Int'l Joint Research
• [Presentation] Trial of remote thyroid examination 10 years after the Fukushima nuclear power accident in COVID-19 pandemic (2022)
  • Author(s): Yoshihiro Noso, Atsuko Imagawa, Akio Haruta, Motomi Ushiyama, Takashi Sawada, Laura Pak, Nailya Chaizhunussova, Ken Inoue, Nobuo Takeichi, Masaharu Hoshi
  • Organizer: The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
  • Int'l Joint Research
• [Presentation] Anxiety and fear about mental and physical health for radiation exposure in the people -importance of dissemination about correct knowledge based on the cooperation in various fields (2022)
  • Author(s): Ken Inoue, Noriyuki Kawano, Nailya Chaizhunussova, Nursultan Seksenbayev, Madina Apbassova, Nobuo Takeichi, Yoshihiro Noso, Masaharu Hoshi
  • Organizer: The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
  • Int'l Joint Research
• [Presentation] Effects of internal exposure to neutron-activated 56MnO2 powder on locomotor activity in rats (2022)
  • Author(s): Keiko Otani, Megu Ohtaki, Nariaki Fujimoto, Darkhan Uzbekov, Ynkar Kairkhanova, Aisulu Saimova, Nailya Chaizhunussova, Dariya Habdarbaeva, Almas Azhimkhanov, Kassym Zhumadilov, Valeriy Stepanenko, Masaharu Hoshi
  • Organizer: The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
  • Int'l Joint Research
• [Presentation] The effect of various doses of ionizing radiation on liver tissue in experiment (2022)
  • Author(s): Bakhyt Ruslanova, Nailya Chaizhunussova, Dariya Shabdarbayeva, Nariaki Fujimoto, Masaharu Hoshi
  • Organizer: The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
  • Int'l Joint Research
• [Presentation] The effects of internal and external exposure on morphological indicators and gene expression in lungs in experiment (rats and mice) (2022)
  • Author(s): Zhaslan Abishev, Nailya Chaizhunussova, Dariya Shabdarbayeva, Nariaki Fujimoto, Masaharu Hoshi
  • Organizer: The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
  • Int'l Joint Research
• [Presentation] Influence of internal and external ionizing radiation on gene expression of the reproductive system in male laboratory animals. (2022)
  • Author(s): Nailya Chaizhunussova, Gauhar Amantayeva, Dariya Shabdarbayeva, Nariaki Fujimoto, Masaharu Hoshi
  • Organizer: The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
  • Int'l Joint Research
• [Presentation] Interlaboratory comparison of EPR tooth enamel dosimetry with investigations of the dose responses of the standard samples (2022)
  • Author(s): Toyoda, S., Inoue, K., Yamaguchi, I., Hoshi, M., Hirota, S., Oka, T., Shimazaki, T., Mizuno, H., Tani, A., Yasuda, H., Gonzales, C. A. B., Okutsu, K., Takahashi, A., Tanaka, N., Todaka, A
  • Organizer: EPR BioDose 2022
  • Int'l Joint Research
• [Presentation] ラット新生仔期被曝による甲状腺腫瘍化に関与する遺伝子発現変化(O2-7-1) (2021)
  • Author(s): 藤本成明, 松山睦美, 中島正洋
  • Organizer: 第94回日本内分泌学会学術総会
• [Presentation] 放射性56MnO2 微粒子曝露による低線量被曝でのラット雄性生殖線機能低下 (2021)
  • Author(s): 藤本成明, 星正治, Chaizhunussova N
  • Organizer: 第5回放射線災害 医科学研究拠点カンファランス
• [Presentation] Biological effects of radioactive particles produced by atomic bombing; animal studies (2021)
  • Author(s): Fujimoto N
  • Organizer: 15th international scientific-practical conference ecology. radiation. health, Semey, Kazakhstan
  • Int'l Joint Research / Invited
• [Presentation] Biological effects of internal exposure to radioactive particles of 56MnO2 in rats (2021)
  • Author(s): Fujimoto N, Chaizhunussova N, Shabdarbayeva D, Gnyrya V, Azhimkhanov A, Kolbayenkov A, Zhumadilov K, Stepanenko V, Hoshi M
  • Organizer: 9th international conference semipalatinsk test site, Kurchatov, Kazakhstani
  • Int'l Joint Research
• [Presentation] International collaboration of radiation risk evaluation in Semipalatinsk, 4th dosimetry and health risk assessment in the Semipalatinsk cohort of subjects (2021)
  • Author(s): Hoshi M
  • Organizer: 4th Dosimetry Meeting
  • Int'l Joint Research
• [Presentation] Animal exposure experiments using Mn-56 dioxide radioactive microparticles, (2021)
  • Author(s): Hoshi M, Chaizhunusova N, Zhumadilov K, Uzbekov D, Shabdarbaeva D, Kairkhanova Y, Amantaeva G, Ruslanova B, Apbassova M et al
  • Organizer: 9th international conference semipalatinsk test site, Kurchatov, Kazakhstani
  • Int'l Joint Research
• [Presentation] International collaboration between Kazakhstan and Japan; Studies with Shakarim University (2021)
  • Author(s): M. Hoshi, S. Duyssembayev, Z. Serikov, A. Klivenko, K. Zhumadilov, A. Zhumalina, P. Kazymbet, M. Bakhtin, A. Sakaguchi, M. Yamamoto, S. Endo, H. Satoh, S. Toyoda, N. Kawano
  • Organizer: Shakarim University Symposium
  • Int'l Joint Research
• [Presentation] Changes in morphology and gene expressions of neonatally X-irradiated thyroid gland in rats (2020)
  • Author(s): Fujimoto N, Matsuu-Matsuyama M, Nakashima M
  • Organizer: 22nd European Congress of Endocrinology
  • Int'l Joint Research
• [Presentation] 結節内結節を伴う甲状腺良性結節の53BP1による分子病理学的特徴解析 (2020)
  • Author(s): 清水智貴、松田勝也、高田奈美、黒濵大和、Mussazhanova Zhanna、Sailaubekova Yerkezhan、大坪智恵子、佐藤伸也、山下弘幸、中島正洋
  • Organizer: 第24回日本臨床内分泌病理学会