Integrated analysis of transcriptional regulation in cancer

• Project/Area Number: 20221009
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Applied genomics
• Research Institution: The University of Tokyo
• Principal Investigator: ABURATANI Hiroyuki 東京大学, 先端科学技術研究センター, 教授 (10202657)
• Co-Investigator(Renkei-kenkyūsha): ISHIKAWA Shumpei 東京大学, 医学部, 准教授 (50418638) ; TSUTSUMI Shuichi 東京大学, 先端科学技術研究センター, 特任准教授 (30345152)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥209,820,000 (Direct Cost: ¥161,400,000、Indirect Cost: ¥48,420,000); Fiscal Year 2012: ¥31,460,000 (Direct Cost: ¥24,200,000、Indirect Cost: ¥7,260,000); Fiscal Year 2011: ¥41,860,000 (Direct Cost: ¥32,200,000、Indirect Cost: ¥9,660,000); Fiscal Year 2010: ¥38,740,000 (Direct Cost: ¥29,800,000、Indirect Cost: ¥8,940,000); Fiscal Year 2009: ¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000); Fiscal Year 2008: ¥50,700,000 (Direct Cost: ¥39,000,000、Indirect Cost: ¥11,700,000)
• Keywords: ゲノム / エピゲノム / がん / 転写制御 / クロマチン / DNAメチル化 / 肝細胞癌 / 膵臓がん / 胃癌 / 機能ゲノミクス / クロマチン免疫沈降 / エビゲノム

Research Abstract

With comprehensive genomic and epigenomic analysis, we investigated aberrant regulation of transcription in cancer cells. We identified the target genes directly driven by the transcription factors involved in cellular differentiation and growth, and revealed that epigenomic landscape is dynamically altered during cellular differentiation, oncogene-induced senescence and viral infection. Finally we reported somatic mutations in pancreatic cancer cell lines and hepatocellular carcinoma genome.

Assessment Rating

Verification Result (Rating)

A

Research Products

• [Journal Article] Genomic approach towards personalized anticancer drug therapy (2012)
  • Author(s): Midorikawa Y, Tsuji S, Takayama T, Aburatani h
  • Journal Title: Pharmacogenomics Volume: 13(2) Issue: 2 Pages: 191-9
  • DOI: 10.2217/pgs.11.157
• [Journal Article] Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency (2012)
  • Author(s): Wang L, Tsutsumi S, Kawaguchi T,Nagasaki K, Tatsuno K, Yamamoto S, SangF, Sonoda K, Sugawara M, Saiura A,Hirono S, Yamaue H, Miki Y, Isomura M,Totoki Y, Nagae G, Isagawa T, Ueda H,Murayama-Hosokawa S, Shibata T,Sakamoto H, Kanai Y, Kaneda A, Noda T,Aburatani H
  • Journal Title: Genome Research Volume: 22(2) Issue: 2 Pages: 208-19
  • DOI: 10.1101/gr.123109.111
  • Peer Reviewed
• [Journal Article] Intermediate methylation epigenotype and its correlation to KRAS mutation in conventional colorectal adenoma (2012)
  • Author(s): Yagi K, Takahashi H, Akagi K, Matsusaka K, Seto Y, Aburatani H, Nakajima A,Kaneda A
  • Journal Title: Am J Pathology Volume: 180(2) Issue: 2 Pages: 616-25
  • DOI: 10.1016/j.ajpath.2011.10.010
  • Peer Reviewed
• [Journal Article] Potential responders to FOLFOX therapy for colorectal cancer by Random Forests analysis (2012)
  • Author(s): Tsuji S, Midorikawa Y, Takahashi T, Yagi K, Takayama T, Yoshida K, Sugiyama Y,Aburatani H
  • Journal Title: Br J Cancer Volume: 106(1) Issue: 1 Pages: 126-32
  • DOI: 10.1038/bjc.2011.505
• [Journal Article] Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation (2012)
  • Author(s): Kudo Y, Aburatani H, et al.
  • Journal Title: Cancer Science Volume: 103 Issue: 4 Pages: 670-676
  • DOI: 10.1111/j.1349-7006.2012.02213.x
  • Peer Reviewed
• [Journal Article] Genomic approach towards personalized anticancer drug therapy (2012)
  • Author(s): Midorikawa Y, Aburatani H, et al.
  • Journal Title: Pharmacogenomics Volume: 13 Pages: 191-199
  • Peer Reviewed
• [Journal Article] Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency (2012)
  • Author(s): Wang L, Aburatani H, et al.
  • Journal Title: Genome Research Volume: 22 Issue: 3 Pages: 208-219
  • DOI: 10.1101/gr
  • Peer Reviewed
• [Journal Article] Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway (2011)
  • Author(s): Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A,Aburatani H, Nakamura T, Akiyama T
  • Journal Title: Nat Commun Volume: 2 Issue: 1 Pages: 548-548
  • DOI: 10.1038/ncomms1551
  • Peer Reviewed
• [Journal Article] Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence (2011)
  • Author(s): Kaneda A, Fujita T, Anai M, Yamamoto S,Nagae G, Morikawa M, Tsuji S, Oshima M,Miyazono K, Aburatani H
  • Journal Title: PLoS Genetics Volume: 7 Issue: 11 Pages: e1002359-e1002359
  • DOI: 10.1371/journal.pgen.1002359
  • URL: https://pure.teikyo.jp/en/publications/c287cb52-be46-4582-ae6f-0c7bd9fc4fdb
  • Peer Reviewed
• [Journal Article] Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation (2011)
  • Author(s): Waki H, Nakamura M, Yamauchi T, Wakabayashi K, Yu J, Hirose-Yotsuya L, Take K, Sun W, Iwabu M, Okada-Iwabu M, Fujita T, Aoyama T, Tsutsumi S, Ueki K, Kodama T, Sakai J, Aburatani H, Kadowaki
  • Journal Title: PLos Genetics Volume: 7 Issue: 10 Pages: e1002311-e1002311
  • DOI: 10.1371/journal.pgen.1002311
  • Peer Reviewed
• [Journal Article] DNA Methylation Profiling of Embryonic Stem Cell Differentiation into the Three Germ Layers (2011)
  • Author(s): Isagawa T, Nagae G, Shiraki N, Fujita T, Sato N, Ishikawa S, Kume S, Aburatani H
  • Journal Title: PLoS ONE Volume: 6(10) Issue: 10 Pages: e26052-e26052
  • DOI: 10.1371/journal.pone.0026052
  • Peer Reviewed
• [Journal Article] Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes (2011)
  • Author(s): Matsusaka K, Kaneda A, Nagae G, Ushiku T, Kikuchi Y, Hino R, Uozaki H, Seto Y,Takada K, Aburatani H, Fukayama M
  • Journal Title: Cancer Res Volume: 71 Issue: 23 Pages: 7187
  • DOI: 10.1158/0008-5472.can-11-1349
  • URL: https://pure.teikyo.jp/en/publications/cdbf4352-6195-46c6-8e34-a2db97c516c8
  • Peer Reviewed
• [Journal Article] ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif (2011)
  • Author(s): Morikawa M, Koinuma D, Tsutsumi S,Vasilaki E, Kanki Y, Heldin CH, Aburatani H, Miyazono K
  • Journal Title: Nucleic Acids Res Volume: 39(20) Issue: 20 Pages: 8712-27
  • DOI: 10.1093/nar/gkr572
  • Peer Reviewed
• [Journal Article] Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells (2011)
  • Author(s): Watanabe, A., et al
  • Journal Title: Proceedings of National Academy of Science U.S.A. Volume: 108 Issue: 30 Pages: 12384-12389
  • DOI: 10.1073/pnas.0906930108
  • Peer Reviewed
• [Journal Article] Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4α in HepG2 cells (2011)
  • Author(s): Kanki Y, Kohro T, Jiang S, Tsutsumi S, Mimura I, Suehiro JI,Wada Y, Ohta Y, Ihara S, Iwanari H, Naito M, Hamakubo T,Aburatani H, Kodama T, Minami T
  • Journal Title: EMBO J Volume: 286 Issue: 34 Pages: 29848
  • DOI: 10.1074/jbc.m110.217745
  • URL: https://pure.teikyo.jp/en/publications/b7e85de7-0e64-4bcb-9255-6fcacfba6759
  • Peer Reviewed
• [Journal Article] High-resolution characterization of a hepatocellular carcinoma genome (2011)
  • Author(s): Totoki Y, Tatsuno K, Yamamoto S, Arai Y, Hosoda F, Ishikawa S, Tsutsumi S,Sonoda K, Totsuka H, Shirakihara T,Sakamoto H, Wang L, Ojima H, Shimada K, Kosuge T, Okusaka T, Kato K, Kusuda J, Yoshida T, Aburatani H & S h i b a t a T
  • Journal Title: Nat Genet Volume: 43(5) Issue: 5 Pages: 464-9
  • DOI: 10.1038/ng.804
  • Peer Reviewed
• [Journal Article] Tissue-specific demethylation in CpG-poor promoters during cellular differentiation (2011)
  • Author(s): Nagae G, Isagawa T, Shiraki N, Fujita T, Yamamoto S, Tsutsumi S, Nonaka A,Yoshiba S, Matsusaka K, Midorikawa Y,Ishikawa S, Soejima H, Fukayama M,Suemori H, Nakatsuji N, Kume S,Aburatani H
  • Journal Title: Hum Mol Genetics Volume: 20(14) Issue: 14 Pages: 2710-21
  • DOI: 10.1093/hmg/ddr170
  • Peer Reviewed
• [Journal Article] MUC13 mucin augments pancreatic tumorigenesis (2011)
  • Author(s): Chauhan SC, Aburatani H, et al.
  • Journal Title: Mol Cancer Ther Volume: 11 Issue: 1 Pages: 24-33
  • DOI: 10.1158/1535-7163.mct-11-0598
  • Peer Reviewed
• [Journal Article] ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis (2011)
  • Author(s): Fujiwara T, Aburatani H, et al.
  • Journal Title: Lung Cancer Volume: 75 Issue: 1 Pages: 119-25
  • DOI: 10.1016/j.lungcan.2011.05.028
  • Peer Reviewed
• [Journal Article] Epigenetically coordinated GATAT2 binding is necessary for endothelium-specific endomucin expression (2011)
  • Author(s): Kanki Y, Kohro T, Jiang S, Tsutsumi S, Mimura I, Suehiro J, Wada Y, Ohta Y, Ihara S, Iwanari H, Naito M, Hamakubo T, Aburatani H, Kodama T, Minami T
  • Journal Title: EMBO J Volume: 30 Issue: 13 Pages: 2582-95
  • DOI: 10.1038/emboj.2011.173
  • Peer Reviewed
• [Journal Article] Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes (2011)
  • Author(s): Nakabayashi K, Aburatani H, et al.
  • Journal Title: Hum Mol Genet Volume: 20 Issue: 16 Pages: 3188-97
  • DOI: 10.1093/hmg/ddr224
  • Peer Reviewed
• [Journal Article] Tumor-suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21 (2011)
  • Author(s): Tsuchiya N, Aburatani H, et al.
  • Journal Title: Cancer Res Volume: 71 Issue: 13 Pages: 4628-4639
  • DOI: 10.1158/0008-5472.can-10-2475
  • Peer Reviewed
• [Journal Article] Tissue-specific emethylation in CpG-poor promoters during cellular differentiation. (2011)
  • Author(s): Nagae G, Isagawa T, Shiraki N, Fujita T, Yamamoto S, Tsutsumi S, Nonaka A, Yoshiba S, Matsusaka K, Midorikawa Y, Ishikawa S, Soejima H, Fukayama M, Suemori H, Nakatsuji N, Kume S, Aburatani H.
  • Journal Title: Hum Mol Genetics accepted
• [Journal Article] High-resolution characterization of a hepatocellular carcinoma genome. (2011)
  • Author(s): Totoki Y
  • Journal Title: Nature genetics Volume: 43 Pages: 464-469
  • Peer Reviewed
• [Journal Article] Tissue-specific demethylation in CpG-poor promoters during cellular differentiation (2011)
  • Author(s): Nagae G
  • Journal Title: Hum Mol Genetics Volume: In press(掲載確定)
  • Peer Reviewed
• [Journal Article] Genome-wide approaches reveal functional IL-4 inducible STAT6 binding to the vascular cell adhesion molecule-1 promoter. (2011)
  • Author(s): Tozawa H
  • Journal Title: Mol Cell Biol Volume: In press(掲載確定)
  • Peer Reviewed
• [Journal Article] Transforming growth factor-β decrease the cancer-initiating cell population within diffuse-type gastric carcinoma cells. (2011)
  • Author(s): Ehata S
  • Journal Title: Oncogene Volume: In press(掲載確定)
  • Peer Reviewed
• [Journal Article] Proteomic analysis of native hepatocyte nuclear factor-4{alpha}(HNF4{alpha})isoforms, phosphorylation status, and interactive cofactors. (2011)
  • Author(s): Daigo K
  • Journal Title: J Biol Chem Volume: 286 Pages: 674-686
  • Peer Reviewed
• [Journal Article] International network of cancer genome projects (2010)
  • Author(s): International Cancer Genome Consortium
  • Journal Title: Nature Volume: 464(7291) Issue: 7291 Pages: 993-8
  • DOI: 10.1038/nature08987
• [Journal Article] Genome-wide single nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instabilitywith poor prognosis and unveil frequent chromosomal imbalances involved in PI3-kinase pathway (2010)
  • Author(s): Murayama-Hosokawa S, Oda K, Nakagawa S, Ishikawa S, Yamamoto S, Shoji K,Ikeda Y, Uehara Y, Fukayama M,McCormick F, Yano T, Taketani Y, Aburatani H
  • Journal Title: Oncogene Volume: 29(13) Issue: 13 Pages: 1897-908
  • DOI: 10.1038/onc.2009.474
• [Journal Article] International Cancer Genome Consortium. International network of cancer genome projects. (2010)
  • Journal Title: Nature 464(7291) Pages: 993-998
• [Journal Article] Genome-wide single nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in P13-kinase pathway. (2010)
  • Author(s): Murayama-Hosokawa S, Oda K, Nakagawa S, Ishikawa S, Yamamoto S, Shoji K, Ikeda Y, Uehara Y, Fukayama M, McCormick F, Yano T, Taketani Y, Aburatani H.
  • Journal Title: Oncogene 29(13) Pages: 1897-1908
• [Journal Article] Testis-specific protein on Y chromosome(TSPY)represses the activity of the androgen receptor in androgen-dependent testicular germ-cell tumors. (2010)
  • Author(s): Akimoto C
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 107 Pages: 19891-19896
  • Peer Reviewed
• [Journal Article] Co-Activation of Epidermal Growth Factor Receptor and c-MET Defines a Distinct Subset of Lung Adenocarcinomas. (2010)
  • Author(s): Matsubara D
  • Journal Title: Am J Pathol. Volume: 177 Pages: 2191-2204
  • Peer Reviewed
• [Journal Article] Integration of cap analysis of gene expression and chromatin, immunoprecipitation analysis on array reveals genome-wide androgen receptor signaling in prostate cancer cells. (2010)
  • Author(s): Takayama K
  • Journal Title: Oncogene Volume: 30 Pages: 619-630
  • Peer Reviewed
• [Journal Article] The G protein-coupled receptor T-cell death-associated gene 8(TDAG8)facilitates tumor development by servin as an extracellular pH sensor. (2010)
  • Author(s): Ihara Y
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 107 Pages: 17309-17314
  • Peer Reviewed
• [Journal Article] Mechanisms of genomic instabilities underlying two common fragile-site-associated loci, PARK2 and DMD, in germ cell and cancer cell lines. (2010)
  • Author(s): Mitsui J
  • Journal Title: Am J Hum Genet. Volume: 87 Pages: 75-89
  • Peer Reviewed
• [Journal Article] Human ROBOl is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells. (2010)
  • Author(s): Seki M
  • Journal Title: FEBS Lett. Volume: 584 Pages: 2909-2915
  • Peer Reviewed
• [Journal Article] International network of cancer genome projects. (2010)
  • Author(s): International Cancer Genome Consortium.
  • Journal Title: Nature. Volume: 464 Pages: 993-998
  • Peer Reviewed
• [Journal Article] Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma (2010)
  • Author(s): Deng YB
  • Journal Title: Cancer Sci. Volume: 101 Pages: 1501-1510
  • Peer Reviewed
• [Journal Article] Identification of chromosomal aberrations of metastatic potential in colorectal gcarcinoma. (2010)
  • Author(s): Yamamoto S
  • Journal Title: Genes Chromosomes Cancer Volume: 49 Pages: 487-496
  • Peer Reviewed
• [Journal Article] Genome-wide single nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in PI3-kinase pathway. (2010)
  • Author(s): Murayama-Hosokawa S
  • Journal Title: Oncogene Volume: 29 Pages: 1897-1908
  • Peer Reviewed
• [Journal Article] Identification of genes preferentially methylated in hepatitis Cvirus-related hepatocellular carcinoma. (2010)
  • Author(s): Deng YB
  • Journal Title: Cancer Science (in press)
  • Peer Reviewed
• [Journal Article] Function of EWS-POU5F1 in Sarcomagenesis and Tumor Cell Maintenance. (2010)
  • Author(s): Fujino T
  • Journal Title: American Journal of Pathology 176 Pages: 1973-1982
  • Peer Reviewed
• [Journal Article] Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells. (2010)
  • Author(s): Murohashi M
  • Journal Title: British Journal of Cancer 102 Pages: 206-212
  • Peer Reviewed
• [Journal Article] NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation. (2010)
  • Author(s): Motohashi H
  • Journal Title: Blood 115 Pages: 677-686
  • Peer Reviewed
• [Journal Article] PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt (2009)
  • Author(s): Kawase T, Ohki R, Shibata T, Tsutsumi S, Kamimura N, Inazawa J, Ohta T, Ichikawa H, Aburatani H, Tashiro F, Taya Y
  • Journal Title: Cell Volume: 136(3) Issue: 3 Pages: 535-50
  • DOI: 10.1016/j.cell.2008.12.002
• [Journal Article] Allelic imbalances and homozygous deletion on 8p23.2 for stepwise progression of hepatocarcinogenesis (2009)
  • Author(s): Midorikawa Y, Yamamoto S, Tsuji S,Kamimura N, Ishikawa S, Igarashi H,Makuuchi M, Kokudo N, Sugimura H,Aburatani H
  • Journal Title: Hepatology Volume: 49(2) Issue: 2 Pages: 513-22
  • DOI: 10.1002/hep.22698
• [Journal Article] ChIP-chip analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in TGF-{beta} signaling (2009)
  • Author(s): Koinuma D, Tsutsumi S, Kamimura N,Taniguchi H,Miyazawa K,Sunamura M , Imamura T, Miyazono K, Aburatani H
  • Journal Title: Mol Cell Biol Volume: 29(1) Issue: 1 Pages: 172-86
  • DOI: 10.1128/mcb.01038-08
• [Journal Article] PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. (2009)
  • Author(s): Kawase T, Ohki R, Shibata T, Tsutsumi S, Kamimura N, Inazawa J, Ohta T, Ichikawa H, Aburatani H, Tashiro F, Taya Y.
  • Journal Title: Cell 136(3) Pages: 535-550
• [Journal Article] Allelic imbalances and homozygous deletion on 8p23.2 for stepwise progression of hepatocarcinogenesis. (2009)
  • Author(s): Midorikawa Y, Yamamoto S, Tsuji S, Kamimura N, Ishikawa S, Igarashi H, Makuuchi M, Kokudo N, Sugimura H, Aburatani H.
  • Journal Title: Hepatology 49(2) Pages: 513-522
• [Journal Article] ChIP-chip analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in TGF-{beta}signaling. (2009)
  • Author(s): Koinuma D, Tsutsumi S, Kamimura N, Taniguchi H, Miyazawa K, Sunamura M, Imamura T, Miyazono K, Aburatani H.
  • Journal Title: Mol Cell Biol. 29(1) Pages: 172-186
• [Journal Article] A wave of nascent transcription on activated human genes. (2009)
  • Author(s): Wada Y
  • Journal Title: Proc Natl Acad Sci USA. 106 Pages: 18357-18361
  • Peer Reviewed
• [Journal Article] Promoter-wide analysis of Smad4 binding sites in human epithelial cells. (2009)
  • Author(s): Koinuma D
  • Journal Title: Cancer Science 100 Pages: 2133-2142
  • Peer Reviewed
• [Journal Article] The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. (2009)
  • Author(s): Wakabayashi KI
  • Journal Title: Mol Cell Biol. 29 Pages: 3544-3555
  • Peer Reviewed
• [Journal Article] PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. (2009)
  • Author(s): Kawase T
  • Journal Title: Cell 136 Pages: 535-550
  • Peer Reviewed
• [Journal Article] Amyloid precursor protein is a primary androgen target gene that promotes prostate cancer growth. (2009)
  • Author(s): Takayama K
  • Journal Title: Cancer Research 69 Pages: 137-142
  • Peer Reviewed
• [Journal Article] Allelic imbalances and homozygous deletion on 8p23.2 for stepwise progression of hepatocarcinogenesis (2009)
  • Author(s): Midorikawa Y
  • Journal Title: Hepatology 49 Pages: 513-522
  • Peer Reviewed
• [Journal Article] ChIP-chip analysis of Smad2/3 binding sites reveals roles of ETSl and TFAP2A in TGF-{beta} signaling (2009)
  • Author(s): Koinuma D
  • Journal Title: Mol Cell Biol. 29 Pages: 172-186
  • Peer Reviewed
• [Journal Article] The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase (2008)
  • Author(s): Hiratsuka S, Watanabe A, Sakurai Y,Akashi-Takamura S, Ishibashi S,Miyake K, Shibuya M, Akira S,Aburatani H, Maru Y
  • Journal Title: Nat Cell Biol Volume: 10(11) Issue: 11 Pages: 1349-55
  • DOI: 10.1038/ncb1794
• [Journal Article] The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. (2008)
  • Author(s): Hiratsuka S, Watanabe A, Sakurai Y, Akashi-Takamura S, Ishibashi S, Miyake K, Shibuya M, Akira S, Aburatani H, Maru Y.
  • Journal Title: Nat Cell Biol. 10(11) Pages: 1349-1355
• [Journal Article] Gli2 Is A Novel Regulator of Sox2 Expression In Telencephalic Neuroepithelial Cells. (2008)
  • Author(s): Takamaga H
  • Journal Title: Stem Cells (印刷中 掲載確定)
  • Peer Reviewed
• [Journal Article] Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF. (2008)
  • Author(s): Torisu Y
  • Journal Title: Cancer Science 99 Pages: 1139-1146
  • Peer Reviewed
• [Journal Article] High-resolution haracterization of a patocellular carcinoma genome.
  • Author(s): Totoki Y, Tatsuno K, Yamamoto S, Arai Y, Hosoda F, Ishikawa S, Tsutsumi S, Sonoda K, Totsuka H, Shirakihara T, Sakamoto H, Wang L, Ojima H, Shimada K, Kosuge T, Okusaka T, Kato K, Kusuda J, Yoshida T, Aburatani H, Shibata T.
  • Journal Title: Nature genetics accepted
• [Presentation] Cancer Genomics to Drug discovery (2012)
  • Author(s): 油谷浩幸
  • Organizer: Next Generation Sequencing Applications Asia
  • Place of Presentation: Singapore
  • Year and Date: 2012-03-28
• [Presentation] Cancer Genomics to Drug discovery (2012)
  • Author(s): 油谷浩幸
  • Organizer: Next Generation Sequencing Applications Asia
  • Place of Presentation: Singapore (Republic of Singapore)(招待講演)
  • Year and Date: 2012-03-28
• [Presentation] 肝がんのパーソナルオンコロジーへ向けて (2012)
  • Author(s): 油谷浩幸
  • Organizer: 第6回新肝臓病研究会
  • Place of Presentation: 甲府(招待講演)
  • Year and Date: 2012-03-02
• [Presentation] Methylation dynamics in cancer (2012)
  • Author(s): 油谷浩幸
  • Organizer: The 15th US-Japan Cellularand Gene Therapy Conference
  • Place of Presentation: Bethesda
  • Year and Date: 2012-02-23
• [Presentation] Methylation dynamics in cancer (2012)
  • Author(s): 油谷浩幸
  • Organizer: The 15th US-Japan Cellular and Gene Therapy Conference
  • Place of Presentation: Bethesda (U.S.A)(招待講演)
  • Year and Date: 2012-02-23
• [Presentation] エピゲノム解析の現状&心筋分化のエピゲノム・ダイナミクス (2012)
  • Author(s): 油谷浩幸
  • Organizer: 第5回iPS細胞・再生医学研究会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2012-02-03
• [Presentation] パーソナルオンコロジーの実現へ向けて (2012)
  • Author(s): 油谷浩幸
  • Organizer: ゲノムテクノロジー第164委員会沖縄分科会
  • Place of Presentation: 那覇(招待講演)
  • Year and Date: 2012-01-25
• [Presentation] エピゲノム解析とトランスレーショナル研究 (2012)
  • Author(s): 油谷浩幸
  • Organizer: 第10回がん・エピゲノム研究会
  • Place of Presentation: 仙台(招待講演)
  • Year and Date: 2012-01-18
• [Presentation] 肝がんのパーソナルオンコロジーへ向けて (2012)
  • Author(s): 油谷浩幸
  • Organizer: 第5回肝がん分子標的治療研究会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2012-01-14
• [Presentation] Cancer genome sequencing (2011)
  • Author(s): 油谷浩幸
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜(招待講演)
  • Year and Date: 2011-12-13
• [Presentation] Personalized oncology (2011)
  • Author(s): 油谷浩幸
  • Organizer: FOCUS symposium
  • Place of Presentation: 仙台(招待講演)
  • Year and Date: 2011-11-30
• [Presentation] Cancer genomics and epigenomics (2011)
  • Author(s): 油谷浩幸
  • Organizer: International Scientific Coordination Network
  • Place of Presentation: モンペリエ
  • Year and Date: 2011-11-24
• [Presentation] Cancer genomics and epigenomics (2011)
  • Author(s): 油谷浩幸
  • Organizer: International Scientific Coordination Network
  • Place of Presentation: モンペリエ(フランス)(招待講演)
  • Year and Date: 2011-11-24
• [Presentation] エピゲノム解析からせまる循環器研究 (2011)
  • Author(s): 油谷浩幸
  • Organizer: 第11回Cardiovascular Frontier Conference
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-11-19
• [Presentation] がんゲノム診断 (2011)
  • Author(s): 油谷浩幸
  • Organizer: 第56回人類遺伝学会
  • Place of Presentation: 幕張(招待講演)
  • Year and Date: 2011-11-12
• [Presentation] Next generation genomic analysis of hepatocellular carcinoma (2011)
  • Author(s): 油谷浩幸
  • Organizer: JSPS 164th committee 4th Kickoff Symposium
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-10-27
• [Presentation] Genomic instability caused by MLH1 haploinsufficiency in pancreatic cancer (2011)
  • Author(s): 油谷浩幸
  • Organizer: US-Japan Cancer Genomics and Epigenomics Workshop
  • Place of Presentation: 京都
  • Year and Date: 2011-10-24
• [Presentation] Genomic instability caused by MLH1 haploinsufficiency in pancreatic cancer (2011)
  • Author(s): 油谷浩幸
  • Organizer: US-Japan Cancer Genomics and Epigenomics Workshop
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-10-24
• [Presentation] エピゲノム解析とゲノム医療 (2011)
  • Author(s): 油谷浩幸
  • Organizer: 第29回千駄木内分泌懇話会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-10-20
• [Presentation] パーソナルゲノム解析がもたらすがん予防・治療戦略 (2011)
  • Author(s): 油谷浩幸
  • Organizer: 第61回日本体質医学会総会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-10-08
• [Presentation] がんエピゲノム創薬 (2011)
  • Author(s): 油谷浩幸
  • Organizer: BioJapan2011
  • Place of Presentation: 横浜(招待講演)
  • Year and Date: 2011-10-06
• [Presentation] 次世代シーケンサーを用いた癌ゲノム解析 (2011)
  • Author(s): 油谷浩幸
  • Organizer: 第6回肺癌分子病態研究会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-09-03
• [Presentation] Regulatory genomics (2011)
  • Author(s): 油谷浩幸
  • Organizer: IMSUT&RCAST GCOE symposium
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-07-15
• [Presentation] Current Challenges & New Technologies (2011)
  • Author(s): 油谷浩幸
  • Organizer: 5th ICGC Scientific Workshop
  • Place of Presentation: 京都
  • Year and Date: 2011-07-10
• [Presentation] Current Challenges & New Technologies (2011)
  • Author(s): 油谷浩幸
  • Organizer: 5th ICGC Scientific Workshop
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-07-10
• [Presentation] がんエピゲノム創薬 (2011)
  • Author(s): 油谷浩幸
  • Organizer: 第10回バイオテクノロジー国際会議
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-06-30
• [Presentation] Next generation genomic analysis of hepatocellular carcinoma (2011)
  • Author(s): 油谷浩幸
  • Organizer: International Symposium on Application of NGS on Genomics and Epigenomics
  • Place of Presentation: 台北
  • Year and Date: 2011-06-27
• [Presentation] Next generation genomic analysis of hepatocellular carcinoma (2011)
  • Author(s): 油谷浩幸
  • Organizer: International Symposium on Application of NGS on Genomics and Epigenomics
  • Place of Presentation: 台北(中国)(招待講演)
  • Year and Date: 2011-06-27
• [Presentation] がんゲノム解析 (2011)
  • Author(s): 油谷浩幸
  • Organizer: 第16回東京肝臓シンポジウム
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-06-11
• [Presentation] エピゲノム解析 (2011)
  • Author(s): 油谷浩幸
  • Organizer: 日本エピジェネティクス研究会
  • Place of Presentation: 熊本(招待講演)
  • Year and Date: 2011-05-19
• [Presentation] エピゲノム修飾の包括的解析によるがん創薬・バイオマーカー探索 (2011)
  • Author(s): 油谷浩幸
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜(招待講演)
  • Year and Date: 2011-04-30
• [Presentation] Integrated genomic analysis of liver cancer (2011)
  • Author(s): 油谷浩幸
  • Organizer: The Latest Advances in Liver Cancer Research
  • Place of Presentation: 舞浜
  • Year and Date: 2011-03-02
• [Presentation] Integrated genomic analysis of liver cancer (2011)
  • Author(s): 油谷浩幸
  • Organizer: 3rd JCA-AACR Special Joint Conference : The Latest Advances in Liver Cancer Research
  • Place of Presentation: 舞浜
  • Year and Date: 2011-03-02
• [Presentation] Chromatin marks in Transcriptional regulation (2010)
  • Author(s): 油谷浩幸
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] Epigenomic analysis of liver cancer (2010)
  • Author(s): 油谷浩幸
  • Organizer: 41th International Symposium of the Princess Takamatsu Cancer Research Fund:Basic and Clinical Frontiers of cancer epigenetics
  • Place of Presentation: 東京
  • Year and Date: 2010-11-18
• [Presentation] Epigenomic analysis of liver cancer (2010)
  • Author(s): 油谷浩幸
  • Organizer: 41th International Symposium of the Princess Takamatsu Cancer Research Fund : Basic and Clinical Frontiers of cancer epigenetics
  • Place of Presentation: 東京
  • Year and Date: 2010-11-18
• [Presentation] ゲノム・エピゲノム情報による症例層別化 (2010)
  • Author(s): 油谷浩幸
  • Organizer: 第48回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-29
• [Presentation] Pancreatic Cancer Exomes (2010)
  • Author(s): 油谷浩幸
  • Organizer: 第55回日本人類遺伝学会
  • Place of Presentation: 大宮
  • Year and Date: 2010-10-28
• [Presentation] Integrated genomic and epigenomic analysis of cancer (2010)
  • Author(s): 油谷浩幸
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] Genome-wide Profiling of Cell Type-Specific Chromatin Regulatory Elements in Adipocyte differentiation (2010)
  • Author(s): 油谷浩幸
  • Organizer: The 5th Asian Epigenomics Meeting
  • Place of Presentation: Jeju,Korea
  • Year and Date: 2010-06-21
• [Presentation] Genome-wide Profiling of Cell Type-Specific Chromatin Regulatory Elements in Adipocyte differentiation (2010)
  • Author(s): 油谷浩幸
  • Organizer: The 5th Asian Epigenomics Meeting
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2010-06-21
• [Presentation] Genomic and epigenomic alterations in liver cancer (2010)
  • Author(s): 油谷浩幸
  • Organizer: Cold Spring Harbor Asia meeting James Watson symposium on Cancer
  • Place of Presentation: Suzhou, China
  • Year and Date: 2010-04-08
• [Presentation] Cancer exome (2009)
  • Author(s): 油谷浩幸
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] Regulatory genomics:Epigenomic regulation of p53 pathway (2009)
  • Author(s): 油谷浩幸
  • Organizer: Northeastern Asian Symposium on Cancer Epigenetics
  • Place of Presentation: Jeju,Korea
  • Year and Date: 2009-11-07
• [Presentation] Epigenetic dynamics 2009 International Conference on Genomics-Human and Beyond (2009)
  • Author(s): 油谷浩幸
  • Place of Presentation: Shenzhen, China
  • Year and Date: 2009-11-04
• [Presentation] Epigenetic dynamics (2009)
  • Author(s): 油谷浩幸
  • Organizer: 2009 International Conference on Genomics-Human and Beyond
  • Place of Presentation: Shenzhen, China
  • Year and Date: 2009-11-04
• [Presentation] 染色体機能への巨視的アプローチ-A wave of nascent transcription (2009)
  • Author(s): 油谷浩幸
  • Organizer: 第62回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-22
• [Presentation] Cancer epigenomics (2009)
  • Author(s): 油谷浩幸
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: Yokohama
  • Year and Date: 2009-10-03
• [Presentation] Epigenomic profiling of cancer (2009)
  • Author(s): 油谷浩幸
  • Organizer: Epigenetics in Development and Diseases Conference : 4th Asian Epigenomics Meeting
  • Place of Presentation: Singaporeシンガポール
  • Year and Date: 2009-08-25
• [Presentation] Integrated analysis of genetic and epigenetic alterations in cancer (2009)
  • Author(s): 油谷浩幸
  • Organizer: 8th International Workshop on Advanced Genomics
  • Place of Presentation: Tokyo
  • Year and Date: 2009-06-18
• [Presentation] Integrated analysis of genetic and epigenetic alterations in liver cancer (2009)
  • Author(s): 油谷浩幸
  • Organizer: 3rd International Kobe Liver Symposium
  • Place of Presentation: Kobe
  • Year and Date: 2009-06-06
• [Presentation] Integrated analysis of genetic and epigenetic alterations in liver cancer (2009)
  • Author(s): 油谷浩幸
  • Organizer: Gordon Research Conference: Cancer Genetics&Epigenetics
  • Place of Presentation: Ventura, CA USA
  • Year and Date: 2009-01-30
• [Presentation] Integrated analysis of genetic and epigenetic alterations in liver cancer (2009)
  • Author(s): 油谷浩幸
  • Organizer: Gordon Research Conference:Cancer Genetics & Epigenetics
  • Place of Presentation: Ventura. CA USA
  • Year and Date: 2009-01-30
• [Presentation] Regulatory genomics:Epigenomic regulation of p53 pathway (2008)
  • Author(s): 油谷浩幸
  • Organizer: Northeastern Asian Symposium on Cancer Epigenetics
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-11-07
• [Presentation] Epigenomic profiling:Global DNA methylation profiles in differentiation from ES cells (2008)
  • Author(s): 油谷浩幸
  • Organizer: 7th Human Genome Organization (HUGO)-Pacific meeting
  • Place of Presentation: Cebu, Phillipine
  • Year and Date: 2008-04-02
• [Presentation] Epigenomic regulation of p53 pathway (2008)
  • Organizer: HGM2008
  • Place of Presentation: Hyderabad
• [Presentation] Epigenetic dynamics
  • Organizer: 2009 International Conference on Genomics-Human and Beyond
  • Place of Presentation: Shenzhen, China
• [Presentation] Genomic and epigenomic alterations in liver cancer.
  • Organizer: Cold Spring Harbor Asia meeting James Watson symposium on Cancer
  • Place of Presentation: Suzhou, China
• [Remarks]
  • URL: http://www.genome.rcast.u-tokyo.ac.jp
• [Remarks]
  • URL: http://www.genome.rcast.u-tokyo.ac.jp/
• [Remarks] ホームページ
• [Remarks]
  • URL: http://www.genome.reast.u-tokyo.ac.jp/
• [Remarks]
  • URL: http://www.genome.rcast.u-tokyo.ac.jp/
• [Remarks]
  • URL: http://www.genome.rcast.u-tokyo.ac.jp/
• [Patent(Industrial Property Rights)] 膵癌の診断薬および治療薬 (2012)
  • Inventor(s): 油谷浩幸、岩成宏子、河野功
  • Industrial Property Rights Holder: 東京大学ほか
  • Acquisition Date: 2012-09-21
  • Overseas
• [Patent(Industrial Property Rights)] 腎癌の診断薬および治療薬 (2012)
  • Inventor(s): 油谷浩幸、深山正久、森川鉄平、河野功、杉山暁
  • Industrial Property Rights Holder: 東京大学ほか
  • Acquisition Date: 2012-10-26
  • Overseas
• [Patent(Industrial Property Rights)] 抗ROBO1抗体を含むPET用腫瘍診断剤 (2012)
  • Inventor(s): 岩成宏子、油谷浩幸、浜窪隆雄、河野功、熊倉嘉貴、伊藤浩孝、先浜俊子、百瀬敏光
  • Industrial Property Rights Holder: 東京大学ほか
  • Acquisition Date: 2012-10-26
  • Overseas
• [Patent(Industrial Property Rights)] 発現量多様性を有する遺伝子の同定法 (2008)
  • Inventor(s): 油谷浩幸、石川俊
  • Industrial Property Rights Holder: 東京大学ほか
  • Acquisition Date: 2008-04-18
  • Overseas
• [Patent(Industrial Property Rights)] 発現量多様性を有する遺伝子の同定法 (2008)
  • Inventor(s): 油谷浩幸、石川俊平
  • Industrial Property Rights Holder: 東京大学
  • Acquisition Date: 2008-04-18