| Co-Investigator(Kenkyū-buntansha) |
OHASHI Toshiro 北海道大学, 大学院工学研究院, 教授 (30270812)
KANNZAKI Makoto 東北大学, 大学院医工学研究科, 准教授 (10272262)
DEGUCHI Shinji 東北大学, 大学院工学研究科, 准教授 (30379713)
SAKAMOTO Naoya 川崎医療福祉大学, 医療技術学部, 准教授 (20361115)
安達 泰治 京都大学, 再生医科学研究所, 教授 (40243323)
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| Budget Amount *help |
¥539,240,000 (Direct Cost: ¥414,800,000、Indirect Cost: ¥124,440,000)
Fiscal Year 2012: ¥85,280,000 (Direct Cost: ¥65,600,000、Indirect Cost: ¥19,680,000)
Fiscal Year 2011: ¥85,280,000 (Direct Cost: ¥65,600,000、Indirect Cost: ¥19,680,000)
Fiscal Year 2010: ¥73,710,000 (Direct Cost: ¥56,700,000、Indirect Cost: ¥17,010,000)
Fiscal Year 2009: ¥128,180,000 (Direct Cost: ¥98,600,000、Indirect Cost: ¥29,580,000)
Fiscal Year 2008: ¥166,790,000 (Direct Cost: ¥128,300,000、Indirect Cost: ¥38,490,000)
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| Research Abstract |
There are many cells sensing mechanical forces in our body and the cells control the functions of tissues and organs to be adapted to mechanical environment. However, the mechanisms were not elucidated yet. In this study, we mainly focused on vascular endothelial cells, osteocytes and myocytes. It became clear that cell-cell and focal adhesions and cytoskeletons such as stress fiber are working as mechanosensors and some proteins in cytoplasm were identified as signal messengers. Mechanical forces were also playing important roles in organogenesis such as valve formation in cardiovascular system.
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