Project/Area Number |
20018002
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | University of Tsukuba |
Principal Investigator |
野口 恵美子 University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (40344882)
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Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥8,600,000 (Direct Cost: ¥8,600,000)
Fiscal Year 2009: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 2008: ¥4,300,000 (Direct Cost: ¥4,300,000)
|
Keywords | アレルギー・喘息 / ゲノム / 遺伝学 |
Research Abstract |
小児アトピー性喘息患者942名vs成人コントロール2370名の55万SNPの全ゲノム関連解析を行った。55万SNPのうち、常染色体に存在し、かつminor allele frequencyが0.01以上のSNPは453,047個であった。さらに、コントロールにおけるHardy Weinberg平衡がP<0.0001である1,170SNPを除外し、最終的な解析データとした。一次解析におけるGenomic Inflation factorは1.053であった。アレル頻度の比較では、6番染色体短腕のHLA領域で強い関連が認められた(P=7.7×10-9)。そのほかにも2番染色領域、12番染色体領域にP<1×10-7が存在した。HLA領域のSNPと小児アトピー性喘息との関連については独立した症例対照サンプルおよび家系サンプルにおいても追認されている(P<0.05) さらに健康成人76名を対象としてHuman 610Quadを使用してタイピングを行い、別の研究成果として得られているCD4陽性T細胞およびCD14陽性モノサイトの網羅的遺伝子発現データ(イルミナHuman Ref8)と遺伝子型データを統合したデータベースの構築を情報支援班の支援を受けて作成しており、今後公開予定としている。
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Report
(2 results)
Research Products
(22 results)
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[Journal Article] S2554X mutation in the filaggrin gene is associated with allergen sensitization in the Japanese population2010
Author(s)
Imoto Y, Enomoto H, Fujieda S, Okamoto M, Sakashita M, Susuki D, Okada M, Hirota T, Tamari M, Ebe K, Arinami T, Noguchi E
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Journal Title
J Allergy Clin Immunol 125
Pages: 500-500
Related Report
Peer Reviewed
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[Journal Article] SMAD3 as an atopic dermatitis susceptibility gene in the Japanese population2009
Author(s)
Otsuka K, Takeshita S, Enomoto H, Takahashi T, Hirota T, Tamari M, Ebe K, Otsuka F, Shibasaki M, Arinami T, Noguchi E
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Journal Title
J Dermatol Sci 55
Pages: 200-2
NAID
Related Report
Peer Reviewed
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[Journal Article] Associations between decay-accelerating factor polymorphisms and allergic respiratory diseases2009
Author(s)
Kawai T, Takeshita S, Imoto Y, Matsumoto Y, Sakashita M, Suzuki D, Shibasaki M, Tamari M, Hirota T, Arinami T, Fujieda S, Noguchi E
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Journal Title
Clin Exp Allergy 39
Pages: 1508-14
Related Report
Peer Reviewed
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[Journal Article] Large scale genotyping study for asthma in the Japanese population2009
Author(s)
Imada Y, Fujimoto M, Hirata K, Hirota T, Suzuki Y, Saito H, Matsumoto K, Akazawa A, Katsunuma T, Yoshihara S, Ebisawa M, Shibasaki M, Arinami T, Tamari M, Noguchi E
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Journal Title
BMC Res Notes 2
Pages: 54-54
Related Report
Peer Reviewed
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[Journal Article] Functional analysis of the thymic stromal lymphopoietin variants in human bronchial epithelial cells2009
Author(s)
Harada M, Hirota T, Jodo AI, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Yoshihara S, Ebisawa M, Saito H, Matsumoto K, Nakamura Y, Ziegler SF, Tamari M
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Journal Title
Am J Respir Cell Mol Biol 40
Pages: 368-374
Related Report
Peer Reviewed
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[Journal Article] Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population, family and case-control study2008
Author(s)
Enomoto H, Hirata K, Otsuka K, Kawai T, Takahashi T, Hirota T, Suzuki Y, Tamari M, Otsuka F, Fujieda S, Arinami T, Noguchi E
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Journal Title
J Hum Genet 57
Pages: 615-621
NAID
Related Report
Peer Reviewed
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[Journal Article] Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population2008
Author(s)
Hirota T, Harada M, Sakashito M, Doi S, Miyatake A, Fujita K, Enomoto T, Ebisawa M, Yoshihara S, Noguchi E, Saito H, Nakamura Y, Tamari M
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Journal Title
J Allergy Clin Immunol 121
Pages: 769-770
Related Report
Peer Reviewed
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[Journal Article] Supportive evidence for reduced expression of GNB1L inschizophrenia2008
Author(s)
Ishiguro H, Koga M, Horiuchi Y, Noguchi E, Morikawa M, Suzuki Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Arinami T
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Alpha-1-antitrypsin and complement component C7 are involved in asthma exacerbation2008
Author(s)
Nishioka T, Uchida K, Meno K, Ishii T, Aoki T, Imada Y, Makino Y, Hirata K, Matsumoto Y, Arinami T, Noguchi E
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Journal Title
Proteomics Clin Appl 2
Pages: 46-54
Related Report
Peer Reviewed
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