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Functional Diversity of Visual Pigments and Photoreceptor Cells

Research Project

Project/Area Number 20227002
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Animal physiology/Animal behavior
Research InstitutionKyoto University

Principal Investigator

SHICHIDA Yoshinori  京都大学, 大学院・理学研究科, 教授 (60127090)

Co-Investigator(Kenkyū-buntansha) IMAMOTO Yasushi  京都大学, 大学院・理学研究科, 准教授 (80263200)
YAMASHITA Takahiro  京都大学, 大学院・理学研究科, 助教 (50378535)
Co-Investigator(Renkei-kenkyūsha) NAKATANI Kei  筑波大学, 大学院・生命環境科学研究科, 准教授 (20125040)
Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥207,740,000 (Direct Cost: ¥159,800,000、Indirect Cost: ¥47,940,000)
Fiscal Year 2012: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2011: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2010: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2009: ¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2008: ¥69,420,000 (Direct Cost: ¥53,400,000、Indirect Cost: ¥16,020,000)
Keywords動物生理化学 / 視覚 / 視物質 / 機能多様性 / 分子メカニズム / マウスモデル
Research Abstract

We have investigated the molecular mechanisms that underlie the diversity of cell responses and physiological functions, using the photoreceptive system of animals as a model system. Differences in molecular properties between rhodopsin and cone visual pigments are the molecular basis of the differences in photoresponse between rods and cones. We characterized differences in molecular properties by using genetically modified mice and extensive in vitro experiments. Additionally, we demonstrated unique properties of visual and non-visual opsins that have independently diversified, and identified the amino acid residues responsible for these properties.

Assessment Rating
Verification Result (Rating)

A

Report

(8 results)
  • 2013 Research Progress Assessment (Verification Result) ( PDF )
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (113 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (57 results) (of which Peer Reviewed: 57 results) Presentation (38 results) (of which Invited: 1 results) Book (10 results) Remarks (8 results)

  • [Journal Article] Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain.2013

    • Author(s)
      M. Yanagawa, T. Yamashita and Y. Shichida
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Issue: 14 Pages: 9593-601

    • DOI

      10.1074/jbc.m112.437780

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chloride-dependent spectral tuning mechanism of L-group cone visual pigments2013

    • Author(s)
      Takahiro Yamashita
    • Journal Title

      Biochemistry

      Volume: 52 Issue: 7 Pages: 1192-1197

    • DOI

      10.1021/bi3016058

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chloride-dependent spectral tuning mechanism of L-group cone visual pigments.2013

    • Author(s)
      Yamashita, T.
    • Journal Title

      Biochemistry

      Volume: 52 Pages: 1192-1197

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino Acid mutation in the transmembrane domain.2013

    • Author(s)
      Yanagawa, M.
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Pages: 9593-9601

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spectroscopic analysis of the effect of chloride on the active intermediates of the primate L group cone visual pigment.2012

    • Author(s)
      T. Morizumi, K. Sato and Y. Shichida
    • Journal Title

      Biochemistry

      Volume: 51 Issue: 50 Pages: 10017-23

    • DOI

      10.1021/bi300995s

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unique haplotype in exon 3 of cone opsin mRNA affects splicing of its precursor, leading to congenital color vision defect.2012

    • Author(s)
      H. Ueyama, S. Muraki-Oda, S. Yamade, S. Tanabe, T. Yamashita, Y. Shichidaand H. Ogita.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 424 Issue: 1 Pages: 152-7

    • DOI

      10.1016/j.bbrc.2012.06.094

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photochemical properties of mammalian melanopsin.2012

    • Author(s)
      T. Matsuyama, T. Yamashita, Y. Imamoto and Y. Shichida
    • Journal Title

      Biochemistry

      Volume: 51 Issue: 27 Pages: 5454-62

    • DOI

      10.1021/bi3004999

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative studies on the late bleaching processes of four kinds of cone visual pigments and rod visual pigment2012

    • Author(s)
      K. Sato, T. Yamashita, Y. Imamoto and Y. Shichida
    • Journal Title

      Biochemistry

      Volume: 51 Issue: 21 Pages: 4300-8

    • DOI

      10.1021/bi3000885

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The C-Terminus of the G Protein α Subunit Controls the Affinity of Nucleotides2012

    • Author(s)
      Naoki Kimata, Takahiro Yamashita, Take Matsuyama, Yasushi Imamoto, Yoshinori Shichida
    • Journal Title

      Biochemistry

      Volume: 51 Issue: 13 Pages: 2768-2774

    • DOI

      10.1021/bi201702d

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A non-mammalian type opsin 5 functions dually in the photoreceptive and non-photoreceptive organs of birds.2012

    • Author(s)
      H. Ohuchi, T. Yamashita, S. Tomonari, S. Fujita-Yanagibayashi, K. Sakai, S. Noji and Y. Shichida
    • Journal Title

      PLoS One

      Volume: 7 Issue: 2 Pages: e31534-e31534

    • DOI

      10.1371/journal.pone.0031534

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photochemical nature of parietopsin.2012

    • Author(s)
      K. Sakai, Y. Imamoto, C.Y. Su, H. Tsukamoto, T. Yamashita, A. Terakita, K.W. Yau and Y. Shichida
    • Journal Title

      Biochemistry

      Volume: 51 Issue: 9 Pages: 1933-41

    • DOI

      10.1021/bi2018283

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Depth perception from image defocus in a jumping spider2012

    • Author(s)
      Takashi Nagata, Mitsumasa Koyanagi, Hisao Tsukamoto, Shinjiro Saeki, Kunio Isono, Yoshinori Shichida, Fumio Tokunaga, Michiyo Kinoshita, Kentaro Arikawa, Akihisa Terakita
    • Journal Title

      Science

      Volume: 335 Issue: 6067 Pages: 469-471

    • DOI

      10.1126/science.1211667

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative studies on the late bleaching processes of four kinds of cone visual pigments and rod visual pigment.2012

    • Author(s)
      Sato, K.
    • Journal Title

      Biochemistry

      Volume: 51 Pages: 4300-4308

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photochemical properties of mammalian melanopsin.2012

    • Author(s)
      Matsuyama, T.
    • Journal Title

      Biochemistry

      Volume: 51 Pages: 5454-5462

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unique haplotype in exon 3 of cone opsin mRNA affects splicing of its precursor, leading to congenital color vision defect.2012

    • Author(s)
      Ueyama, H.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 424 Pages: 152-157

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spectroscopic analysis of the effect of chloride on the active intermediates of the primate L group cone visual pigment.2012

    • Author(s)
      Morizumi, T.
    • Journal Title

      Biochemistry

      Volume: 51 Pages: 10017-10023

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A non-mammalian type opsin 5 functions dually in the photoreceptive and non-photoreseptive organs of birds2012

    • Author(s)
      H.Ohuchi
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vertebrate ancient-long opsin has molecular properties intermediate between those of vertebrate and invertebrate visual pigments2011

    • Author(s)
      Keita Sato, Takahiro Yamashita, Hideyo Ohuchi, Yoshinori
    • Journal Title

      Biochemistry

      Volume: 50 Issue: 48 Pages: 10484-10490

    • DOI

      10.1021/bi201212z

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative fluorescence resonance energy transfer analysis of metabotropic glutamate receptors: implications about the dimeric arrangement and rearrangement upon ligand bindings.2011

    • Author(s)
      M. Yanagawa, T. Yamashita and Y. Shichida
    • Journal Title

      J. Biol. Chem

      Volume: 286 Issue: 26 Pages: 22971-81

    • DOI

      10.1074/jbc.m110.206870

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chimeric microbial rhodopsins containing the third cytoplasmic loop of bovine rhodopsin2011

    • Author(s)
      A.Nakatsuma, T.Yamashita, K.Sasaki, A.Kawanabe, K.Inoue, Y.Furutani, Y.Shichida, H.Kandori
    • Journal Title

      Biophys.J

      Volume: 100 Issue: 8 Pages: 1874-1882

    • DOI

      10.1016/j.bpj.2011.02.054

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beta-arrestin functionally regulates the non-bleaching pigment parapinopsin in lamprey pineal.2011

    • Author(s)
      E. Kawano-Yamashita, M. Koyanagi, Y. Shichida, T. Oishi, S. Tamotsu and A. Terakita
    • Journal Title

      PLoS One

      Volume: 6 Issue: 1 Pages: e16402-e16402

    • DOI

      10.1371/journal.pone.0016402

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chimeric microbial rhodopsins containing the third cytoplasmic loop of bovine rhodopsin.2011

    • Author(s)
      A.Nakatsuma
    • Journal Title

      Biophys.J.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beta-arrestin functionally regulates the nonbleaching pigment parapinopsin in lamprey pineal.2011

    • Author(s)
      E.Kawano-Yamashita
    • Journal Title

      PLoS One

      Volume: e16402

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein.2010

    • Author(s)
      T. Yamashita, H. Ohuchi, S. Tomonari, K. Ikeda, K. Sakai and Y. Shichida
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 107 Issue: 51 Pages: 22084-9

    • DOI

      10.1073/pnas.1012498107

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evolution and mechanism of spectral tuning of blue-absorbing visual pigments in butterflies.2010

    • Author(s)
      M. Wakakuwa, A. Terakita, M. Koyanagi, D.G. Stavenga, Y. Shichidaand K. Arikawa
    • Journal Title

      PLoS One

      Volume: 5 Issue: 11 Pages: e15015-e15015

    • DOI

      10.1371/journal.pone.0015015

    • NAID

      120006575985

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photosensitivities of rhodopsin mutants with a displaced counterion2010

    • Author(s)
      K. Tsutsui and Y. Shichida
    • Journal Title

      Biochemistry

      Volume: 49 Issue: 47 Pages: 10089-97

    • DOI

      10.1021/bi101020p

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of the second extracellular loop of rhodopsin by characterizing split variants2010

    • Author(s)
      K. Sakai, Y. Imamoto, T. Yamashitaand Y. Shichida
    • Journal Title

      Photochem. Photobiol. Sci.

      Volume: 9 Issue: 11 Pages: 1490-7

    • DOI

      10.1039/c0pp00183j

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple functions of Schiff base counterion in rhodopsins.2010

    • Author(s)
      K. Tsutsui and Y. Shichida
    • Journal Title

      Photochem. Photobiol. Sci.

      Volume: 9 Issue: 11 Pages: 1426-34

    • DOI

      10.1039/c0pp00134a

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vertebrate rhodopsin adaptation to dim light via rapid meta-II intermediate formation.2010

    • Author(s)
      T. Sugawara, H. Imai, M. Nikaido, Y. Imamoto and N. Okada
    • Journal Title

      Mol. Biol. Evol.

      Volume: 27 Issue: 3 Pages: 516-19

    • DOI

      10.1093/molbev/msp252

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A pivot between helices V and VI near the retinal binding site is necessary for activation in rhodopsins2010

    • Author(s)
      H. Tsukamoto, A. Terakita and Y. Shichida
    • Journal Title

      J. Biol. Chem.

      Volume: 285 Issue: 10 Pages: 7351-7

    • DOI

      10.1074/jbc.m109.078709

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Covalent bond between ligand and receptor required for efficient activation in rhodopsin.2010

    • Author(s)
      T. Matsuyama, T. Yamashita, H. Imai and Y. Shichida
    • Journal Title

      J. Biol. Chem

      Volume: 285 Issue: 11 Pages: 8114-21

    • DOI

      10.1074/jbc.m109.063875

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      K. Tsutsui, Y. Shichida
    • Journal Title

      Biochemistry 49

      Pages: 10089-10097

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      H. Tsukamoto, A. Terakita, Y. Shichida
    • Journal Title

      J.Biol.Chem 285

      Pages: 7351-7

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      T. Matsuyama, T. Yamashita, H. Imai, Y. Shichida
    • Journal Title

      J.Biol.Chem 285

      Pages: 8114-8121

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein.2010

    • Author(s)
      T.Yamashita
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 107 Pages: 22084-22089

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolution and mechanism of spectral tuning of blue-absorbing visual pigments in butterflies.2010

    • Author(s)
      M.Wakakuwa
    • Journal Title

      PLoS One

      Volume: e15015

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photosensitivities of rhodopsin mutants with a displaced counterion.2010

    • Author(s)
      K.Tsutsui
    • Journal Title

      Biochemistry

      Volume: 49 Pages: 10089-10091

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of the second extracellular loop of rhodopsin by characterizing split variants.2010

    • Author(s)
      K.Sakai
    • Journal Title

      Photochem.Photobiol.Sci.

      Volume: 9 Pages: 1490-1497

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple functions of Schiff base counterion in rhodopsins.2010

    • Author(s)
      K.Tsutsui
    • Journal Title

      Photochem.Photobiol.Sci.

      Volume: 9 Pages: 1426-1434

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Covalent bond between ligard and receptor required for efficient activation in Rh2010

    • Author(s)
      T.Matsuyama
    • Journal Title

      J.Biol.Chem. 285

      Pages: 8114-8121

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation switch in the transmembrane domain of metabotropic glutamate receptor.2009

    • Author(s)
      M. Yanagawa, T. Yamashita and Y. Shichida
    • Journal Title

      Mol. Pharmacol

      Volume: 76 Issue: 1 Pages: 201-7

    • DOI

      10.1124/mol.109.056549

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evolution of opsins and phototransduction.2009

    • Author(s)
      Y. Shichida and T. Matsuyama
    • Journal Title

      Philos. Trans. R Soc. Lond. B Biol. Sci

      Volume: 384 Issue: 1531 Pages: 2881-95

    • DOI

      10.1098/rstb.2009.0051

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct observation of pH-dependent equilibrium between metarhodopsin I and II and pH-independent interaction of metarhodosin II with transducin C-terminal peptide.2009

    • Author(s)
      K. Sato, T. Morizumi, T. Yamashita and Y. Shichida
    • Journal Title

      Biochemistry

      Volume: 49 Issue: 4 Pages: 736-41

    • DOI

      10.1021/bi9018412

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] G protein subtype specificity of rhodopsin intermediates metarhodopsin Ib and metarhodopsin II.2009

    • Author(s)
      T. Morizumi, N. Kimata, A. Terakita, Y. Imamoto, T. Yamashita and Y. Shichida
    • Journal Title

      Photochem. Photobiol.

      Volume: 85 Issue: 1 Pages: 57-62

    • DOI

      10.1111/j.1751-1097.2008.00396.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Y. Shichida, T. Matsuyama
    • Journal Title

      Philos.Trans.R.Soc.Lond.B Biol.Sci 364

      Pages: 2881-2895

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Activation switch in the transmembrane domain of mGluR2009

    • Author(s)
      M.Yanagawa
    • Journal Title

      Mol.Pharmacol. 76

      Pages: 201-207

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct observation of pH-dependent equilibrium between metarhodopsin I and II2009

    • Author(s)
      K.Sato
    • Journal Title

      Biochemistry 49

      Pages: 736-741

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermal recovery of iodopsin from photobleaching intermediates2008

    • Author(s)
      Y. Imamoto and Y. Shichida
    • Journal Title

      Photochem. Photobiol.

      Volume: 84 Issue: 4 Pages: 941-8

    • DOI

      10.1111/j.1751-1097.2008.00332.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] E113 is required for the efficient photoisomerization of the unprotonated chromophore in a UV-absorbing visual pigment2008

    • Author(s)
      K. Tsutsui, H. Imai and Y. Shichida
    • Journal Title

      Biochemistry

      Volume: 47 Issue: 41 Pages: 10829-33

    • DOI

      10.1021/bi801377v

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conformational change of the transmembrane helices II and IV of metabotropic glutamate receptor involved in G protein activation.2008

    • Author(s)
      T. Yamashita, A. Terakita, T. Kai and Y. Shichida
    • Journal Title

      J. Neurochem.

      Volume: 106 Issue: 2 Pages: 850-9

    • DOI

      10.1111/j.1471-4159.2008.05443.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pigmented and nonpigmented ocelli in the brain vesicle of the ascidian larva2008

    • Author(s)
      T. Horie, D. Sakurai, H. Ohtsuki, A. Terakita, Y. Shichida, J. Usukura, T. Kusakabe and M. Tsuda
    • Journal Title

      J. Comp. Neurol.

      Volume: 509 Issue: 1 Pages: 88-102

    • DOI

      10.1002/cne.21733

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] First Cytoplasmic Loop of Glucagon-like Peptide-1 Receptor Can Function at the Third Cytoplasmic Loop Position of Rhodopsin.2008

    • Author(s)
      T. Yamashita, K. Tose, and Y. Shichid
    • Journal Title

      Photochem. Photobiol

      Volume: 84 Issue: 4 Pages: 931-936

    • DOI

      10.1111/j.1751-1097.2008.00327.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression and comparative characterization of Gq-coupled invertebrate visual pigments and melanopsin.2008

    • Author(s)
      A. Terakita, H. Tsukamoto, M. Koyanagi, M. Sugahara, T. Yamashitaand Y. Shichida
    • Journal Title

      J. Neurochem.

      Volume: 105 Issue: 3 Pages: 883-890

    • DOI

      10.1111/j.1471-4159.2007.05184.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article]2008

    • Author(s)
      T. Yamashita, H. Ohuchi, S. Tomonari, K. Ikeda, K. Sakai, Y. Shichida
    • Journal Title

      Proc.Natl.Acad.Sci.USA 10

      Pages: 22084-22089

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] E113 is required for the efficient photoisomerization of the unprotonated chromophore in a UV-absorbing visual2008

    • Author(s)
      Tsutsui K, Imai H, Shichida Y
    • Journal Title

      Biochemistry 47

      Pages: 10829-10833

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conformational change of the transmembrane helices IT and TV of metabotropic glutamate receptor involved in G2008

    • Author(s)
      Yamashita T, Terakita A, Kai T, Shichida Y
    • Journal Title

      J Neurochem. 106

      Pages: 850-859

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and comparative characterization of Gqcoupled invertebrate visual pigments and melanopsin.2008

    • Author(s)
      Terakita A, Tsukaraoto H, Koyanagi M, Sugahara M, Yamashita T
    • Journal Title

      J Neurochem. 105

      Pages: 883-90

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Rod and Cone pigments: Molecular properties and functional diversity2012

    • Author(s)
      Y. Shichida
    • Organizer
      15th International Conference on Retinal Proteins
    • Place of Presentation
      Ascona/Switzerland
    • Year and Date
      2012-10-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular properties of vertebrate non-visual opsins, Opn5 and Opn5-like protein2012

    • Author(s)
      T. Yamashita
    • Organizer
      15th International Conference on Retinal Proteins
    • Place of Presentation
      Ascona/Switzerland
    • Year and Date
      2012-10-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 非哺乳類脊椎動物が持つ光受容タンパク質Opn5L2の解析2012

    • Author(s)
      山下高廣
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 非哺乳類脊椎動物が持つ光受容タンパク質Opn5L1の分子特性解析2012

    • Author(s)
      佐藤恵太
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規Opn5類似タンパク質の分子特性解析2012

    • Author(s)
      湯本茜
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウスメラノプシンの光応答特性2012

    • Author(s)
      松山オジョス武
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] Rod and cone visual pigments: Molecular properties and functional diversity2012

    • Author(s)
      Shichida, Y.
    • Organizer
      15th International Conference on Retinal Proteins.
    • Place of Presentation
      Ascona, Switzerland
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 最近機能解析の始まったOpn5の意外な光受容機能:光活性化と不活性化2011

    • Author(s)
      七田芳則
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川市大雪クリスタルホール/北海道
    • Year and Date
      2011-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 最近機能解析の始まったOpn5の意外な光受容機能:光活性化と不活性化2011

    • Author(s)
      七田芳則
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      大雪クリスタルホール(旭川市)(招待講演)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Single Molecule Detection of Rhodopsin Activation2011

    • Author(s)
      Y. Imamoto
    • Organizer
      第49回日本生物物理学会年会シンポジウム
    • Place of Presentation
      兵庫県立大/兵庫県
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] What should we learn from animal opsin diversification?2011

    • Author(s)
      T. Yamashita
    • Organizer
      第49回日本生物物理学会年会シンポジウム
    • Place of Presentation
      兵庫県立大/兵庫県
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular properties of Opn5 and its functions2011

    • Author(s)
      T. Yamashita
    • Organizer
      5th Asia and Oceania Conference on Photobiology
    • Place of Presentation
      奈良県新公会堂/奈良県
    • Year and Date
      2011-08-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Activation mechanism of visual transduction studied by fluorescence spectroscopy2011

    • Author(s)
      T. Yamashita
    • Organizer
      5th Asia and Oceania Conference on Photobiology
    • Place of Presentation
      奈良県新公会堂/奈良県
    • Year and Date
      2011-07-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional evolution of opsins2011

    • Author(s)
      T. Yamashita
    • Organizer
      第13回日本進化学会年会シンポジウム
    • Place of Presentation
      京都大/京都府
    • Year and Date
      2011-07-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 分子からみた光受容の多様性2011

    • Author(s)
      七田芳則
    • Organizer
      日本光医学・光生物学会第33回年会
    • Place of Presentation
      大阪大/大阪府
    • Year and Date
      2011-07-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 光センサ蛋白質の物性と機能メカニズム2010

    • Author(s)
      今元 泰
    • Organizer
      大阪大学生命機能研究科研究交流会「FBSコロキウム」
    • Place of Presentation
      大阪大/大阪府
    • Year and Date
      2010-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 視覚・光受容のメカニズムと進化2010

    • Author(s)
      七田芳則
    • Organizer
      徳島大学「医工連携ネットワーク形成」に関する講演会
    • Place of Presentation
      徳島大/徳島県
    • Year and Date
      2010-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 生理的温度条件下における桿体、錐体視物質の光反応過程の比較解析2010

    • Author(s)
      矢野雅裕、今元泰、木股直規、山下高廣、七田芳則
    • Organizer
      日本動物学会第81回大会
    • Place of Presentation
      東京大学
    • Year and Date
      2010-09-23
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 生理的温度条件下における桿体、錐体視物質の光反応過程の比較解析2010

    • Author(s)
      矢野雅裕
    • Organizer
      日本動物学会第81回大会
    • Place of Presentation
      東京都 東京大学
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular mechanism regulating active state formation and G protein activation of a prototypical GPCR, vertebrate rhodopsin2010

    • Author(s)
      T. Yamashita
    • Organizer
      第48回日本生物物理学会年会シンポジウム
    • Place of Presentation
      東北大/宮城県
    • Year and Date
      2010-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Low activation efficiency of transducin by cone visual pigment is attributed to the short lifetime of meta-II intermediate2010

    • Author(s)
      Y. Imamoto, I. Seki, T.Yamashita, Y.Shichida
    • Organizer
      14th International Conference on Retinal Proteins
    • Place of Presentation
      Santa Cruz (USA)
    • Year and Date
      2010-08-02
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] ロドプシン類の機能多様性:変異体解析からなにがわかるか2010

    • Author(s)
      Y. Shichida
    • Organizer
      分子研研究会
    • Place of Presentation
      分子研/愛知県
    • Year and Date
      2010-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional diversity and evolution of rhodopsins2009

    • Author(s)
      Y. Shichida
    • Organizer
      第25回国際生物学賞記念シンポジウム
    • Place of Presentation
      京都大/京都府
    • Year and Date
      2009-12-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Light-induced conformational change of photoactive yellow protein2009

    • Author(s)
      Y. Imamoto
    • Organizer
      第25回国際生物学賞記念シンポジウム
    • Place of Presentation
      京都大/京都府
    • Year and Date
      2009-12-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional Diversity of Vertebrate Rhodopsin2009

    • Author(s)
      Y. Shichida
    • Organizer
      15th International Congress on Photobiology
    • Place of Presentation
      Dusseldorf/Germany
    • Year and Date
      2009-06-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional Diversity of Vertebrate Rhodopsin2009

    • Author(s)
      Y.Shichida
    • Organizer
      15th International Congress on Photobiology
    • Place of Presentation
      Dusseldorf (Germany)
    • Year and Date
      2009-06-20
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Functional Diversity of Vertebrate Rhodopsin2009

    • Author(s)
      Y.Shichida
    • Organizer
      15^(th) International Congress on Photobiology
    • Place of Presentation
      Dusseldorf, Germany
    • Year and Date
      2009-06-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evolution of Vertebrate Vision :Rods and Cones2009

    • Author(s)
      Y. Shichida
    • Organizer
      The 18th CDB Meeting
    • Place of Presentation
      理研/兵庫県
    • Year and Date
      2009-04-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 蛋白質の構造変化:構造から予測される反応と実際の反応2008

    • Author(s)
      Y. Imamoto
    • Organizer
      第46回日本生物物理学会年会シンポジウム
    • Place of Presentation
      福岡国際会議場/福岡県
    • Year and Date
      2008-12-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 代謝型グルタミン酸受容体の膜貫通領域における構造変化解析2008

    • Author(s)
      T. Yamashita
    • Organizer
      第46回日本生物物理学会年会シンポジウム
    • Place of Presentation
      福岡国際会議場/福岡県
    • Year and Date
      2008-12-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional diversity of visual pigments2008

    • Author(s)
      T. Yamashita
    • Organizer
      4th Asia Oceania Conference on Photobiology
    • Place of Presentation
      Varanasi/India
    • Year and Date
      2008-11-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Association of Rhodopsin and Regulatory Protein2008

    • Author(s)
      Y. Imamoto
    • Organizer
      n of Rhodopsin and Regulatory Protein」 4th Asia Oceania Conference on Photobiology
    • Place of Presentation
      Varanasi/India
    • Year and Date
      2008-11-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional diversity of visual pigments.2008

    • Author(s)
      Y.Shichida
    • Organizer
      4th Asia Oceania Conference on Photobiology
    • Place of Presentation
      Varanasi
    • Year and Date
      2008-11-25
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] E113 is required for the efficient photoisomerization in UV-absorbing visual pigments2008

    • Author(s)
      K. Tsutsui, H. Imai, Y. Shichida
    • Organizer
      13th International Conference on Retinal Proteins
    • Place of Presentation
      Barcelona(Spain)
    • Year and Date
      2008-06-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Functional diversity of animal rhodopsins2008

    • Author(s)
      Y. Shichida
    • Organizer
      13th International Conference on Retinal Proteins
    • Place of Presentation
      Barcelona/Spain
    • Year and Date
      2008-06-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional diversity of animal rhodopsins2008

    • Author(s)
      Y.Shichida
    • Organizer
      13th International Conference on Retinal Proteins
    • Place of Presentation
      Barcelona (Spain)
    • Year and Date
      2008-06-17
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 視物質の進化2008

    • Author(s)
      七田芳則
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大/大阪府
    • Year and Date
      2008-04-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 蛋白質構造変化の伝播メカニズム2008

    • Author(s)
      今元 泰
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大/大阪府
    • Year and Date
      2008-04-18
    • Related Report
      2012 Final Research Report
  • [Book] Evolution and Senses2013

    • Author(s)
      Y. Shichida, T. Yamashita, H. Imai and T. Kishida
    • Publisher
      Springer
    • Related Report
      2012 Final Research Report
  • [Book] 「多様な光環境への動物の適応メカニズム」 「生き物たちのつづれ織り上」2012

    • Author(s)
      七田芳則、山下高廣
    • Publisher
      京都大学学術出版会
    • Related Report
      2012 Final Research Report
  • [Book] タンパク質共役型受容体の二量体化による機能制御メカニズム2011

    • Author(s)
      柳川正隆、七田芳則
    • Total Pages
      949
    • Related Report
      2012 Final Research Report
  • [Book] 脊椎動物新規紫外光受容タンパク質~ヒトも紫外線を感じる?~2011

    • Author(s)
      山下高廣
    • Related Report
      2012 Final Research Report
  • [Book] 「脊椎動物の視細胞が光を受けるしくみ」 「見える光、見えない光」2009

    • Author(s)
      山下高廣、七田芳則
    • Publisher
      共立出版
    • Related Report
      2012 Final Research Report
  • [Book] 脊椎動物の視細胞が光を受けるしくみ 見える光、見えない光(日本比較生理生化学会編)2009

    • Author(s)
      山下高廣、七田芳則
    • Publisher
      共立出版
    • Related Report
      2010 Self-evaluation Report
  • [Book] 代謝型グルタミン酸受容体の細胞質領域の構造変化2008

    • Author(s)
      山下高廣
    • Related Report
      2012 Final Research Report
  • [Book] 「視覚の進化」ルネッサンス京都21 五感シリーズIV 「眼がとらえた情報がこころに与える影響」大東肇・中井吉英 編2008

    • Author(s)
      七田芳則
    • Publisher
      オフィスエム
    • Related Report
      2012 Final Research Report
  • [Book] 「眼がとらえた情報がこころに与える影響」(「視覚の進化」ルネッサンス京都21 五感シリーズIV)(大東肇・中井吉英編)2008

    • Author(s)
      七田芳則
    • Publisher
      オフィスエム
    • Related Report
      2010 Self-evaluation Report
  • [Book] 視覚の進化2008

    • Author(s)
      七田芳則
    • Total Pages
      180
    • Publisher
      オフィスェム
    • Related Report
      2008 Annual Research Report
  • [Remarks] 2010年12月8日掲載 朝日新聞、毎日新聞、京都新聞、徳島新聞(共同通信社配信記事)

    • Related Report
      2012 Final Research Report
  • [Remarks] 2011年1月24日掲載 読売新聞

    • Related Report
      2012 Final Research Report
  • [Remarks] ホームページ

    • URL

      http://photo1.biophys.kyoto-u.ac.jp/shichida/home_jp.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://photo1.biophys.kyoto-u.ac.jp/shichida/home_jp.html

    • Related Report
      2011 Annual Research Report
  • [Remarks] 報道関連情報

    • Related Report
      2010 Self-evaluation Report
  • [Remarks] 2010年12月に米国科学アカデミー紀要に掲載された論文(Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein)が朝日新聞、京都新聞、毎日新聞、読売新聞に掲載され、共同通信社によって配信された

    • Related Report
      2010 Self-evaluation Report
  • [Remarks] ホームページ

    • URL

      http://photo1.biophys.kyoto-u.ac.jp/shichida/home_jp.html

    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://photo1.biophys.kyoto-u.ac.jp/shichida/home_jp.html

    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2019-07-29  

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