| Budget Amount *help |
¥91,130,000 (Direct Cost: ¥70,100,000、Indirect Cost: ¥21,030,000)
Fiscal Year 2012: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2011: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
Fiscal Year 2010: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
Fiscal Year 2009: ¥26,130,000 (Direct Cost: ¥20,100,000、Indirect Cost: ¥6,030,000)
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| Research Abstract |
In this project, we have developed a conceptually new and versatile method for constructing a variety of artificial double-stranded helical polymers and oligomers with specific functions involving chiral recognition, asymmetric catalysis, and self-replication. We have successfully synthesized a series of complementary double-stranded helical polymers and oligomers with a controlled helicity that showed unique DNA-like perfect sequence and molecular length recognition and replication via amplification of the helical chirality. The determination of the helical structures is also achieved by direct microscopic observations of the polymers. We also discovered an intriguing double helical molecule that exhibited a reversible spring-like extension-contraction motion triggered by external stimuli. We developed practically useful chiral materials for separating enantiomers and producing single enantiomers as asymmetric catalysts.
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