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Structure and dynamics of actin filament complex:mechanism of calcium regulation of muscle contraction

Research Project

Project/Area Number 20227008
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Biophysics
Research InstitutionNagoya University

Principal Investigator

MAEDA Yuichiro  名古屋大学, 理学研究科, 特任教授 (10321811)

Co-Investigator(Kenkyū-buntansha) NARITA Akihiro  名古屋大学, 理学研究科, 助教 (30360613)
Co-Investigator(Renkei-kenkyūsha) KAINOSHO Masatsune  名古屋大学, 理学研究科, 研究顧問 (20137029)
WATANABE Nobuhisa  名古屋大学, シンクロトロン光研究センター, 教授 (70212321)
Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥191,360,000 (Direct Cost: ¥147,200,000、Indirect Cost: ¥44,160,000)
Fiscal Year 2012: ¥47,840,000 (Direct Cost: ¥36,800,000、Indirect Cost: ¥11,040,000)
Fiscal Year 2011: ¥47,840,000 (Direct Cost: ¥36,800,000、Indirect Cost: ¥11,040,000)
Fiscal Year 2010: ¥47,840,000 (Direct Cost: ¥36,800,000、Indirect Cost: ¥11,040,000)
Fiscal Year 2009: ¥47,840,000 (Direct Cost: ¥36,800,000、Indirect Cost: ¥11,040,000)
Keywords細胞運動 / 細胞骨格 / アクチン・トレッドミリング / 筋収縮の調節 / アクチン / アクチンフィラメント / アクチンのトレッドミリング / 筋収縮のカルシウム調節 / トロポニン / 遺伝性心疾患 / X線繊維回折 / 高分解能構造解析 / 蛋白質の構造・動態・機能 / NMR / X線結晶解析 / 高分解能電子顕微鏡解析 / アクチンのトレッドミリング / 筋収縮のカルシウム調節
Research Abstract

Actin is one of the most abundant proteins in eukaryotic cells, and preforms numerous crucial cellular functions. In muscle cells, actin monomers assemble into filamentous aggregates, play roles in muscle contraction and its regulation, while in non-muscle cells, actin drives cell motility through cycles of assembly and disassembly between monomers and filaments. In this project, the 3D structure of the actin filament was first elucidated, as well as structures of complex of actin with other proteins. Based on these structures, we have gained mechanistic understanding of actin cellular functions.

Assessment Rating
Verification Result (Rating)

A

Report

(7 results)
  • 2013 Research Progress Assessment (Verification Result) ( PDF )
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (118 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (43 results) (of which Peer Reviewed: 38 results) Presentation (65 results) (of which Invited: 10 results) Book (4 results) Remarks (6 results)

  • [Journal Article] Physicochemical analysis from real-time imaging of liposome tabulation reveals the characteristic of individual F-BAR domain proteins2013

    • Author(s)
      Takiguchi Y, Itoh T, Tsujita K, Yamada S, Yanagisawa M, Fujiwara K, Ichikawa M, Yamamoto A, Takiguchi K
    • Journal Title

      Langmuir

      Volume: 29 Issue: 1 Pages: 328-336

    • DOI

      10.1021/la303902q

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Actin branching in the initiation and maintenance of lamellipodia.2012

    • Author(s)
      Vinzenz M., Nemethova M., Schur F., Mueller J., Narita A., Urban E., Winkler C., Schmeiser C., Koestler S. A., Rottner K., Resch G. P., Maeda Y. & Small, J. V
    • Journal Title

      J Cell Sci

      Volume: 125 Pages: 2775-85

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct determination of actin polarity in the cell.2012

    • Author(s)
      Narita, A., Mueller, J., Urban, E., Vinzenz, M., Small, J. V. & Maeda, Y
    • Journal Title

      J Mol Biol

      Volume: 419 Pages: 359-68

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct determination of actin polarity in the cell2012

    • Author(s)
      Narita Akihiro
    • Journal Title

      J.Mol.Biol.

      Volume: 419 Issue: 5 Pages: 359-68

    • DOI

      10.1016/j.jmb.2012.03.015

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Actin Branching in the initiation and maintenance of lamellipodia2012

    • Author(s)
      Vinzenz M
    • Journal Title

      J.Cell Science

      Volume: 125(11) Pages: 3775-85

    • DOI

      10.1242/jcs.107623

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel actin-like filament structure from Clostridium tetani2012

    • Author(s)
      Narita Akihiro
    • Journal Title

      J. Biol.Chem

      Volume: 287(25): Issue: 25 Pages: 21121-9

    • DOI

      10.1074/jbc.m112.341016

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microtubule-like properties of the bacterial actin homolog ParM-R12012

    • Author(s)
      Narita Akihiro
    • Journal Title

      J. Biol.Chem

      Volume: 287(44) Issue: 44 Pages: 37078-88

    • DOI

      10.1074/jbc.m111.319491

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the actin A108-P112 loop in the polymerization and ATPase activities2012

    • Author(s)
      Iwasa Mitsusada
    • Journal Title

      J. Biol.Chem

      Volume: 287(52) Pages: 43270-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for the slow dynamics of the actin filament pointed end.2011

    • Author(s)
      Narita A, Oda T & Maeda Y
    • Journal Title

      EMBO J

      Volume: 30 Pages: 1230-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Merits of the double-stranded form of the actin filament revealed by structures of the filament ends2011

    • Author(s)
      Narita, A
    • Journal Title

      Commun Integr Biol

      Volume: 4 Pages: 692-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Minimum requirements for the actin-like treadmilling motor system.2011

    • Author(s)
      Narita, A
    • Journal Title

      Bioarchitecture

      Volume: 1 Pages: 205-208

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electron microscopic visualization of the filament binding mode of actin -binding proteins.2011

    • Author(s)
      Ito, T., Hirayama, T., Taki, M., Iyoshi, S., Dai, S., Takeda, S., Kimura-Sakiyama, C., Oda, T., Yamamoto, Y., Maeda, Y. & Narita, A.
    • Journal Title

      filament binding mode of actin -binding proteins. J Mol Biol

      Volume: 408 Pages: 26-39

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human spire interacts with the barbed end of the actin filament.2011

    • Author(s)
      Ito T, Narita A, Hirayama T, Taki M, Iyoshi, S., Yamamoto, Y., Maeda, Y. & Oda, T.
    • Journal Title

      J Mol Biol

      Volume: 408 Pages: 18-25

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Actin Capping protein and its inhibitor CARMIL : how intrinsically disordered regions function2011

    • Author(s)
      Takeda Shuichi
    • Journal Title

      Phys Biol.

      Volume: 8(3) Issue: 3 Pages: 35005-35005

    • DOI

      10.1088/1478-3975/8/3/035005

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transformation of acto HMM assembly confined in cell-sized liposome2011

    • Author(s)
      K. Takiguchi, M. Negishi, Y. T.-Takiguchi, M. Homma, and K. Yoshikawa
    • Journal Title

      Langmuir

      Volume: 27(18) Issue: 18 Pages: 11528-11535

    • DOI

      10.1021/la2016287

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Minimum requirements for the actin-like treadmilling motor system.2011

    • Author(s)
      Narita Akihiro
    • Journal Title

      Bio Architecture

      Volume: 1(5) Pages: 205-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Merits of the double-stranded form of the actin filament revealed by structures of the filament ends2011

    • Author(s)
      Narita Akihiro
    • Journal Title

      Communicative and Integrative Biology

      Volume: 4(6) Pages: 692-5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for the slow dynamics of the actin filament pointed end2011

    • Author(s)
      Narita, A., Oda, T., Ma, C.
    • Journal Title

      EMBO J.

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Electron Microscopic Visualization of the Filament Building Mode of Actin-Binding Proteins2011

    • Author(s)
      Ito T., Hirayama T., Taki M., Iyoshi S., Dai S., Takeda S., Kimura-Sakiyama C., Oda T., Yamamoto Y., Maeda Y., Narita A.
    • Journal Title

      The Journal of Molecular Biology

      Volume: 408(1) Pages: 26-39

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human Spire Interacts with the Barbed End of the Actin Filament2011

    • Author(s)
      Ito T., Narita A., Hirayama T., Taki M., Iyoshi S., Yamamoto Y., Maeda Y., Oda T.
    • Journal Title

      The Journal of Molecular Biology

      Volume: 408(1) Pages: 18-25

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for the slow dynamics of the actin filament pointed end2011

    • Author(s)
      Narita A., Oda T., Maeda Y.
    • Journal Title

      The EMBO Journal

      Volume: 30(7) Pages: 1230-1237

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two distinct mechanisms for actin capping protein regulation--steric and allosteric inhibition.2010

    • Author(s)
      Takeda, S., Minakata, S., Koike, R., Kawahata, I., Narita, A., Kitazawa, M., Ota, M., Yamakuni, T., Maeda, Y. & Nitanai, Y
    • Journal Title

      PLoS Biol

      Volume: 8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple Conformations of F-actin.2010

    • Author(s)
      Oda, T. & Maeda, Y
    • Journal Title

      Structure

      Volume: 18 Pages: 761-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two distinct mechanisms for actin capping protein regulation-steric and allosteric inhibition2010

    • Author(s)
      Takeda, S., Minakata, S., Koike,R.,Kawahata, I., Narita, A., Kitazawa, M., Ota, M., Yamakuni, T., Maed, Nitanai, Y.
    • Journal Title

      PLoS Biol 8

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Suprastructures and dynamic properties of mycobacterium tuberculosis FtsZ2010

    • Author(s)
      Popp D., Iwasa M., Erickson HP., Narita A., Maeda Y., Robinson RC.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 285(15) Pages: 11281-11289

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymeric structures and dynamic properties of the bacterial actin Alfa2010

    • Author(s)
      Popp D., Narita A., Ghoshdastider U., Maeda K., Maeda Y., Oda T., Fujisawa T., Onishi H., Ito K., Robinson RC
    • Journal Title

      The Journal of Molecular Biology

      Volume: 397 Pages: 1031-1041

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Filament structure, organization and dynamics in MreB sheets2010

    • Author(s)
      Popp D., Narita A., Maeda K., Fujisawa T., Ghoshdastider U., Iwasa M., Maeda Y., Robinson RC
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 285(21) Pages: 15858-15865

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two Distinct Mechanisms for Actin Capping Protein Regulation-Steric and Allosteric Inhibition2010

    • Author(s)
      Takeda S., Minakata S., Koike R., Kawahata I., Narita A., Kitazawa M., Ota M., Yamakuni T., Maeda Y., Nitanai Y.
    • Journal Title

      PloS Biology

      Volume: 8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple conformations of F-actin2010

    • Author(s)
      Oda T., Maeda Y.
    • Journal Title

      Structure

      Volume: 18 Pages: 761-767

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The nature of the globular- to fibrous-actin transition.2009

    • Author(s)
      Oda, T., Iwasa, M., Aihara, T., Maeda, Y. & Narita, A
    • Journal Title

      Nature

      Volume: 457 Pages: 441-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional aberration of myofibrils by cardiomyopathy-causing mutations in the coiled-coil region of the troponin-core domain.2009

    • Author(s)
      Matsumoto, F., Maeda, K., Chatake, T., Maeda, Y. & Fujiwara, S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 382 Pages: 205-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The nature of the globular to fibrous-actin transition2009

    • Author(s)
      Oda, T., Iwasa, M., Aihara, T., Masa_Y., Narita, A.
    • Journal Title

      Nature 457

      Pages: 441-445

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] The nature of the G-to F-actin transition2009

    • Author(s)
      Oda T, Iwasa M, Aihara T, Maeda Y, Narita A.
    • Journal Title

      Nature 457

      Pages: 441-446

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FtsZ condensates : An in vitro electron microscopy study2009

    • Author(s)
      Popp D, Iwasa M, Narita N, Erickson HP, Maeda Y
    • Journal Title

      Biopolymers 91

      Pages: 340-350

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional aberration of myofibrils by cardiomyopathy-causingmutations in the coiled-coil region in the Troponin-core domain2009

    • Author(s)
      Matsumoto F, Maeda K, Chatake T, Maeda Y, Fujiwara S
    • Journal Title

      Biochem. Biophys. Res. Com. 382

      Pages: 205-209

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular structure of the ParM polymer and the mechanism leading to its nucleotide-driven dynamic instability.2008

    • Author(s)
      Popp, D., Narita, A., Oda, T., Fujisawa, T., Matsuo, H., Nitanai, Y., Iwasa, M., Maeda, K., Onishi, H. & Maeda, Y
    • Journal Title

      EMBO J

      Volume: 27 Pages: 570-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two-crystal structures of tropomyosin C-terminal fragment 176-273: exposure of the hydrophobic core to the solvent destabilizes the tropomyosin molecule2008

    • Author(s)
      Minakata, S., Maeda, K., Oda, N., Wakabayashi, K., Nitanai, Y. & Maeda, Y
    • Journal Title

      Biophys J

      Volume: 95 Pages: 710-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual roles of Gln137 of actin revealed by recombinant human cardiac muscle alpha-actin mutants.2008

    • Author(s)
      Iwasa M, Maeda K, Narita A, Maeda Y & Oda T
    • Journal Title

      J Biol Chem

      Volume: 283 Pages: 21045-53

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two-crystal structures of tropomyosin C-terminal fragment 176-273 : exposure of the hydrophobic core to the solvent destabilizes the tropomyosin molecule2008

    • Author(s)
      Minakata, S., Maeda, K., Oda, N., Wakabayashi, K., Nitanai, Y., Needs, X.
    • Journal Title

      Biophys J. 95

      Pages: 710-719

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Dual roles of Glnl37 of actin revealed by recombinant human cardiac muscle alpha-actin mutants2008

    • Author(s)
      Iwasa, M., Maeda, K., Narita. A., Maed., Oda, T.
    • Journal Title

      J Biol Chem 283

      Pages: 21045-21053

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Two crystal structures of tropomyosin C-terminal fragment 176-273 : exposure of the hydrophobic core to the solvent destabilizes the tropomyosin molecule2008

    • Author(s)
      Minakata S, Maeda K, Oda N, Wakabayashi K, Nitanai Y, Maeda Y.
    • Journal Title

      Biophysical J. 9

      Pages: 710-719

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of short-range forces on the length distribution of fibrous cytoskeletal proteins2008

    • Author(s)
      David Popp, Nir S. Gov, Mitsusada Iwasa, Yuichiro Maeda
    • Journal Title

      Biopolymers. 89

      Pages: 711-721

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual Roles of Q137 of Actin Revealed by Recombinant Human Cardiac Muscle a-Actin Mutants2008

    • Author(s)
      Mitsusada Iwasa, Kayo Maeda, Akihiro Narita, Yuichiro Maeda, Toshiro Oda
    • Journal Title

      J. Biol. Chem. . 283

      Pages: 21045-21053

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Conformational and energetic cycle of actin in polymerization and depolymerization, EMBO-FEBS Lecture Course2012

    • Author(s)
      Maeda Y. Oda T., Narita A
    • Organizer
      The 27th European Cytoskeleton Forum Meeting
    • Place of Presentation
      Pecs, Hungary
    • Year and Date
      2012-11-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 重合能を持つ蛋白質の結合が膜ドメインの形成に与える影響の支持平面二重膜を用いた直接間接2012

    • Author(s)
      山田 駿介
    • Organizer
      日本膜学会第34回年会
    • Place of Presentation
      早稲田大学(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 構造解析から迫るアクチンフィラメント動態Structural analysis of the actin filament in vitro and vivo2012

    • Author(s)
      成田 哲博
    • Organizer
      日本顕微鏡学会第68回学術講演会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 分子動力学法によるcapping protein(CP)の動的構造の解析 Structural fluctuations of capping proteins analyzed by molecular dynamics simulations"2012

    • Author(s)
      Koike R.
    • Organizer
      第50回日本生物物理学会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 精製タンパク質の構造から in situ の構造まで:電顕を利用して From purified protein structures in situ structures using EM2012

    • Author(s)
      Miyazaki N.
    • Organizer
      第50回日本生物物理学会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] アクチン様トレッドミリングモータが満たすべき最小条件 Minimum requirements for the achin-like treadmilling motor system2012

    • Author(s)
      成田 哲博
    • Organizer
      第50回日本生物物理学会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] STEMトモグラフィー法を用いた細菌及び真核細胞内超分子複合体の可視化 Structural visualization of supramolecules in bacterial and eukaryotic cells using STEM tomography2012

    • Author(s)
      小池 雅文
    • Organizer
      第50回日本生物物理学会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] F-BARによるリポソームのチューブレーションのリアルタイム観察 Real-time observation of liposome by F-BAR2012

    • Author(s)
      瀧口 陽子
    • Organizer
      第50回日本生物物理学会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Conformational and energetic cycle of actin in polymerization and depolymerization2012

    • Author(s)
      Maeda Yuichiro
    • Organizer
      EMBO-FEBS Lecture Course, Novel Biophysical Approaches in the Investigation of the Cytoskeleton, The 27th European Cytoskeleton Forum Meeting
    • Place of Presentation
      Hotel Platinus Pecs(Hungary)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 裏打ち蛋白質の添加による脂質二重膜内に形成されたドメインの安定化2012

    • Author(s)
      山田 駿介
    • Organizer
      「細胞を創る」研究会5.0
    • Place of Presentation
      東京工業大学(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 分子ロボティクス---感覚と知能を備えた分子ロボットの創成---プロジェクト紹介「分子ロボットの運動」2012

    • Author(s)
      小林 聡
    • Organizer
      SSI2012講演会
    • Place of Presentation
      ウィル愛知(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Inhibitation mechanism of actin capping protein by phosphatidylinositol bisphosphate2012

    • Author(s)
      Kato Fumika
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Structural analysis of the actin filament in vivo and in vitro2012

    • Author(s)
      Narita Akihiro
    • Organizer
      Joint Seminar Centre for BioImaging Sciences - Structural biology division of Japan EM
    • Place of Presentation
      IMCB (Singapore)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] "Structural analysis of NA+driven flagellar motor embedded in the membrane of Vibrio alginolyticus by electron tomography2012

    • Author(s)
      Koike Masafumi
    • Organizer
      Sensory Transduction in Microorganisms at Grordon Research Conference
    • Place of Presentation
      Ventura Beach Marriott CA.(USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structural analysis of the actin filament network in the cell2012

    • Author(s)
      Narita Akihiro
    • Organizer
      Direction of future in biological electron microscopy
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Actin Polymerization correlates with the flattening of actin molecule2012

    • Author(s)
      Iwasa Mitsusada
    • Organizer
      56th Annual meeting Biophysical Society
    • Place of Presentation
      SanDiego Convention Center CA.(USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Does rigidified Capping Protein lose the affinity for the actin filamentB-end ?2012

    • Author(s)
      Maeda Yuichjro
    • Organizer
      International Workshop "from Structure to Dynamics" for Our Understanding of Protein-Protein Interactions
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structural analysis of the actin filament in vitro and in vivo2012

    • Author(s)
      Narita Akihiro
    • Organizer
      International Workshop "from Structure to Dynamics" for Our Understanding of Protein-Protein Interactions
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] "Spatial structure of cytoskeleton associated with nuclear membrane2012

    • Author(s)
      Minakata Shiho
    • Organizer
      International Workshop "from Structure to Dynamics" for Our Understanding of Protein-Protein Interactions
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] "Supramolecular structural analysis by STEM electron tomography2012

    • Author(s)
      Koike Masafumi
    • Organizer
      International Workshop "from Structure to Dynamics" for Our Understanding of Protein-Protein Interactions
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] nhibition technique of troponin molecule aggregation in structural analysis by NMR2012

    • Author(s)
      Sakiyama-Kimura Chieko
    • Organizer
      International Workshop "from Structure to Dynamics" for Our Understanding of Protein-Protein Interactions
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Real-time observation of F-BAR-induced liposome tubulation2012

    • Author(s)
      Tanaka-Takiguchi Yohko
    • Organizer
      International Workshop "from Structure to Dynamics" for Our Understanding of Protein-Protein Interactions
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Reconstruction of Active Cytoskeletal Networks in Cell-Sized Liposomes2012

    • Author(s)
      Takiguchi Kingo
    • Organizer
      International Workshop "from Structure to Dynamics" for Our Understanding of Protein-Protein Interactions
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Two distinct mechanisms for actin capping protein regulation2012

    • Author(s)
      Takeda Shuichi
    • Organizer
      International Workshop "from Structure to Dynamics" for Our Understanding of Protein-Protein Interactions
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] "New method for identify the ABP binding sites on the actin filament2012

    • Author(s)
      Dai Shuheng
    • Organizer
      International Workshop "from Structure to Dynamics" for Our Understanding of Protein-Protein Interactions
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 分子と細胞をつなぐ線維状蛋白質構造解析2012

    • Author(s)
      Narita AKihiro
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨大学(山梨県)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Two distinct mechanisms for actin capping protein regulation2011

    • Author(s)
      Takeda S
    • Organizer
      Embo Lecture Courese The 26th. European Cytoskeletal Forum Meeting "Actin-Based Motility", Stresa
    • Place of Presentation
      Lake Maggiore, Italy
    • Year and Date
      2011-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Single particle analysis for actinfilaments and olher cytoskeletal Fi1aments.2011

    • Author(s)
      NaritaA
    • Organizer
      顕微鏡学会アジア若手シンポジウム
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-05-23
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] アクチン原子レベルのメカニズム2011

    • Author(s)
      成田哲博
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学蛋白質研究所
    • Year and Date
      2011-02-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Static View of the Dynamic Actin Filament2011

    • Author(s)
      Maeda Y
    • Organizer
      Muscle & Molecular Motors at Gordon Research Conference
    • Place of Presentation
      New London, NH., USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Structural insights into mechanism of the actin treadmilling2011

    • Author(s)
      Maeda Y
    • Organizer
      IX European Symposium of he Protein Society
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2012 Final Research Report
  • [Presentation] Structural insights into mechanism of the actin treadmilling2011

    • Author(s)
      Maeda Yuichiro
    • Organizer
      IX European Symposium of he Protein Society
    • Place of Presentation
      Stockholm Univ. Stockholm(Sweden)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 細胞骨格のための単粒子解析法 Single particle analysis for cytoskeletal proteins2011

    • Author(s)
      成田 哲博
    • Organizer
      第11回日本蛋白質科学会年会
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪府)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] アクチンキャッピングタンパク質、およびCARMILの天然変性領域によるアクチンダイナミックス制御機構 Functional roles of intrinsically disordered regions in actin capping protein and its inhibitor CARMIL for actin dynamics regulation2011

    • Author(s)
      武田 修一
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学(北海道)
    • Related Report
      2011 Annual Research Report
  • [Presentation] A Static View of the Dynamic Actin Filament2011

    • Author(s)
      Maeda Yuichiro
    • Organizer
      Muscle & Molecular Motors at Gordon Research Conference
    • Place of Presentation
      Colby-Sawyer College NH.(USA)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Two distinct mechanisms for actin capping protein regulation2011

    • Author(s)
      Takeda Shuichi
    • Organizer
      Motile & Contractile Systems at Gordon Research Conference
    • Place of Presentation
      Colby-Sawyer College NH.(USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] コフィリンでfull-decorateされたアクチンフィラメントの高分解能構造決定2011

    • Author(s)
      田中 康太郎
    • Organizer
      第51回日本生物物理学会若手の会夏の学校
    • Place of Presentation
      関西セミナーハウス(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Actin capping protein and its inhibitor CARMIL how intrisically disordered regions function アクチンキャッピング蛋白質とその活性阻害蛋白質CARMILに含まれる天然変性領域の作用機構2011

    • Author(s)
      Takeda Shuichi
    • Organizer
      第49回日本生物物理学会
    • Place of Presentation
      兵庫県立大学(兵庫県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Visualization of Vibrio Na+-driven flagellar motor structure embedded in cell membrane by electron microscopy 菌体細胞膜に埋まったビブリオ菌のナトリウムイオン駆動型べん毛モーター構造の電子顕微鏡による可視化2011

    • Author(s)
      Koike Masafumi
    • Organizer
      第49回日本生物物理学会
    • Place of Presentation
      兵庫県立大学(兵庫県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] A structural analysis of actin cytoskeleton in the cell 細胞内アクチン細胞骨格の構造解析2011

    • Author(s)
      Narita Akihiro
    • Organizer
      第49回日本生物物理学会
    • Place of Presentation
      兵庫県立大学(兵庫県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] High-resolution structural determination of the cofilin-decorated actin filament by single-particle analysis of cryo-electron micrographs2011

    • Author(s)
      Tanaka Kotaro
    • Organizer
      第49回日本生物物理学会
    • Place of Presentation
      兵庫県立大学(兵庫県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞を動かす原動力としてのアクチン重合体:構造研究から見えてきた離合集散のメカニズム  The actin filament as a cytomotive filament: structural insight into the mechanism of assembly-disassembly2011

    • Author(s)
      前田 雄一郎
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会館(京都府)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Two distinct mechanisms for actin capping protein regulation2011

    • Author(s)
      Takeda Shuichi
    • Organizer
      EMBO Lecture Courese: The 26th. European Cytoskeletal Forum Meeting "Actin-Based Motility"
    • Place of Presentation
      Hotel Palma, Stresa(Italy)
    • Related Report
      2011 Annual Research Report
  • [Presentation] High-Resolution structural determination of the cofilin-decorated actin filament by single-particle analysis of cryo-electron micrographs2011

    • Author(s)
      Tanaka Kotaro
    • Organizer
      EMBO Lecture Courese: The 26th. European Cytoskeletal Forum Meeting "Actin-Based Motility"
    • Place of Presentation
      Hotel Palma, Stresa (Italy)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Morphological and Topological Transformations That Are Induced into Cell -Sized Giant Liposomes2011

    • Author(s)
      Takiguchi Kingo
    • Organizer
      IEEE 2011 International Symposium on Micro-NanoMechatronics and Human Science (MHS2011) & Symposium on "COE for Education and Research of Micro-Nano Mechatronics
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 分子から細胞までをつなぐ繊維状蛋白質複合体構造解析2011

    • Author(s)
      成田 哲博
    • Organizer
      第2回神経科学と構造生物学の融合
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] NMRによる構造解析におけるトロポニン分子会合の阻害法Inhibition technique of troponin molecule aggregation in structural analysis by NMR2011

    • Author(s)
      﨑山(木邑)智恵子
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 繊維状タンパク質複合体のための単粒子解析法2010

    • Author(s)
      成田哲博
    • Organizer
      生体構造解析分科会
    • Place of Presentation
      湯沢ニューオータニホテル
    • Year and Date
      2010-12-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structure basis for our understanding of the actin treadmilling2010

    • Author(s)
      前田雄一郎
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      東北大学
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 天然変性ペプチドCARMILによるアクチンキャッピングプロテインの活性制御機構2010

    • Author(s)
      武田修一
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      東北大学
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Single particle analysis for actin filaments and other cytoskeletal filaments2010

    • Author(s)
      成田哲博
    • Organizer
      2010年顕微鏡学会アジア若手シンポジウム
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2010-05-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Two Distinct Mechanisms for Actin Capping Protein Regulation-Steric and Allosteric Inhibitation2010

    • Author(s)
      武田修一
    • Organizer
      第62回日本細胞生物学会年会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-05-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Single Particle analysis for actin filaments and other cytoskeletal filaments2010

    • Author(s)
      Narita A., Maeda Y
    • Organizer
      The 66th. Annual Meeting of the Japanese Society of Microscopy Nagoya
    • Place of Presentation
      Japan.
    • Related Report
      2012 Final Research Report
  • [Presentation] Two distinct mechanismss for actin capping protein regulation-Steric and allosteric infibition2010

    • Author(s)
      Maeda Y
    • Organizer
      Alpbach meeting, Myosin Muscle and Many other motors
    • Place of Presentation
      Alpbach, Austria
    • Related Report
      2012 Final Research Report
  • [Presentation] High resolution structure and basic properties of F-actin2009

    • Author(s)
      Madda Y, et al
    • Organizer
      Inernational Union of Physiological Sciences (IUPS)
    • Place of Presentation
      Kyoto, International Conference Hall
    • Year and Date
      2009-07-29
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Towards understanding the basic properties of F-actin2009

    • Author(s)
      Madda Y
    • Organizer
      Biochemical Interactions : from molecules to Function
    • Place of Presentation
      Velen (Mtlnsterland), German
    • Year and Date
      2009-04-23
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Towards understanding the basic properties of F-actin2009

    • Author(s)
      Maeda Y
    • Organizer
      Biochemical Interactions : from molecules to Function
    • Place of Presentation
      Valen, Germany
    • Related Report
      2012 Final Research Report
  • [Presentation] High resolution structure and basic properties of F-actin2009

    • Author(s)
      Maeda Y., Oda T., Narita A., Iwasa M., Maeda K., Aihara T
    • Organizer
      International Union of Physiological Sciences(IUPS)
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] アクチン細胞骨格系の構造解析2008

    • Author(s)
      前田雄一郎
    • Organizer
      NEDO特別講座 構造生物学講座
    • Place of Presentation
      京都大学・理学部
    • Year and Date
      2008-09-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Nature of G-to F-actin translation2008

    • Author(s)
      Macda Y.
    • Organizer
      Gordon Research Conferences on "Muscle and molecular motors"
    • Place of Presentation
      New London NH., USA
    • Year and Date
      2008-07-02
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] The nature of G- to F-actin transition2008

    • Author(s)
      Maeda Y.
    • Organizer
      Gordon Research Conferences on "Muscleand molecular motors"
    • Place of Presentation
      New London, NH, USA
    • Year and Date
      2008-07-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 独自の画像解析法による正常蛋白質複合体の三次元構造決定2008

    • Author(s)
      成田哲博
    • Organizer
      日本顕微鏡学会第64回学術講演会
    • Place of Presentation
      京都・国際会議場
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 家族性心筋症と調節蛋白質トロポニンの構造の揺れ2008

    • Author(s)
      前田雄一郎
    • Organizer
      第56回循環力学研究会
    • Place of Presentation
      東京・興和創薬(株)講堂
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Nature of Gto F-actin transition2008

    • Author(s)
      Maeda Y, Oda T, Narita A
    • Organizer
      Goradon Research Conference, "Muscle and molecular motors"
    • Place of Presentation
      New London, NH, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 海洋性ビブリオ菌が持つNa+駆動型極べん毛モーターの電子線トモグラフィによる可視化

    • Author(s)
      小池 雅文
    • Organizer
      第48回日本細菌学会中部支部総会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Book] 「細胞運動のメカニズム」、現代生物科学入門3,構造機能生物学、第二章2011

    • Author(s)
      前田雄一郎・小田俊郎
    • Publisher
      岩波書店
    • Related Report
      2012 Final Research Report
  • [Book] 現代生物科学入門 3.構造機能生物学, 第2章 細胞運動のメカニズム2011

    • Author(s)
      前田雄一郎、小田俊郎
    • Total Pages
      163
    • Publisher
      岩波書店
    • Related Report
      2011 Annual Research Report
  • [Book] 現代生物科学入門3構造機能生物学([細胞運動のメカニズム亅)2章2011

    • Author(s)
      前田雄一郎、小田俊郎
    • Publisher
      岩波害店
    • Related Report
      2010 Self-evaluation Report
  • [Book] 「細胞運動のメカニズム」構造機能生物学第2章現代生物科学入門第3巻2011

    • Author(s)
      前田雄一郎, 小田俊郎
    • Total Pages
      62
    • Publisher
      岩波書店
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://str.bio.nagoya-u.ac.jp:8080/Plone

    • Related Report
      2012 Final Research Report
  • [Remarks] 名古屋大学構造生物学研究センター

    • URL

      http://str.bio.nagoya-u.ac.jp:8080/Plone

    • Related Report
      2012 Annual Research Report
  • [Remarks] 名古屋大学構造生物学研究センター

    • URL

      http://str.bio.nagoya-u.ac.jp:8080/Plone

    • Related Report
      2011 Annual Research Report
  • [Remarks] 2008文部科学大臣表彰・若手科学者賞(成田)

    • URL

      http://str.bio.nagoya-u.ac.jp:8O8O/Plone

    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://str.bio.nagoya-u.ac.jp:8080/Plone

    • Related Report
      2010 Annual Research Report
  • [Remarks] 成田哲博 平成20年度 文部科学大臣表彰若手科学賞

    • Related Report
      2008 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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