Comprehensive study of innate immunity

• Project/Area Number: 20002008
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: AKIRA Shizuo 大阪大学, 免疫学フロンティア研究センター, 教授 (50192919)
• Co-Investigator(Kenkyū-buntansha): TAKEUCHI Osamu 大阪大学, 微生物病研究所, 准教授 (10379092) ; KAWAI Taro 大阪大学, 微生物病研究所, 准教授 (50456935) ; SAITOH Tatsuya 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (60456936) ; SATOH Takashi 大阪大学, 免疫学フロンティア研究センター, 特任助教 (60619716)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥873,080,000 (Direct Cost: ¥671,600,000、Indirect Cost: ¥201,480,000); Fiscal Year 2012: ¥206,960,000 (Direct Cost: ¥159,200,000、Indirect Cost: ¥47,760,000); Fiscal Year 2011: ¥206,960,000 (Direct Cost: ¥159,200,000、Indirect Cost: ¥47,760,000); Fiscal Year 2010: ¥157,690,000 (Direct Cost: ¥121,300,000、Indirect Cost: ¥36,390,000); Fiscal Year 2009: ¥141,830,000 (Direct Cost: ¥109,100,000、Indirect Cost: ¥32,730,000); Fiscal Year 2008: ¥159,640,000 (Direct Cost: ¥122,800,000、Indirect Cost: ¥36,840,000)
• Keywords: 自然免疫 / 炎症性疾患 / 感染症 / サイトカイン / インターフェロン / 生活習慣病 / 炎症 / マクロファージ / 好中球 / パターン認識受容体 / シグナル伝達 / 蛋白質分解 / 遺伝子発現 / Toll-like receptor / エピジェネティクス / H3K27メチル化 / ユビキチン化 / 病原体センサー / オートファジー / 自己免疫疾患

Research Abstract

Innate immune system is critically involved in host defense and inflammation. Innate immune system senses microbial components by pattern-recognition receptors and induces host defense response. However, innate immune system also senseshost-derived stimulatory factors and often causes development of inflammatory diseases. We have conducted a comprehensive study of innate immunity, and have revealed mechanisms underlying development of infectious and inflammatory diseases

Assessment Rating

Verification Result (Rating)

A+

Research Products

• [Journal Article] Poly IC Triggers a Cathepsin D- and IPS-1-Dependent Pathway to Enhance Cytokine Production and Mediate Dendritic Cell Necroprosis. (2013)
  • Author(s): Zou J, Kawai T, Tsuchida T, Kozaki T, Tanaka H, Shin KS, Kumar H, Akira S.
  • Journal Title: Immunity. Volume: 38(49) Issue: 4 Pages: 717-728
  • DOI: 10.1016/j.immuni.2012.12.007
  • Peer Reviewed
• [Journal Article] Critical role of Trib1 for the differentiation of adipose tissue-resident macrophages maintaining metabolic homeostasis. (2013)
  • Author(s): Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi O, Akira S
  • Journal Title: Nature Volume: 495(7442) Issue: 7442 Pages: 524-528
  • DOI: 10.1038/nature11930
  • Peer Reviewed
• [Journal Article] Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. (2013)
  • Author(s): Takuma Misawa, Michihiro Takahama, Tatsuya Kozaki, Hanna Lee, Jian Zhou, Tatsuya Saitoh, Shizuo Akira
  • Journal Title: Nature Immunology Volume: 14(5) Issue: 5 Pages: 454-460
  • DOI: 10.1038/ni.2550
  • Peer Reviewed
• [Journal Article] Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activaion via MAPKs. (2013)
  • Author(s): Ori D
  • Journal Title: J Immunol Volume: 190(8) Issue: 8 Pages: 4037-4045
  • DOI: 10.4049/jimmunol.1300173
  • Peer Reviewed
• [Journal Article] mRNA degradation by the endoribonuclease Regnase-1/ZC3H12a/MCPIP-1. (2013)
  • Author(s): Uehata T
  • Journal Title: Biochim Biophys Acta Volume: 印刷中 Issue: 6-7 Pages: 708-713
  • DOI: 10.1016/j.bbagrm.2013.03.001
  • Peer Reviewed
• [Journal Article] DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING traffickining (2013)
  • Author(s): Takeshi Kondo, Junya Kobayashi, Tatusya Saitoh, Kenta Maruyama. Ken J. Ishii, Glen N. Barber, Kenshi、Komatsu, Shizuo Akira, and Taro Kawai
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 110 Issue: 8 Pages: 2969-2974
  • DOI: 10.1073/pnas.1222694110
  • Peer Reviewed
• [Journal Article] The transcription factor Jun dimerization protein 2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation (2012)
  • Author(s): kenta Maruyama, Masahiro Fukasaka, Alexis Vandenbon, Tatsuya Saitoh, Takumi Kawasaki, Takeshi Kondo, Kazunari K. Yokoyama, Hiroyasu Kidoya, Nobuyuki Takakura, Daron Standley, Osamu Takeuchi, and Shizuo Akira
  • Journal Title: Immunity Volume: 37 Issue: 6 Pages: 1024-1036
  • DOI: 10.1016/j.immuni.2012.08.022
  • Peer Reviewed
• [Journal Article] Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1. (2012)
  • Author(s): Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iawasaki H. Omori H, Yamaoka S, Yamamoto N, Akira S.
  • Journal Title: Cell Host Microbe. Volume: 12(1) Issue: 1 Pages: 109-116
  • DOI: 10.1016/j.chom.2012.05.015
  • Peer Reviewed
• [Journal Article] Dissecting negative regulation of Toll-like receptor signaling. (2012)
  • Author(s): Kondo T
  • Journal Title: Trends Immunol Volume: 33(9) Issue: 9 Pages: 449-458
  • DOI: 10.1016/j.it.2012.05.002
  • Peer Reviewed
• [Journal Article] Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. (2011)
  • Author(s): Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, Akira S.
  • Journal Title: Immunity. Volume: 34 Issue: 3 Pages: 352-363
  • DOI: 10.1016/j.immuni.2011.03.010
  • Peer Reviewed
• [Journal Article] The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. (2011)
  • Author(s): Iwasaki H, Takeuchi O, Teraguchi S, Matsushita K, Uehata T, Kuniyoshi K, Satoh T, Saitoh T, Matsushita M, Standley DM, Akira S.
  • Journal Title: Nat Immunol. Volume: 12 Issue: 12 Pages: 1167-1175
  • DOI: 10.1038/ni.2137
  • Peer Reviewed
• [Journal Article] Epigenetic control of macrophage polarization (2011)
  • Author(s): Takeuchi O, et al
  • Journal Title: Eur J Immunol Volume: 41 Issue: 9 Pages: 2490-2493
  • DOI: 10.1002/eji.201141792
  • Peer Reviewed
• [Journal Article] Innate immunity and adjuvants (2011)
  • Author(s): Akira S
  • Journal Title: Philos Trans R Soc Lond B Biol Sci Volume: 366 Pages: 2748-2755
  • Peer Reviewed
• [Journal Article] Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity (2011)
  • Author(s): Kawasaki T, et al
  • Journal Title: Immunol Rev Volume: 243 Issue: 9 Pages: 61-73
  • DOI: 10.1002/emmm.201100160
  • Peer Reviewed
• [Journal Article] Toll-like receptors and their crosstalk with other innate receptors in infection and immunity (2011)
  • Author(s): Kawai T, et al
  • Journal Title: Immunity Volume: 34 Pages: 637-650
  • Peer Reviewed
• [Journal Article] A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity (2011)
  • Author(s): Fujimoto K, et al
  • Journal Title: J Immunol Volume: 186 Pages: 6287-6295
  • Peer Reviewed
• [Journal Article] Antiviral protein Viperin promotes TOll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells (2011)
  • Author(s): Saitoh T, et al
  • Journal Title: Immunity Volume: 34 Pages: 352-363
  • Peer Reviewed
• [Journal Article] NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections. (2011)
  • Author(s): Kumar, H., Pandey, S., Zou, J., Kumagai, Y., Takahashi, K., Akira, S., Kawai, T.
  • Journal Title: J Immunol Volume: 186(2) Pages: 994-1000
  • Peer Reviewed
• [Journal Article] Pathogen recognition by the innate immune system. (2011)
  • Author(s): Kumar, H., Kawai, T., Akira, S.
  • Journal Title: Int Rev Immunol Volume: 30(1) Pages: 16-34
  • Peer Reviewed
• [Journal Article] The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA. (2010)
  • Author(s): Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, Kawai T, Akira S.
  • Journal Title: Immunity. Volume: 35(59) Pages: 765-776
  • Peer Reviewed
• [Journal Article] The Jmjd3-Irf4 axis regulates M2 macropharge polarization and host responses against helminth infection. (2010)
  • Author(s): Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Kumagai Y, Miyake T, Matsuyama T, Yui K, Okazaki T, Saitoh T, Honma K, Nakai,K Akira S.
  • Journal Title: Nat Immunol. Volume: 11(10) Issue: 10 Pages: 936-944
  • DOI: 10.1038/ni.1920
  • Peer Reviewed
• [Journal Article] The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA. (2010)
  • Author(s): Tsuchida, T., Zou, J., Saitoh, T., Kumar, H., Abe, T., Matsuura, Y., Kawai, T., Akira, S.
  • Journal Title: Immunity 35(5) Pages: 765-776
  • Peer Reviewed
• [Journal Article] The Jmjd3-lrf4 axis regulates M2 macropharge polarization and host responses against helminth infection. (2010)
  • Author(s): Satoh, T., Takeuchi, O., Vandenbon, A., Yasuda, K., Kumagai, Y., Miyake, T., Matsuyama, T., Yui, K., Okazaki, T., Saitoh, T., Honma, K., Nakai, K.and Akira, S.
  • Journal Title: Nat Immunol. 11(10) Pages: 936-944
  • Peer Reviewed
• [Journal Article] The role of pattern-recognition receptors in innate immunity:update on Toll-like receptors. (2010)
  • Author(s): Kawai, T.and Akira, S.
  • Journal Title: Nat Immunol. 11(5) Pages: 373-384
  • Peer Reviewed
• [Journal Article] Pattern recognition receptors and inflammation. (2010)
  • Author(s): Takeuchi, O., Akira, S.
  • Journal Title: Cell 140(6) Pages: 805-820
  • Peer Reviewed
• [Journal Article] Regulation of dsDNA-induced innate immune responses by membrane trafficking. (2010)
  • Author(s): Saitoh, T., Fujita, N., Yoshimori, T., Akira, S.
  • Journal Title: Autophagy Volume: 6(3) Pages: 430-432
  • Peer Reviewed
• [Journal Article] Pattern recognition receptors and inflammation. (2010)
  • Author(s): Takeuchi, O., Akira, S.
  • Journal Title: Cell Volume: 140(6) Pages: 805-820
  • Peer Reviewed
• [Journal Article] Identification and functions of pattern-recognition receptors. (2010)
  • Author(s): Kumagai, Y., Akira, S.
  • Journal Title: J Allergy Clin Immunol Volume: 125(5) Pages: 985-992
  • Peer Reviewed
• [Journal Article] The role of pattern-recognition receptors in innate immunity : update on Toll-like receptors. (2010)
  • Author(s): Kawai, T., Akira, S.
  • Journal Title: Nat Immunol Volume: 11(5) Pages: 373-384
  • Peer Reviewed
• [Journal Article] Regulation of innate immune responses by autophagy-related proteins. (2010)
  • Author(s): Saitoh, T., Akira, S.
  • Journal Title: J Cell Biol Volume: 189(6) Pages: 925-935
  • Peer Reviewed
• [Journal Article] The Jmjd3-Irf4 axis regulates M2 macropharge polarization and host responses against helminth infection. (2010)
  • Author(s): Satoh, T., Takeuchi, O., Vandenbon, A., Yasuda, K., Kumagai, Y., Miyake, T., Matsuyama, T., Yui, K., Okazaki, T., Saitoh, T., Honma, K., Nakai, K., Akira, S.
  • Journal Title: Nat Immunol Volume: 11(10) Pages: 936-944
  • Peer Reviewed
• [Journal Article] I{kappa}B{zeta} is essential for natural killer cell activation in response to IL-12 and IL-18. (2010)
  • Author(s): Miyake, T., Satoh, T., Kato, H., Matsushita, K., Kumagai, Y., Vandenbon, A., Tani, T., Muta, T., Akira, S., Takeuchi, O.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 107(41) Pages: 17680-17685
  • Peer Reviewed
• [Journal Article] The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA. (2010)
  • Author(s): Tsuchida, T., Zou, J., Saitoh, T., Kumar, H., Abe, T., Matsuura, Y., Kawai, T., Akira, S.
  • Journal Title: Immunity Volume: 35(5) Pages: 765-776
  • Peer Reviewed
• [Journal Article] LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. (2010)
  • Author(s): Satoh T, Kato H, Kumagai Y, Yoneyama M, Sato S, Matsushita K, Tsujimura T, Fujita T, Akira S, Takeuchi O.
  • Journal Title: Proc Natl Acad Sci USA. 107(4) Pages: 1512-1517
  • Peer Reviewed
• [Journal Article] TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. (2009)
  • Author(s): Kawagoe T, Takeuchi O, Takabatake Y, Kato H, Isaka Y, Tsujimura T, Akira S.
  • Journal Title: Nat Immunol. Volume: 10(9) Issue: 9 Pages: 965-972
  • DOI: 10.1038/ni.1771
  • Peer Reviewed
• [Journal Article] Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. (2009)
  • Author(s): Matsushita K, Takeuchi O, Standley D, Kumagai Y, Kawagoe T, Miyake T, Satoh T, Kato H, Tsujimura T, Nakamura H, Akira S.
  • Journal Title: Nature. Volume: 458(7242) Issue: 7242 Pages: 1185-1190
  • DOI: 10.1038/nature07924
  • Peer Reviewed
• [Journal Article] TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. (2009)
  • Author(s): Kawagoe, T., Takeuchi, O., Takabatake, Y., Kato, H., Isaka, Y., Tsujimura, T., Akira S.
  • Journal Title: Nat Immunol 10(9) Pages: 965-972
  • Peer Reviewed
• [Journal Article] Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. (2009)
  • Author(s): Nakamura, H., Akira S.
  • Journal Title: Nature 458(7242) Pages: 1185-1190
  • Peer Reviewed
• [Journal Article] TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-(alpha) production in plasmacytoid dendritic cells. (2009)
  • Author(s): Kumagai Y, Kumar H, Koyama S, Kawai T, Takeuchi O, Akira S.
  • Journal Title: J Immunol. 182(7) Pages: 3960-3964
  • Peer Reviewed
• [Journal Article] Zc3h12a is an Base essential for controlling immune responses by regulating mRNA decay. (2009)
  • Author(s): Matsushita K^*, Takeuchi O^*, Standley DM, Kumagai Y, Kawagoe T, Miyake T, Satoh T, Kato H, Tsuiimura T, Nakamura H, Akira S.
  • Journal Title: Nature. 458(7242) Pages: 1185-1190
  • Peer Reviewed
• [Journal Article] Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-I and TRIF-dependent pathways. (2009)
  • Author(s): Miyake T, Kumagai Y, Kato H, Guo Z, Matsushita K, Satoh T, Kawagoe T, Kumar H, Jang MH, Kawai T, Tani T, Takeuchi O, Akira S.
  • Journal Title: J Immunol. 183(4) Pages: 2522-2528
  • Peer Reviewed
• [Journal Article] TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. (2009)
  • Author(s): Kawagoe T^*, Takeuchi O*, Takabatake Y, Kato H, Isaka Y, Tsujimura T, Akira S.
  • Journal Title: Nat Immunol. 10(9) Pages: 965-972
  • Peer Reviewed
• [Journal Article] Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. (2009)
  • Author(s): Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S.
  • Journal Title: Proc Natl Acad Sci USA. 106(49) Pages: 20842-20846
  • Peer Reviewed
• [Journal Article] Immune Interventions of Human Diseases through Toll-Like Receptors. (2009)
  • Author(s): Coban, C., Ishii, K.J., Akira,S
  • Journal Title: Adv Exp Med Biol. 655 Pages: 63-80
  • Peer Reviewed
• [Journal Article] Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal beta-glucan. (2009)
  • Author(s): Kumar, H., Kumagai, Y., Tsuchida, T., Koening, P.A., Satoh, T., Guo, Z., Jang, M.H., Saitoh, T., Akira, S., Kawai, T.
  • Journal Title: J Immunol. 183(12) Pages: 8061-8067
  • Peer Reviewed
• [Journal Article] [Regulation of allergy by innate immune system] Nippon Rinsho.] (2009)
  • Author(s): Kumagai, Y., Akira, S.
  • Journal Title: Nippon Rinsho. 67(11) Pages: 2055-2061
  • Peer Reviewed
• [Journal Article] Toll-like receptors and innate immunity. Biochem Biophys Res Commun. (2009)
  • Author(s): Kumar, H., Kawai, T., Akira, S
  • Journal Title: Biochem Biophys Res Commun 388(4) Pages: 621-625
  • Peer Reviewed
• [Journal Article] Inante immunity to Pathogens : diversity in receptors for microbial recog nition (2009)
  • Author(s): Akira S.
  • Journal Title: Immunol Rev 227(1) Pages: 5-8
  • Peer Reviewed
• [Journal Article] Innate immunity to virus infection (2009)
  • Author(s): Takeuchi O, Akira S.
  • Journal Title: Immunol Rev. 227(1) Pages: 75-86
  • Peer Reviewed
• [Journal Article] Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. (2008)
  • Author(s): Saitoh T, Fujita N, Jang M.H, Uematsu S, Yang B.G, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Tsujimura T, Takeuchi O, Yoshimori T, Akira S.
  • Journal Title: Nature. Volume: 456(7219) Issue: 7219 Pages: 264-268
  • DOI: 10.1038/nature07383
  • Peer Reviewed
• [Journal Article] Regulation of humoral and cellular gut immunityby lamina propria dendritic cells expressing Toll-like receptor 5. (2008)
  • Author(s): Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T,Yamamoto M, Yokoda Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S.
  • Journal Title: Nat Immunol. Volume: 9(7) Issue: 7 Pages: 769-776
  • DOI: 10.1038/ni.1622
  • Peer Reviewed
• [Journal Article] Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. (2008)
  • Author(s): Saitoh, T., Fujita, N., Jang, M.H., Uematsu, S., Yang, B.G., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., Tanaka, K., Tsujimura, T., Takeuchi, O., Yoshimori, T., Akira S.
  • Journal Title: Nature 456(7219) Pages: 264-268
  • Peer Reviewed
• [Journal Article] Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. (2008)
  • Author(s): Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y, Saitoh T, Kawai T, Takeuchi O, Akira S.
  • Journal Title: Nat Immunol 9(6) Pages: 684-691
  • NAID: 40016500618
  • Peer Reviewed
• [Journal Article] Regulation of humoral and cellular gut immunity by lamina propria de ndritic cells expressing Toll-like receptor 5 (2008)
  • Author(s): Uematsu S, Fujimoto K, Jang M.H, Yang B.G, Jung Y. J, Nish iyama M, Sato S, Tsujimura T, Yamamoto M, Yokoda Y, Kiyono H, Miyasaka M, Ishii KJ, Akir a S
  • Journal Title: Nat Immunol 9(7) Pages: 769-776
  • Peer Reviewed
• [Journal Article] Host innate immune receptors and beyond : making sense of microbial infections (2008)
  • Author(s): Ishii KJ, Koyama S, Nakagawa A, Coban C, Akira S
  • Journal Title: Cell Host Microbe. 3(6) Pages: 352-363
  • Peer Reviewed
• [Journal Article] Length-dependent recognition of double-stranded ribonucleic acids by rethinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 (2008)
  • Author(s): Kato H, Takeuchi O, Mikamo-Satoh E, Hirai R, Kawai T, Matsushita K, Hiiragi A, Dermody T.S, Fujita T, Akira S.
  • Journal Title: J Exp Med. 205(7) Pages: 1601-1610
  • Peer Reviewed
• [Journal Article] Pathogen recognition by innate receptors (2008)
  • Author(s): Kumagai Y, Takeuchi O, Akira S.
  • Journal Title: J Infect Chemother 14(2) Pages: 86-92
  • NAID: 10021193501
  • Peer Reviewed
• [Journal Article] Innate immune response to viral infection (2008)
  • Author(s): Koyama S, Ishii KJ, Coban C, Akira S.
  • Journal Title: Cytokine 43(3) Pages: 336-341
  • Peer Reviewed
• [Journal Article] Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1 beta production (2008)
  • Author(s): Saitoh T, Fujita N, Jang M.H, Uematsu S, Yang B.G, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Tsujimura T, Takeuchi O, Yoshimori T, Akira S
  • Journal Title: Nature. 456(7219) Pages: 264-268
  • Peer Reviewed
• [Journal Article] RIG-I-like antiviral protein in files (2008)
  • Author(s): Takeuchi O, Akira S.
  • Journal Title: Nat Immunol 9(12) Pages: 1327-1328
  • Peer Reviewed
• [Journal Article] Toll-like receptor and RIG-L-like receptor aignaling (2008)
  • Author(s): Kawai T, Akira S.
  • Journal Title: Ann N Y Acad. 1143 Pages: 1-20
  • Peer Reviewed
• [Journal Article] Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay
  • Author(s): Matsushita K, Takeuchi O, Standley D, Kumagai Y, Kawagoe T, Miyake T, Satoh T, Kato II, Tsujimura T, Nakamura H, Akira S
  • Journal Title: Nature (In press)
  • Peer Reviewed
• [Presentation] (2012)
  • Author(s): 審良静男、自然免疫
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2012-12-05
• [Presentation] Innate Immune Responses (2012)
  • Author(s): Akira S
  • Organizer: EUROPEAN CONGRESS OF IMMUNOLOGY
  • Place of Presentation: Scottish Exhibition & Conference Centre (Scotland)
  • Year and Date: 2012-09-06
• [Presentation] 自然免疫の新しい考え方 (2012)
  • Author(s): 審良静男
  • Organizer: 日本薬学会132年会
  • Place of Presentation: 北海道大学(北海道)(招待講演)
  • Year and Date: 2012-03-31
• [Presentation] 自然免疫と寄生虫感染 (2012)
  • Author(s): 審良静男
  • Organizer: 第81回日本寄生虫学会大会
  • Place of Presentation: 兵庫医科大学(兵庫)(招待講演)
  • Year and Date: 2012-03-24
• [Presentation] 免疫応答の制御に必須のエンドリボヌクレアーゼ、Regnase-1/Zc3h12a (2012)
  • Author(s): 審良静男
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 国立京都国際会館(京都)(招待講演)
  • Year and Date: 2012-03-15
• [Presentation] 自然免疫と脂質異常 (2012)
  • Author(s): 審良静男
  • Organizer: 第24回腎と脂質研究会
  • Place of Presentation: メルパルク京都(京都)(招待講演)
  • Year and Date: 2012-03-03
• [Presentation] 自然免疫の最近の進歩 (2012)
  • Author(s): 審良静男
  • Organizer: 全身性炎症疾患の病因・病態の解明に関する研究助成・第1回研究発表会
  • Place of Presentation: 霞山会館(東京)(招待講演)
  • Year and Date: 2012-02-11
• [Presentation] 自然免疫と炎症・免疫疾患 (2012)
  • Author(s): 審良静男
  • Organizer: 第3回先進医療フォーラム
  • Place of Presentation: 大阪国際会議場(大阪)(招待講演)
  • Year and Date: 2012-01-21
• [Presentation] Pathogen Recognition by Mammalian Innate Immunity (2011)
  • Author(s): Shizuo Akira
  • Organizer: Frontier in Biomedical Research, HKU2011
  • Place of Presentation: The Cheung Kung Hai Conference Centre (Hong Kong)(招待講演)
  • Year and Date: 2011-12-09
• [Presentation] Regulation of the immune response by the zinc finger domain containing nuclease, Regnase-1/Zc3h12a (2011)
  • Author(s): Shizuo Akira
  • Organizer: 第28回国際心臓研究学会
  • Place of Presentation: 学術総合センター(東京)(招待講演)
  • Year and Date: 2011-12-03
• [Presentation] Innate Immunity and Pathogen Recognition (2011)
  • Author(s): Shizuo Akira
  • Organizer: AIMECS2011
  • Place of Presentation: 京王プラザホテル(東京)(招待講演)
  • Year and Date: 2011-12-02
• [Presentation] Dissection of signaling pathways through innate receptors that sense foreign nucleic acids (2011)
  • Author(s): Taro Kawai
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)(招待講演)
  • Year and Date: 2011-11-27
• [Presentation] The Role of mRNA Degradation in Immunity and Inflammation (2011)
  • Author(s): Shizuo Akira
  • Organizer: Bio-Rheumatology International Congress(BRIC) Tokyo, The 8^<th> GARN Meeting
  • Place of Presentation: ヒルトン東京ベイホテル(千葉)(招待講演)
  • Year and Date: 2011-11-14
• [Presentation] 新しい自然免疫学 (2011)
  • Author(s): 審良静男
  • Organizer: 「自然免疫、その新展開」シンポジウム
  • Place of Presentation: 東商ホール(東京)(招待講演)
  • Year and Date: 2011-11-04
• [Presentation] 自然免疫の最前線 (2011)
  • Author(s): 審良静男
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都)(招待講演)
  • Year and Date: 2011-09-24
• [Presentation] 自然免疫と炎症 (2011)
  • Author(s): 審良静男
  • Organizer: 第28回日本医学会総会
  • Place of Presentation: 東東ビッグサイト(東京)(招待講演)
  • Year and Date: 2011-09-18
• [Presentation] Nucleic Acids Sensing by innate immunity. (2011)
  • Author(s): Akira S
  • Organizer: International Union of Microbiological Societies 2011 Congress(IUMS2011).
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2011-09-16
• [Presentation] Nucleic Acids Sensing by innate immunity (2011)
  • Author(s): Shizuo Akira
  • Organizer: International Union of Microbiological Societies 2011 Congress(IUMS2011)
  • Place of Presentation: 札幌コンベンションセンター(北海道)(招待講演)
  • Year and Date: 2011-09-16
• [Presentation] 自然免疫と炎症・免疫応答 (2011)
  • Author(s): 審良静男
  • Organizer: 第64回神奈川リウマチ医会
  • Place of Presentation: かながわ労働プラザ(神奈川)(招待講演)
  • Year and Date: 2011-07-30
• [Presentation] 自然免疫:病原体認識と炎症応答 (2011)
  • Author(s): 審良静男
  • Organizer: 第41回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 甲府富士屋ホテル(山梨)(招待講演)
  • Year and Date: 2011-07-16
• [Presentation] 自然免疫と炎症 (2011)
  • Author(s): 審良静男
  • Organizer: 第20回栃木膠原病と腎カンファランス
  • Place of Presentation: 宇都宮グランドホテル(栃木)(招待講演)
  • Year and Date: 2011-07-08
• [Presentation] Innate immunity and viral recognition (2011)
  • Author(s): Shizuo Akira
  • Organizer: 45^<th> Joint Working Conference on Immunology and Viral Deseases
  • Place of Presentation: Stanford University(USA)(招待講演)
  • Year and Date: 2011-06-20
• [Presentation] 自然免疫:認識・シグナル・応答 (2011)
  • Author(s): 審良静男
  • Organizer: 第15回腸内細菌学会
  • Place of Presentation: 東京医科歯科大学(東京)(招待講演)
  • Year and Date: 2011-06-16
• [Presentation] 自然免疫と炎症反応 (2011)
  • Author(s): 審良静男
  • Organizer: 第32回日本炎症・再生医学会
  • Place of Presentation: 国立京都国際会館(京都)(招待講演)
  • Year and Date: 2011-06-02
• [Presentation] Innate immunity and inflammatory response (2011)
  • Author(s): Shizuo Akira
  • Organizer: The 76^<th> Japanese Society of Interferon & Cytokine Research, The 19^<th> International Symposium on Molecular Cell Biology of Macrophages 2011
  • Place of Presentation: 全日空ゲートタワーホテル大阪(大阪)(招待講演)
  • Year and Date: 2011-05-26
• [Presentation] Zc3h12a, a zinc finger domain-containing RNase involved in the immune response (2011)
  • Author(s): Shizuo Akira
  • Organizer: TNF2011
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫)(招待講演)
  • Year and Date: 2011-05-17
• [Presentation] Rapid degradation of Zc3h12a to TLR/IL-1R stimulation regulates inflammatory gene expression (2011)
  • Author(s): Osamu Takeuchi
  • Organizer: Toll2011
  • Place of Presentation: Riva del Garda Congress Center(Italy)
  • Year and Date: 2011-05-07
• [Presentation] Innate Immune Regulation revealed by gene targeting (2011)
  • Author(s): Akira S
  • Organizer: Toll2011
  • Place of Presentation: Riva del Garda Congress Center(Italy)
  • Year and Date: 2011-05-04
• [Presentation] Innate Immune Regulation revealed by gene targeting (2011)
  • Author(s): Shizuo Akira
  • Organizer: Toll2011
  • Place of Presentation: Riva del Garda Congress Center(Italy)(招待講演)
  • Year and Date: 2011-05-04
• [Presentation] 自然免疫と病原体認識 (2011)
  • Author(s): 審良静男
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)(招待講演)
  • Year and Date: 2011-04-29
• [Presentation] 病原体認識機構とその活性化メカニズム (2011)
  • Author(s): 審良静男
  • Organizer: 第85回日本感染症学会総会・学術講演会
  • Place of Presentation: ザ・プリンス パークタワー東京(東京)(招待講演)
  • Year and Date: 2011-04-22
• [Presentation] Functional Role of LPS-Inducible Genes Revealed by Gene Targeting (2011)
  • Author(s): Shizuo Akira
  • Organizer: A FP7 funded Workshop Advances in Immunology and Cancer Biology
  • Place of Presentation: Bogazici University(Turkey)(招待講演)
  • Year and Date: 2011-04-15
• [Presentation] Innate immunity and Pathogen Recognition (2011)
  • Author(s): Shizuo Akira
  • Organizer: Towards Comprehensive Understanding of Immune Dynamism (TSUID2011)
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2011-03-01
• [Presentation] TLR Signaling and the immune response (2011)
  • Author(s): Shizuo Akira
  • Organizer: Cold Spring Harbor Asia Conference on Infection & Immunity
  • Place of Presentation: Suzhou Dushu Lake Conference Center(China)(招待講演)
• [Presentation] 自然免疫の最近の進歩 (2010)
  • Author(s): 審良静男
  • Organizer: 第35回自然免疫賦活技術研究会
  • Place of Presentation: サンメッセ香川(香川)(招待講演)
  • Year and Date: 2010-12-24
• [Presentation] 病原体認識受容体と免疫応答 (2010)
  • Author(s): 審良静男
  • Organizer: 第17回外科侵襲とサイトカイン研究会
  • Place of Presentation: ホテル ザ・マンハッタン(千葉)(招待講演)
  • Year and Date: 2010-12-11
• [Presentation] 自然免疫と病原体認識 (2010)
  • Author(s): 審良静男
  • Organizer: 第6回千葉小児感染・アレルギー懇話会
  • Place of Presentation: 京成ホテルミラマーレ(千葉)(招待講演)
  • Year and Date: 2010-12-02
• [Presentation] 自然免疫システムにおける微生物病認識と免疫応答機構の解明 (2010)
  • Author(s): 審良静男
  • Organizer: 慶應医学賞記念講演
  • Place of Presentation: 慶應義塾大学(東京)(招待講演)
  • Year and Date: 2010-11-29
• [Presentation] Innate Immune Responses : Pathogen Recognition and Signaling (2010)
  • Author(s): Shizuo Akira
  • Organizer: MTC Celebrating KI 200 years
  • Place of Presentation: Kalolinska Institute (Sweden)(招待講演)
  • Year and Date: 2010-11-23
• [Presentation] 自然免疫と病原体認識レセプター (2010)
  • Author(s): 審良静男
  • Organizer: 2010年度日中医学交流会議
  • Place of Presentation: 日本医師会館(東京)(招待講演)
  • Year and Date: 2010-11-11
• [Presentation] Function of LPS-inducible genes, Zc3h12a and JMJD3 revealed by gene targeting (2010)
  • Author(s): Shizuo Akira
  • Organizer: The CSI-IFReC Joint Symposium on Immunology
  • Place of Presentation: The Zhejiang Xizi Hotel (China)(招待講演)
  • Year and Date: 2010-11-02
• [Presentation] 自然免疫の最近の進歩 (2010)
  • Author(s): 審良静男
  • Organizer: ワクチンフォーラム2010
  • Place of Presentation: 新宿明治安田生命ホール(東京)(招待講演)
  • Year and Date: 2010-09-14
• [Presentation] Innate immunity and Pathogen Recognition (2010)
  • Author(s): Shizuo Akira
  • Organizer: WMIC2010
  • Place of Presentation: 京都国際会議場(京都)(招待講演)
  • Year and Date: 2010-09-08
• [Presentation] Functional analysis of LPS-inducible genes, zc3h12a and JMJD3 by gene targeting (2010)
  • Author(s): Shizuo Akira
  • Organizer: 第10回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫)(招待講演)
  • Year and Date: 2010-09-07
• [Presentation] Roles of TLR inducible genes revealed by gene targeting (2010)
  • Author(s): Akira S.
  • Organizer: 14th International Congress of Immunology.
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-08-23
• [Presentation] Roles of TLR inducible genes revealed by gene targeting. (2010)
  • Author(s): Shizuo Akira
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-08-23
• [Presentation] Roles of TLR inducible genes revealed by gene targeting (2010)
  • Author(s): Shizuo Akira
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(兵庫)(招待講演)
  • Year and Date: 2010-08-23
• [Presentation] 自然免疫の最前線 (2010)
  • Author(s): 審良静男
  • Organizer: 第15回日本病態プロテアーゼ学会学術集会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)(招待講演)
  • Year and Date: 2010-08-20
• [Presentation] To11-1ike receptor and innate immunity. (2010)
  • Author(s): Shizuo Akira
  • Organizer: WorldPharma2010
  • Place of Presentation: The BellaCenter(Denmark)
  • Year and Date: 2010-07-21
• [Presentation] Toll-like receptor and innate immunity (2010)
  • Author(s): Shizuo Akira
  • Organizer: WorldPharma 2010
  • Place of Presentation: The Bella Center (Denmark)(招待講演)
  • Year and Date: 2010-07-21
• [Presentation] 自然免疫と炎症 (2010)
  • Author(s): 審良静男
  • Organizer: 8^<th> Future Forum Japan Symposium
  • Place of Presentation: ザ・プリンスパークタワー東京(東京)(招待講演)
  • Year and Date: 2010-07-17
• [Presentation] 感染防御の要:自然免疫 (2010)
  • Author(s): 審良静男
  • Organizer: 第9回国際バイオEXPO
  • Place of Presentation: 東京ビッグサイト(東京)(招待講演)
  • Year and Date: 2010-06-30
• [Presentation] 自然免疫の最近の進歩:TLRによって誘導される遺伝子群の機能 (2010)
  • Author(s): 審良静男
  • Organizer: 第75回インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 北九州国際会議場(福岡)(招待講演)
  • Year and Date: 2010-06-25
• [Presentation] 自然免疫と動脈硬化 (2010)
  • Author(s): 審良静男
  • Organizer: 第5回Hypertension Meeting
  • Place of Presentation: ヒルトン大阪(大阪)(招待講演)
  • Year and Date: 2010-06-17
• [Presentation] Functional Analysis of TLR Inducible Genes by Gene Targeting (2010)
  • Author(s): Akira S
  • Organizer: Keystone Symposia.
  • Place of Presentation: Trinity College Dublin (Ireland)
  • Year and Date: 2010-06-08
• [Presentation] Fanctional Analysis of TLR Inducible Genes by Gene Targeting. (2010)
  • Author(s): Shizuo Akira
  • Organizer: Keystone Symposia
  • Place of Presentation: Trinity College Dublin(Ireland)
  • Year and Date: 2010-06-08
• [Presentation] Functional Analysis of TLR Inducible Genes by Gene Targeting. (2010)
  • Author(s): Shizuo Akira
  • Organizer: Keystone Symposia
  • Place of Presentation: Trinity College Dubhn (Ireland)(招待講演)
  • Year and Date: 2010-06-08
• [Presentation] 自然免疫における認識・シグナル・応答 (2010)
  • Author(s): 審良静男
  • Organizer: 日本生化学会九州支部例会
  • Place of Presentation: 鹿児島大学・稲盛会館(鹿児島)(招待講演)
  • Year and Date: 2010-05-22
• [Presentation] 自然免疫:炎症と獲得免疫誘導の要 (2010)
  • Author(s): 審良静男
  • Organizer: 第31回癌免疫外科研究会
  • Place of Presentation: ホテルニューオータニ大阪(大阪)(招待講演)
  • Year and Date: 2010-05-21
• [Presentation] 自然免疫と炎症・免疫応答 (2010)
  • Author(s): 審良静男
  • Organizer: 第53回春季日本歯周病学会学術大会
  • Place of Presentation: 盛岡市民文化ホール(岩手)(招待講演)
  • Year and Date: 2010-05-14
• [Presentation] TLR応答の抑制機序とその破綻 (2010)
  • Author(s): 審良静男
  • Organizer: 第54回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸ポートピアホテル(兵庫)(招待講演)
  • Year and Date: 2010-04-22
• [Presentation] 自然免疫の最近の進歩 (2010)
  • Author(s): 審良静男
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋国際会議場(愛知)(招待講演)
  • Year and Date: 2010-04-17
• [Presentation] Sensing of nucleic acids by innate immunity. (2010)
  • Author(s): Shizuo Akira
  • Organizer: 13^<th> International Conference on lymphocyte Activation and Immune Regularion
  • Place of Presentation: The Fairmont Newport Beach(USA)
  • Year and Date: 2010-02-05
• [Presentation] Pathogen Recognition and Signaling in Mammalian Innate Immunity (2009)
  • Author(s): Akira S.
  • Organizer: NCMLS Sympusium 2009
  • Place of Presentation: Institute of Biomedical Science, Taiwan
  • Year and Date: 2009-11-05
• [Presentation] Zc3h12a, a negative regulator in the TLR response (2009)
  • Author(s): Akira S
  • Organizer: Cellular and Cytokine Interactions in Health and Disease 2009
  • Place of Presentation: The Lisbon Congress Center(Portugal)
  • Year and Date: 2009-10-19
• [Presentation] Zc3h12a a negative regulator in the TLR response. (2009)
  • Author(s): Shizuo Akira
  • Organizer: Cellular and Cytokine Interactions in Health and Disease 2009
  • Place of Presentation: The Lisbon Congress Center(Portugal)
  • Year and Date: 2009-10-19
• [Presentation] Zc3h12a, a negative regulator in the TLR response (2009)
  • Author(s): Akira S.
  • Organizer: Cellular and Cytokine Interactions in Health and Disease 2009
  • Place of Presentation: The Lsibon Congress Center, Portgal
  • Year and Date: 2009-10-19
• [Presentation] 自然免疫の最近の進歩 (2009)
  • Author(s): 審良静男
  • Organizer: 第17回呼吸器疾患・感染症研究会
  • Place of Presentation: 帝国ホテル大阪、大阪
  • Year and Date: 2009-08-22
• [Presentation] 自然免疫と炎症 (2009)
  • Author(s): 審良静男
  • Organizer: 第27回日本骨代謝学会学術集会
  • Place of Presentation: 神戸ポートピアホテル、兵庫
  • Year and Date: 2009-07-24
• [Presentation] Zc3h12a, a TLR inducible-ribonuclease involved in IL-6mRNA degradation. (2009)
  • Author(s): Akira S.
  • Organizer: Singapore-Osaka, 1st Joint SlgN-IFReC Meeting 2009
  • Place of Presentation: Biopolis, 2 MATRIX Leve14, Singapore
  • Year and Date: 2009-06-18
• [Presentation] 自然免疫と自己免疫病 (2009)
  • Author(s): 審良静男
  • Organizer: 第21回日本アレルギー学会春季臨床大会
  • Place of Presentation: 長良川国際会議場、岐阜
  • Year and Date: 2009-06-04
• [Presentation] 自然免疫と獲得免疫 (2009)
  • Author(s): 審良静男
  • Organizer: 第46回日本小児外科学会学術集会
  • Place of Presentation: 大阪国際会議場、大阪
  • Year and Date: 2009-06-02
• [Presentation] Zc3h12, a TLR inducibleribonuclease involved in IL-6mRNA dearadation. (2009)
  • Author(s): Akira S.
  • Organizer: The First International Kishimoto Foundation Symposium.
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-05-25
• [Presentation] Zc3h12a, a TLR inducible-ribonuclease involved in IL-6mRNA degradation. (2009)
  • Author(s): Shizuo Akira
  • Organizer: The Firast International Kishimoto Foundation Symposium
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-05-25
• [Presentation] Zc3h12, a TLR inducible-ribonuclease involved in IL-6mRNA dearadation. (2009)
  • Author(s): Akira S.
  • Organizer: The First International Kishimoto Foundation Symposium
  • Place of Presentation: 大阪国際会議場、大阪
  • Year and Date: 2009-05-25
• [Presentation] 自然免疫の最近の進歩 (2009)
  • Author(s): 審良静男
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場、大阪
  • Year and Date: 2009-05-21
• [Presentation] ノックアウトマウスを用いた自然免疫機構の解明 (2009)
  • Author(s): 審良静男
  • Organizer: 第56回日本実験動物学会総会
  • Place of Presentation: 大宮ソニックシティ、埼玉
  • Year and Date: 2009-05-14
• [Presentation] Negative Regulation of TLR response. (2009)
  • Author(s): Shizuo Akira
  • Organizer: The ASCI/AAP Joint Meeting.
  • Place of Presentation: The Fairmont Chicago(USA)
  • Year and Date: 2009-04-25
• [Presentation] Negative Regulation of TLR Response. (2009)
  • Author(s): Akira S.
  • Organizer: The ASCI/AAP Ioint Meeting
  • Place of Presentation: The Fairmont Chicago, USA
  • Year and Date: 2009-04-25
• [Presentation] 自然免疫による病原体認識とシグナル伝達 (2009)
  • Author(s): 審良静男
  • Organizer: BMC研究会
  • Place of Presentation: 泉ガーデン、東京
  • Year and Date: 2009-04-19
• [Presentation] 自然免疫と病原体認識レセプター (2009)
  • Author(s): 審良静男
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-03-26
• [Presentation] Innate Immunity : Pathogen Recognition and inflammation (2009)
  • Author(s): Akira S.
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-03-20
• [Presentation] 自然免疫の最近の進歩 (2009)
  • Author(s): 審良静男
  • Organizer: 第35回感染症フォーラム
  • Place of Presentation: 浦和ワシントンホテル
  • Year and Date: 2009-02-14
• [Presentation] Sensing of nucleic acids by innate immunity (2009)
  • Author(s): Akira S.
  • Organizer: 13th International Conference on Lymphocyte Activation and Immune Regulation
  • Place of Presentation: The Fairmont Newport Beach, USA
  • Year and Date: 2009-02-05
• [Presentation] The role of Toll-like receptors in intestinal inflammation and immunity (2008)
  • Author(s): Akira S.
  • Organizer: The 38^<th> Annual Scientific Meeting
  • Place of Presentation: National Convention Centre(Australia)
  • Year and Date: 2008-12-11
• [Presentation] 自然免疫の最近の進歩 (2008)
  • Author(s): 審良静男
  • Organizer: 第38回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2008-12-01
• [Presentation] 自然免疫研究の最前線 (2008)
  • Author(s): 審良静男
  • Organizer: 第58回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-11-29
• [Presentation] Toll-like Receptorと粘膜免疫 (2008)
  • Author(s): 審良静男
  • Organizer: F-MF合同フォーラム2008
  • Place of Presentation: 東京大学安田講堂
  • Year and Date: 2008-11-21
• [Presentation] 自然免疫とウイルス感染 (2008)
  • Author(s): 審良静男
  • Organizer: 第40回日本小児感染症学会総会
  • Place of Presentation: 名古屋市中小企業振興会館
  • Year and Date: 2008-11-15
• [Presentation] Innate Immunity for Viral Infection (2008)
  • Author(s): Akira S.
  • Organizer: The 57^<th> fall conference of the Korean Association of Immunologists
  • Place of Presentation: Seong-Eui BLDG. & Catholic Research Institute of Medical Center(Korea)
  • Year and Date: 2008-11-13
• [Presentation] Pathogen Recognition by innate immunity and its signaling (2008)
  • Author(s): Shizuo Akira
  • Organizer: 日 独免疫セミナー2008
  • Place of Presentation: シーホークホテル福岡
  • Year and Date: 2008-11-04
• [Presentation] Pathogen Recognition by innate immunity and its signaling (2008)
  • Author(s): Akira S.
  • Organizer: 日独免疫セミナー2008
  • Place of Presentation: シーホークホテル福岡
  • Year and Date: 2008-11-04
• [Presentation] 自然免疫 : 病原体認識とシグナル伝達 (2008)
  • Author(s): 審良静男
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-29
• [Presentation] 自然免疫の最近の進歩 (2008)
  • Author(s): 審良静男
  • Organizer: 第53回日本生殖医学会総会・学術講演会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-10-22
• [Presentation] Toll-like receptors-pathogen recognition and immune response (2008)
  • Author(s): Akira S.
  • Organizer: The Bernard Halpern Symposium of Immunology
  • Place of Presentation: University of Paris
  • Year and Date: 2008-10-10
• [Presentation] Atg16L1, an autophagy protein (2008)
  • Author(s): Akira S
  • Organizer: controls endotoxin-induced inflammasome activation. Toll2008
  • Place of Presentation: Hotel Cascais Miragem (Portgual)
  • Year and Date: 2008-09-25
• [Presentation] ATg 16L1, an autophagy protein, controls endotoxin-induced inflammasome activation. (2008)
  • Author(s): Shizuo Akira
  • Organizer: Tol12008
  • Place of Presentation: Hotel Cascais Miragem(Portugal)
  • Year and Date: 2008-09-25
• [Presentation] ATg 16L1, an autophagy protein, controls endotoxin-induced inflammasome activation (2008)
  • Author(s): Akira S.
  • Organizer: Toll2008
  • Place of Presentation: Hotel Cascais Miragem(Portgual)
  • Year and Date: 2008-09-25
• [Presentation] Innate immune response in intestine (2008)
  • Author(s): Akira S.
  • Organizer: 第8回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2008-09-09
• [Presentation] The role of TLR5-expressing CD11c+lamina propria cells in induction of adaptive immunity (2008)
  • Author(s): Akira S.
  • Organizer: RCAI-JSI International Symposium on Immunology 2008
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-06-26
• [Presentation] 自然免疫 : 病原体認識とシグナル伝達 (2008)
  • Author(s): 審良静男
  • Organizer: 第12回京都分子血液フォーラム
  • Place of Presentation: ホテルフジタ京都
  • Year and Date: 2008-06-21
• [Presentation] 自然免疫システムとアレルギー (2008)
  • Author(s): 審良静男
  • Organizer: 第20回日本アレルギー学会春季臨床大会
  • Place of Presentation: ホテル日航東京
  • Year and Date: 2008-06-13
• [Presentation] 自然免疫システムと腸管免疫 (2008)
  • Author(s): 審良静男
  • Organizer: 神戸免疫アレルギー談話会
  • Place of Presentation: ホテルオークラ神戸
  • Year and Date: 2008-06-05
• [Presentation] 自然免疫における病原体認識とシグナル伝達 (2008)
  • Author(s): 審良静男
  • Organizer: 日本分子生物学会第8回春季シンポジウム
  • Place of Presentation: 京王プラザホテル札幌
  • Year and Date: 2008-05-27
• [Presentation] Regulation of the innate immune response.
  • Author(s): Shizuo Akira
  • Organizer: 14th XIV Servier-IGIS Symposium
  • Place of Presentation: The Royal Riviera Hotel(France)
  • Invited
• [Presentation] 自然免疫の最近の進歩
  • Author(s): 審良 静男
  • Organizer: 第６２回サイテックサロン
  • Place of Presentation: 東京大学（東京都）
  • Invited
• [Presentation] Sterile Inflammation in Innate Immune Responses.
  • Author(s): Shizuo Akira
  • Organizer: JST-CREST Symposium Froniters in Immunology and Inflammation:From Molecules to Disease（招待講演）
  • Place of Presentation: 一ツ橋メモリアルホール（東京都）
  • Invited
• [Presentation] 自然免疫の新しい考え方
  • Author(s): 審良 静男
  • Organizer: 第２００回生命科学フォーラム
  • Place of Presentation: 日本記者クラブ（東京都）
  • Invited
• [Presentation] 自然免疫による病原体認識とシグナル伝達
  • Author(s): 審良 静男
  • Organizer: 第３回癌・免疫若手セミナー
  • Place of Presentation: 大阪大学（大阪府）
  • Invited
• [Presentation] 自然免疫と炎症反応
  • Author(s): 審良 静男
  • Organizer: 大阪バイオサイエンス創立２５周年記念シンポジウム
  • Place of Presentation: 大阪市中央公会堂（大阪府）
  • Invited
• [Presentation] 自然免疫による炎症応答
  • Author(s): 審良 静男
  • Organizer: 第８５回日本生化学会大会
  • Place of Presentation: 福岡国際会議場（福岡県）
  • Invited
• [Presentation] 自然免疫の最近の進歩
  • Author(s): 審良 静男
  • Organizer: 16回 日本統合医療学会（IMJ大阪大会）
  • Place of Presentation: 大阪大学（大阪府）
  • Invited
• [Presentation] 自然免疫
  • Author(s): 審良 静男
  • Organizer: 第４１回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] The zinc finger domain containing nuclease, Regunase-1/Zc3h12a controls T cell activation.
  • Author(s): Shizuo Akira
  • Organizer: 橋本病百周年記念国際シンポジウム「自己免疫疾患の病因解明と治療法開発への挑戦」
  • Place of Presentation: アクロス福岡（福岡県）
  • Invited
• [Presentation] Innate Immunity and Inflammatory Responses.
  • Author(s): Shizuo Akira
  • Organizer: MRC International Symposia
  • Place of Presentation: Ramada Plaza Cheongju(Korea)
  • Invited
• [Presentation] 自然免疫とM2マクロファージ
  • Author(s): 審良 静男
  • Organizer: 第６２回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場（大阪府）
  • Invited
• [Presentation] 自然免疫の最近の進歩
  • Author(s): 審良 静男
  • Organizer: Infection and Immunity Research Symposium III
  • Place of Presentation: ヒルトン福岡シーホークホテル（福岡県）
  • Invited
• [Presentation] Innate Immune Response and Inflammation.
  • Author(s): Shizuo Akira
  • Organizer: International Endotoxin & Innate Immunity Society Meeting 2012, Homeostatic Inflammation Symposium, Japan Endotoxin and Innate Immunity Society 2012
  • Place of Presentation: 学術総合センター（東京都）
  • Invited
• [Presentation] Innate Immune Response and Inflammation.
  • Author(s): Shizuo Akira
  • Organizer: he 34th Naito Conference " Infection, Immunity and their Control for Health: Barrier and Vaccine for Infection and Immunity"
  • Place of Presentation: シャトレーゼ ガトー キングダム 札幌（北海道）
  • Invited
• [Presentation] Nucleic acid recognition by innate immunity.
  • Author(s): Shizuo Akira
  • Organizer: The 12th International Symposium on Dendritic Cells(DC2012)
  • Place of Presentation: Daegu Exhibition & Convention Center(Korea)
  • Invited
• [Presentation] Innate immunity and inflammatory responses.
  • Author(s): Shizuo Akira
  • Organizer: French-Japanese Meeting
  • Place of Presentation: フランス大使館（東京都）
  • Invited
• [Presentation] Innate Immune Responses.
  • Author(s): Shizuo Akira
  • Organizer: EUROPEAN CONGRESS OF IMMUNOLOGY
  • Place of Presentation: Scottish Exhibition & Conference Centre(Scotland)
  • Invited
• [Presentation] Anti-viral response in innate immunity.
  • Author(s): Shizuo Akira
  • Organizer: "Non-self RNA sensing in virus infected cells and activation of antiviral immunity"The 2012 Les Treilles Meeting
  • Place of Presentation: Fondation des Treilles(France)
  • Invited
• [Presentation] Pathogen recognition and innate immunity.
  • Author(s): Shizuo Akira
  • Organizer: 第14回国際組織細胞化学会議（ICHC2012）
  • Place of Presentation: 国立京都国際会館（京都府）
  • Invited
• [Presentation] Innate Immunity in mammals.
  • Author(s): Shizuo Akira
  • Organizer: 第１５回国際分子・植物・微生物相互作用学会（IS-MPMI)
  • Place of Presentation: 国立京都国際会館（京都府）
  • Invited
• [Presentation] 自然免疫とマクロファージ
  • Author(s): 審良 静男
  • Organizer: 第１回AIR CONFERENCE
  • Place of Presentation: パレスホテル大宮（埼玉県）
  • Invited
• [Presentation] 自然免疫の最近の進歩
  • Author(s): 審良 静男
  • Organizer: 第20回統合医療機能性食品国際会議（ICNIM)
  • Place of Presentation: ロイトン札幌（北海道）
  • Invited
• [Presentation] 自然免疫の最近の進歩
  • Author(s): 審良 静男
  • Organizer: 第１回ＯＹＣバイオシンポジウム～最新医学研究の展開「脳・免疫・がん」～
  • Place of Presentation: 日本工業倶楽部会館（東京都）
  • Invited
• [Presentation] 自然免疫と炎症
  • Author(s): 審良 静男
  • Organizer: 第３３回日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡（福岡県）
  • Invited
• [Presentation] 自然免疫と炎症
  • Author(s): 審良 静男
  • Organizer: 第２回大阪内分泌代謝カンファレンス
  • Place of Presentation: 大阪大学（大阪）
  • Invited
• [Presentation] Innate Immunity and Inflammation.
  • Author(s): Shizuo Akira
  • Organizer: The 5th International Singapore Symposium of Immunology
  • Place of Presentation: University Town(Singapore)
  • Invited
• [Presentation] Innate Immune Responses.
  • Author(s): Shizuo Akira
  • Organizer: The 10th CIMT Annual Meeting
  • Place of Presentation: Congress Centrum Mainz(Germany)
  • Invited
• [Presentation] Innate Immunity and Inflammation.
  • Author(s): Shizuo Akira
  • Organizer: XX Mexican Congress of Immunology
  • Place of Presentation: Fiesta Americana Merida(Mexico)
  • Invited
• [Presentation] Innate Immunity and Inflammation.
  • Author(s): Shizuo Akira
  • Organizer: The 2012 Spring Conference of the Korean Association of Immunologists
  • Place of Presentation: Kyoyuk munhwa hoekhwan(Korea)
  • Invited
• [Remarks]
  • URL: http://hostdefense.ifrec.osaka-u.ac.jp/ja/index.html
• [Remarks] 大阪大学免疫学フロンティア研究センター 自然免疫学研究室
  • URL: http://hostdefense.ifrec.osaka-u.ac.jp/ja/index.html
• [Remarks]
  • URL: http://hostdefense.ifrec.osaka-u.ac.jp/jp/index.html
• [Remarks]
  • URL: http://hostdefense.ifrec.osaka-u.ac.jp/ja/index.html
• [Remarks]
  • URL: http://hostdefense.ifrec.osaka-u.ac.jp/ja/index.html
• [Remarks]
  • URL: http://hostdefense.ifrec.osaka-u.ac.jp/ja/index.html