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Study of IP_3 receptor/Ca^<2+> signaling in neural plasticity and brain development and differentiation

Research Project

Project/Area Number 20220007
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Neurochemistry/Neuropharmacology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

MIKOSHIBA Katsuhiko  独立行政法人理化学研究所, 発生神経生物研究チーム, チームリーダー (30051840)

Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥207,610,000 (Direct Cost: ¥159,700,000、Indirect Cost: ¥47,910,000)
Fiscal Year 2012: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2011: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2010: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2009: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2008: ¥41,210,000 (Direct Cost: ¥31,700,000、Indirect Cost: ¥9,510,000)
Keywords神経伝達物質 / 受容体 / IP_3 / カルシウム振動 / 小胞体ストレス / グリア細胞 / 自己免疫疾患 / 心疾患 / IRBIT / IP3受容体 / 神経可塑性 / カルシウムイオン / トランスグルタミナーゼ / アストロサイト / IP_3受容体 / シナプス可塑性 / カルシウムイオンチャネル / マクロピノサイトーシス / 成長円錐の退縮 / 記憶・学習 / チャネルの開口メカニズム / カルシウムイオンセンサー / 心臓形態形成 / アルツハイマー病 / ハンチントン病 / GABAA受容体 / 量子ドット / 急性膵炎 / 外分泌障害 / 骨形成異常 / 嗅覚障害 / プロテインキナーゼC基質80K-H / Homer3
Research Abstract

IP_3 is important in cell signaling but requires the IP_3 receptor (IP_3R) to mediate all of its effects. Structural and biochemical studies indicate that the IP_3R provides a platform for molecules to interact, and combinations of associated molecules results which we discovered such as ERp44, GRP78, 80K-H et al, in functional diversity of cell signaling. IP_3Rs determine the trajectory of cell signaling by working as a signaling hub for interaction with differential molecular complexes which we discovered for various cell functions. The IP_3R signaling trajectory, in turn, plays a crucial role in cellular functions, in addition, IRBIT which is released from IP_3R as 3^<rd> messenger, also plays a variety of role. The abnormality of IP_3R signaling results in diseases such as neuronal degeneration, learning deficient, cardiogenesis abnormality, osteoporosis, auto-immune-disease, acute pancreatitis. We have developed ultra-sensitive genetically encoded Ca^<2+> indicator, Ca^<2+> pump indicator and established in vivo imaging of the cerebellum and cerebral cortex by two photon microscopy to study more in detail.

Assessment Rating
Verification Result (Rating)

A

Report

(8 results)
  • 2013 Research Progress Assessment (Verification Result) ( PDF )
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (228 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (119 results) (of which Peer Reviewed: 108 results) Presentation (79 results) (of which Invited: 12 results) Book (7 results) Remarks (9 results) Patent(Industrial Property Rights) (14 results) (of which Overseas: 2 results)

  • [Journal Article] A fluorescence-based assay for the measurement of S-adenosylhomocysteine hydrolase activity in biological samples2013

    • Author(s)
      Hudec
    • Journal Title

      Anal Biochem.

      Volume: 433(2) Issue: 2 Pages: 95-101

    • DOI

      10.1016/j.ab.2012.10.014

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin-dependent kinase 5 is required for normal cerebellar development2013

    • Author(s)
      Kumaszawa A
    • Journal Title

      Mol Cell Neuroscience

      Volume: 52 Pages: 97-105

    • DOI

      10.1016/j.mcn.2012.10.007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Boronic acid inhibitors of acyl protein thioesterase 1 and 22013

    • Author(s)
      Zimmermann, T.J., Burger, M., Tashiro, E., Kondoh, Y., Martinez, N.E., Gormer, K., Rosin-steiner, S., Shimizu, T. Ozaki, S., Mikoshiba, K., Watanabe, N., Hall, D., Vetter, I.R., Osada, H., Hedberg, C., & Waldmann, H
    • Journal Title

      ChemBioChem

      Volume: 14 Issue: 1 Pages: 115-122

    • DOI

      10.1002/cbic.201200571

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chaperone stress 70 protein (STCH) binds and regulates two acid/base transporters NBCe1-B and NHE12013

    • Author(s)
      Bae JS
    • Journal Title

      J Biol Chem.

      Volume: 288(9) Issue: 9 Pages: 6295-305

    • DOI

      10.1074/jbc.m112.392001

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inositol 1,4,5-Trisphosphate receptor regulates replication, differentiation, infectivity, and virulence of the parasitic protist Trypanosoma cruzi2013

    • Author(s)
      Hashimoto M
    • Journal Title

      Mol Microbiology

      Volume: 87(6) Issue: 6 Pages: 1133-50

    • DOI

      10.1111/mmi.12155

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses2013

    • Author(s)
      Tanaka M
    • Journal Title

      Molecular Brain

      Volume: 6 Issue: 1 Pages: 6-6

    • DOI

      10.1186/1756-6606-6-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Revisiting Channel Allostery: A Coherent Mechanism in IP_3 and Ryanodine Receptors2012

    • Author(s)
      Hamada K, Mikoshiba K
    • Journal Title

      Science Signaling

      Volume: 5(225) Pages: 24-24

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Receptor-selective diffusion barrier enhances sensitivity of astrocytic processes to metabotropic glutamate receptor stimulation2012

    • Author(s)
      Arizono M, Bannai H, Nakamura K, Niwa F, Enomoto M, Matsu-Ura T, Miyamoto A, Sherwood MW, Nakamura T, Mikoshiba K
    • Journal Title

      Science Signaling

      Volume: 218

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of inositol 1, 4, 5-trisphosphate receptors during preconditioning low-frequency stimulation leads to reversal of long-term potentiation in hippocampal CA1 neurons2012

    • Author(s)
      Yamazaki Y
    • Journal Title

      Neuroscience

      Volume: 207 Pages: 1-11

    • DOI

      10.1016/j.neuroscience.2012.01.045

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Discovery and Structural Investigation of the IP(3) Receptor and the Associated IRBIT Protein2012

    • Author(s)
      Mikoshiba K.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 740 Pages: 281-304

    • DOI

      10.1007/978-94-007-2888-2_12

    • ISBN
      9789400728875, 9789400728882
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Receptor-selective diffusion barrier enhances sensitivity of astrocytic processes to metabotropic glutamate receptor stimulation2012

    • Author(s)
      Arizono M
    • Journal Title

      Science Signaling

      Volume: 5(218) Issue: 218

    • DOI

      10.1126/scisignal.2002498

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gephyrin-Independent GABA(A)R Mobility and Clustering during Plasticity2012

    • Author(s)
      Niwa F
    • Journal Title

      PLoS One

      Volume: 7(4) Issue: 5

    • DOI

      10.1371/annotation/d186036a-da60-47d1-8e3c-7e225a3539ae

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of hair shedding by the type 3 IP3 receptor2012

    • Author(s)
      Sato-Miyaoka M
    • Journal Title

      J Investigative Dermatology

      Volume: 132(9) Issue: 9 Pages: 2137-47

    • DOI

      10.1038/jid.2012.141

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cot Kinase Promotes Ca2+ Oscillation/Calcineurin-independent Osteoclastogenesis by Stabilizing NFATc1 Protein2012

    • Author(s)
      Kuroda Y
    • Journal Title

      Mol Cell Biology

      Volume: 32(14) Issue: 14 Pages: 2954-63

    • DOI

      10.1128/mcb.05611-11

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A coherent mechanism in IP3 and ryanodine receptors2012

    • Author(s)
      Hamada K
    • Journal Title

      Science Signaling

      Volume: 5(225) Issue: 225

    • DOI

      10.1126/scisignal.2003148

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative and stochastic calcium releases from multiple calcium puffsites generate calcium microdomains in intact HeLa cells.2012

    • Author(s)
      Nakamura H, Bannai H, Inoue T, Michikawa T, Sano M, Mikoshiba K.
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 29 Pages: 24563-24572

    • DOI

      10.1074/jbc.m111.311399

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type 2 inositol 1,4,5-trisphosphate receptor is predominantly involved in agonist-induced Ca(2+) signaling in Bergmann glia.2012

    • Author(s)
      Tamamushi S, Nakamura T, Inoue T, Ebisui E, Sugiura K, Bannai H, Mikoshiba K
    • Journal Title

      Neuroscience Research

      Volume: 74 Issue: 1 Pages: 32-41

    • DOI

      10.1016/j.neures.2012.06.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockage of spontaneous Ca2+ oscillation causes cell death in intraerythrocitic Plasmodium falciparum2012

    • Author(s)
      Enomoto M
    • Journal Title

      PLoS ONE

      Volume: 7(7) Issue: 7 Pages: e39499-e39499

    • DOI

      10.1371/journal.pone.0039499

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT2012

    • Author(s)
      Bauer PO
    • Journal Title

      Molecular Neurodegeneration

      Volume: 7(1) Issue: 1 Pages: 43-43

    • DOI

      10.1186/1750-1326-7-43

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative comparison of novel GCaMP-type genetically encoded Ca2+ indicators in mammalian neurons2012

    • Author(s)
      Yamada Y
    • Journal Title

      Front Cell Neuroscience

      Volume: 6(41) Pages: 1-9

    • DOI

      10.3389/fncel.2012.00041

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal overexpression of IP3 receptor 2 is detrimental in mutant SOD1 mice2012

    • Author(s)
      Staats KA
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 429(3-4) Issue: 3-4 Pages: 210-213

    • DOI

      10.1016/j.bbrc.2012.10.094

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutual antagonism between IP3RII and miRNA-133a regulates calcium signals and cardiac hypertrophy2012

    • Author(s)
      Drawnel FM
    • Journal Title

      J Cell Biology

      Volume: 199(5) Issue: 5 Pages: 783-98

    • DOI

      10.1083/jcb.201111095

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Discovery of the IP3 Receptor2012

    • Author(s)
      Mikoshiba K.
    • Journal Title

      Messenger

      Volume: 1(2) Issue: 2 Pages: 95-107

    • DOI

      10.1166/msr.2012.1009

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prior synaptic inputs are engraved on the following synaptic plasticity with Inositol 1,4,5-trisphosphate receptor activation in hippocampal neurons2012

    • Author(s)
      Goto J
    • Journal Title

      Messenger

      Volume: 1(2) Issue: 2 Pages: 121-132

    • DOI

      10.1166/msr.2012.1013

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] パスツールと北里柴三郎をつなぐ「予防医学」の志2012

    • Author(s)
      御子柴克彦
    • Journal Title

      東京人 7月増刊

      Volume: 313 Pages: 100-100

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Phosphorylation of CRMP2 (Collapsin Response Mediator Protein 2) Is Involved in Proper Dendritic Fisld Organization2012

    • Author(s)
      Yamashita N
    • Journal Title

      J Neurosci

      Volume: 32(4) Issue: 4 Pages: 1360-1365

    • DOI

      10.1523/jneurosci.5563-11.2012

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] in vivo実験医学の新たな幕開け-個体観察による疾患解明と新しい治療の進歩-2012

    • Author(s)
      御子柴克彦
    • Journal Title

      実験医学

      Volume: 30(2増刊) Pages: 1-3

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 小胞体ストレス、レドックス制御、カルシウムシグナルと細胞死2012

    • Author(s)
      肥後剛康、濱田耕造、御子柴克彦
    • Journal Title

      実験医学

      Volume: 30(2増刊) Pages: 224-230

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium2011

    • Author(s)
      Shinohara T, Michikawa T, Enomoto M, Goto J, Iwai M, Matsu-ura T, Yamazaki H, Miyamoto A, Suzuki A, Mikoshiba K
    • Journal Title

      Proc. Natl. Acad. Sci

      Volume: 108(37) Pages: 15486-91

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Syntaxin 1B suppresses macropinocytosis and semaphorin 3A-induced growth cone collapse2011

    • Author(s)
      Kabayama H, Takeuchi M, Taniguchi M, Tokushige N, Kozaki S, Mizutani A, Nakamura T, Mikoshiba K
    • Journal Title

      J. Neuroscience

      Volume: 31(20) Pages: 7357-64

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypomyelination Phenotype Caused by Impaired Differentiation of Oligodendrocytes in Emx1-cre Mediated Cdk5 Conditional Knockout Mice2011

    • Author(s)
      He X, Takahashi S, Suzuki H, Hashikawa T, Kulkarni AB, Mikoshiba K, Ohshima T
    • Journal Title

      Neurochem Res

      Volume: 36(7) Issue: 7 Pages: 1293-1303

    • DOI

      10.1007/s11064-010-0391-0

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of Cortical Neuron Migration by the Reelin Signaling Pathway2011

    • Author(s)
      Honda T, Kobayashi K, Mikoshiba K, Nakajima K
    • Journal Title

      Neurochem Res

      Volume: 36(7) Issue: 7 Pages: 1270-1279

    • DOI

      10.1007/s11064-011-0407-4

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ORAI1-mediated calciumc influx is required for human cytotoxic lymphocyte degranulation and target cell lysis2011

    • Author(s)
      Maul-Pavicic A, et al
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108(8) Issue: 8 Pages: 3324-9

    • DOI

      10.1073/pnas.1013285108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway2011

    • Author(s)
      Yang D
    • Journal Title

      J Clin Invest

      Volume: 121(3) Issue: 3 Pages: 956-65

    • DOI

      10.1172/jci43475

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of BMP, FGF, calcium signaling, and Zic proteins in vertebrate neuroectodermal differentiation2011

    • Author(s)
      Aruga J
    • Journal Title

      Neurochem Res

      Volume: 36(7) Issue: 7 Pages: 1286-92

    • DOI

      10.1007/s11064-011-0422-5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of inositol 1,4,5-trisphosphate receptors in the post synaptic expression of guinea pig hippocampal mossy fiber depotentiation2011

    • Author(s)
      Yamazaki Y
    • Journal Title

      Brain Res

      Volume: 1387 Pages: 19-28

    • DOI

      10.1016/j.brainres.2011.02.088

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field2011

    • Author(s)
      Nakazawa M
    • Journal Title

      J Mol Cell Cardiol

      Volume: 51(1) Issue: 1 Pages: 58-66

    • DOI

      10.1016/j.yjmcc.2011.02.014

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dissociation of inositol polyphosphates from the C2B domain of synaptotagmin facilitates spontaneous release of catechol amines in adrenal chromaffin cells. A suggestive evidence of a fusion clamp by synaptotagmin2011

    • Author(s)
      Sasakawa N
    • Journal Title

      Neuropharmacology

      Volume: 60(7-8) Issue: 7-8 Pages: 1364-70

    • DOI

      10.1016/j.neuropharm.2011.03.005

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inositol 1,4,5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B2011

    • Author(s)
      Tanaka S
    • Journal Title

      J Physiol Sci

      Volume: 61(3) Issue: 3 Pages: 221-9

    • DOI

      10.1007/s12576-011-0140-4

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly cooperative dependence of sarco/endoplasmic reticulum calcium ATPase (SERCA) 2a pump activity on cytosolic calcium in living cells2011

    • Author(s)
      Satoh K
    • Journal Title

      J Biol Chem

      Volume: 286(23) Issue: 23 Pages: 20591-9

    • DOI

      10.1074/jbc.m110.204685

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] InsP3 receptors and Orai channels in pancreatic acinar cells : co-localization and its consequences2011

    • Author(s)
      Lur G
    • Journal Title

      Biochem J

      Volume: 436(2) Issue: 2 Pages: 231-9

    • DOI

      10.1042/bj20110083

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Syntaxin 1B Suppresses Macropinocytosis and Semaphorin 3A-Induced Growth Cone Collapse2011

    • Author(s)
      Kabayama H
    • Journal Title

      J Neurosci

      Volume: 31(20) Issue: 20 Pages: 7357-64

    • DOI

      10.1523/jneurosci.2718-10.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of IP_3 receptor in development2011

    • Author(s)
      Mikoshiba K
    • Journal Title

      Cell Calcium

      Volume: 49(5) Issue: 5 Pages: 331-40

    • DOI

      10.1016/j.ceca.2010.12.006

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IP_3 signaling is required for cilia formation and left-right body axis determination in Xenopus embryos2011

    • Author(s)
      Hatayama M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 410(3) Issue: 3 Pages: 520-524

    • DOI

      10.1016/j.bbrc.2011.06.014

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inositol 1,4,5-trisphosphate receptor-mediated calcium release in Purkinje cells : from molecular mechanism to behavior2011

    • Author(s)
      Goto JI
    • Journal Title

      Cerebellum

      Volume: 10(4) Issue: 4 Pages: 820-33

    • DOI

      10.1007/s12311-011-0270-5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals2011

    • Author(s)
      Nakamura TY
    • Journal Title

      Circ Res

      Volume: 109(5) Issue: 5 Pages: 512-23

    • DOI

      10.1161/circresaha.111.248864

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium2011

    • Author(s)
      Shinohara T
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108(37) Issue: 37 Pages: 15486-91

    • DOI

      10.1073/pnas.1101677108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitive comparison of genetically encoded Ca^<2+> indicators in cortical pyramidl cells and cerebellar Purkinje cells2011

    • Author(s)
      Yamada Y
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 5(18) Pages: 1-10

    • DOI

      10.3389/fncel.2011.00018

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic ablation and chemical inhibition of IP3R1 reduce mutant huntingtin aggregation2011

    • Author(s)
      Bauer PO
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 16(1-2) Issue: 1-2 Pages: 13-7

    • DOI

      10.1016/j.bbrc.2011.10.096

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Astrocyte calcium signaling transforms cholinergic modulation to cortical plastcity in vivo2011

    • Author(s)
      Takata N
    • Journal Title

      J Neurosci

      Volume: 31(49) Issue: 49 Pages: 18155-65

    • DOI

      10.1523/jneurosci.5289-11.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potent transglutaminase inhibitors, dithio ss-aminoethyl ketones2011

    • Author(s)
      Ozaki S., et al
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 21(1) Pages: 377-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway2011

    • Author(s)
      Yang D., et al
    • Journal Title

      J Clin Invest.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous network activity visualized by ultrasensitive Ca^<2+> indicators, yellow Cameleon-Nano2010

    • Author(s)
      Horikawa K*, Yamada Y*, Matsuda T, Kobayashi K, Hashimoto M, Matsu-Ura T, Miyawaki A, Michikawa T, Mikoshiba K, Nagai T
    • Journal Title

      Nature Methods (*equal contribution)

      Volume: 7(9) Pages: 729-32

    • NAID

      120002834691

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of ER stress-induced brain damage by IP3 receptor2010

    • Author(s)
      Higo T, Hamada K, Nakamura T, Hattori M, Mikoshiba K
    • Journal Title

      Neuron (表紙に採用)

      Volume: 68(5) Pages: 865-878

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous network activity visualized by ultrasensitive Ca^<2+> indicators, yellow Cameleon-Nano.2010

    • Author(s)
      Horikawa K, Yamada Y, Matsuda T, Kbayashi K, Hashimoto M, Matsu-Ura T, Miyawaki A, Michikawa T, Mikoshiba K, Nagai T.
    • Journal Title

      Nat Methods. 7(9)

      Pages: 729-732

    • NAID

      120002834691

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Mechanism of ER stress-induced brain damage by IP3 receptor.2010

    • Author(s)
      Higo T, Hamada K, Nakamura T, Hattori M, Mikoshiba K.
    • Journal Title

      Neuron 68(5)

      Pages: 865-878

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Intracellular calcium ion dynamics involved in long-term potentiation in hippocampal CA1 neurons in mice lacking the IP_3 type 1 receptor2010

    • Author(s)
      Yoshioka M., et al
    • Journal Title

      Neuroscience Research

      Volume: 67(2) Pages: 149-155

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of inositol-1,4,5-trisphosphate receptors in the bidire ctional synaptic plasticity induced in hippocampal CA1 neurons by 1-10 Hz low-frequency stimulation2010

    • Author(s)
      Fujii S., et al
    • Journal Title

      Neuroscience

      Volume: 168 Pages: 346-358

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auto-luminescent genetically-encoded ratiometric indicator for real-time Ca^<2+> imaging at the single cell level2010

    • Author(s)
      Saito K., et al
    • Journal Title

      PLoS One

      Volume: 5(4)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the Inositol (1,4,5)-Triphosphate Calcium Gate Receptor is Required for HIV-1 Gag Release2010

    • Author(s)
      Ehrlich L.S., et al
    • Journal Title

      J Virol.

      Volume: 4(13) Pages: 6438-51

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The IP_3 receptor regulates cardiac hypertrophy in response to select stimuli2010

    • Author(s)
      Nakayama H., et al
    • Journal Title

      Circulation Research

      Volume: 107(5) Pages: 659-66

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 in Purkinje cells is regulated by calcium and actin filaments2010

    • Author(s)
      Fukatsu K., et al
    • Journal Title

      J Neurochemistry

      Volume: 114(6) Pages: 1720-33

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the IP3R1 promoter-driven nls-lacZ transgene in Purkinje cell parasagittal arrays of developing mouse cerebellum2010

    • Author(s)
      Furutama D., et al
    • Journal Title

      J Neurosci.Research

      Volume: 88 Pages: 2810-25

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous network activity visualized by ultrasensitive Ca^<2+> indicators, yellow Cameleon-Nano2010

    • Author(s)
      Horikawa K., et al
    • Journal Title

      Nature Methods

      Volume: 7(9) Pages: 729-32

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] JNK phosphorylates Ser332 of doublecortin and regulates its function in neurite extension and neuronal migration2010

    • Author(s)
      Jin J., et al
    • Journal Title

      Dev Neurobiology

      Volume: 70(14) Pages: 929-42

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defective membrane expression of the Na^+-HCO_3- cotransporter NBCe1 is associated with familial migraine2010

    • Author(s)
      Suzuki M., et al
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 107(36) Pages: 15963-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tyr-167/Trp-168 in type1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening2010

    • Author(s)
      Yamazaki H., et al
    • Journal Title

      J Biol Chem.

      Volume: 285(46) Pages: 36081-91

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene Knock-Outs of Inositol 1,4,5-Trisphosphate Receptors Types 1 and 2 Result in Perturbation of Cardiogenesis2010

    • Author(s)
      Uchida K., et al
    • Journal Title

      PLoS One

      Volume: 5(9)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural studies of inositol 1,4,5-trisphosphate receptor : coupling ligand binding to channel gating2010

    • Author(s)
      Chan J., et al
    • Journal Title

      J Biol Chem.

      Volume: 285(46) Pages: 36092-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of ER stress-induced brain damage by IP_3 receptor2010

    • Author(s)
      Higo T., et al
    • Journal Title

      Neuron

      Volume: 68(5) Pages: 865-878

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中枢神経系の発生と分化-IP_3受容体の発見とその機能の解明2010

    • Author(s)
      御子柴克彦
    • Journal Title

      日本病態生理学会雑誌

      Volume: 19(1) Pages: 51-58

    • Related Report
      2010 Annual Research Report
  • [Journal Article] IP_3-IP_3レセプター2010

    • Author(s)
      御子柴克彦
    • Journal Title

      生体の科学

      Volume: 61(5) Pages: 442-443

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Two novel 2-aminoethyl diphenylborinate(2-APB)analogues differentially activate and inhibit store-operated Ca(2+)entry via STIM proteins2010

    • Author(s)
      Goto J.I., et al
    • Journal Title

      Cell Calcium 47(1)

      Pages: 1-10

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potent transglutaminase inhibitors, aryl beta-aminoethyl ketones2010

    • Author(s)
      Ozaki S., et al
    • Journal Title

      Bioorg Med Chem Lett. 20

      Pages: 1141-1144

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of bisboron compounds and their strong inhibitory activity on store-operated calcium entry2010

    • Author(s)
      Suzuki A.Z., et al
    • Journal Title

      Bioorg Med Chem Lett. 20

      Pages: 1395-1398

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Triller A. Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics2009

    • Author(s)
      Bannai H, Levi S, Schweizer C, Inoue T, Launey T, Racine V, Sibarita JB, Mikoshiba K
    • Journal Title

      Neuron

      Volume: 62(5) Pages: 670-82

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Control of Neuronal Growth Cone Navigation by Asymmetric Inositol 1,4,5-Trisphosphate Signals2009

    • Author(s)
      Akiyama H, Matsu-ura T, Mikoshiba K, and Kamiguchi H
    • Journal Title

      Science Signaling

      Volume: 2(79)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics.2009

    • Author(s)
      Bannai H, Levi S, Schweizer C, Inoue T, Launey T, Racine V, Sibarita JB, Mikoshiba K, Triller A.
    • Journal Title

      Neuron 62(5)

      Pages: 670-682

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Control of Neuronal Growth Cone Navigation by Asymmetric Inositol 1,4,5-Trisphosphate Signals.2009

    • Author(s)
      Akiyama H, Matsu-ura T, Mikoshiba K, Kamiguchi H.
    • Journal Title

      Science Signaling 2(79)

      Pages: 34-34

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes2009

    • Author(s)
      Higazi D.R., et al
    • Journal Title

      Molecular Cell 33(4)

      Pages: 472-482

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage2009

    • Author(s)
      Ando H., et al
    • Journal Title

      J Neurochemistry 109(2)

      Pages: 539-50

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inositol 1,4,5-triphosphate receptor-binding protein released with Inositol 1,4, 5-triphosphate(IRBIT), associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation2009

    • Author(s)
      Kiefer H., et al
    • Journal Title

      J Biol Chem. 284

      Pages: 10694-705

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of Cupidin/Homer2 with two actincytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines2009

    • Author(s)
      Shiraishi-Yamaguchi H., et al
    • Journal Title

      BMC Neuroscience 10(1)

      Pages: 25-25

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of Neurite Outgrowth Mediated by Neuronal Calcium Sensor-1 and Inositol 1.4.5-Trisphosphate Receptor in Nerve Growth Cones2009

    • Author(s)
      Iketani M., et al
    • Journal Title

      Neuroscience 61(3)

      Pages: 743-752

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stability of folding structure of Zic zinc finger proteins2009

    • Author(s)
      Sakai-Kato K., et al
    • Journal Title

      Biochem Biophys Res Commun 384(3)

      Pages: 362-5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics2009

    • Author(s)
      Bannai H., et al
    • Journal Title

      Neuron 62(5)

      Pages: 670-82

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics2009

    • Author(s)
      Gerasimenko J.V., et al
    • Journal Title

      Proc Natl Acad Sci U S A 106(26)

      Pages: 10758-63

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control of neuronal growth cone navigation by asymmetric inositol 1,4,5-trisphosphate siqnals2009

    • Author(s)
      Akiyama H., et al
    • Journal Title

      Science Signaling 2(79)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] G-protein-coupled receptor kinase-interacting proteins inhibit apoptosis by inositol 1,4,5-triphosphate receptor-mediated Ca2+ signal reaulation2009

    • Author(s)
      Zhang S., et al
    • Journal Title

      J Biol Chem. 284(42)

      Pages: 29158-69

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Knockdown of Cav2.1 calcium channels is sufficient to induce neurological disorders observed in natural occurring Cacna1a mutants in mice2009

    • Author(s)
      Saito H., et al
    • Journal Title

      Biochem Biophys Res Commun. 390(3)

      Pages: 1029-33

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中枢神経系の発生と分化-IP3受容体の発見とその機能の解明2009

    • Author(s)
      御子柴克彦
    • Journal Title

      内藤財団時報 84

      Pages: 18-25

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Ca^<2+> induces macropinocytosis via F-actin depolymerization during growth cone collapse2009

    • Author(s)
      Hiroyuki K., et al.
    • Journal Title

      Mol Cell Neurosci 40

      Pages: 27-38

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 80K-H interacts with inositol 1,4,5-trisphosphate receptors and regulates IP3-induced calcium release activity2009

    • Author(s)
      Kawaai K., et al.
    • Journal Title

      J Biol Chem. 284

      Pages: 372-80

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Insights into Ca^<2+>-dependent Regulation of Inositol 1,4,5,-trisphosphate Receptors by CaBP12009

    • Author(s)
      Li C., et al.
    • Journal Title

      J Biol Chem. 284

      Pages: 2472-81

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IRBIT coordinates epithelial fluid and HCO3-secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct2009

    • Author(s)
      Yang D., et al.
    • Journal Title

      J Clin Invest. 119

      Pages: 193-202

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmental changes in the regulation of calcium-dependent neurite outgrowth2009

    • Author(s)
      Arie Y., et al.
    • Journal Title

      Biochem Biophys Res Commun 379

      Pages: 11-15

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Postmenopausal Patient with Tangier Disease Developing Sjogren's Syndrome2009

    • Author(s)
      Miyachi K., et al.
    • Journal Title

      J Rheumatol. 36

      Pages: 208-209

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage2009

    • Author(s)
      Ando H., et al.
    • Journal Title

      J Neurochem.

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inositol 1,4,5-triphosphate receptor-binding protein released with Inositol 1,4,5-triphosphate (IRBIT), associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation2009

    • Author(s)
      Helene K., et al.
    • Journal Title

      J Biol Chem.

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IP_3レセプター発見への道2009

    • Author(s)
      御子柴克彦
    • Journal Title

      脳21-私の研究エポック- 12

      Pages: 147-156

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Osteoblasts induce Ca^<2+> oscillation-independent NFATc1 activation during osteoclastogenesis2008

    • Author(s)
      Kuroda Y., Hisatsune C., …Mikoshiba K
    • Journal Title

      Proc. Natl. Acad. Sci

      Volume: 105(25) Pages: 8643-8648

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteoblasts induce Ca^<2+> oscillation-independent NFATc1 activation during osteoclastogenesis2008

    • Author(s)
      Kuroda Y., Hisatsune C., Nakamura T., Matsuo K., Mikoshiba K.
    • Journal Title

      Proc.Natl.Acad.Sci. 105(25)

      Pages: 8643-8648

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] From Ca^<2+> in muscle contraction to IP_3 receptor/Ca^<2+> signaling In memory of Setsuro Ebashi2008

    • Author(s)
      Mikoshiba K.
    • Journal Title

      Biochem Biophys Res Commun. 369

      Pages: 57-61

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Type 2 and type 3 inositol 1,4,5-trisphosphate IP_3 receptors promote the differentiation of granule cell precursors in the postnatal cerebellum2008

    • Author(s)
      Futatsugi A, et al.
    • Journal Title

      J Neurochem. 105

      Pages: 1153-1164

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predominant role of type 1 IP_3 receptor in aortic vascular muscle contraction2008

    • Author(s)
      Zhou H., et al.
    • Journal Title

      Biochem Biophys Res Commun. 369

      Pages: 213-219

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA2008

    • Author(s)
      Sakai-Kato K., et al.
    • Journal Title

      Biochim Biophys Acta. 1784

      Pages: 1011-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of SAD Kinase by Ca^<2+>/Calmodulin-Dependent Protein Kinase Kinase2008

    • Author(s)
      Fujimoto T., et al.
    • Journal Title

      Biochemistry 47

      Pages: 4151-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase2008

    • Author(s)
      Ogawa M., et al.
    • Journal Title

      Genes Cells 13

      Pages: 397-409

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Syntaxin 6 regulates nerve growth factor-dependent neurite outgrowth2008

    • Author(s)
      Kabayama H., et al.
    • Journal Title

      Neurosci Lett. 436

      Pages: 340-344

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly2008

    • Author(s)
      Inoue T., et al.
    • Journal Title

      J Neurosci. 18

      Pages: 4712-25

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynactin is essential for growth cone advance2008

    • Author(s)
      Abe T. K., et al.
    • Journal Title

      Biochem Biophys Res Commun. 372

      Pages: 418-22

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of Homer3 by Calcium/Calmodulin-Dependent Kinase II Regulates a Coupling State of Its TargetMolecules in Purkinje Cells2008

    • Author(s)
      Mizutani A., et al.
    • Journal Title

      J Neurosci. 28

      Pages: 5369-82

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATP modulation of Ca^<2+> release by type-2 and type-3 InsP3R : Differing ATP sensitivities and molecular determinants of action2008

    • Author(s)
      Betzenhauser M. J., et al.
    • Journal Title

      J Biol Chem. 283

      Pages: 21579-87

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors2008

    • Author(s)
      Fukuda N., et al.
    • Journal Title

      Eur J Neurosci. 27

      Pages: 2665-75

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis2008

    • Author(s)
      Kuroda Y., et al.
    • Journal Title

      Proc. Natl. Acad. Sci. 105

      Pages: 8643-48

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redistribution of microtubules in dendrites of hippocampal CA1 neurons after tetanic stimulation during long-term potentiation2008

    • Author(s)
      Mitsuyama, F., et al.
    • Journal Title

      Ital. J. Anat. Embryol. 113

      Pages: 17-27

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of Ca^<2+> Signaling in Cell Function with Special Reference to Exocrine Secretion2008

    • Author(s)
      Mikoshiba K., et al.
    • Journal Title

      Cornea, Supplement 27

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain2008

    • Author(s)
      Hatayama M., et al.
    • Journal Title

      Hum Mol Genet. 17

      Pages: 3459-73

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経研究の今後:分子から病態へ Toward a future Research in Neurology : molecular analysis of brain disorder2008

    • Author(s)
      御子柴克彦
    • Journal Title

      臨床神経学 48

      Pages: 815-20

    • Related Report
      2008 Annual Research Report
  • [Presentation]2012

    • Author(s)
      Mikoshiba K
    • Organizer
      1st Asia Dry Eye Society Advisory Board Meeting
    • Place of Presentation
      (ホテルペニンスラ、東京), Special Lecture
    • Year and Date
      2012-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation]2012

    • Author(s)
      Mikoshiba K
    • Organizer
      FASEB 会議 招待講演
    • Year and Date
      2012-06-20
    • Related Report
      2012 Final Research Report
  • [Presentation]2012

    • Author(s)
      Mikoshiba K
    • Organizer
      カロリンスカ研究所セミナー
    • Place of Presentation
      (ストックホルム) Lecture
    • Year and Date
      2012-03-01
    • Related Report
      2012 Final Research Report
  • [Presentation] IP3レセプター:発見から新しい情報伝達系への展開-生理機能と病態像の解明へ向けて-2012

    • Author(s)
      御子柴克彦
    • Organizer
      岡山大学医学部セミナー
    • Place of Presentation
      岡山大学(招待講演)
    • Year and Date
      2012-02-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] OBOE outreach research at Riken BSI2012

    • Author(s)
      御子柴克彦
    • Organizer
      OBOE
    • Place of Presentation
      Gnesta, Sweden
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Blockage of IP3 receptor of Trypanosoma cruzi and malaria parasite (Plasmodium falciparum) results in dysregulation of cell cycle progression and cell death2012

    • Author(s)
      御子柴克彦
    • Organizer
      FASEB -Calcium & Cell Function-
    • Place of Presentation
      Snowmass Village CO USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Recent advances of IP3 receptor research: ~towards the understanding the mechanism of ER stress induced cell damage~2012

    • Author(s)
      御子柴克彦
    • Organizer
      1st Asia Dry Eye Society Advisory Board Meeting
    • Place of Presentation
      Hotel PENINSULA, TOKYO
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オリジナルな研究で世界をリードする にはどうしたらよいか2012

    • Author(s)
      御子柴克彦
    • Organizer
      第56回神経化学会若手研究者育成セミナー
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] IP3 ligand-gated Ca2+ channel : structure and its variety of Physiological and pathological functions2011

    • Author(s)
      御子柴克彦
    • Organizer
      第10回JBSバイオフロンティア国際シンポジウムNew Aspects of Phospholipid Biology and Medicine 2011
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2011-11-15
    • Related Report
      2011 Annual Research Report
  • [Presentation]2011

    • Author(s)
      Mikoshiba K
    • Organizer
      Ion Channel Signaling Mechanisms: From Basic Science to Clinical Application, Plenary Talk
    • Place of Presentation
      Marrakesh, Morocco
    • Year and Date
      2011-10-31
    • Related Report
      2012 Final Research Report
  • [Presentation] IP3 receptor/Ca2+ channel : gating mechanism and its role in health and disease2011

    • Author(s)
      御子柴克彦
    • Organizer
      Ion Channel Signaling Mechanisms : From Basic Science to Clinical Application
    • Place of Presentation
      Marrakesh, Morocco(招待講演)
    • Year and Date
      2011-10-31
    • Related Report
      2011 Annual Research Report
  • [Presentation]2011

    • Author(s)
      Mikoshiba K
    • Organizer
      International Society for Neurochemistry (ISN) and the European Society for Neurochemistry (ESN) 23rd ISN-ESN Congress, Plenary Lecture (Athene, Greek) (2人のノーベル賞受賞者 Roger Tsien 教授 Linda Buck 教授と一緒に招待された.)
    • Year and Date
      2011-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] IP3 receptor/calcium channel as a signaling hub : role in development, brain function and brain damage2011

    • Author(s)
      御子柴克彦
    • Organizer
      International Society for Neurochemistry (ISN) and the European Society for Neurochemistry (ESN) 23rd ISN-ESN Congress
    • Place of Presentation
      Athene, Greek(招待講演)
    • Year and Date
      2011-09-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞内Ca2+動態と情報伝達-その生理と病態-2011

    • Author(s)
      御子柴克彦
    • Organizer
      Cardio-Renal Metabolism and Senescence 2011
    • Place of Presentation
      社団法人クラブ関東、東京(招待講演)
    • Year and Date
      2011-09-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞内カルシウム制御機構~生理現象から心発生・心疾患の解明へむけて~2011

    • Author(s)
      御子柴克彦
    • Organizer
      第75回日本循環器学会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-08-03
    • Related Report
      2011 Annual Research Report
  • [Presentation]2011

    • Author(s)
      Mikoshiba K
    • Organizer
      The 17th International Symposium on Ca^<2+>-Binding Proteins and Ca^<2+> Function in Health and Disease, Plenary Lecture
    • Place of Presentation
      北京、中国
    • Year and Date
      2011-07-20
    • Related Report
      2012 Final Research Report
  • [Presentation] IP3 receptor/Ca2+ channel : mechanism of gating, development, ER stress and neurodegeneration2011

    • Author(s)
      御子柴克彦
    • Organizer
      The 17th International Symposium on Ca2+-Binding Proteins and Ca2+ Function in Health and Disease, Ebashi Lecture
    • Place of Presentation
      北京、中国(招待講演)
    • Year and Date
      2011-07-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 正常と異常の比較から生命現象の本質をのぞく2011

    • Author(s)
      御子柴克彦
    • Organizer
      第2回先端医療センターMonthly letter
    • Place of Presentation
      臨床研究情報センター、神戸(招待講演)
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of calcium in development, brain function and disease2011

    • Author(s)
      御子柴克彦
    • Organizer
      BK21 Program
    • Place of Presentation
      ソウル国立大学、韓国(招待講演)
    • Year and Date
      2011-05-02
    • Related Report
      2011 Annual Research Report
  • [Presentation]2011

    • Author(s)
      Mikoshiba K
    • Organizer
      World Class Univerisity (WCU) Professor プログラムLecture
    • Place of Presentation
      ソウル国立大学、韓国
    • Year and Date
      2011-04-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Modern biological and biophysical techniques in health and disease2011

    • Author(s)
      御子柴克彦
    • Organizer
      World Class Univerisity (WCU) Professorプログラムソウル国立大学医学部
    • Place of Presentation
      ソウル国立大学、韓国(招待講演)
    • Year and Date
      2011-04-28
    • Related Report
      2011 Annual Research Report
  • [Presentation]2011

    • Author(s)
      Mikoshiba K
    • Organizer
      Symposium Frontiers in Epithelial Transport 2011 (Yonsei Univeristy, Seoul Korea) Invited Speaker
    • Place of Presentation
      Yonsei Univeristy, Seoul Korea
    • Year and Date
      2011-04-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of IRBIT, a pseudo ligand of IP3 receptor : from discovery to its various cell function2011

    • Author(s)
      御子柴克彦
    • Organizer
      Frontiers in Epithelial Transport 2011
    • Place of Presentation
      Yonsei Univeristy, Seoul Korea(招待講演)
    • Year and Date
      2011-04-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞内カルシウム制御機構~生理現象から心発生・心疾患の解明へむけて~2011

    • Author(s)
      御子柴克彦
    • Organizer
      第75回日本循環器学会真下記念講演
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小胞体ストレス・カルシウムシグナル・神経変性2011

    • Author(s)
      御子柴克彦
    • Organizer
      第4回In vivo実験医学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-02-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structure and function of inositol IP_3 receptor and its diverse cell function2011

    • Author(s)
      御子柴克彦
    • Organizer
      The Johns Hopkins University, SPECIAL NEUROSCIENCE RESEARCH SEMINAR
    • Place of Presentation
      Baltimore, MD USA
    • Year and Date
      2011-02-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gating mechanisms of IP3 receptor and ER stress-inducedbrain damage2011

    • Author(s)
      御子柴克彦
    • Organizer
      Karolinska Institutet Seminar
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2011-02-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] IP3レセプター/Ca2+チャネルの構造と機能及びその生理的役割2010

    • Author(s)
      御子柴克彦
    • Organizer
      日立基礎研究講演会
    • Place of Presentation
      (株)日立製作所基礎研究所埼玉県比企郡鳩山町(招待講演)
    • Year and Date
      2010-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Brain damage : how to protect from ER stress?2010

    • Author(s)
      御子柴克彦
    • Organizer
      スウェーデンカロリンスカ研究所200年特別記念シンポジウム
    • Place of Presentation
      在日スウェーデン大使館(東京)(特別講演)
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mechanism of ER stress-induced brain damage by IP3 receptor2010

    • Author(s)
      御子柴克彦
    • Organizer
      Karolinska Institute seminar
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2010-10-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Discovery of IP_3 receptor and its role in health and disease2010

    • Author(s)
      御子柴克彦
    • Organizer
      ソウル国立大学医学部
    • Place of Presentation
      Seoul National University, Korea(invited seminar)
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Significance of calcium homeostasis in neurological disorders2010

    • Author(s)
      御子柴克彦
    • Organizer
      ソウル国立大学医学部
    • Place of Presentation
      Seoul NationalUniversity, Korea(invited lecture)
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation]2010

    • Author(s)
      Mikoshiba K
    • Organizer
      FASEB Summer Research Conference(Corolado, USA)Invited Speaker
    • Place of Presentation
      Corolado, USA
    • Year and Date
      2010-06-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳の研究と日仏交流2010

    • Author(s)
      御子柴克彦
    • Organizer
      日仏生物学会172回例会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of Ca2+ dynamics in cell function and diseases2010

    • Author(s)
      御子柴克彦
    • Organizer
      WCU Distinguished Lecture Series
    • Place of Presentation
      Seoul National University, Korea
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細細胞内カルシウム動態の生理機能と病態像:自己免疫疾患の治療と創薬へむけて2010

    • Author(s)
      御子柴克彦
    • Organizer
      第54回日本リウマチ学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] カルシウムがひもとく生命の神秘2010

    • Author(s)
      御子柴克彦
    • Organizer
      会津医学会講演会
    • Place of Presentation
      会津若松市
    • Year and Date
      2010-02-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳神経の機序解明かうら生体の謎にせまる~分子からみた in vivo サイエンス~2010

    • Author(s)
      御子柴克彦
    • Organizer
      実験中央研究所2010年新春セミナープログラム
    • Place of Presentation
      川崎
    • Year and Date
      2010-01-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 中枢神経系の発生と分化-IP_3受容体の発見とその機能の解明2010

    • Author(s)
      御子柴克彦
    • Organizer
      第20回日本病態生理学会細見記念講演
    • Place of Presentation
      奈良県立医科大学
    • Year and Date
      2010-01-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Structure and function of inositol IP_3 receptor2010

    • Author(s)
      御子柴克彦
    • Organizer
      FASEB Summer Research Conference
    • Place of Presentation
      Steamboat Springs, Colorado, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] IP_3 receptor : the structure-function and its role in cell function and disease2010

    • Author(s)
      御子柴克彦
    • Organizer
      11th European Calcium Society Meeting
    • Place of Presentation
      Warsaw, Poland
    • Related Report
      2010 Annual Research Report
  • [Presentation]2009

    • Author(s)
      Mikoshiba K
    • Organizer
      Plenary Lecture, 16^<th>Symposium on Ca^<2+>- Binding Proteins and Ca^<2+> Function in Health and Disease (Puchon, Chille)
    • Place of Presentation
      Puchon, Chille
    • Year and Date
      2009-11-16
    • Related Report
      2012 Final Research Report
  • [Presentation] IP_3 ligand gated Ca^<2+> channel : structure and its variety of physiological and pathological functions2009

    • Author(s)
      御子柴克彦
    • Organizer
      16th Symposium on Ca^<2+>-Binding Proteins and Ca2+ Function in Health and Disease
    • Place of Presentation
      Chille
    • Year and Date
      2009-11-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] IP_3受容体Ca^<2+>チャネルと細胞間接着の機能的接点2009

    • Author(s)
      御子柴克彦
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] カルシウムがひもとく生命の神秘2009

    • Author(s)
      御子柴克彦
    • Organizer
      学習院大学生命科学シンポジウム「生命の秘密を解く鍵をもと第6回」
    • Place of Presentation
      学習院大学
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation]2009

    • Author(s)
      Mikoshiba K
    • Organizer
      第36回国際生理学会(IUPS09)シンポジウム(京都)Symposium Lecture
    • Place of Presentation
      京都
    • Year and Date
      2009-08-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Calcium dynamics through IP3 receptors2009

    • Author(s)
      御子柴克彦
    • Organizer
      第36回国際生理学会(IUPS09)シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Novel Immaging technology & Discovery in Development and Neural Function(IP_3-Ca^<2+> signaling)2009

    • Author(s)
      御子柴克彦
    • Organizer
      第36回国際生理学会(IUPS09)ニコンランチョンセミナー
    • Place of Presentation
      京都
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] IP_3 receptor/Ca^<2+> channel : New signaling cascade in brain function and disease2009

    • Author(s)
      御子柴克彦
    • Organizer
      World Class Univerisity(WCU)
    • Place of Presentation
      ソウル、韓国
    • Year and Date
      2009-07-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳神経系の発生と分化の分子細胞生物学的解析-IP3受容体の発見とその解析を中心として-2009

    • Author(s)
      御子柴克彦
    • Organizer
      第129回奈良医学会
    • Place of Presentation
      奈良県立医科大学
    • Year and Date
      2009-06-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] IP3 ligand gated Ca2+ channel : Unique gating mechanisms result in a variety of physiological and pathological functions2009

    • Author(s)
      御子柴克彦
    • Organizer
      OBOE meeting at Karolinska Institute
    • Place of Presentation
      スウエーデン
    • Year and Date
      2009-06-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 中枢神経系の発生と分化-IP□受容体の発見とその機能の解明2009

    • Author(s)
      御子柴克彦
    • Organizer
      第40回内藤記念科学振興賞 受賞記念科学講演会
    • Place of Presentation
      経団連会館 東京
    • Year and Date
      2009-02-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 最新の脳科学が迫る神経疾患の解明と創薬2009

    • Author(s)
      御子柴克彦
    • Organizer
      第14回サイテックサロン
    • Place of Presentation
      東京大学
    • Year and Date
      2009-01-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular and Cellular Mechanism of Brain Development2009

    • Author(s)
      御子柴克彦
    • Organizer
      World Class Univerisity(WCU)
    • Place of Presentation
      ソウル、韓国
    • Related Report
      2009 Annual Research Report
  • [Presentation] La production d'oscillations calciques par Ie recepteur a IP3 : une propriete essentielle des systemes vivants2008

    • Author(s)
      御子柴克彦
    • Organizer
      Journee Francophone de la Recherche 2008 (JFR2008)
    • Place of Presentation
      東京大学
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞内のCaイオンと生命現象2008

    • Author(s)
      御子柴克彦
    • Organizer
      慶應義塾大学医学部横浜三四会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳神経科学の研究戦略-神経疾患解明と創薬を目指して-2008

    • Author(s)
      御子柴克彦
    • Organizer
      かわさきサイエンス&テクノロジーフォーラム2008
    • Place of Presentation
      川崎
    • Year and Date
      2008-11-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳神経障害の発症と病因の分子機構2008

    • Author(s)
      御子柴克彦
    • Organizer
      関東地区脳血管障害懇話会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-14
    • Related Report
      2008 Annual Research Report
  • [Presentation]2008

    • Author(s)
      Mikoshiba K
    • Organizer
      Sherrington Lecture
    • Place of Presentation
      Liverpool, England
    • Year and Date
      2008-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of Calcium Ions in Development, Brain Function and Disorders2008

    • Author(s)
      御子柴克彦
    • Organizer
      20th Annual Conference, The Academy of Europe, Sherrington Lecture
    • Place of Presentation
      Liverpool, UK
    • Year and Date
      2008-09-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Role of Calcium Ions in Development, Brain Function and Disorders2008

    • Author(s)
      御子柴克彦
    • Organizer
      Seminar at department of Neuroscience, Pasteur Institute
    • Place of Presentation
      Paris, France
    • Year and Date
      2008-09-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞内カルシウムイオンの異常に伴う細胞機能の障害2008

    • Author(s)
      御子柴克彦
    • Organizer
      第26回ヒト細胞学会学術集会
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2008-08-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳の神秘へ挑む2008

    • Author(s)
      御子柴克彦
    • Organizer
      Shujitsu Science Cafe
    • Place of Presentation
      岡山県 就実大学
    • Year and Date
      2008-08-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Recent progress of brain research2008

    • Author(s)
      御子柴克彦
    • Organizer
      Science and technology meeting at European Union
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-06-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Recent advances in IP_3 receptor/calcium signaling2008

    • Author(s)
      御子柴克彦
    • Organizer
      Karolinska Institute special Seminar
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2008-06-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Recent advances in IP_3 receptor/calcium signaling2008

    • Author(s)
      御子柴克彦
    • Organizer
      Linkopings University special seminar
    • Place of Presentation
      Linkopings University special seminar
    • Year and Date
      2008-06-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞内Ca^<2+>動態とIP_3レセプター2008

    • Author(s)
      御子柴克彦
    • Organizer
      自治医科大学大学院医学研究科開設周年記念特別講演会
    • Place of Presentation
      栃木県下野市自治医科大学
    • Year and Date
      2008-05-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Calcium signal : on the tracks of Setsuro Ebashi2008

    • Author(s)
      Katsuhiko Mikoshiba
    • Organizer
      Roma
    • Place of Presentation
      Italy
    • Year and Date
      2008-05-08
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Role of the InsP3 receptor and calcium signaling in development and brain function and diseases2008

    • Author(s)
      御子柴克彦
    • Organizer
      The Calcium signal : on the tracks of Setsuro Ebashi
    • Place of Presentation
      Roma, Italy
    • Year and Date
      2008-05-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular Genetic analysis of neurodegenerative disorders2008

    • Author(s)
      御子柴克彦
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka
    • Related Report
      2008 Annual Research Report
  • [Presentation] 神経研究の今後:分子から病態へ2008

    • Author(s)
      御子柴克彦
    • Organizer
      日本神経学会総会-神経疾患の解明と治療
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Novel technology changes the traditional concept: Enhanced sensitivity of astrocytic process to mGluR stimulation and semaphorin 3A-induced growth cone collapse

    • Author(s)
      御子柴克彦
    • Organizer
      Developmental Biology for Regenerative Medicine (DBRM) Seminar
    • Place of Presentation
      Karolinska Institute, Stockholm, Sweden
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 正常と異常の間 ―脳の病気を考える―

    • Author(s)
      御子柴克彦
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Role of IP3 receptor/ Ca2+ signaling in development, brain function and brain damage

    • Author(s)
      御子柴克彦
    • Organizer
      慶應サマースクール
    • Place of Presentation
      慶應大学、信濃町、東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Brain Function and RNA and novel technologies

    • Author(s)
      御子柴克彦
    • Organizer
      Epigenetics & non-coding RNA joint meeting
    • Place of Presentation
      理研梅太郎ホール、和光
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 新しい技術開発が従来の概念を打ち壊す

    • Author(s)
      御子柴克彦
    • Organizer
      Center for Molecular Imaging Science Seminar
    • Place of Presentation
      理研分子イメージングセンター、神戸
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 脳障害から脳をいかに守るか-小胞体ストレスと神経変性

    • Author(s)
      御子柴克彦
    • Organizer
      《ルイ・パスツール生誕190周年記念》「脳神経障害からの回復を目指して」 ~パスツール研究所 ジャン=ピエール・シャンジュー教授来日シンポジウム~
    • Place of Presentation
      神田、東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 次代(あす)を荷う子を育てるために ~脳科学からの視点~

    • Author(s)
      御子柴克彦
    • Organizer
      全日本私立幼稚園PTA連合会PTA全国大会記念講演
    • Place of Presentation
      アルカディア市ヶ谷 私学会館 東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 高次神経機能とIP3受容体カルシウムシグナリング~その生理・病態と薬学的アプローチ~

    • Author(s)
      御子柴克彦
    • Organizer
      私立大学戦略的研究基盤慶成支援事業:現代人が抱える疾患による脳高次機能変化に関する薬学的研究 特別講演
    • Place of Presentation
      星薬科大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Isolation of Inositol 1,4,5-Trisphosphate Receptor-Associating Protein and Selective Knockdown "Using RNA Interference Inositol Phosphates and Lipids - Methods and Protocols- Chapter 92010

    • Author(s)
      Mizutani A, Kawaai K, Hisatsune C, Ando H, Michikawa T, Mikoshiba K
    • Publisher
      The Humana Press Inc
    • Related Report
      2012 Final Research Report
  • [Book] Inositol Phosphates and Lipids-Methods and Protocols2010

    • Author(s)
      Mizutani A., et al
    • Total Pages
      239
    • Publisher
      Humana Press
    • Related Report
      2010 Annual Research Report
  • [Book] Springer, Handbook of "Neurochemistry and Molecular Neurobiology 3rd Edition .Neural Signaling Mechanisms- Cyclin-Dependent Kinase 5 (御子柴がエディターであり、3 Chapter の著者である)2009

    • Author(s)
      Mikoshiba K
    • Total Pages
      631
    • Publisher
      Springer
    • Related Report
      2012 Final Research Report
  • [Book] Handbook of Neurochemistry and Molecular Neurobiology2009

    • Author(s)
      Katsuhiko Mikoshiba (editor)
    • Total Pages
      622
    • Publisher
      Springer
    • Related Report
      2010 Self-evaluation Report
  • [Book] Handbook of Neurochemistry and Molecular Neurobiology 3^<rd> Edition -Neural Signaling Mechanisms-Cyclin-Dependent Kinase 52009

    • Author(s)
      Ohshima T, Mikoshiba K
    • Total Pages
      631
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report
  • [Book] Handbook of Neurochemistry and Molecular Neurobiology 3^<rd> Edition -Neural Signaling Mechanisms- Structure of IP_3 Receptor2009

    • Author(s)
      Yamazaki H, Mikoshiba K
    • Total Pages
      631
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report
  • [Book] Handbook of Neurochemistry and Molecular Neurobiology 3^<rd> Edition -Neural Signaling Mechanisms- IP_3 Receptor and Ca2+ signaling2009

    • Author(s)
      Hisatsune T, Mikoshiba K
    • Total Pages
      631
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report
  • [Remarks] (ポッドキャスト) Science Signaling Podcast(サイエンス誌のオフィスからの電話の会話が放送された)

    • URL

      http://www.brain.riken.jp/jp/faculty/details/29

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://stke.sciencemag.org/cgi/content/full/sigtrans;5/219/pc8

    • Related Report
      2012 Final Research Report
  • [Remarks] (テレビ出演)NHK E テレ サイエンスZERO 『生命を動かす"魔法の金属"』30 分番組として御子柴の研究成果をとりあげてくれ、NHK へ出向き、出演した。また、研究室での取材もあった。 2011 年6 月25 日放送。英語版に直され、海外で2013 年5 月27 日に放映された。

    • Related Report
      2012 Final Research Report
  • [Remarks] NHK E テレ サイエンスZERO 『バイオイメージングが医療を変える』研究室での取材内容が放映された。 2010 年12月4 日放送

    • Related Report
      2012 Final Research Report
  • [Remarks] 理研BSI 御子柴 克彦, M.D., Ph.D.

    • URL

      http://www.brain.riken.jp/jp/faculty/details/29

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.brain.riken.jp/jp/faculty/details/29

    • Related Report
      2011 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.brain.riken.jp/jp/k_mikoshiba.html

    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.brain.riken.jp/jp/k_mikoshiba.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.brain.riken.jp/jp/k_mikoshiba.html

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] IP_3 受容体結合蛋白質による細胞内標的分子の制御2012

    • Inventor(s)
      御子柴克彦、安東英明、水谷顕洋
    • Industrial Property Rights Holder
      御子柴克彦、安東英明、水谷顕洋
    • Acquisition Date
      2012-08-28
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 小胞体カルシウムATP アーゼ2011

    • Inventor(s)
      御子柴克彦、松浦徹、佐藤嘉名与
    • Industrial Property Rights Holder
      御子柴克彦、松浦徹、佐藤嘉名与
    • Filing Date
      2011-01-14
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] マラリアの治療方法、マラリア原虫の殺虫方法、及びその利用2011

    • Inventor(s)
      御子柴克彦、榎本匡宏、河津信一郎
    • Industrial Property Rights Holder
      御子柴克彦、榎本匡宏、河津信一郎
    • Filing Date
      2011-11-10
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] IP_3 指示薬2011

    • Inventor(s)
      御子柴克彦、松浦徹、道川貴章、井上貴文
    • Industrial Property Rights Holder
      御子柴克彦、松浦徹、道川貴章、井上貴文
    • Industrial Property Number
      2004-309686
    • Acquisition Date
      2011-08-26
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 新規ビスホウ素化合物2011

    • Inventor(s)
      御子柴克彦、尾崎庄一郎、鈴木商信、中村健
    • Industrial Property Rights Holder
      御子柴克彦、尾崎庄一郎、鈴木商信、中村健
    • Acquisition Date
      2011-09-13
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ホウ素化合物及びその用途2011

    • Inventor(s)
      御子柴克彦、濱田耕造、寺内明子、貫名信行、後藤純一、尾崎庄一郎、鈴木商信、戎井悦子
    • Industrial Property Rights Holder
      御子柴克彦、濱田耕造、寺内明子、貫名信行、後藤純一、尾崎庄一郎、鈴木商信、戎井悦子
    • Industrial Property Number
      2008-207315
    • Filing Date
      2011-01-14
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 小胞体カルシウATPアーゼ動態指示薬及びその利用2011

    • Inventor(s)
      御子柴克彦、松浦徹、佐藤嘉名与
    • Industrial Property Rights Holder
      御子柴克彦、松浦徹、佐藤嘉名与
    • Industrial Property Number
      2011-005797
    • Filing Date
      2011-01-14
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 蛋白質阻害剤2010

    • Inventor(s)
      御子柴克彦、濱田耕造、寺内明子
    • Industrial Property Rights Holder
      御子柴克彦、濱田耕造、寺内明子
    • Filing Date
      2010-04-09
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 蛋白質架橋阻害剤及びその用途2010

    • Inventor(s)
      御子柴克彦、濱田耕造、寺内明子、貫名信行、後藤純一、尾崎庄一郎、鈴木商信、戎井悦子
    • Industrial Property Rights Holder
      御子柴克彦、濱田耕造、寺内明子、貫名信行、後藤純一、尾崎庄一郎、鈴木商信、戎井悦子
    • Filing Date
      2010-05-19
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 蛋白質架橋阻害剤及びその用途2010

    • Inventor(s)
      御子柴克彦、濱田耕造、寺内明子
    • Industrial Property Rights Holder
      御子柴克彦、濱田耕造、寺内明子
    • Industrial Property Number
      2010-090527
    • Filing Date
      2010-04-09
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 蛋白質阻害剤2009

    • Inventor(s)
      御子柴克彦、貫名信行、尾崎庄一郎、濱田耕造、後藤純一、鈴木商信、戎井悦子、寺内明子
    • Industrial Property Rights Holder
      御子柴克彦、貫名信行、尾崎庄一郎、濱田耕造、後藤純一、鈴木商信、戎井悦子、寺内明子
    • Filing Date
      2009-08-11
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 蛋白質架橋阻害剤およびその用途2009

    • Inventor(s)
      御子柴克彦、貫名信行、尾崎庄一郎、濱田耕造、後藤純一、鈴木商信、戎井悦子、寺内明子
    • Industrial Property Rights Holder
      御子柴克彦、貫名信行、尾崎庄一郎、濱田耕造、後藤純一、鈴木商信、戎井悦子、寺内明子
    • Filing Date
      2009-11-06
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 蛋白質架橋阻害剤2009

    • Inventor(s)
      御子柴克彦、濱田耕造、寺内明子、貫名信行、後藤純一、尾崎庄一郎、鈴木商信、戎井悦子
    • Industrial Property Rights Holder
      御子柴克彦、濱田耕造、寺内明子、貫名信行、後藤純一、尾崎庄一郎、鈴木商信、戎井悦子
    • Filing Date
      2009-08-11
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 蛋白質架橋阻害剤及びその用途2009

    • Inventor(s)
      御子柴克彦、濱田耕造、寺内明子、貫名信行、後藤純一、尾崎庄一郎、鈴木商信、戎井悦子
    • Industrial Property Rights Holder
      御子柴克彦、濱田耕造、寺内明子、貫名信行、後藤純一、尾崎庄一郎、鈴木商信、戎井悦子
    • Industrial Property Number
      2009-255518
    • Filing Date
      2009-11-06
    • Related Report
      2010 Self-evaluation Report

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Published: 2008-04-01   Modified: 2019-07-29  

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