| Project/Area Number |
20012027
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKAHASHI Chiaki Kyoto University, がん研究所, 教授 (50283619)
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| Co-Investigator(Renkei-kenkyūsha) |
SHAMMA Awad 金沢大学, がん研究所, 助教 (50402839)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 2009: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 2008: ¥9,000,000 (Direct Cost: ¥9,000,000)
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| Keywords | がん / がん抑制遺伝子 / がん遺伝子 / 細胞老化 / DNA損傷 / Rb / Ras / 悪性化 / クロマチンリモデリング / がん幹細胞 / セネセンス / DNA損傷応答 / 前がん病変 / イソプレニル化 |
|---|
| Research Abstract |
We analyzed Rb-heterozygous mice simultaneously lacking various Rb-related genes. We proved that Rb-deficient carcinogenesis is antagonized by cellular senescence and DNA damage response in a Ras-dependent manner. We also discovered that Rb inactivation upregulates number of genes involved in protein isoprenylation via E2F or SREBP leading to accelerated membrane trafficking of Ras. In addition, we discovered that RECK, an antagonistic downstream target of Ras, regulates beta1-integrin and EGFR signaling.
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