| Co-Investigator(Renkei-kenkyūsha) |
OIKAWA Shinichi 日本医科大学, 医学部, 教授 (30142946)
OKA Yoshitomo 東北大学, 大学院医学系研究科, 教授 (70175256)
ARAI Hiroyuki 東北大学, 加齢医学研究所, 教授 (30261613)
SHIMOSEGAWA Tooru 東北大学, 大学院医学系研究科, 教授 (90226275)
KIMURA Fumiko 東北大学, 大学院農学研究科, 助教た (50321980)
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| Budget Amount *help |
¥202,670,000 (Direct Cost: ¥155,900,000、Indirect Cost: ¥46,770,000)
Fiscal Year 2012: ¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000)
Fiscal Year 2011: ¥33,930,000 (Direct Cost: ¥26,100,000、Indirect Cost: ¥7,830,000)
Fiscal Year 2010: ¥35,620,000 (Direct Cost: ¥27,400,000、Indirect Cost: ¥8,220,000)
Fiscal Year 2009: ¥61,360,000 (Direct Cost: ¥47,200,000、Indirect Cost: ¥14,160,000)
Fiscal Year 2008: ¥37,700,000 (Direct Cost: ¥29,000,000、Indirect Cost: ¥8,700,000)
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| Research Abstract |
Oxidation of lipids generates lipid hydroperoxide. Through the quantitative analysis of clinical sample with CL-HPLC and LC-MS/MS, and using the functional assessment with cell culture study and animal study, we have proved that the hydroperoxidation of biological lipid results functional deterioration of cells and tissues. Our results also indicated the lipid hydroperoxide of body causes the related disorders like arteriosclerosis and dementia. Antioxidative food components; vitamin E, polyphenol, carotenoid, suppress lipid oxidation in vivo and are useful as antisenescence-nutrient.
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