Development of a useful tool adding a microbial component to tumor cell as vaccine adjuvant
Project/Area Number |
20200075
|
Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
|
Allocation Type | Single-year Grants |
Research Field |
Experimental pathology
Biological pharmacy
|
Research Institution | Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses |
Principal Investigator |
AKAZAWA Takashi 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 研究所, 研究員 (80359299)
|
Co-Investigator(Renkei-kenkyūsha) |
INOUE Norimitsu 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 研究所, 部長 (80252708)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Fiscal Year 2010: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2009: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2008: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
|
Keywords | 腫瘍 / アジュバント / ワクチン / 創薬設計 / 自然免疫 / Toll-like receptor / がん免疫療法 / 腫瘍免疫 / 樹状細胞 / BCG-CWS |
Research Abstract |
It is essential to develop effective immunoadjuvants for tumor immunotherapy. We created new adjuvants based on the structure of mycoplasmal lipopeptide, which is a toll-like receptor (TLR) 2 ligand. Adjuvant engineering, substituting a functional motif for bacterial origin sequence of lipopeptide, is our novel drug design strategy. We succeeded in development of useful synthetic adjuvants through the evaluation of new TLR2 ligands with additional functions such as targeting ability to immune cells or modification ability to tumor cells.
|
Report
(4 results)
Research Products
(40 results)
-
-
-
-
-
[Journal Article] IFN-gamma markedly cooperates with intratumoral dendritic cell vaccine in dog tumormodels2010
Author(s)
Mito K, Sugiura K, Ueda K,Hori T, Akazawa T, Yamate J, Nakagawa H, Hatoya S, Inaba M, Inoue N, IkeharaS, Inaba T.
-
Journal Title
Cancer Res.
Volume: 70(18)
Pages: 7093-101
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] IFN-gamma markedly cooperates with intratumoral dendritic cell vaccine in dog tumor models2010
Author(s)
Mito K, Sugiura K, Ueda K, Hori T, Akazawa T, Yamate J, Nakagawa H, Hatoya S, Inaba M, Inoue N, Ikehara S, Inaba T
-
Journal Title
Cancer Research
Volume: 70(18)
Pages: 7093-7101
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] Innate immune therapy with a Bacillus Calmette-Guerin cell wall skeleton after radical surgery for non-small cell lung cancer: a case-control study2009
Author(s)
Kodama K, Higashiyama M, TakamiK, Oda K, Okami J, Maeda J, Akazawa T, Matsumoto M, Seya T, Wada M, Toyoshima K.
-
Journal Title
Surg Today.
Volume: 39(3)
Pages: 194-200
NAID
Related Report
Peer Reviewed
-
-
[Journal Article] Innate immune therapy with a Bacillus Calmette-Guerin cell wall skeleton after radical surgery for non-small cell lung cancer: A case-control study2009
Author(s)
Kodama K, Higashiyama M, Takami K, Oda K, Okami J, Maeda J, Akazawa T, Matsumoto M, Seya T, Wada M, Toyoshima K.
-
Journal Title
Surg Today 39(3)
Pages: 194-200
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-