Molecular basis of the function and generation of Foxp3-expressing regulatory T cells

• Project/Area Number: 20002007
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University (2011-2012); Kyoto University (2008-2010)
• Principal Investigator: SAKAGUCHI Shimon 大阪大学, 免疫学フロンティア研究センター, 教授 (30280770)
• Co-Investigator(Kenkyū-buntansha): OHKURA Naganari 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (20300949) ; NISHIKAWA Hiroyoshi 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (10444431) ; YAMAGUCHI Tomoyuki 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (80402791) ; ITO Yoshinaga 京都大学, 再生医科学研究所, 助教 (60614013)
• Co-Investigator(Renkei-kenkyūsha): KONDO Gen 京都大学, 再生医科学研究所, 准教授 (40243258) ; KITABAYASHI Issei 国立がんセンター研究所, 分子腫瘍学部長 (20261175) ; TANIUCHI Ichiro 理化学研究所, 免疫転写制御研究チーム, チームリーダー (20284573)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥598,260,000 (Direct Cost: ¥460,200,000、Indirect Cost: ¥138,060,000); Fiscal Year 2012: ¥101,270,000 (Direct Cost: ¥77,900,000、Indirect Cost: ¥23,370,000); Fiscal Year 2011: ¥101,270,000 (Direct Cost: ¥77,900,000、Indirect Cost: ¥23,370,000); Fiscal Year 2010: ¥101,270,000 (Direct Cost: ¥77,900,000、Indirect Cost: ¥23,370,000); Fiscal Year 2009: ¥141,180,000 (Direct Cost: ¥108,600,000、Indirect Cost: ¥32,580,000); Fiscal Year 2008: ¥153,270,000 (Direct Cost: ¥117,900,000、Indirect Cost: ¥35,370,000)
• Keywords: FOXP3 / 制御性T細胞 / 自己免疫病 / Tリンパ球 / CTLA-4 / 免疫制御 / 制御性Ｔ細胞 / エピゲノム / Ｔリンパ球 / Ｔ細胞抗原レセプター / T細胞抗原レセプター

Research Abstract

We have studied the mechanisms of how regulatory T (Treg) cells control immune responses and how their function and lineage stability can be maintained. We showed that several Treg-specific molecules were engaged in the control of antigen-presenting cells and thereby responsible for suppressing immune responses and that Treg-specific epigenetic changes were essential for the stability of Treg function. In addition, we showed that human Tregs were functionally dissected into three subsets and that this classification was instrumental in understanding the pathogenetic mechanisms of immunological diseases.

Assessment Rating

Verification Result (Rating)

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Research Products

• [Journal Article] Development and Maintenance of Regulatory T cells. (2013)
  • Author(s): Ohkura N, Kitagawa Y, Sakaguchi S.
  • Journal Title: Immunity Volume: 38 Pages: 414-423
• [Journal Article] Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes (2013)
  • Author(s): Hirayama M, Nishikawa H, Nagata Y, Tsuji T, Kato T, Kageyama S, Ueda S, Sugiyama D, Hori S, Sakaguchi S, Ritter G, Old LJ, Gnjatic S, Shiku H.
  • Journal Title: Eur J Immunol
• [Journal Article] T cell receptor stimulation-induced epigenetic changes and foxp3 expression are independent and complementary events required for Treg cell development. (2012)
  • Author(s): Ohkura N, Hamaguchi M, Morikawa H, Sugimura K, Tanaka A, Ito Y, Osaki M, Tanaka Y, Yamashita R, Nakano N, Huehn J, Fehling HJ, Sparwasser T, Nakai K, Sakaguchi S.
  • Journal Title: Immunity. Volume: 37 Pages: 785-99
• [Journal Article] Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth (2012)
  • Author(s): Hansen W, Hutzler M, Abel S, Alter C, Stockmann C, Kliche S, Albert J, Sparwasser T, Sakaguchi S, Westendorf AM, Schadendorf D, Buer J, Helfrich I.
  • Journal Title: J Exp Med. Volume: 209 Pages: 2001-16
• [Journal Article] Intracellular tumor-associated antigens represent effective targets for passive immunotherapy. (2012)
  • Author(s): Noguchi, T., Kato, T., Wang, L., Maeda,Y., Ikeda, H., Sato, E., Knuth, A., Gnjatic, S., Ritter, G., Sakaguchi, S., Old, L. J., Shiku, H., and Nishikawa, H
  • Journal Title: Cancer Res. Volume: 72 Pages: 1672-1682
• [Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon. (2012)
  • Author(s): Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K.
  • Journal Title: J Immunol. Volume: 189 Pages: 2869-78
• [Journal Article] Multiple treg suppressive modules and their adaptability. (2012)
  • Author(s): Wing JB, Sakaguchi S
  • Journal Title: Front Immunol. Volume: 3 Pages: 178-178
• [Journal Article] Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma. (2012)
  • Author(s): Nishikawa, H., Maeda, Y., Ishida, T.,Gnjatic, S., Sato, E., Mori, F.,Sugiyama, D., Ito, A., Fukumori, Y., Utsunomiya, A., Inagaki, H., Old, L. J., Ueda, R., and Sakaguchi, S.
  • Journal Title: Blood. Volume: 119 Pages: 3097-3104
• [Journal Article] T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man. (2012)
  • Author(s): Sakaguchi, S., Benham, H., Cope,A. P., Thomas, R.
  • Journal Title: Immunol Cell Biol. Volume: 90 Pages: 277-87
• [Journal Article] Re-establishingimmunological self- tolerance in autoimmune disease. (2012)
  • Author(s): Sakaguchi, S., Powrie, F., Ransohoff, R. M.
  • Journal Title: Nat Med. Volume: 18 Pages: 54-58
• [Journal Article] Factors affecting operational tolerance after pediatric living-donor liver transplantation: impact of early post-transplant events and HLA match. (2012)
  • Author(s): Ohe, H., Waki, K., Yoshitomi, M., Morimoto, T., Nafady-Hego, H., Satoda,N., Li, Y., Zhao, X., Sakaguchi, S., Uemoto, S., Bishop, G. A., Koshiba, T
  • Journal Title: Transpl Int. Volume: 25 Pages: 97-106
• [Journal Article] Differential effects of inhibition of bone morphogenic protein (BMP) signalling on T-cell activation and differentiation (2012)
  • Author(s): Yoshioka, Y., Ono, M., Osaki, M., Konishi, I., Sakaguchi, S.
  • Journal Title: Eur J Immunol Volume: 42 Pages: 749-759
• [Journal Article] Factors affecting operational tolerance after pediatric living-donor liver transplantation: impact of early post-transplant events and HLA match (2012)
  • Author(s): Ohe, H., Waki, K., Yoshitomi, M., Morimoto, T., Nafady-Hego, H., Satoda, N., Li, Y., Zhao, X., Sakaguchi, S., Uemoto, S., Bishop, G. A., Koshiba, T.
  • Journal Title: Transpl Int Volume: 25 Pages: 97-106
  • Peer Reviewed
• [Journal Article] A Novel Model of Rheumatoid Arthritis-Associated Interstitial Lung Disease in SKG Mice (2012)
  • Author(s): Keith, R. C., Powers, J. L., Redente, E. F., Sergew, A., Martin, R. J., Gizinski, A., Holers, V. M., Sakaguchi, S., Riches, D. W
  • Journal Title: Exp Lung Res Volume: 38 Pages: 55-66
  • Peer Reviewed
• [Journal Article] Re-establishing immunological self-tolerance in autoimmune disease (2012)
  • Author(s): Sakaguchi, S., Powrie, F., Ransohoff, R. M
  • Journal Title: Nat Med Volume: 18 Pages: 54-58
  • Peer Reviewed
• [Journal Article] T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man (2012)
  • Author(s): Sakaguchi, S., Benham, H., Cope, A. P., Thomas, R
  • Journal Title: Immunol Cell Biol Volume: 90 Pages: 277-87
  • Peer Reviewed
• [Journal Article] Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma (2012)
  • Author(s): Nishikawa, H., Maeda, Y., Ishida, T., Gnjatic, S., Sato, E., Mori, F., Sugiyama, D., Ito, A., Fukumori, Y., Utsunomiya, A., Inagaki, H., Old, L. J., Ueda, R., and Sakaguchi, S
  • Journal Title: Blood Volume: 119 Pages: 3097-3104
  • Peer Reviewed
• [Journal Article] .Pregnancy amelioration of arthritis in SKG mice corresponds with alterations in serum amyloid A3 levels (2012)
  • Author(s): Shaw LA, Stefanski AL, Peterson LK, Rumer KK, Vondracek A, Phang TL, Sakaguchi S, Winn VD, Dragone LL
  • Journal Title: Am J Clin Exp Immunol Volume: 1 Pages: 12-19
  • Peer Reviewed
• [Journal Article] Multiple treg suppressive modules and their adaptability (2012)
  • Author(s): Wing JB, Sakaguchi S
  • Journal Title: Front Immunol Volume: 3 Pages: 178-178
  • Peer Reviewed
• [Journal Article] Regulatory T cells expressing PPAR-γ control inflammation in obesity (2012)
  • Author(s): Hamaguchi M, Sakaguchi S
  • Journal Title: Cell Metab Volume: 16 Pages: 4-6
  • Peer Reviewed
• [Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon (2012)
  • Author(s): Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K
  • Journal Title: J Immunol Volume: 189 Pages: 2869-78
  • Peer Reviewed
• [Journal Article] Intracellular tumor-associated antigens represent effective targets for passive immunotherapy (2012)
  • Author(s): Noguchi, T., Kato, T., Wang, L., Maeda, Y., Ikeda, H., Sato, E., Knuth, A., Gnjatic, S., Ritter, G., Sakaguchi, S., Old, L. J., Shiku, H., and Nishikawa, H
  • Journal Title: Cancer Res Volume: 72 Pages: 1672-1682
  • Peer Reviewed
• [Journal Article] Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth (2012)
  • Author(s): Hansen W, Hutzler M, Abel S, Alter C, Stockmann C, Kliche S, Albert J, Sparwasser T, Sakaguchi S, Westendorf AM, Schadendorf D, Buer J, Helfrich I
  • Journal Title: J Exp Med Volume: 209 Pages: 2001-16
  • Peer Reviewed
• [Journal Article] T cell receptor stimulation-induced epigenetic changes and foxp3 expression are independent and complementary events required for Treg cell development (2012)
  • Author(s): Ohkura N, Hamaguchi M, Morikawa H, Sugimura K, Tanaka A, Ito Y, Osaki M, Tanaka Y, Yamashita R, Nakano N, Huehn J, Fehling HJ, Sparwasser T, Nakai K, Sakaguchi S
  • Journal Title: Immunity Volume: 37 Pages: 785-99
  • Peer Reviewed
• [Journal Article] Treg cells acquire new directions, cytokines navigate (2012)
  • Author(s): Ohkura N, Sakaguchi S
  • Journal Title: Immunity Volume: 37 Pages: 443-4
  • Peer Reviewed
• [Journal Article] T-cell receptor signaling and the pathogenesis of autoimmune arthritis : insights from mouse and man (2012)
  • Author(s): Sakaguchi, S., Benham, H., Cope, A.P., Thomas, R.
  • Journal Title: Immunol Cell Biol Volume: 90 Pages: 277-87
  • Peer Reviewed
• [Journal Article] T.Factors affecting operational tolerance after pediatric living-donor liver transplantation : impact of early post-transplant events and HLA match (2012)
  • Author(s): Ohe, H., Waki, K., Yoshitomi, M., Morimoto, T., Nafady-Hego, H., Satoda, N., Li, Y., Zhao, X., Sakaguchi, S., Uemoto, S., Bishop, G.A., Koshiba, T.
  • Journal Title: Transpl Int Volume: 25 Pages: 97-106
  • Peer Reviewed
• [Journal Article] The long-term survival potential of mature T lymphocytes is programmed during development in the thymus (2012)
  • Author(s): Sinclair, C, Saini, M., van der Loeff, I.S., Sakaguchi, S., Seddon, B.
  • Journal Title: Sci Signal Volume: 4
  • Peer Reviewed
• [Journal Article] Two modes of immune suppression by Foxp3(十) regulatory T cells under inflammatory or non-inflammatory conditions (2012)
  • Author(s): Yamaguchi, T., Wing, J.B., Sakaguchi, S.
  • Journal Title: Semin Immunol Volume: 23 Pages: 424-430
  • Peer Reviewed
• [Journal Article] Thymus, innate immunity and autoimmune arthritis : interplay of gene and environment (2012)
  • Author(s): Sakaguchi, S., Tanaka, S., Tanaka, A., Ito, Y., Maeda, S., Sakaguchi, N., Hashimoto, M.
  • Journal Title: FEBS Lett Volume: 585 Pages: 3633-3639
  • Peer Reviewed
• [Journal Article] FOXP3(+) regulatory T cells : control of FOXP3 expression by pharmacological agents (2012)
  • Author(s): Ohkura, N., Hamaguchi, M., Sa kaguchi, S.
  • Journal Title: Trends Pharmacol.Sci Volume: 32 Pages: 158-66
  • Peer Reviewed
• [Journal Article] SLAP Deficiency Enhances Number and Function of Tregs Preventing Chronic Autoimmune Arthritis in SKG Mice (2012)
  • Author(s): Peterson, L.K., Shaw, L.A., Joetham, A., Sakaguchi, S., Gelf, E.W., Dragone, L.L.
  • Journal Title: J.Immunol. Volume: 186 Pages: 2273-2281
  • Peer Reviewed
• [Journal Article] Cell-autonomous and -nonautonomous functions of CTLA-4 for negative control of immune responses (2011)
  • Author(s): Wing, K., Yamaguchi, T., Sakaguchi, S.
  • Journal Title: Trends Immunol. Volume: 32 Pages: 428-43
• [Journal Article] The long-term survival potential of mature T lymphocytes is programmed during development in the thymus. (2011)
  • Author(s): Sinclair, C., Saini, M., van der Loeff, I. S., Sakaguchi, S., Seddon, B
  • Journal Title: Sci Signal. Volume: 4(199)
• [Journal Article] Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions (2011)
  • Author(s): Yamaguchi, T., Wing, J. B., Sakaguchi, S.
  • Journal Title: Semin Immunol. Volume: 23 Pages: 424-430
• [Journal Article] innate immunity and autoimmune arthritis: interplay of gene and environment. (2011)
  • Author(s): Sakaguchi, S., Tanaka, S., Tanaka,A., Ito, Y., Maeda, S., Sakaguchi, N., Hashimoto, M. Thymus
  • Journal Title: FEBS Lett. Volume: 585 Pages: 3633-3639
• [Journal Article] FOXP3(+) regulatory T cells: control of FOXP3 expression by pharmacological agents (2011)
  • Author(s): 3633-3639, 2011.18. Ohkura, N., Hamaguchi, M., Sakaguchi, S.
  • Journal Title: Trends Pharmacol. Sci. Volume: 32 Pages: 158-66
• [Journal Article] Minimal but essential doses of immunosuppression: A more realistic approach to improve long-term outcomes for pediatric living-donor liver transplantation (2011)
  • Author(s): Ohe, H., Li, Y., Nafady-Hego, H., Kayo, W., Sakaguchi, S., Wood, K., Calne,R., Uemoto, S., Koshiba, T.
  • Journal Title: Transplantation Volume: 91 Pages: 808-810
• [Journal Article] HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. (2011)
  • Author(s): Satou, Y., Yasunaga, J., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P. L., Ohkura, N., Yamaguchi, T., Ono, M., Sakaguchi, S., Matsuoka, M.
  • Journal Title: PLoS Pathog. Volume: 7(2)
  • NAID: 120002807462
• [Journal Article] Human FoxP3(+) regulatory T cells in systemic autoimmune diseases (2011)
  • Author(s): Miyara, M., Gorochov, G., Ehrenstein, M., Musset, L., Sakaguchi,S., Amoura, Z.
  • Journal Title: Autoimmun. Rev Volume: 10 Pages: 744-755
• [Journal Article] FoxP3+CD4+ regulatory T cells: their knowns and unknowns. (2011)
  • Author(s): Miyara, M., and Sakaguchi, S
  • Journal Title: Immunol. Cell. Biology. Volume: 89 Pages: 346-351
• [Journal Article] SLAP Deficiency Enhances Number and Function of Tregs Preventing Chronic Autoimmune Arthritis in SKG Mice. (2011)
  • Author(s): Peterson, L. K., Shaw, L. A., Joetham, A., Sakaguchi, S., Gelfand, E. W.,and Dragone, L. L.
  • Journal Title: J. Immunol. Volume: 186 Pages: 1173-1181
• [Journal Article] Stimulation of the glucocorticoid- induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens. (2011)
  • Author(s): Cote, A. L., Zhang, P., O'Sullivan,J. A., Jacobs, V. L., Clemis, C. R., Sakaguchi, S., Guevara-Patino, J. A., and Turk, M. J.
  • Journal Title: J. Immunol. Volume: 186 Pages: 275-283
• [Journal Article] Regulatory T cells: history and perspective. (2011)
  • Author(s): Sakaguchi, S.
  • Journal Title: Methods in Molecular Biology. Volume: 77 Pages: 1-13
• [Journal Article] Cell-autonomous and -nonautonomous functions of CTLA-4 for negative control of immune responses (2011)
  • Author(s): Wing, K., Yamaguchi, T, Sakaguchi, S.
  • Journal Title: Trends Immunol Volume: 32 Pages: 428-433
  • Peer Reviewed
• [Journal Article] Damping by depletion (2011)
  • Author(s): Sakaguchi, S., Wing K.
  • Journal Title: Science Volume: 332 Pages: 542-543
  • Peer Reviewed
• [Journal Article] Maturation of effector regulatory T cells (2011)
  • Author(s): Ohkura, N., Sakaguchi, S.
  • Journal Title: Nat Immunol Volume: 12 Pages: 283-284
  • Peer Reviewed
• [Journal Article] TCR diversity and Treg cells, sometimes more is more (2011)
  • Author(s): Wing, J.B., Sakaguchi, S.
  • Journal Title: Eur J Immunol Volume: 41 Pages: 3097-3100
  • Peer Reviewed
• [Journal Article] Histological changes in chronic autoimmune SKG-arthritis evaluated by quantitative three-dimensional stereological estimators (2011)
  • Author(s): Keller, K.K., Stengaard-Pedersen, K., Dagnass-Hansen, F., Nyengaard, J.R., Sakaguchi, S., Hauge, E.M.
  • Journal Title: Clin.Exp.Rheumatol Volume: 29 Pages: 536-43
  • Peer Reviewed
• [Journal Article] Pillars Article : Immunologic Self-Tolerance Maintained by Activated T Cells Expressing IL-2 Receptor α-Chains (CD25). Breakdown of a Single Mechanism of Self-Tolerance Causes Various Autoimmune Diseases (2011)
  • Author(s): Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., Toda, M.
  • Journal Title: J.Immunol Volume: 186 Pages: 3808-21
  • Peer Reviewed
• [Journal Article] Minimal but essential doses of immunosuppression : A more realistic approach to improve long-term outcomes for pediatric living-donor liver transplantation (2011)
  • Author(s): Ohe, H., Li, Y, Nafady-Hego, H., Kayo, W., Sakaguchi, S., Wood, K., Calne, R., Uemoto, S., Koshiba, T.
  • Journal Title: Transplantation Volume: 91 Pages: 808-810
  • Peer Reviewed
• [Journal Article] HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo (2011)
  • Author(s): Satou, Y., Yasunaga, J., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P.L., Ohkura, N., Yamaguchi, T., Ono, M., Sakaguchi, S., Matsuoka, M.
  • Journal Title: PLoS Pathog Volume: 7(2)
  • NAID: 120002807462
  • Peer Reviewed
• [Journal Article] Human FoxP3(+) regulatory T cells in systemic autoimmune diseases (2011)
  • Author(s): Miyara, M., Gorochov, G., Ehrenstein, M., Musset, L., Sakaguchi, S., Amoura, Z.
  • Journal Title: Autoimmun.Rev Volume: 10 Pages: 744-755
  • Peer Reviewed
• [Journal Article] FoxP3+CD4+ regulatory T cells : their knowns and unknowns (2011)
  • Author(s): Miyara, M., Sakaguchi, S.
  • Journal Title: Immunol.Cell.Biology Volume: 89 Pages: 346-351
  • Peer Reviewed
• [Journal Article] CSF-1-dependent red pulp macrophages regulate CD4 T cell responses (2011)
  • Author(s): Kurotaki, D., Kon, S., Bae, K., Ito, K., Matsui, Y., Nakayama, Y., Kanayama, M., Kimura, C., Narita, Y., Nishimura, T., Iwabuchi, K., Mack, M., van Rooijen, N., Sakaguchi, S., Uede, T., Morimoto, J.
  • Journal Title: J.Immunol Volume: 186 Pages: 2229-2237
  • Peer Reviewed
• [Journal Article] Stimulation of the glucocorticoid-induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens (2011)
  • Author(s): Cote, A.L., Zhang, P., O'Sullivan, J.A., Jacobs, V.L., Clemis, C.R., Sakaguchi, S., Guevara-Patino, J.A., Turk, M.J.
  • Journal Title: J.Immunol Volume: 186 Pages: 275-283
  • Peer Reviewed
• [Journal Article] Regulatory T cells : history and perspective (2011)
  • Author(s): Sakaguchi, S.
  • Journal Title: Methods in Molecular Biology Volume: 77 Pages: 1-13
  • Peer Reviewed
• [Journal Article] CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection. (2010)
  • Author(s): Snell, L. M., McPherson, A. J., Lin, G. H., Sakaguchi, S., Pandolfi, P. P., Riccardi, C., and Watts, T. H.
  • Journal Title: J.Immunol. Volume: 185 Pages: 7223-7234
• [Journal Article] Perturbations of both non-regulatory and regulatory FOXP3(+) T cells in patients with malignant melanoma. (2010)
  • Author(s): Fujii, H., Arakawa, A., Kitoh, A., Miyara, M., Kato, M., Kore-Eda, S., Sakaguchi, S., Miyachi, Y., Tanioka, M., and Ono, M.
  • Journal Title: Br. J. Dermatol. Volume: 164 Pages: 1052-1060
• [Journal Article] Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals. (2010)
  • Author(s): Mitsui, J., Nishikawa, H., Muraoka, D., Wang, L., Noguchi, T., Sato,E., Kondo, S., Allison, J. P., Sakaguchi,S., Old, L. J., Kato, T., and Shiku, H.
  • Journal Title: Clin. Cancer Res. Volume: 16 Pages: 2781-91
• [Journal Article] Regulatory T cells in tumor immunity (2010)
  • Author(s): Nishikawa, H., and Sakaguchi, S
  • Journal Title: Int. J. Cancer. Volume: 127 Pages: 759-67
• [Journal Article] Regulatory T cells: roles of Tcell erceptor for their development and function. (2010)
  • Author(s): Ohkura, N., and Sakaguchi, S
  • Journal Title: Semin. Immunopathol. Volume: 32 Pages: 95-106
• [Journal Article] FOXP3+ regulatory T cells in the human system. (2010)
  • Author(s): Sakaguchi, S., Miyara, M., Costantino, C. M., and Hafler, D. A.
  • Journal Title: Nat. Rev. Immunol. Volume: 185 Pages: 2295-305
• [Journal Article] Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion. (2010)
  • Author(s): Teng, M.W., Swann, J.B., von Scheidt B, Sharkey, J., Zerafa, N., McLaughlin, N., Yamaguchi, T., Sakaguchi, S., Darcy, P.K., and Smyth,M.J.
  • Journal Title: Cancer Res Volume: 70 Pages: 2665-2674
• [Journal Article] Therapeutic Glucocorticoid-Induced TNF Receptor-Mediated Amplification of CD4+ T Cell Responses Enhances Antiparasitic Immunity. (2010)
  • Author(s): Haque, A., Stanley, A. C., Amante,F. H., Rivera, F. D., Zhou, Y., Kuns, R. D., Yardley, V., Sakaguchi, S., Hill, G. R., and Engwerda, C. R
  • Journal Title: J. Immunol. Volume: 184 Pages: 2583-2592
• [Journal Article] Complement drives Th-17 cell differentiation and triggers autoimmune disease. (2010)
  • Author(s): Hashimoto, M., Hirota, K., Yoshitomi, H., Maeda, S., Teradaira, S.,Akizuki, S., Prieto-Martin, P., Nomura, T., Sakaguchi, N., Kohl, J., Heyman, B.,Takahashi, M., Fujita, T., Mimori, T., Sakaguchi, S.
  • Journal Title: J. Exp. Med. Volume: 207 Pages: 1135-43
• [Journal Article] Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function. (2010)
  • Author(s): Tanaka, S., Maeda, S., Hashimoto. M., Teradaira, S., Hirota,K., Yoshitomi, H., Katakai, T., Shimizu, A., Nomura, T., Sakaguchi, N., and Sakaguchi, S.
  • Journal Title: J. Immunol. Volume: 185 Pages: 2295-305
• [Journal Article] Regulatory T cells exert checks and balances on self-tolerance and autoimmunity. (2010)
  • Author(s): Wing, K., and Sakaguchi, S.Regulatory T cells exert checks and
  • Journal Title: Nat. Immunol Volume: 11 Pages: 7-13
• [Journal Article] Complement drives Th-17 cell differentiation and triggers autoimmune disease. (2010)
  • Author(s): Hashimoto, M., Hirota, K., Yoshitomi, H., Maeda, S., Teradaira, S., Akizuki, S., Prieto-Martin, P., Nomura, T., Sakaguchi, N., Kohl, J., Heyman, B., Takahashi, M., Fujita, T., Mimori, T., Sakaguchi, S.
  • Journal Title: J.Exp.Med. 207 Pages: 1135-1143
  • Peer Reviewed
• [Journal Article] FOXP3+ regulatory T cells in the human system. (2010)
  • Author(s): Sakaguchi, S., Miyara, M., Costantino, C.M., Hafler, D.A.
  • Journal Title: Nat.Rev.Immunol. Volume: 185 Pages: 2295-305
  • Peer Reviewed
• [Journal Article] Regulatory T cells : roles of Tcell erceptor for their development and function. (2010)
  • Author(s): Ohkura, N., Sakaguchi, S.
  • Journal Title: Semin.Immunopathol. Volume: 32 Pages: 95-106
  • Peer Reviewed
• [Journal Article] Regulatory T cells in tumor immunity. (2010)
  • Author(s): Nishikawa, H., Sakaguchi, SOld, L.J., Kato, T., Shiku, H.
  • Journal Title: Int.J.Cancer Volume: 127 Pages: 759-67
  • Peer Reviewed
• [Journal Article] Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals. (2010)
  • Author(s): Mitsui, J., Nishikawa, H., Muraoka, D., Wang, L., Noguchi, T., Sato, E., Kondo, S., Allison, J.P., Sakaguchi, S.
  • Journal Title: Clin.Cancer Res. Volume: 16 Pages: 2781-91
  • Peer Reviewed
• [Journal Article] The generation of donor-specific CD4+CD25++CD45RA+ naive regulatory T cells in operationally tolerance patients after pediatric living-donor liver transplantation. (2010)
  • Author(s): Nafady-Hego, H., Li, Y., Ohe, H., Zhao, X., Satoda, N., Sakaguchi, S., Wood, K., Uemoto, S., Koshiba, T.
  • Journal Title: Transplantation Volume: 90 Pages: 1547-55
  • Peer Reviewed
• [Journal Article] Conditional stability of T cells. (2010)
  • Author(s): Sakaguchi, S.
  • Journal Title: Nature Volume: 468 Pages: 41-42
  • Peer Reviewed
• [Journal Article] Perturbations of both non-regulatory and regulatory FOXP3(+) T cells in patients with malignant melanoma. (2010)
  • Author(s): Fujii, H., Arakawa, A., Kitoh, A., Miyara, M., Kato, M., Kore-Eda, S., Sakaguchi, S., Miyachi, Y., Tanioka, M., Ono, M.
  • Journal Title: Br.J.Dermatol.doi Volume: 10.1111 Pages: 1365-2133
  • Peer Reviewed
• [Journal Article] CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection. (2010)
  • Author(s): Snell, L.M., McPherson, A.J., Lin, G.H., Sakaguchi, S., Pandolfi, P.P., Riccardi, C., Watts, T.H.
  • Journal Title: J.Immunol Volume: 185 Pages: 7223-34
  • Peer Reviewed
• [Journal Article] Foxo1 and Foxo3 help Foxp3. (2010)
  • Author(s): Ohkura N, Sakaguchi S
  • Journal Title: Immunity Volume: 33 Pages: 835-7
  • Peer Reviewed
• [Journal Article] Regulatory T cells : history and perspective. (2010)
  • Author(s): Sakaguchi, S.
  • Journal Title: Methods in Molecular Biology Volume: 77 Pages: 1-13
  • Peer Reviewed
• [Journal Article] Stimulation of the glucocorticoid-induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens. (2010)
  • Author(s): Cote, A.L., Zhang, P., O'Sullivan, J.A., Jacobs, V.L., Clemis, C.R., Sakaguchi, S., Guevara-Patino, J.A., Turk, M.J.
  • Journal Title: J.Immunol Volume: 186 Pages: 275-83
  • Peer Reviewed
• [Journal Article] Chronic arthritis leads to disturbances in the bone collagen network. (2010)
  • Author(s): Caetano-Lopes J, Nery AM, Canhao H, Duarte J, Cascao R, Rodrigues A, Perpetuo IP, Abdulghani S, Amaral PM, Sakaguchi S, Konttinen YT, Graca L, Vaz MF, Fonseca JE.
  • Journal Title: Arthritis Res Ther. 12(1):R9
  • Peer Reviewed
• [Journal Article] Regulation of Zap 70 expression during thymic development allows temporal separation of CD4 and CD8 repertoire selection at different signaling thresholds. (2010)
  • Author(s): Saini M, Sinclair C, Marshall D, Tolaini M, Sakaguchi S, Seddon B.
  • Journal Title: Science Signaling. 3(114):ra23.
  • Peer Reviewed
• [Journal Article] Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion. (2010)
  • Author(s): Teng, M.W., Swann, J.B., von Scheidt B, Sharkey, J., Zerafa, N., McLaughlin, N., Yamaguchi, T., Sakaguchi, S., Darcy, P.K., Smyth, M.J.
  • Journal Title: Cancer Res. 70 Pages: 2665-2674
  • Peer Reviewed
• [Journal Article] Therapeutic Glucocorticoid-Induced TNF Receptor-Mediated Amplification of CD4+ T Cell Responses Enhances Antiparasitic Immunity. (2010)
  • Author(s): Haque A, Stanley AC, Amante FH, Rivera FD, Zhou Y, Kuns RD, Yardley V, Sakaguchi S, Hill GR, Engwerda CR.
  • Journal Title: J Immunol. 184 Pages: 2583-2592
  • Peer Reviewed
• [Journal Article] Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions. (2009)
  • Author(s): Onodera, T., Jang, M. H., Guo, Z., Yamasaki, M., Hirata, T., Bai, Z., Tsuji,N. M., Nagakubo, D., Yoshie, O., Sakaguchi, S., Takikawa, O., and Miyasaka, M.
  • Journal Title: J. Immunol Volume: 183 Pages: 5608-5614
• [Journal Article] Regulatory T cells: how do they suppress immune responses? (2009)
  • Author(s): Sakaguchi, S., Wing, K., Onishi,Y.
  • Journal Title: Int. Immunol Volume: 21 Pages: 1105-11
  • NAID: 10027389567
• [Journal Article] Indispensable role of Runx1/Cbf・complexes for in vivo suppressive function of FoxP3+regulatory T cells (2009)
  • Author(s): Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi, H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi,Y., Taniuchi, I., and Sakaguchi, S.
  • Journal Title: Immunity. Volume: 31 Pages: 609-620
• [Journal Article] Dynamics of peripheral tolerance and immune regulation mediated by Treg (2009)
  • Author(s): Sakaguchi, S., Wing, K., and Yamaguchi, T.
  • Journal Title: Eur. J. Immunol Volume: 39 Pages: 2331-6
• [Journal Article] CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2 (2009)
  • Author(s): Okamura, T., Fujio, K., Shibuya,M., Sumitomo, S., Shoda, H., Sakaguchi,S., and Yamamoto, K.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 106 Pages: 13974-9
• [Journal Article] M., Wing, K., and Sakaguchi, S. Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion. (2009)
  • Author(s): Miyara, M., Wing, K., and Sakaguchi, S.
  • Journal Title: J Allergy Clin Immunol Volume: 123 Pages: 749-55
• [Journal Article] Functional delineation and differentiation dynamics of human CD4(+) T cells expressing the FoxP3 transcription factor. (2009)
  • Author(s): Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Gorochov, G., and Sakaguchi, S.
  • Journal Title: Immunity Volume: 30 Pages: 899-911
• [Journal Article] Differential control of alloantigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance. (2009)
  • Author(s): Nagahama, K., Fehervari, Z., Oida, T., Ogawa, O., and Sakaguchi, S.
  • Journal Title: Int.Immunol. Volume: 21 Pages: 379-391
  • NAID: 10025385421
• [Journal Article] Requirement of protocol biopsy before and after complete cessation of immunosuppression following liver transplantation. (2009)
  • Author(s): Yoshitomi, M., Koshiba, T., Haga, H., Li, Y., Zhao, X., Cheng, D., Miyagawa, A., Sakashita, H., Tsuruyama T., Ueda, M., Wood, K., Sakaguchi S., Manabe, T., Tanaka, K., and Uemoto, S.
  • Journal Title: Transplantation. Volume: 87 Pages: 606-614
• [Journal Article] Indispensable role of in vivo suppressive function of FoxP3+ regulatory T cells. (2009)
  • Author(s): Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi, H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi, Y., Taniuchi, I., Sakaguchi, S.
  • Journal Title: Immunity. 31 Pages: 609-620
  • Peer Reviewed
• [Journal Article] Functional delineation and differentiation dynamics of human CD4(+) T cells expressing the FoxP3 transcription factor. (2009)
  • Author(s): Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Gorochov, G., Sakaguchi, S.
  • Journal Title: Immunity. 30 Pages: 899-911
  • Peer Reviewed
• [Journal Article] Functional delineation and differentiation dynamics of human CD4(+) Tcells expressing the FoxP3 transcription factor. (2009)
  • Author(s): Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Guy Gorochov, G., Sakaguchi, S.
  • Journal Title: Immunity. 30 Pages: 899-911
  • Peer Reviewed
• [Journal Article] Indispensable role of Runxl/Cbf complexes for in vivo suppressive function of FoxP^<3+> regulatory T cells. (2009)
  • Author(s): Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi,Y., Taniuchi, I., Sakaguchi, S.
  • Journal Title: Immunity. 31 Pages: 609-620
  • Peer Reviewed
• [Journal Article] Differential control of alloantigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance. (2009)
  • Author(s): Nagahama, K., Fehervari, Z., Oida, T., Ogawa, 0., Sakaguchi, S.
  • Journal Title: Int.Immunol. 21 Pages: 379-391
  • NAID: 10025385421
  • Peer Reviewed
• [Journal Article] A novel modifier of regulatory T cells (2009)
  • Author(s): Ohkura, N,. Sakaguchi, S.
  • Journal Title: Nat Immunol. 10 Pages: 385-686
  • Peer Reviewed
• [Journal Article] Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion. (2009)
  • Author(s): Miyara, M., Wing, K., Sakaguchi, S.
  • Journal Title: J Allergy Clin Immunol. 123 Pages: 749-755
  • Peer Reviewed
• [Journal Article] Dynamics of peripheral tolerance and immune regulation mediated by Treg. (2009)
  • Author(s): Sakaguchi, S., Wing, K., Yamaguchi, T.
  • Journal Title: Eur. J.Immunol. 39 Pages: 2331-2336
  • Peer Reviewed
• [Journal Article] Regulatory T cells : how do they suppress immune responses? (2009)
  • Author(s): Sakaguchi S, Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T.
  • Journal Title: Int. Immunol. 21 Pages: 1105-1111
  • NAID: 10027389567
  • Peer Reviewed
• [Journal Article] Regulatory T cells exert checks and balances on self-tolerance and autoimmunity. (2009)
  • Author(s): Wing K, Sakaguchi S.
  • Journal Title: Nat. Immunol. 11 Pages: 7-13
  • Peer Reviewed
• [Journal Article] Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis (2009)
  • Author(s): Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchis Yoshifuji H, Nojima T, Ohmura K, Fujii T, Mimori T.
  • Journal Title: Arthritis Rheum. 60 Pages: 2294-2303
  • Peer Reviewed
• [Journal Article] CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2. (2009)
  • Author(s): Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, Yamamoto K.
  • Journal Title: Proc Natl Acad Sci U S A. 106 Pages: 13974-13949
  • Peer Reviewed
• [Journal Article] Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes : functional involvement of the CTLA-4B7 and CCL22/CCR4 interacoons. (2009)
  • Author(s): Onodera T, Jang MH, Guo Z, Yamasaki M, Hirata T, Bai Z, Tsuji NM, Nagakubo D, Yoshie O, Sakaguchi S, Takikawa O, Miyasaka M.
  • Journal Title: J.Immunol. 183 Pages: 5608-5614
  • Peer Reviewed
• [Journal Article] Requirement of protocol biopsy before and after complete cessation of immunosuppression following liver transplantation. (2009)
  • Author(s): Yoshitomi, M., Koshiba, T., Haga, H., Li, Y., Zhao, X., Cheng, D., Miyagawa, A., Sakashita, H., Tsuruyama T., Ueda, M., Wood, K., Sakaguchi S., Manabe, T., Tanaka, K., Uemoto, S.
  • Journal Title: Transplantation. 87 Pages: 606-614
  • Peer Reviewed
• [Journal Article] Immune rejection of mouse tumors expressing mutated self. (2009)
  • Author(s): Duan F, Lin Y, Liu C, Engelhorn ME, Cohen AD, Curran M, Sakaguchi S, Merghoub T, Terzulli S, Wolchok JD, Houghton AN.
  • Journal Title: Cancer Res. 69 Pages: 3545-3553
  • Peer Reviewed
• [Journal Article] Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours. (2009)
  • Author(s): Piao J,Kamimura Y, Iwai H, Cao Y, Kikuchi K, Hashiguchi M, Masunaga T, Jiang H, Tamura K, Sakaguchi S, Azuma M.
  • Journal Title: Immunity. 127 Pages: 489-499
  • Peer Reviewed
• [Journal Article] Therapeutic Immunity by Adoptive Tumor-primed CD4(+)T-cell Transfer in Combination With In Vivo GITR Ligation. (2009)
  • Author(s): Liu, Z., Tian, S., Falo, L.D.Jr, Sakaguchi, S., You, Z.
  • Journal Title: Mol Ther. 17 Pages: 1274-1284
  • Peer Reviewed
• [Journal Article] Value of FOXP3 Expression in Peripheral Blood as Rejection Marker After Miniature Swine Lung Transplantation. (2008)
  • Author(s): Satoda, N., Shoji, T., Wu, Y., Fujinaga, T., Chen, F., Aoyama, A., Zhang, J. T., Takahashi, A., Okamoto, T., Matsumoto, I., Sakai, H., Li, Y., Zhao,X., Manabe, T., Kobayashi, E., Sakaguchi, S., Wada, H., Ohe, H., Uemoto, S., Tottori, J., Bando, T., Date
  • Journal Title: J. Heart Lung Transplant Volume: 27 Pages: 1293-1301
• [Journal Article] CTLA-4 control over Foxp3+regulatory T cell function (2008)
  • Author(s): Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., and Sakaguchi, S.
  • Journal Title: Science. Volume: 322 Pages: 271-275
• [Journal Article] The presence of FOXP3 expressing T cells within grafts of tolerance human liver transplant recipients. (2008)
  • Author(s): Li, Y., Zhao, X., Cheng, D., Haga, H., Tsuruyama, T., Wood, K., Sakaguchi, S., Tanaka, K., Uemoto, S., and Koshiba, T.
  • Journal Title: Transplantation Volume: 86 Pages: 1837-1843
• [Journal Article] Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. (2008)
  • Author(s): Onishi, Y., Fehervari, Z., Yamaguchi, T., and Sakaguchi, S
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 29 Pages: 10113-10118
• [Journal Article] Regulatory T cells and immune tolerance (2008)
  • Author(s): Sakaguchi, S., Yamaguchi, T., Nomura, T., and Ono, M.
  • Journal Title: Cell Volume: 133 Pages: 775-787
• [Journal Article] Regulatory T cellsin the past and for the future. (2008)
  • Author(s): Sakaguchi, S.
  • Journal Title: ur. J. Immunol. Volume: 38 Pages: 901-937
• [Journal Article] CTLA-4 control over Foxp3+ regulatory T cell function. (2008)
  • Author(s): Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., Sakaguchi, S.
  • Journal Title: Science. 322 Pages: 271-275
  • Peer Reviewed
• [Journal Article] Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. (2008)
  • Author(s): Onishi, Y., Fehervari, Z., Yamaguchi, T., Sakaguchi, S.
  • Journal Title: Proc.Natl.Acad.Sci.USA. 29 Pages: 10113-10118
  • Peer Reviewed
• [Journal Article] CTLA-4 control over Foxp3^+regulatory T cell funtion (2008)
  • Author(s): Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M.
  • Journal Title: Science 322 Pages: 271-275
• [Journal Article] Regulatory T cell and immune tolerance (2008)
  • Author(s): Sakaguchi, S., Yamaguchi, T., and Ono, M
  • Journal Title: Cell 133 Pages: 775-787
• [Journal Article] Foxp^<3+> natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation (2008)
  • Author(s): Onishi, Y., Fehervari, Z., Yamaguchi, T., and Sakaguchi. S.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 29 Pages: 10113-10118
• [Journal Article] Construction of self-recognizing regulatory T cells from conventional T cells by controllingCTLA-4 and IL-2 expression.
  • Author(s): Yamaguchi T, Kishi A, Osaki M, Morikawa H, Prieto-Martin P, Wing K, Saito T, and Sakaguchi S.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: (In press)
• [Presentation] The Molecular Basis of Treg-Mediated Suppression (2013)
  • Author(s): Shimon Sakaguchi
  • Organizer: The 2nd NIF Winter School 2013 on Advanced Immunology
  • Place of Presentation: SIgN(Singapore)
  • Invited
• [Presentation] Genetic and epigenetic control of regulatory T cell development (2013)
  • Author(s): Shimon Sakaguchi
  • Organizer: JST-CREST International Symposium Frontiers in Immunology and Inflammation From Molecules to Disease
  • Place of Presentation: ＪＳＴ本部（東京）
  • Invited
• [Presentation] Molecular basis of regulatory T cells development and their functional stability (2012)
  • Author(s): Shimon Sakaguchi
  • Organizer: Centre for Immune Regulation University of Oslo
  • Place of Presentation: Grand Hotel (Norway)(招待講演)
  • Year and Date: 2012-03-30
• [Presentation] Molecular basis of regulatory T cells development and their functional stability (2012)
  • Author(s): Shimon Sakaguchi
  • Organizer: Helmholtz Centre for Infection Research
  • Place of Presentation: Braunschweig (Germany)(招待講演)
  • Year and Date: 2012-03-28
• [Presentation] Treg development and function (2012)
  • Author(s): Shimon Sakaguchi
  • Organizer: International Symposium Migration and Regulation : Managing immune-mediated diseases
  • Place of Presentation: Berlin-Brandenburgische Akademie der Wissenschaften, Berlin (Germany)(招待講演)
  • Year and Date: 2012-03-26
• [Presentation] Molecular basis of regulatory T cells development and their functional stability (2012)
  • Author(s): Shimon Sakaguchi
  • Organizer: Max Planck Institute of Neurobiology
  • Place of Presentation: MPI fur Neurobiologie (Germany)(招待講演)
  • Year and Date: 2012-03-22
• [Presentation] Roles of concurrent epigenetic conversion and Foxp3 expression for the development of regulatory T cells (2012)
  • Author(s): Shimon Sakaguchi
  • Organizer: Winter School 2012 on Advanced Immunology
  • Place of Presentation: 淡路夢舞台(兵庫)(招待講演)
  • Year and Date: 2012-01-19
• [Presentation] Regulatory T cells for Immune Regulation (2012)
  • Author(s): Shimon Sakaguchi
  • Organizer: International symposium : Infection, immunity and cacer
  • Place of Presentation: 芝蘭会館(京都)(招待講演)
  • Year and Date: 2012-01-16
• [Presentation] 遺伝子変異と発病の間のブラックボックス解明のために構造生物学ができること (2012)
  • Author(s): 坂口志文
  • Organizer: 日本学術会議公開シンポジウム
  • Place of Presentation: 日本学術会議大講堂(東京)(招待講演)
  • Year and Date: 2012-01-09
• [Presentation] Genetic basis of the development and function of natural Foxp3-expressing regulatory T cells (2012)
  • Author(s): Shimon Sakaguchi
  • Organizer: novo nordisk innovation summit Tokyo 2012 chronic inflammation and autoimmune diseases
  • Place of Presentation: シェラトン都ホテル東京（東京）
  • Invited
• [Presentation] 制御性T細胞による免疫応答制御 (2012)
  • Author(s): 坂口志文
  • Organizer: 第66回日本栄養・食糧学会
  • Place of Presentation: 東北大学（仙台）
  • Invited
• [Presentation] Roles of concurrent epigenetic conversion and Foxp3 expression for the development and function of regulatory T cells (2012)
  • Author(s): Shimon Sakaguchi
  • Organizer: International Symposium Dynamism of Immune Reactions & Regulation
  • Place of Presentation: 大阪国際会議場（大阪）
  • Invited
• [Presentation] 制御性T細胞による免疫応答制御 (2012)
  • Author(s): 坂口志文
  • Organizer: The 4th BMC(Brainstorming MedicalConference)
  • Place of Presentation: 泉ガーデンコンファレンスセンター（東京）
  • Invited
• [Presentation] 制御性T細胞による免疫応答制御 (2012)
  • Author(s): 坂口志文
  • Organizer: 第14回白馬シンポジウムin京都
  • Place of Presentation: 京都市国際交流会館（京都）
  • Invited
• [Presentation] Genetic and Epigenetic Basis of Regulatory T Cell Function in Their Clinical Application (2012)
  • Author(s): Shimon Sakaguchi
  • Organizer: FOCiS (Federation of Clinical Immunology Societies)2012
  • Place of Presentation: Vancouver,BC<, Canada(Vancouve,r Canada)
  • Invited
• [Presentation] 制御性T細胞と免疫寛容、免疫制御 (2012)
  • Author(s): 坂口志文
  • Organizer: 第14回日本免疫学会免疫サマースクール2012
  • Place of Presentation: ラフォーレ那須（那須）
  • Invited
• [Presentation] 制御性T細胞と自己免疫病 (2012)
  • Author(s): 坂口志文
  • Organizer: 第２回T-cell Camp
  • Place of Presentation: ヒルトン小田原リゾート＆スパ（小田原）
  • Invited
• [Presentation] Genetic and Epigenetic Control of Regulatory T cellFunction (2012)
  • Author(s): Shimon Sakaguchi
  • Organizer: 3rd European Congress of Immunology
  • Place of Presentation: University of Glasgow(Glasgow, UK)
  • Invited
• [Presentation] 制御性T細胞による免疫応答制御 (2012)
  • Author(s): 坂口志文
  • Organizer: 第13回運動器科学研究会
  • Place of Presentation: アピカルイン京都（京都）
  • Invited
• [Presentation] Genetic and Epigenetic Control of Regulatory T cell Development and Function (2012)
  • Author(s): Shimon Sakaguchi
  • Organizer: French-Japanese Meeting
  • Place of Presentation: フランス大使館（東京）
  • Invited
• [Presentation] Genetic and Epigenetic Control of Regulatory T cell Development (2012)
  • Author(s): Shimon Sakaguchi
  • Organizer: The 12th International Symposium on Dendritic Cells
  • Place of Presentation: EXCO,Deagu(Daegu Korea)
  • Invited
• [Presentation] Genetic and Epigenetic Control of Regulatory T cell Development (2012)
  • Author(s): Shimon Sakaguchi
  • Organizer: The Third International Conference on Regulatory T Cells and Helper T Cell Subsets and Clinical Application in Human Diseases
  • Place of Presentation: Renaissance Shanghai Pudong Hotel(Shanghai China)
  • Invited
• [Presentation] Genetic and Epigenetic Control of Regulatory T cell Development (2012)
  • Author(s): Shimon Sakaguchi
  • Organizer: The 34th Naito Conference on Infection, Immunity and their Control for Health: Mucosal Barrier, Pathogen and Vaccine
  • Place of Presentation: シャトレーゼ ガトーキングダム札幌（札幌）
  • Invited
• [Presentation] T cell signaling, Regulatory T cells, and Autoimmune Diseases (2012)
  • Author(s): Shimon Sakaguchi
  • Organizer: 橋本病百周年記念国際シンポジウム International Symposium II
  • Place of Presentation: アクロス福岡（福岡）
  • Invited
• [Presentation] 制御性T細胞による免疫応答制御 (2012)
  • Author(s): 坂口志文
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸）
  • Invited
• [Presentation] 制御性T細胞を標的とした免疫応答制御の展望 (2012)
  • Author(s): 坂口志文
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸）
  • Invited
• [Presentation] Induction of tumor immunity by targeting regulatory T cells (2011)
  • Author(s): Shimon Sakaguchi
  • Organizer: Joint Symposium of Seoul St.Mary's Hop, Osaka Univ.Postech
  • Place of Presentation: Seoul St, Mary's Hospital (Korea)(招待講演)
  • Year and Date: 2011-12-19
• [Presentation] Control of Immune Responses by Regulatory T Cells (2011)
  • Author(s): Shimon Sakaguchi
  • Organizer: 10^<th> Faculty Research Symposium Frontiers in Biomedical Research
  • Place of Presentation: Cheung Kung Hai Conference Centre (China)(招待講演)
  • Year and Date: 2011-12-09
• [Presentation] Regulatory T cells for immune tolerance and homeostasis (2011)
  • Author(s): Shimon Sakaguchi
  • Organizer: Institut Federatif de Recherche Bio-Medicale de Toulouse INSERM
  • Place of Presentation: Toulouse(France)(招待講演)
  • Year and Date: 2011-11-22
• [Presentation] Regulatory T cells for immune tolerance and homeostasis (2011)
  • Author(s): Shimon Sakaguchi
  • Organizer: nstitut Pasteur, Immunology Department Seminar
  • Place of Presentation: Paris(France)(招待講演)
  • Year and Date: 2011-11-21
• [Presentation] 制御性T細胞による免疫応答制御 (2011)
  • Author(s): 坂口志文
  • Organizer: 自治医科大学大学院特別セミナー
  • Place of Presentation: 自治医科大学(栃木)(招待講演)
  • Year and Date: 2011-09-27
• [Presentation] 制御性T細胞による免疫応答制御 (2011)
  • Author(s): 坂口志文
  • Organizer: 東京大学医科学研究所大学院特別セミナー
  • Place of Presentation: 東京大学(東京)(招待講演)
  • Year and Date: 2011-09-12
• [Presentation] 制御性T細胞による免疫応答制御 (2011)
  • Author(s): 坂口志文
  • Organizer: 久留米大学大学院講義
  • Place of Presentation: 久留米大学(福岡)(招待講演)
  • Year and Date: 2011-06-01
• [Presentation] T細胞シグナル、制御性T細胞、自己免疫病 (2011)
  • Author(s): 坂口志文
  • Organizer: 東京大学大学院GCOEセミナー
  • Place of Presentation: 東京大学(東京)(招待講演)
  • Year and Date: 2011-05-26
• [Presentation] 制御性T細胞による免疫応答制御 (2011)
  • Author(s): 坂口志文
  • Organizer: 第62回未来医療セミナー
  • Place of Presentation: 大阪大学医学部講義棟C講堂(大阪)(招待講演)
  • Year and Date: 2011-04-20
• [Presentation] T cell signaling, regulatory T cells, and self-tolerance (2011)
  • Author(s): Shimon Sakaguchi
  • Organizer: Advances in Targeted Therapies
  • Place of Presentation: Hotel Radisson Blu (Croatia)(招待講演)
• [Presentation] TCR signaling and autoimmune arthritis (2011)
  • Author(s): Shimon Sakaguchi
  • Organizer: Australian Rheumatology Association 52^<nd> Annual Scientific Meeting
  • Place of Presentation: Brisbane Convention and Exhibition Centre (Australia)(招待講演)
• [Presentation] Regulatory T Cells for immunological self-tolerance and immune homeostasis (2011)
  • Author(s): Shimon Sakaguchi
  • Organizer: 14^<th> Australasian Autoimmunity Workshop
  • Place of Presentation: The University of Queens land(Australia)(招待講演)
• [Presentation] Therapeutic modalities-future prospects (2011)
  • Author(s): Shimon Sakaguchi
  • Organizer: The Herrenhausen Symposium on Autoimmunity
  • Place of Presentation: Kloster Seeon, (Germany)(招待講演)
• [Presentation] 制御性T細胞による免疫応答制御 (2011)
  • Author(s): 坂口志文
  • Organizer: 第21回日本サイトメトリ-学会学術集会
  • Place of Presentation: 京都市国際交流会館(京都)(招待講演)
• [Presentation] 制御性T細胞による腫瘍免疫応答の制御 (2011)
  • Author(s): 坂口志文
  • Organizer: 第15回日本がん免疫学会総会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)(招待講演)
• [Presentation] 制御性T細胞による免疫応答制御 (2011)
  • Author(s): 坂口志文
  • Organizer: 日本免疫学会第13回免疫サマースクール
  • Place of Presentation: ラフォーレ蔵王リゾート&スパ(山形)(招待講演)
• [Presentation] Autoimmune arthritis caused by systemic alteration of the T cell immune system (2011)
  • Author(s): Shimon Sakaguchi
  • Organizer: 39^<th> Congress of the German Society of Rheumatology
  • Place of Presentation: ICM&ndash InternationalCongrees Centre Munich( Germany)(招待講演)
• [Presentation] 制御性T細胞による免疫応答制御 (2011)
  • Author(s): 坂口志文
  • Organizer: 第47回日本移植学会総会
  • Place of Presentation: 仙台国際センター(福島県)(招待講演)
• [Presentation] Regulatory T Cells for immunological tolerance and immune homeostasis (2011)
  • Author(s): Shimon Sakaguchi
  • Organizer: 8^<th> Nestle International Nutrition Symposium Nutrition & the Immune System
  • Place of Presentation: Lausanne (Switzerland)(招待講演)
• [Presentation] 制御性T細胞による免疫応答制御 (2011)
  • Author(s): 坂口志文
  • Organizer: 第61回日本アレルギー学会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)(招待講演)
• [Presentation] Regulatory T Cells for the control of physiological and pathological immune responses (2011)
  • Author(s): Shimon Sakaguchi
  • Organizer: 6^<th> European Workshop on Immune-Mediated Inflammatory Diseases
  • Place of Presentation: Radisson Blu(France)(招待講演)
• [Presentation] Biology of Regulatory T Cells (2011)
  • Author(s): 坂口志文
  • Organizer: BMT Tandem Meetings
  • Place of Presentation: ハワイ(アメリカ)
• [Presentation] 制御性T細胞による免疫応答制御 (2010)
  • Author(s): 坂口志文
  • Organizer: 第7回生物学的製剤治療研究会
  • Place of Presentation: 横浜
  • Year and Date: 2010-07-22
• [Presentation] Control of immune responses by regulatory T cells. (2010)
  • Author(s): 坂口志文
  • Organizer: International Conference in Sapporo 2010
  • Place of Presentation: 北海道
  • Year and Date: 2010-07-02
• [Presentation] Control of Immune Responses by Regulatory T Cells. (2010)
  • Author(s): 坂口志文
  • Organizer: Gladstone Institute of Virology and Immunology Seminar Series
  • Place of Presentation: サンフランシスコ(アメリカ)
  • Year and Date: 2010-05-06
• [Presentation] 制御性T細胞による免疫応答制御 (2010)
  • Author(s): 坂口志文
  • Organizer: 第6回皮膚免疫疾患研究会
  • Place of Presentation: 大阪
  • Year and Date: 2010-04-08
• [Presentation] Regulatory T cells for self-tolerance. (2010)
  • Author(s): Shimon Sakaguchi
  • Organizer: 14thInternational Congress of Immunology
  • Place of Presentation: 神戸
• [Presentation] T cell signaling, regulatory T cells, and self-tolerance. (2010)
  • Author(s): Shimon Sakaguchi
  • Organizer: 97thAnnual Meeting of the American Association of Immunologist
  • Place of Presentation: Baltimore, USA
• [Presentation] Construction of regulatory T cells without FoxP3. (2010)
  • Author(s): T.Yamaguchi, A.Kishi, M.Osaki, S.Sakaguchi
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸
• [Presentation] Analysis of epigenetic status in regulatory T cells. (2010)
  • Author(s): N.Ohkura, M.Hamaguchi, K.Sugimura, A.Tanaka, N.Sasaki S.Sakaguchi
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸
• [Presentation] SKGマウスにおける関節炎発症のメカニズム (2010)
  • Author(s): 坂口志文
  • Organizer: 第54回日本リウマチ学会総会・学術総会
  • Place of Presentation: 神戸
• [Presentation] State-of-the-Art Address. Regulatory T cells for immunological tolerance. (2010)
  • Author(s): 坂口志文
  • Organizer: American Transplantation Congress 2010
  • Place of Presentation: サンディエゴ(アメリカ)
• [Presentation] T cell signaling, regulatory T cells, and self-tolerance. (2010)
  • Author(s): 坂口志文
  • Organizer: 97^<th> Annual Meeting of the American Association of Immunologist
  • Place of Presentation: ボルチモア(アメリカ)
• [Presentation] Regulatory T Cells in Innate and Adaptive Immunity. (2010)
  • Author(s): 坂口志文
  • Organizer: 2010 Keystone Symposia Innate Immunity : Mechanisms Linking with Adaptive Immunity
  • Place of Presentation: ダブリン(アイルランド)
• [Presentation] 制御性T細胞による免疫応答制御 (2010)
  • Author(s): 坂口志文
  • Organizer: 第26回日本DDS学会
  • Place of Presentation: 大阪
• [Presentation] Control of immune responses by regulatory T cells. (2010)
  • Author(s): 坂口志文
  • Organizer: IFReC-New Zealand Immunology Workshop
  • Place of Presentation: 大阪
• [Presentation] Treg cells. (2010)
  • Author(s): 坂口志文
  • Organizer: 14^<th> Congress of Asia Pacific League of Associations for Rheumatology
  • Place of Presentation: 香港(中国)
• [Presentation] Th17 and Treg in inflammatory diseases. (2010)
  • Author(s): 坂口志文
  • Organizer: 14^<th> Congress of Asia Pacific League of Associations for Rheumatology
  • Place of Presentation: 香港(中国)
• [Presentation] Keynote lecture Construction of regulatory T cells without Foxp3. (2010)
  • Author(s): 坂口志文
  • Organizer: The second International Conference on Regulatory T Cells and Th17 Cells and Clinical Application in Human Diseases China Tregs/Th17
  • Place of Presentation: 上海(中国)
• [Presentation] T cell signaling, Treg, and autoimmunity. (2010)
  • Author(s): 坂口志文
  • Organizer: The second International Conference on Regulatory T Cells and Th17 Cells and Clinical Application in Human Diseases China Tregs 2010
  • Place of Presentation: 上海(中国)
• [Presentation] Regulatory T cells for self-tolerance. (2010)
  • Author(s): 坂口志文
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸
• [Presentation] Regulatory T cells for immunological tolerance and immune homeostasis. (2010)
  • Author(s): 坂口志文
  • Organizer: International Symposium for Immunology of Reproduction (ISIR-Osaka 2010)
  • Place of Presentation: 大阪
• [Presentation] Altered TCR signaling as a cause of autoimmune disease. (2010)
  • Author(s): 坂口志文
  • Organizer: FROM THE LABORATORY TO THE CLINIC : Differences between immunity and inflammation in mice and men : Reasons for translational failures?
  • Place of Presentation: オックスフォード(イギリス)
• [Presentation] T cell signaling, regulatory T cells and self-tolerance. (2010)
  • Author(s): 坂口志文
  • Organizer: 40^<th> Annual Meeting German Society for Immunology
  • Place of Presentation: ライプツヒ(ドイツ)
• [Presentation] T-cell signaling, regulatory T cells and self-tolerance (2010)
  • Author(s): 坂口志文
  • Organizer: 8^<th> German-Japan Symposium
  • Place of Presentation: クックスハーフェン(ドイツ)
• [Presentation] 制御性T細胞による免疫応答制御 (2010)
  • Author(s): 坂口志文
  • Organizer: 日本臨床検査自動化学会第42回大会
  • Place of Presentation: 神戸
• [Presentation] T cell signaling, regulatory T cells and self-tolerance. (2010)
  • Author(s): 坂口志文
  • Organizer: The 2010 Cold Spring Harbor Asia Conference : Frontier of Immunology in Health & Diseases
  • Place of Presentation: 蘇州市(中国)
• [Presentation] The molecular basis of the development and function of regulatory T cells. (2010)
  • Author(s): 坂口志文
  • Organizer: The 2010 Fall Conference of The Korean Association of Immunologists
  • Place of Presentation: ソウル(韓国)
• [Presentation] Overview and Mechanisms of Treg Suppression. (2010)
  • Author(s): 坂口志文
  • Organizer: British Society for Immunology Annual Congress
  • Place of Presentation: リバプール(イギリス)
• [Presentation] Control of immune responses by regulatory T cells (2010)
  • Author(s): Shimon Sakaguchi
  • Organizer: 8^<th> EAACI-GAZLEN-Immunology Winter School
  • Place of Presentation: Germany,Gralnau, Garmlsah-Partenklrohan
• [Presentation] CTLA-4-dependent mechanism of Treg-mediated in vivo and in vitro suppression. (2009)
  • Author(s): Shimon Sakaguchi
  • Organizer: WORLD IMMUNE REGULATION MEETING-III
  • Place of Presentation: Davos, Switzerland
• [Presentation] T cell signaling, regulatory T cells and autoimmunity. (2009)
  • Author(s): Shimon Sakaguchi
  • Organizer: Tolerance and Development. The Foundation des Treilles
  • Place of Presentation: Tourtour France
• [Presentation] Regulatory T cells for immunological tolerance and immune homeostasis (2009)
  • Author(s): Shimon Sakaguchi
  • Organizer: The First International Kishimoto Foundation Symposium Immune Regulation : Present and Future
  • Place of Presentation: 大阪
• [Presentation] T cell signaling, regulatory T cells and self-tolerance. (2009)
  • Author(s): Shimon Sakaguchi
  • Organizer: The 5^<th> International Workshop of Kyoto T Cell Conference.
  • Place of Presentation: 京都
• [Presentation] Suppression Mechanisms of Foxp3^+ Regulatory T Cells (2009)
  • Author(s): Shimon Sakaguchi
  • Organizer: FOCIS 2009
  • Place of Presentation: San Francisco USA
• [Presentation] Control of immune response by regulatory T cells (2009)
  • Author(s): Shimon Sakaguchi
  • Organizer: 45^<th> Joint Committee Meeting Japan-U.S. Cooperative Medical Science Program
  • Place of Presentation: 札幌
• [Presentation] T cell signaling, regulatory T cells and autoimmunity. (2009)
  • Author(s): Shimon Sakaguchi
  • Organizer: Cellular and Genetic View on Autoimmunity. RCAI-JSI International Symposium on Immunology 2009
  • Place of Presentation: 横浜
• [Presentation] Regulatory T cells for immune tolerance and homeostasis towards their clinical use (2009)
  • Author(s): Shimon Sakaguchi
  • Organizer: TWINCORE-Symposium Infection Research and Beyond
  • Place of Presentation: Hannover Germany
• [Presentation] CTLA-4 for Treg-mediated suppression, Tolerance and Immunoregulation (2009)
  • Author(s): Shimon Sakaguchi
  • Organizer: From basic mechanisms to therapeutic applications, Satellite Symposium of the European Congress of Immunology
  • Place of Presentation: Berlin, Germany
• [Presentation] CTLA-4 Dependent Mechanism of Treg-Mediated In Vivo and In Vitro Suppression in Tumor Immunity (2009)
  • Author(s): Shimon Sakaguchi
  • Organizer: Control of Cancer Immunosuppression The Challenge for Cancer Vaccine Development The XVII^<th> Meeting in the Cancer Research Institute International Cancer Immunotherapy Symposium Series
  • Place of Presentation: New York USA
• [Presentation] T cell signaling, regulatory T cells and self-tolerance. (2009)
  • Author(s): Shimon Sakaguchi
  • Organizer: 1^<st> International Conference on Immune Tolerance
  • Place of Presentation: Boston U.S.A.
• [Presentation] Regulatory T cells for immune tolerance and tumor immunity (2009)
  • Author(s): Shimon Sakaguchi
  • Organizer: International Symposium on Immunotherapy and immunodeficiency
  • Place of Presentation: Heidelberg, Germany
• [Presentation] Tolerance (2009)
  • Author(s): Shimon Sakaguchi
  • Organizer: 10^<th> FIMSA(Federation of Immunological Society of Asia-Oceania)Advanced Immunology Training Course
  • Place of Presentation: Australia, Tanga looma
• [Presentation] T cell signaling for dominant and recessive self-tolerance (2009)
  • Author(s): Shimon Sakaguchi
  • Organizer: ASI(Australasian Society for Immunology)39^<th> Annual Scientific Meeting
  • Place of Presentation: Australia, Canrad Jupiters Queensland
• [Presentation] Regulatory T cells for the control of immunological diseases. (2008)
  • Author(s): Shimon Sakaguchi
  • Organizer: 2008 Keio Medical Science Prize Commemorative Symposium
  • Place of Presentation: 東京
  • Year and Date: 2008-11-22
• [Presentation] Roleof regulatory Tcell intorelace and autoimmunity (2008)
  • Author(s): Shimon Sakaguchi
  • Organizer: EurAPS International Symposium on Molecular Background of tolerance and Autoimmunity
  • Place of Presentation: Helsinki, Finland
  • Year and Date: 2008-04-10
• [Presentation] Regulatory T cells for immune tolerance and homeostasis (2008)
  • Author(s): Shimon Sakaguchi
  • Organizer: The 4th Congress of the Federation of Immunology Societies of Asia-Oceania 2008
  • Place of Presentation: Taipei Taiwan
• [Presentation] 制御性T細胞と腫瘍免疫
  • Author(s): 坂口志文
  • Organizer: 第１回癌・免疫若手セミナー
  • Place of Presentation: 大阪大学医学部付属病院（大阪）
  • Invited
• [Presentation] 制御性T細胞による免疫応答制御
  • Author(s): 坂口志文
  • Organizer: 第18回千葉基礎・臨床免疫セミナー
  • Place of Presentation: 千葉大学医学部（千葉）
  • Invited
• [Presentation] 制御性T細胞による免疫応答制御
  • Author(s): 坂口志文
  • Organizer: 第10回北東北血液研究会
  • Place of Presentation: 秋田温泉さとみコンベンションホール（秋田）
  • Invited
• [Presentation] 制御性T細胞による免疫応答制御
  • Author(s): 坂口志文
  • Organizer: 第2回北摂呼吸器・アレルギー研究会
  • Place of Presentation: 大阪大学銀杏会館（大阪）
  • Invited
• [Presentation] 制御性T細胞による免疫応答制御
  • Author(s): 坂口志文
  • Organizer: 第12回先端医療センターMonthly Lecture
  • Place of Presentation: 先端医療センター（神戸）
  • Invited
• [Presentation] Genetic and Epigenetic Control of Regulatory T cell Function
  • Author(s): Shimon Sakaguchi
  • Organizer: National Institute for Medical Research
  • Place of Presentation: National Institute for Medical Research(Mill Hill, UK)
  • Invited
• [Presentation] 制御性T細胞による免疫応答制御
  • Author(s): 坂口志文
  • Organizer: 2012 Young Physician Workshop
  • Place of Presentation: 京都ブライトンホテル（京都）
  • Invited
• [Presentation] 制御性T細胞による免疫応答制御
  • Author(s): 坂口志文
  • Organizer: 大阪医科大学大学院特別講義
  • Place of Presentation: 大阪医科大学（大阪）
  • Invited
• [Presentation] Regulatory T cells in autoimmune diseases
  • Author(s): Shimon Sakaguchi
  • Organizer: 橋本病百周年記念国際シンポジウム International Symposium I
  • Place of Presentation: アクロス福岡（福岡）
  • Invited
• [Presentation] Control of immune responses by regulatory T cells
  • Author(s): Shimon Sakaguchi
  • Organizer: Tri-Institutional Immunology and Microbial Pathogenesis Program Research Seminar Series
  • Place of Presentation: Memorial Sloan-Kettering Cancer Center(New York USA)
  • Invited
• [Presentation] Control of immune responses by regulatory T cells
  • Author(s): Shimon Sakaguchi
  • Organizer: Immunology seminar Series Harvard Medical School
  • Place of Presentation: ハーバード大学（Boston USA）
  • Invited
• [Presentation] Control of immune responses by regulatory T cells
  • Author(s): Shimon Sakaguchi
  • Organizer: Immunology seminar Series Massachusetts General Hospital
  • Place of Presentation: マサセチューセッツ大学（Boston USA）
  • Invited
• [Patent(Industrial Property Rights)] Induction of Regulatory T Cell-resistant Helper CD4+ T Cells (2008)
  • Inventor(s): Nishikawa, H; Tsuji, T; Ritter, G; Old, LJ; Galan, JE
  • Industrial Property Rights Holder: LICR 12/262831
  • Filing Date: 2008-10-31
  • Overseas
• [Patent(Industrial Property Rights)] 4型葉酸受容体も発現を指標とした制御性T細胞の検出方法、及び免疫賦活剤 (2008)
  • Inventor(s): 坂口志文
  • Industrial Property Rights Holder: 坂口志文
  • Filing Date: 2008-12-19
• [Patent(Industrial Property Rights)] 4型葉酸受容体も発現を指標とした制御性T細胞の検出方法、及び免疫賦活剤 (2008)
  • Inventor(s): 坂口志文
  • Industrial Property Rights Holder: 坂口志文
  • Acquisition Date: 2008-12-19
• [Patent(Industrial Property Rights)] 4型葉酸受容体も発現を指標とした制御性T細胞の検出方法、及び免疫賦活剤 (2008)
  • Inventor(s): 坂口志文
  • Industrial Property Rights Holder: 坂口志文
  • Filing Date: 2008-12-19