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多元的イメージングによる系列操作の神経基盤の統合的解明

Research Project

Project/Area Number 20019041
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

花川 隆  National Center of Neurology and Psychiatry, 神経研究所疾病研究第七部, 室長 (30359830)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2009: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2008: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywords運動制御 / イメージング / 神経回路 / 認知 / 磁気刺激
Research Abstract

タイミングの認知と生成は系列行動の最も重要な基本要素の一つである。タイミング認知・生成に関わる脳領域と領域間の機能連関を明らかにするため、健常成人14名においてfMRI研究を行った(Aso et al. in press)。被験者は、数百msの刺激間隔(ISI)で提示される視覚刺激のISI長短判定(タイミング認知)、提示された刺激のISIを二回のボタン押し運動として再生(タイミング再生)する課題を行った。対照条件として、視覚刺激のサイズの大小判定課題とボタンの即時押し課題をそれぞれ用いた。fMRIは3テスラ装置を用いたエコープラナーイメージ撮像により行った。タイミング認知と再生は、それぞれの対照条件との比較において、共通して前頭前野、島皮質、下頭頂葉から上側頭回、小脳の有意な活動増加を伴った。また小脳の活動はタイミング認知課題において右半球、タイミング再生課題において左半球でより著明であった。これら小脳のタイミング認知・再生における活動は、大脳皮質と小脳が形成する神経回路の機能を反映すると仮定し、小脳の活動部位をシード領域として用いるpsycho-physiological interaction解析を行った。その結果、小脳活動との相関が課題依存性に変化する部位としてSMAが同定され、このSMA領域はタイミング認知課題の際に右小脳と、タイミング再生課題の際に左小脳と大きな相関を示していた。タイミング認知と再生機能に、SMAと小脳の機能連関が重要であることが示された。この結果は、タイミングの認知と生成がともにSMAと小脳が構成する神経回路の機能に依存していることを示唆する。再生の場合、SMAが生成する運動計画指令に基づき、小脳が次に運動を生成すべきタイミングを予測していると考えられるが、タイミング認知の際にも同じ回路が使われていると解釈できる。

Report

(2 results)
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (46 results)

All 2010 2009 2008 Other

All Journal Article (22 results) (of which Peer Reviewed: 20 results) Presentation (23 results) Book (1 results)

  • [Journal Article] Differential effect of double-pulse TMS applied to dorsal premotor cortex and precuneus during internal operation of visuospatial information.2010

    • Author(s)
      Oshio R, Tanaka S, Sadato N, Sokabe M, Hanakawa T, Honda M
    • Journal Title

      NeuroImage 49

      Pages: 1108-15

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gait disturbance associated with white matter changes : a gait analysis and blood flow study.2010

    • Author(s)
      Iseki K, Hanakawa T, et al.
    • Journal Title

      NeuroImage 49

      Pages: 1659-66

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 運動計画における前頭前野と運動前野の役割2009

    • Author(s)
      花川隆
    • Journal Title

      Clinical Neuroscience 27

      Pages: 799-802

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 脳機能イメージングによるヒト二足歩行の中枢神経制御機構の解明2009

    • Author(s)
      花川隆
    • Journal Title

      Equilibrium Research 68

      Pages: 176-182

    • NAID

      10026088310

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of insula and cingulate cortices in control and suppression of natural urges.2009

    • Author(s)
      Lerner A, Bagic A, Hanakawa T, et al.
    • Journal Title

      Cerebral Cortex 19

      Pages: 218-23

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional coupling underlying motor and cognitive functions of the dorsal premotorcortex.2009

    • Author(s)
      Abe M, Hanakawa T
    • Journal Title

      Behavioural Brain Research 198

      Pages: 13-23

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Connectivity and signal intensity in the parieto-occipital cortex predicts top-downattentional effect in visual masking : an fMRI study based on individual differences.2009

    • Author(s)
      Tsubomi H, Ikeda T, Hanakawa T, Hirose N, Fukuyama H, Osaka N
    • Journal Title

      NeuroImage 45

      Pages: 587-97

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimulus-response profile during single-pulse transcranial magnetic stimulation to the primary motor cortex.2009

    • Author(s)
      Hanakawa T, Mima T, Matsumoto R, et al.
    • Journal Title

      Cerebral Cortex 19

      Pages: 2605-15

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel composite targeting method using high-field magnetic resonance imaging for subthalamic nucleus deep brain stimulation.2009

    • Author(s)
      Toda H, Sawamoto N, Hanakawa T, et al.
    • Journal Title

      Journal of Neurosurgery 111

      Pages: 737-45

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of the cortical GABAergic inhibitory system in catatonic stupor : a case report with neuroimaging.2009

    • Author(s)
      Iseki K, et al(8人省略5番目)
    • Journal Title

      Epileptic Disorders 11

      Pages: 126-31

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of pinch force in the lower leg by anodal transcranial direct current stimulation.2009

    • Author(s)
      Tanaka S, Hanakawa T, Honda M, Watanabe K
    • Journal Title

      Experimental Brain Research 196

      Pages: 459-65

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is the insula responsible for suppression of natural urges?2009

    • Author(s)
      Lerner A, Bagic A, Hanakawa T, Boudreau EA, Pagan F, Mari Z, Bara-Jimenez W, Aksu M, Sato S, Murphy DL, Hallett M
    • Journal Title

      Cerebral Cortex 19

      Pages: 218-223

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional coupling underlying motor and cognitive functions of the dorsal premotor cortex2009

    • Author(s)
      Abe M, Hanakawa T
    • Journal Title

      Behavioural Brain Research 198

      Pages: 13-23

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The representation of blinking movement in cingulate motor areas : a functional magnetic resonance imaging study2008

    • Author(s)
      Hanakawa T, Dimyan MA, Hallett M
    • Journal Title

      Cerebral Cortex 18

      Pages: 930-937

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Motor planning, imagery and execution : a time-course study with functional MRI2008

    • Author(s)
      Hanakawa T, Dimyan MA, Hallett M
    • Journal Title

      Cerebral Cortex 18

      Pages: 2775-2788

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural mechanisms involved in observation and imagery of gait movement2008

    • Author(s)
      Iseki K, Hanakawa T, Shinozaki J, Nankaku M, Fukuyama H.
    • Journal Title

      Neuroimage 41

      Pages: 1021-1031

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The stereokinetic effect reveals different roles of the lateral occipito-temporal and parietal cortex for 3-D perception from motion : An fMRI study2008

    • Author(s)
      Yamamoto T, Takahashi S, Hanakawa T, Urayama S, Fukuyama H, Ejima Y.
    • Journal Title

      Journal of Vision 8

      Pages: 1-17

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High resolution MRI revealed small orbitofrontal traumatic lesions responsible for behavioral changes2008

    • Author(s)
      Namiki C, Yamada M, Yoshida H, Hanakawa T, Fukuyama H, Murai T
    • Journal Title

      Neurocase 14

      Pages: 474-479

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemispheric asymmetry of the arcuate fasciculus in patients with unilateral language dominancy defined by Wada test2008

    • Author(s)
      Matsumoto R, Okada T, Mikuni N, Mitsueda T, Taki J, Sawamoto N, Hanakawa T, Miki Y, Ikeda A, Hashimoto N, Fukuyama H, Takahashi R I Z, Bara-Jimenez W, Aksu M, Sato S, Murphy DL, Hallett M
    • Journal Title

      Journal of Neurology 255

      Pages: 1703-1711

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 基底核と認知2008

    • Author(s)
      花川隆
    • Journal Title

      分子精神医学 8

      Pages: 41-47

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Differential Contribution of the Supplementary Motor Area to Stabilization of a Procedural Motor Skill Acquired through Different Practice Schedules.

    • Author(s)
      Tanaka S, Honda M, Hanakawa T, Cohen LG
    • Journal Title

      Cerebral Cortex (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebro-cerebellar Interactions Underlying Temporal Information Processing.

    • Author(s)
      Aso K, Hanakawa T, Aso T, Fukuyama H
    • Journal Title

      Journal of Cognitive Neuroscience (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Pathophysiology of gait disturbance in age-related white matter changes : a combinedgait analysis and blood flow study2010

    • Author(s)
      Iseki K, Hanakawa T, Hallett M, Fukuyama H
    • Organizer
      The 3rd International Congress on Gait and Mental Function
    • Place of Presentation
      Omni Shoreham Hotel, Washington DC, USA
    • Year and Date
      2010-02-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] The neural correlates of the sensorimotor rhythms as revealed by simultaneous EEG-fMRI : implications for brain-computer interfaces2009

    • Author(s)
      Hanakawa T, Kaneko E, Omata K
    • Organizer
      The 3rd International Symposium on Mobiligence 2009
    • Place of Presentation
      淡路夢舞台、淡路島
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多次元イメージングによる神経ネットワークの評価2009

    • Author(s)
      花川隆
    • Organizer
      第39回日本臨床神経生理学会:シンポジウム
    • Place of Presentation
      北九州国際会議場、北九州
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] EEG-fMRI同時計測における呼吸変動の影響2009

    • Author(s)
      小俣圭、花川隆、本田学
    • Organizer
      第39回日本臨床神経生理学会
    • Place of Presentation
      北九州国際会議場、北九州
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 閉眼安静状態における中心部□律動および□律動に相関する脳活動2009

    • Author(s)
      金子瑛士、花川隆、小俣圭、本田学
    • Organizer
      第39回日本臨床神経生理学会
    • Place of Presentation
      北九州国際会議場、北九州
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Towazds Understanding of Neural Control of Movement : Simultaneous Mulitidisciplinary Neuroimaging2009

    • Author(s)
      花川隆
    • Organizer
      磁気刺激の臨床応用と安全性に関する研究会
    • Place of Presentation
      北九州国際会議場、北九州
    • Year and Date
      2009-11-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neuroimaging Approach to Understanding of Gait Disturbances in Parkinson's Disease and Related Disorders2009

    • Author(s)
      花川隆
    • Organizer
      第18回パーキンソン病治療研究会
    • Place of Presentation
      赤坂プリンスホテル、東京
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Correlation between cortico-subcortical gray matter volume and proficiency in second language2009

    • Author(s)
      細田千尋、花川隆、田中悟志、成相直、大野喜久雄、本田学
    • Organizer
      第32回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 運動・認知迅速操作における基底核の機能2009

    • Author(s)
      花川隆, Mark Hallett
    • Organizer
      第32回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of cerebro-cerebellar interactions in temporal information processing2009

    • Author(s)
      麻生謙二、花川隆、麻生俊彦、福山秀直
    • Organizer
      第32回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of simultaneous recording of spontaneous EEG and fMRI2009

    • Author(s)
      小俣圭、森本雅子、花川隆、本田学
    • Organizer
      第32回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 整形外科領域における脳機能イメージング応用の可能性2009

    • Author(s)
      花川隆
    • Organizer
      第9回群馬大学整形外科卒後研修会
    • Place of Presentation
      群馬大学、前橋
    • Year and Date
      2009-08-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 競技経験が運動予測および予測に関わる脳活動に及ぼす影響について2009

    • Author(s)
      持永新、古田島浩子、花川隆、柳原大
    • Organizer
      第17回日本運動生理学会大会
    • Place of Presentation
      慈恵医科大学、東京
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Keynote : Neuroimaging Studies of Motor-related Behavior2009

    • Author(s)
      Hanakawa T
    • Organizer
      Japan-Italy International Seminar : Musculoskeletal System and Computational Neuroscience for Rehabilitation
    • Place of Presentation
      Istituto Italiano di Tecnologia, Genoa, Italy
    • Year and Date
      2009-06-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanisms underlying cognitive and motor slowing in Parkinson's disease2009

    • Author(s)
      Hanakawa T, Hallett M
    • Organizer
      13^<th> International Congress of Movement Disorder Society
    • Place of Presentation
      Le Palais Des Congres de Paris, Paris, France
    • Year and Date
      2009-06-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] パーキンソン病の認知・運動遅延の神経基盤2009

    • Author(s)
      花川隆
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台国際センター、仙台
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多モダリティイメージングによる脳領域間連関計測へのアプローチ2008

    • Author(s)
      花川隆
    • Organizer
      第38回日本臨床神経生理学会・学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-11-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Parallel basal ganglia-frontal cortical loops for the control of motor and congnitive agility2008

    • Author(s)
      Hanakawa T, Hallett M
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2008-11-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 歩行-中枢2008

    • Author(s)
      花川隆
    • Organizer
      第67回日本めまい平衡学会総会
    • Place of Presentation
      秋田
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Does mental rotation of hands and feet involve somatotopically organized brain regions?2008

    • Author(s)
      HanakawaT, Hosoda C, Honda M
    • Organizer
      14th Annual Meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2008-06-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 行動制御における大脳基底核・皮質系の役割 : 脳機能イメージングからの知見2008

    • Author(s)
      花川隆
    • Organizer
      ロボティクス・メカトロニクス講演会2008
    • Place of Presentation
      長野
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 運動実行・認知処理速度に関わる基底核皮質活動2008

    • Author(s)
      花川隆、Mark Hallett
    • Organizer
      第2回Motor Control研究会
    • Place of Presentation
      岡崎
    • Year and Date
      2008-05-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 運動・認知実行速度に関わる脳活動とその加齢性変化2008

    • Author(s)
      花川隆、Mark Hallett
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Book] シリーズ移動知第2巻身体適応-歩行運動の神経機構とシステムモデル第三章第二・三節pp.81-97(土屋和男、高草木薫、萩原直道編)2010

    • Author(s)
      花川隆
    • Total Pages
      320
    • Publisher
      オーム社
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2018-03-28  

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