Role of endoplasmic reticulum stress pathway in bipolar disorder

• Project/Area Number: 20023035
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: KATO Tadafumi The Institute of Physical and Chemical Research, 精神疾患動態研究チーム, チームリーダー (30214381)
• Research Collaborator: 垣内 千尋 ; 林 朗子 ; 笠原 和起 ; 窪田 美恵 ; 福家 聡 ; 岩本 和也 ; 高田 篤 ; 石渡 みずほ ; 宮内 妙子 ; 亀谷 瑞枝 ; 磯野 蕗子 ; 小森 敦子
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥27,200,000 (Direct Cost: ¥27,200,000); Fiscal Year 2009: ¥13,600,000 (Direct Cost: ¥13,600,000); Fiscal Year 2008: ¥13,600,000 (Direct Cost: ¥13,600,000)
• Keywords: 双極性障害 / 小胞体ストレス / GABA / ミトコンドリアDNA

Research Abstract

Neurons lacking XBP1 showed diminished upregulation of GABAergic marker genes (somatostatin, neuropeptide Y, calbindin) in response to BDNF. Knockout (KO) mice of Wfs1, the gene regulated by XBP1, showed slight but significant behavioral phenotypes in emotion-related behavior. Double mutant mice, Wfs1 KO and Polg transgenic, showed exaggerated behavioral phenotypes. The brain regions accumulating mtDNA deletions in Polg1 Tg mice were identified.

Research Products

• [Journal Article] Effect of mood stabilizers on gene expression in lymphoblastoid cells. (2010)
  • Author(s): S ugawara H, Iwamoto K, Bundo M, Ishiwata M, Ueda J, Kakiuchi C, Ishigooka J, Kato T
  • Journal Title: Journal of Neural Transmission 117 Pages: 155-164
  • Peer Reviewed
• [Journal Article] Effect of mood stabilizers on gene expression in lymphoblastoid cells (2010)
  • Author(s): Sugawara Hiroko
  • Journal Title: Journal of Neural Transmission 117 Pages: 155-164
  • Peer Reviewed
• [Journal Article] Mitochondrial DNA haplogroup analysis in patients with bipolar disorder. (2009)
  • Author(s): K azuno A, Munakata K, Mori K, Nanko S, Kunugi H, Nakamura K, Mori N, Yamada K, Yoshikawa T, Kato N, Kato T
  • Journal Title: American Journal of Medical Genetics, Part B (Neuropsychiatric Genetics) 150B Pages: 243-247
  • Peer Reviewed
• [Journal Article] Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder. (2009)
  • Author(s): H ayashi A, Kasahara T, Kametani M, Toyota T, Yoshikawa T, Kato T
  • Journal Title: International Journal of Neuropsychopharmacology 12 Pages: 33-43
  • Peer Reviewed
• [Journal Article] Valproate, a mood stabilizer, induces WFS1 expression and modulates its interaction with ER stress protein GRP94. (2009)
  • Author(s): K akiuchi C, Ishigaki S, Oslowski CM, Fonseca SG, Kato T, Urano F
  • Journal Title: PLoS One 4
  • Peer Reviewed
• [Journal Article] Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder (2009)
  • Author(s): Hayashi Akiko
  • Journal Title: The international journal of Neuropsychopharmacology 12 Pages: 33-43
  • Peer Reviewed
• [Journal Article] Mitochondrial DNA haplogroup analysis in patients with bipolar disorder (2009)
  • Author(s): Kazuno An-a
  • Journal Title: American journal of Medical Genetics. Part B(Neuropsychiatric Genetics) 150 Pages: 243-247
  • Peer Reviewed
• [Journal Article] Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder (2009)
  • Author(s): Hayashi Akiko
  • Journal Title: Int J Neuropsychopharmacol 12 Pages: 33-34
  • Peer Reviewed
• [Journal Article] Valproate, a mood stabilizer, induces WSFI expression and modulates its interaction with ER stress protein GRP94 (2009)
  • Author(s): Kakiuchi Chihiro
  • Journal Title: PLoS ONE 4
  • Peer Reviewed
• [Journal Article] Attenuated BDNF-induced upregulation of GABAergic markers in neurons lacking Xbp1. (2008)
  • Author(s): H ayashi A, Kasahara T, Kametani M, Kato T
  • Journal Title: Biochemical and Biophysical Research Communications 376 Pages: 758-763
  • Peer Reviewed
• [Journal Article] Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder. (2008)
  • Author(s): Kato T, Ishiwata M, Yamada K, Kasahara T, Kakiuchi C, Iwamoto K, Kawamura K, Ishihara H, Oka Y
  • Journal Title: Neuroscience Research 61 Pages: 143-158
  • Peer Reviewed
• [Journal Article] Attenuated BDNF-induced upregulation of GABAergic markers in neurons lacking Xbpl. (2008)
  • Author(s): Hayashi Akiko
  • Journal Title: Biochem Biophys Res Commun. 376 Pages: 758-763
  • Peer Reviewed
• [Journal Article] Behavioral and gene expression analyses of Wfsl knockout mice as a possible animal model of mood disorder (2008)
  • Author(s): Kato Tadafumi
  • Journal Title: Neurosci Res. 61 Pages: 143-158
  • Peer Reviewed
• [Remarks]
  • URL: http://www.brain.riken.go.jp/labs/mdmd/topics.htm
• [Remarks]
  • URL: http://www.brain.riken.go.jp/labs/mdmd/topics.htm