Drug development by the molecular mechanism-based analysis of stress signaling

• Project/Area Number: 20229004
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: ICHIJO Hidenori 東京大学, 薬学研究科(研究院), 教授 (00242206)
• Co-Investigator(Kenkyū-buntansha): NAGURO Isao 東京大学, 大学院薬学系研究科, 講師 (80401222) ; NISHITOH Hideki 宮崎大学, 医学部, 教授 (00332627) ; 武田 弘資 東京大学, 大学院・薬学系研究科, 准教授 (10313230) ; 野口 拓也 東京大学, 大学院・薬学系研究科, 助教 (20431893)
• Project Period (FY): 2008-05-12 – 2013-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥208,520,000 (Direct Cost: ¥160,400,000、Indirect Cost: ¥48,120,000); Fiscal Year 2012: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000); Fiscal Year 2011: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000); Fiscal Year 2010: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000); Fiscal Year 2009: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000); Fiscal Year 2008: ¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
• Keywords: ストレス / ASKファミリー / MAPキナーゼ / アポトーシス / 浸透圧 / PGAM5

Research Abstract

The stress response is one of the most fundamental biological processes, and its disruption results in a wide variety of diseases. We demonstrated that ASK family kinases, including ASK1, ASK2 and ASK3, play pivotal roles in the recognition of physico-chemical stresses and induction of cellular stress responses. Here, we found through the analysis of ASK1 signalosome components that ASK1 activity is tightly regulated by ubiquitination by Roquin-2 E3 ligase and USP9X deubiquitinating enzyme. ASK3, a recently identified ASK family member, was found to exhibit a bidirectional change in its activity in response to osmotic stress. Furthermore, we have found the SOD1-Derlin-1 interaction functions as an intracellular zinc concentration sensor that converts zinc deficiency into mild ER stress and induces a physiological ER stress response to maintain zinc homeostasis. These findings will shed light on the development of diagnosis, prevention and treatment of various stress-related diseases.

Assessment Rating

Verification Result (Rating)

A

Research Products

• [Journal Article] The DEAH-Box RNA Helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses (2014)
  • Author(s): Mosallanejad, K., Sekine, Y., Ishikura-Kinoshita, S., Kumagai, K., Nagano, T., Matsuzawa, A., Takeda, K., Naguro, I. and Ichijo, H.
  • Journal Title: Sci. Signal. Volume: 7 Issue: 323
  • DOI: 10.1126/scisignal.2004841
  • Peer Reviewed
• [Journal Article] ASK1 promotes the contact hypersensitivity response through IL-17 production (2014)
  • Author(s): Mizukami, J. Sato, T., Camps, M., Ji, H., Rueckle, T., Swinnen, D., Tsuboi, R., Takeda, K. and Ichijo, H
  • Journal Title: Sci. Rep. Volume: 4 Issue: 1 Pages: 4714-4714
  • DOI: 10.1038/srep04714
  • NAID: 120006986607
  • Peer Reviewed / Open Access
• [Journal Article] Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses (2014)
  • Author(s): Maruyama, T., Araki, T., Kawarazaki, Y., Naguro, I., Heynen, S., Aza-Blanc, P., Ronai, Z., Matsuzawa, A. and Ichijo, H.
  • Journal Title: Sci. Signal. Volume: 7 Issue: 309
  • DOI: 10.1126/scisignal.2004822
  • Peer Reviewed / Open Access
• [Journal Article] Apoptosis Signal-Regulating Kinase 1 (ASK1) as a therapeutic target (2014)
  • Author(s): Kawarazaki, Y., Ichijo, H. and Naguro, I.
  • Journal Title: Expert Opinion on Therapeutic Targets Volume: 18 Issue: 6 Pages: 651-664
  • DOI: 10.1517/14728222.2014.896903
  • Peer Reviewed
• [Journal Article] Depletion of apoptosis signal-regulating kinase 1 prevents bile duct ligation-induced necroinflammation and subsequent peribiliary fibrosis. (2014)
  • Author(s): Noguchi, H., Yamada, S., Nabeshima, A., Guo, X., Tanimoto, A., Wang, K.Y., Kitada, S., Tasaki, T., Takama, T., Shimajiri, S., Horlad, H., Komohara, Y., Izumi, H., Kohno, K., Ichijo, H. and Sasaguri, Y.
  • Journal Title: Am. J. Pathol. Volume: 184 Issue: 3 Pages: 644-661
  • DOI: 10.1016/j.ajpath.2013.11.030
  • Peer Reviewed
• [Journal Article] The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts. (2014)
  • Author(s): Matsui, H., Fukuno, N., Kanda, Y., Kantoh, Y., Chida, T., Nagaura, Y., Suzuki, O., Nishitoh, H., Takeda, K., Ichijo, H., Sawada, Y., Sasaki, K., Kobayashi, T. and Tamura, S.
  • Journal Title: J. Biol. Chem. Volume: 289 Issue: 10 Pages: 6438-6450
  • DOI: 10.1074/jbc.m113.536300
  • Peer Reviewed / Open Access
• [Journal Article] Apoptosis signal-regulating kinase 1 is a novel target molecule for cognitive impairment induced by chronic cerebral hypoperfusion. (2014)
  • Author(s): Toyama K, Koibuchi N, Uekawa K, Hasegawa Y, Kataoka K, Katayama T, Sueta D, Ma MJ, Nakagawa T, Yasuda O, Tomimoto H, Ichijo H, Ogawa H, Kim-Mitsuyama S
  • Journal Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 34 Issue: 3 Pages: 616-625
  • DOI: 10.1161/atvbaha.113.302440
  • Peer Reviewed
• [Journal Article] SOD1 as a molecular switch for initiating the homeostatic ER stress respouse under zinc deficiency. (2013)
  • Author(s): Homma, K., Fujisawa. T., Tsuburaya, N., Yamaguchi, N., Kadowaki, H., Takeda, K., Nishitoh, H., Matsuzawa, A., Naguro, I., and Ichijo, H.
  • Journal Title: Molecular Cell Volume: 52 Issue: 1 Pages: 75-86
  • DOI: 10.1016/j.molcel.2013.08.038
  • Peer Reviewed
• [Journal Article] Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic s cell exhaustion (2013)
  • Author(s): Yamaguchi, K., Takeda, K., Kadowaki, H., Ueda, I., Namba, Y., Ouchi, Y. Nishitoh, H. and Ichijo, H.
  • Journal Title: Biochim. Biophys. Acta. Volume: 1830 Issue: 6 Pages: 3656-3663
  • DOI: 10.1016/j.bbagen.2013.01.029
  • Peer Reviewed
• [Journal Article] Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling (2013)
  • Author(s): Shiizaki, S., Naguro, I. and Ichijo, H.
  • Journal Title: Adv. Biol. Regul. Volume: 53 Issue: 1 Pages: 135-144
  • DOI: 10.1016/j.jbior.2012.09.006
  • Peer Reviewed
• [Journal Article] Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin. (2013)
  • Author(s): Takada, E., Furuhata, M., Nakae, S., Ichijo, H., Sudo, K. and Mizuguchi, J.
  • Journal Title: Int. Arch. Allergy Immunol. Volume: 162 Issue: 2 Pages: 104-114
  • DOI: 10.1159/000353240
  • Peer Reviewed
• [Journal Article] Integration of the Apoptosis signal-regulating kinase 1-mediated stress signaling with the Akt/PKB-IκB kinase cascade (2013)
  • Author(s): Puckett, M.C., Goldman, E.H., Cockrell, L.M., Huang, B., Kasinski, A.L., Du, Y., Wang, C.Y., Lin, A., Ichijo, H., Khuri, F. and Fu, H.
  • Journal Title: Mol. Cell. Biol. Volume: 33 Issue: 11 Pages: 2252-2259
  • DOI: 10.1128/mcb.00047-13
  • Peer Reviewed
• [Journal Article] Apoptosis Signal-regulating Kinase 1 deficiency attenuates vascular injury-induced neointimal hyperplasia by suppressing apoptosis in smooth muscle cells. (2013)
  • Author(s): Tasaki, T., *Yamada, S., Guo, X., Tanimoto, A., Wang, K-T., Nabeshima, A., Kitada, S., Noguchi H., Kimura, S., Shimajiri, S., Kohno, K., Ichijo, H. and Sasaguri, Y.
  • Journal Title: Am. J. Pathol. Volume: 182 Issue: 2 Pages: 597-609
  • DOI: 10.1016/j.ajpath.2012.10.008
  • Peer Reviewed
• [Journal Article] Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury. (2013)
  • Author(s): Katome, T., Namekata, K., Guo, X., Semba, K., Kittaka, D., Kawamura, K., Kimura, A., Harada, C., Ichijo, H., Mitamura, Y. and Harada, T.
  • Journal Title: Cell Death Differ. Volume: 20 Issue: 2 Pages: 270-280
  • DOI: 10.1038/cdd.2012.122
  • Peer Reviewed
• [Journal Article] ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney. (2012)
  • Author(s): Naguro I., et al.
  • Journal Title: Nature Communications Volume: 3 Issue: 1 Pages: 1285-1285
  • DOI: 10.1038/ncomms2283
  • Peer Reviewed
• [Journal Article] The kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5 (2012)
  • Author(s): Yusuke Sekine, Ryo Hatanaka, Takeshi Watanabe. Naoki Sono, Shun-ichiro Iemura, Tohru Natsume, Erina Kuranaga, Masayuki Miura, Kohsuke Takeda, and Hidenori Ichijo
  • Journal Title: Molecular Cell Volume: 48 Issue: 5 Pages: 1-13
  • DOI: 10.1016/j.molcel.2012.09.018
  • NAID: 120007150217
  • Peer Reviewed
• [Journal Article] Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5 (2012)
  • Author(s): Sekine, S., et al.
  • Journal Title: J. Biol. Chem. Volume: 287 Issue: 41 Pages: 34635-34645
  • DOI: 10.1074/jbc.m112.357509
  • Peer Reviewed
• [Journal Article] A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants. (2012)
  • Author(s): Fujisawa, T., Homma, K., et al.
  • Journal Title: Ann Neurol Volume: 72 Issue: 5 Pages: 739-749
  • DOI: 10.1002/ana.23668
  • Peer Reviewed
• [Journal Article] Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway (2012)
  • Author(s): Soga, M., Matsuzawa, A., Ichijo, H.
  • Journal Title: Int. J. Cell Biol. Volume: 2012 Pages: 439587-439587
  • DOI: 10.1155/2012/439587
  • Peer Reviewed
• [Journal Article] Roles for the stress-responsive kinase ASK1 and ASK2 in tumorigenesis (2012)
  • Author(s): Kamiyama, M., Sato, T., Takeda, K. and Ichijo, H.
  • Journal Title: Chemibiomolecular Science: At the Frontier of Chemistry and Biology, Shibasaki, M., Iino, M. Osada, H.(Eds)(Springer Japan KK) Pages: 145-153
• [Journal Article] Therapeutic targets in the ASK1-dependent stress signaling pathways (2012)
  • Author(s): Hayakawa, R., Hayakawa, T., Takeda, K. and Ichijo, H.
  • Journal Title: Proceedings of the Japan Academy, Series B Volume: 88 Issue: 8 Pages: 434-453
  • DOI: 10.2183/pjab.88.434
  • NAID: 130001924759
  • ISSN: 0386-2208, 1349-2896
  • Peer Reviewed
• [Journal Article] The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses (2012)
  • Author(s): Kanamaru, Y., Sekine S., Ichijo, H. and Takeda, K.
  • Journal Title: J. Signal Transduc. Volume: 2012 Pages: 12-12
  • DOI: 10.1155/2012/931215
  • Peer Reviewed
• [Journal Article] Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer. (2012)
  • Author(s): Hayakawa, Y., Hirata, Y., Sakitani, K., Nakagawa, H., Nakata, W., Kinoshita, H., Takahashi, R., Takeda, K., Ichijo, H., Maeda1, S. and Koike, K.
  • Journal Title: Cancer Sci. Volume: 103 Issue: 12 Pages: 2181-2185
  • DOI: 10.1111/cas.12024
  • Peer Reviewed
• [Journal Article] ASK1 promotes apoptosis of normal and malignant plasma cells. (2012)
  • Author(s): Lin, F.R., Huang, S.Y., Hung, K.H., Su, S.T., Chung, C.H., Matsuzawa, A., Hsiao, M., Ichijo, H. and Lin, K.I.
  • Journal Title: Blood Volume: 120 Issue: 5 Pages: 1039-1047
  • DOI: 10.1182/blood-2011-12-399808
  • Peer Reviewed
• [Journal Article] Novel mechanism of angiotensin II-induced cardiacinjury in hypertensive rats : the critical role of ASK1 (2012)
  • Author(s): Nako, H., et al.
  • Journal Title: Hypertens.Res. Volume: 35 Issue: 2 Pages: 194-200
  • DOI: 10.1038/hr.2011.175
  • Peer Reviewed
• [Journal Article] Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster (2012)
  • Author(s): Ishida, Y., et al.
  • Journal Title: PloS ONE Volume: 7 Issue: 2 Pages: 3006-3016
  • DOI: 10.1371/journal.pone.0030265
  • Peer Reviewed
• [Journal Article] Apoptosis Signal-Regulating Kinase 1 Mediates MPTP Toxicity and Regulates Glial Activation (2012)
  • Author(s): Lee, K.W.
  • Journal Title: PloS ONE Volume: 7 Issue: 1 Pages: e29935-e29935
  • DOI: 10.1371/journal.pone.0029935
  • Peer Reviewed
• [Journal Article] ER stress activates the NLRP3 inflammasome via an UPR-independent pathway (2012)
  • Author(s): P. Menu, A. Mayor, R. Zhou, A. Tardivel, H. Ichijo, K. Mori and J. Tschopp
  • Journal Title: Cell Death Dis. Volume: 3 Issue: 1 Pages: e261-e261
  • DOI: 10.1038/cddis.2011.132
  • Peer Reviewed
• [Journal Article] Deletion of apoptosis signal regulating kinase-1 prevents ventilatorinduced lung injury in mice (2012)
  • Author(s): Makena, P.S., et al.
  • Journal Title: Am.J.Respir.Cell Mol.Biol Volume: (in press) Issue: 4 Pages: 461-469
  • DOI: 10.1165/rcmb.2011-0234oc
  • Peer Reviewed
• [Journal Article] p38 MAP kinase regulates the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors (2011)
  • Author(s): Sekine,Y., Takagahara,S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K., and Ichijo, H.
  • Journal Title: J. Cell Sci. Volume: 124 Issue: 17 Pages: 3006-3016
  • DOI: 10.1242/jcs.085902
  • Peer Reviewed
• [Journal Article] Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins (2011)
  • Author(s): Hayakawa, T., Kato, K., Hayakawa, R., Hisamoto, N., Matsumoto, K., Takeda, K. and Ichijo, H.
  • Journal Title: Genetics Volume: 187 Issue: 3 Pages: 785-792
  • DOI: 10.1534/genetics.110.124883
  • Peer Reviewed
• [Journal Article] MAPKs in mammalian oxidative stress responses (2011)
  • Author(s): Runchel, C., Matsuzawa, A., and Ichijo, H.
  • Journal Title: Antioxid. Redox Signal. Volume: 15 Issue: 1 Pages: 205-218
  • DOI: 10.1089/ars.2010.3733
• [Journal Article] Apoptosis signaling kinases: from stress response to health outcomes (2011)
  • Author(s): Takeda, K., Naguro, I., Nishitoh, H., Matsuzawa, A. and Ichijo, H.
  • Journal Title: Antioxid. Redox Signal. Volume: 15 Issue: 3 Pages: 719-761
  • DOI: 10.1089/ars.2010.3392
  • Peer Reviewed
• [Journal Article] HSV infection induces production of ROS which potentiate signaling from pattern recognition receptors : role for S-gluta hionylation of TRAF3 and 6 (2011)
  • Author(s): Dosal, RG.
  • Journal Title: PLoS Pathogens Volume: 7 Issue: 9 Pages: e1002250-e1002250
  • DOI: 10.1371/journal.ppat.1002250
  • Peer Reviewed
• [Journal Article] Apoptosis Signal-Regulating Kinase 1 Deficiency Accelerates Hyperlipidemia-Induced Atheromatous Plaques via Suppression of Macrophage Apoptosis (2011)
  • Author(s): Yamada, S.
  • Journal Title: Arterioscler.Thromb.Vasc.Biol. Volume: 31 Issue: 7 Pages: 1555-1564
  • DOI: 10.1161/atvbaha.111.227140
  • Peer Reviewed
• [Journal Article] Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated MAPK (2011)
  • Author(s): Nakagawa, H.
  • Journal Title: Hepatology Volume: 54 Issue: 1 Pages: 185-195
  • DOI: 10.1002/hep.24357
  • Peer Reviewed
• [Journal Article] Identification of novel ASKI inhibitors using virtual screening. (2011)
  • Author(s): Okamoto, M., et al.
  • Journal Title: Bioorg.Med.Chem. Volume: 19 Pages: 486-489
  • Peer Reviewed
• [Journal Article] Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase(ASK)family proteins (2011)
  • Author(s): Hayakawa, T., et al.
  • Journal Title: Genetics Volume: 187 Pages: 785-792
  • Peer Reviewed
• [Journal Article] Apoptosis signal-regulating kinase 1 and cyclin D 1 compose apositive feedback loop contributing to tumor growth in gastric cancer. (2011)
  • Author(s): Hayakawa, Y., et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA. Volume: 108 Pages: 780-785
  • Peer Reviewed
• [Journal Article] MAPKs in mammalian oxidative stress responses. (2011)
  • Author(s): Runchel, C., et al.
  • Journal Title: Antioxid.Redox Signal Volume: (掲載確定)
  • Peer Reviewed
• [Journal Article] Apoptosis signaing inases : from stress response to health outcomes. (2011)
  • Author(s): Takeda, K., et al.
  • Journal Title: Antioxid.Redox Signal. Volume: (掲載確定)
  • Peer Reviewed
• [Journal Article] ER stress-induced cell death and inflammatory signaling : atherapeutic insight into intractable diseases. (2011)
  • Author(s): Shimizu, Y., et al.
  • Journal Title: Endoplasmic Reticulum Stress and Human Disease Volume: In press(掲載確定)
  • Peer Reviewed
• [Journal Article] CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response (2010)
  • Author(s): Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishitoh, H. and Ichijo H.
  • Journal Title: EMBO J. Volume: 4 Issue: 15 Pages: 2501-2514
  • DOI: 10.1038/emboj.2010.141
• [Journal Article] ASK1: Molecule Pages (2010)
  • Author(s): Matsuzawa, A., Takeda, K. and Ichijo, H.
  • Journal Title: UCSD-Nature Signaling Gateway
  • DOI: 10.1038/mp.a002816.01
  • Peer Reviewed
• [Journal Article] Regulation of Apoptosis Signal-regulating Kinase 1 in redox signaling (2010)
  • Author(s): Katagiri, K., Matsuzawa, A. and Ichijo H.
  • Journal Title: Methods in Enzymology Volume: 474 Pages: 277-288
  • DOI: 10.1016/s0076-6879(10)74016-7
• [Journal Article] CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. (2010)
  • Author(s): Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro. I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishitoh, H., Ichijo H.
  • Journal Title: EMBO J. 4 Pages: 2501-2514
• [Journal Article] The Loss of PGAM5 Suppresses the_Mitochondrial Degeneration Caused by Inactivation of PINKI in Drosophila. (2010)
  • Author(s): Imai, Y., et al.
  • Journal Title: PLoS Genef Volume: 6
  • Peer Reviewed
• [Journal Article] Regulation of the severity of neuroinflammation and demyelination by TLR-ASKI-p38_pathway. (2010)
  • Author(s): Guo, X., et al.
  • Journal Title: EMBO Molecular Medicine Volume: 2 Pages: 504-515
  • Peer Reviewed
• [Journal Article] Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts. (2010)
  • Author(s): Roy, S., et al.
  • Journal Title: Cardiovasc Res. Volume: 87 Pages: 647-655
  • Peer Reviewed
• [Journal Article] poptsis osigna-regu ating inase 1 deficiency eliminates cardiovascular injuries.induced by high-salt diet. (2010)
  • Author(s): Kataoka, K., et al.
  • Journal Title: J.Hypertens. Volume: 29 Pages: 76-84
  • Peer Reviewed
• [Journal Article] Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis. (2010)
  • Author(s): Mnich, S.J., et al.
  • Journal Title: Int.Immunopharmacol. Volume: 10 Pages: 1170-1176
  • Peer Reviewed
• [Journal Article] ASKI : Molecule Pages (2010)
  • Author(s): Matsuzawa, A., et al.
  • Journal Title: UCSD-Nature Signaling Gateway
  • Peer Reviewed
• [Journal Article] CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. (2010)
  • Author(s): Maruyama, T., et al.
  • Journal Title: EMBO J. Volume: 4 Pages: 2501-2514
  • Peer Reviewed
• [Journal Article] Regulation of Apoptosis Signal-regulating Kinase l in redox signaling. (2010)
  • Author(s): Katagiri, K., et al.
  • Journal Title: Methods in Enzymology Volume: 474 Pages: 277-288
  • Peer Reviewed
• [Journal Article] ASK1 deficiency attenuates neural cell death in GLAST deficientmice, a model of normal tension glaucoma. (2010)
  • Author(s): Harada, C., et al.
  • Journal Title: Cell Death Differ. Volume: 17 Pages: 1751-1759
  • Peer Reviewed
• [Journal Article] Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1(ASK1)-deficientmice. (2010)
  • Author(s): Kumakura, K., et al.
  • Journal Title: Neurosci.Res. 66 Pages: 313-320
  • Peer Reviewed
• [Journal Article] Apoptosis Signal-Regulating Kinase 1 regulates colitis and colitis-associated tumorigenesis via the innate immune responses. (2010)
  • Author(s): Hayakawa, Y., et al.
  • Journal Title: Gastroenterology 138 Pages: 1055-1067
  • Peer Reviewed
• [Journal Article] Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation. (2010)
  • Author(s): Seong, H.A., et al.
  • Journal Title: J.Biol.Chem. 285 Pages: 2397-2414
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): 武田弘資, 他
  • Journal Title: 創薬科学の魅力-東京大学大学院薬学系研究科からの発信-(廣川書店) Pages: 317-333
• [Journal Article] Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death (2009)
  • Author(s): Nagai, H,, Noguchi, T., Homma, K., Katagiri, K., Takeda, K., Matsuzawa, A. and Ichijo H.
  • Journal Title: Mol. Cell Volume: 36 Issue: 5 Pages: 805-818
  • DOI: 10.1016/j.molcel.2009.10.016
• [Journal Article] Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/ threonine phosphatase to activate ASK1 (2009)
  • Author(s): Takeda, K., Komuro, Y., Hayakawa, T., Oguchi, H., Ishida, Y., Murakami, S., Noguchi, T., Kinoshita, H., Sekine, Y., Iemura, S., Natsume, T., and Ichijo H.
  • Journal Title: Proc. Natl. Acad. Sci. USA. Volume: 106 Issue: 30 Pages: 12301-12305
  • DOI: 10.1073/pnas.0901823106
• [Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis (2009)
  • Author(s): Iriyama, T., Takeda, K., Nakamura, H., Morimoto, Y., Kuroiwa, T., Mizukami, J., Umeda, T., Noguchi, T., Naguro, I., Nishitoh, H., Saegusa, K., Tobiume, K., Homma, T., Shimada, Y., Tsuda, H., Aiko, S., Imoto, I., Inazawa, J., Chida, K., Kamei, Y., Kozuma, S., Taketani, Y., Matsuzawa, A. and Ichijo H.
  • Journal Title: EMBO J. Volume: 28 Issue: 7 Pages: 843-853
  • DOI: 10.1038/emboj.2009.32
• [Journal Article] USP14 inhibits ER-associated degradation via interaction with IRE1alpha (2009)
  • Author(s): Nagai, A., Kadowaki, H., Maruyama, T., Takeda, K., Nishitoh, H. and Ichijo, H.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 379 Issue: 4 Pages: 995-1000
  • DOI: 10.1016/j.bbrc.2008.12.182
• [Journal Article] Signaling pathways in invertebrate immune and stress response (2009)
  • Author(s): Hatanaka, R., Sekine, Y., Hayakawa, T., Takeda, K. and Ichijo H.
  • Journal Title: Invertebrate Survival Journal Volume: 6 Pages: 32-43
• [Journal Article] The roles of ASK family proteins in stress responses and diseases (2009)
  • Author(s): Hattori, K., Naguro, I., Runchel, C. and Ichijo H.
  • Journal Title: Cell Communication and Signaling Volume: 7 Issue: 1 Pages: 9-9
  • DOI: 10.1186/1478-811x-7-9
• [Journal Article] Stress-Activated MAP Kinase Cascades in Cellular Senescence (2009)
  • Author(s): Maruyama, J., Naguro, I., Takeda, K. and Ichijo H.
  • Journal Title: Curr. Med. Chem. Volume: 16 Issue: 10 Pages: 1229-1235
  • DOI: 10.2174/092986709787846613
• [Journal Article] Ubiquitin-like sequence in ASKI plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death. (2009)
  • Author(s): Nagai, H., Noguchi, T., Homma, K., Katagiri, K., Takeda, K., Matsuzawa, A., Ichijo H.
  • Journal Title: Mol. Cell 36 Pages: 805-818
• [Journal Article] Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. (2009)
  • Author(s): Takeda, K., Komuro, Y., Hayakawa, T., Oguchi, H., Ishida, Y., Murakami, S., Noguchi, T., Kinoshita, H., Sekine, Y., Iemura, S., Natsume, T., Ichijo H.
  • Journal Title: Proc.Natl.Acad.Sci.USA. 106 Pages: 12301-12305
• [Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. (2009)
  • Author(s): Iriyama, T., Takeda, K., Nakamura, H., Morimoto, Y., Kuroiwa, T., Mizukami, J., Umeda, T., Noguchi, T., Naguro, I., Nishitoh, H., Saegusa, K., Tobiume, K., Homma, T., Shimada, Y., Tsuda, H., Aiko, S., Imoto, I., Inazawa, J., Chida, K., Kamei, Y., Kozuma, S., Taketani, Y., Matsuzawa, A., Ichijo, H.
  • Journal Title: EMBO J. 28 Pages: 843-853
• [Journal Article] Apoptosis Signal-Regulating Kinase(ASK)-1 Mediates Apoptosis through activation of JNK1 following Engagement of Membrane Immunoglobulin. (2009)
  • Author(s): Furuhata, M.
  • Journal Title: Exp.Cell.Res. 315 Pages: 3467-3476
  • Peer Reviewed
• [Journal Article] Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A. (2009)
  • Author(s): Cekic, C., et al.
  • Journal Title: J.Bilo.Chem. 284 Pages: 31982-31991
  • Peer Reviewed
• [Journal Article] Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death. (2009)
  • Author(s): Nagai, H, et al.
  • Journal Title: Mol.Cell 36 Pages: 805-818
  • Peer Reviewed
• [Journal Article] A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis. (2009)
  • Author(s): Kundu M, et al.
  • Journal Title: Nat.Immunol. 10 Pages: 918-926
  • Peer Reviewed
• [Journal Article] Critical role of apoptosis signal-regulating kinase 1 in aldosterone/salt-induced cardiac inflammation and fibrosis. (2009)
  • Author(s): Nakamura, T., et al.
  • Journal Title: Hypertension 54 Pages: 544-551
  • Peer Reviewed
• [Journal Article] Mitochondrial Phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. (2009)
  • Author(s): Takeda, K., et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA. 13 Pages: 653-664
  • Peer Reviewed
• [Journal Article] Serine 58 of 14-3-3{zeta}is a molecular switch regulating ASK1 and oxidant stress-induced cell death. (2009)
  • Author(s): Zhou, J., et al.
  • Journal Title: Mol.Cell.Biol. 29 Pages: 4167-4176
  • Peer Reviewed
• [Journal Article] Targeting ASK1 in ER stress-related Neurodegenerative Diseases. (2009)
  • Author(s): Homma, K., et al.
  • Journal Title: Expert Opinion on Therapeutic Targets 13 Pages: 653-664
  • Peer Reviewed
• [Journal Article] Signaling pathways in invertebrate immune and stress response. (2009)
  • Author(s): Hatanaka, R., et al.
  • Journal Title: Invertebrate Survival Journal 6 Pages: 32-43
  • Peer Reviewed
• [Journal Article] The roles of ASK family proteins in stress responses and diseases. (2009)
  • Author(s): Hattori, K., et al.
  • Journal Title: Cell Communication and Signaling 7 Pages: 9-9
  • Peer Reviewed
• [Journal Article] Stress-Activated MAP Kinase Cascades in Cellular Senescence. (2009)
  • Author(s): Maruyama, J., et al.
  • Journal Title: Curr.Med.Chem. 16 Pages: 1229-1235
  • Peer Reviewed
• [Journal Article] Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. (2009)
  • Author(s): Galluzzi, L., et al.
  • Journal Title: Cell Death Differ. 16 Pages: 1093-1107
  • Peer Reviewed
• [Journal Article] Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1. (2009)
  • Author(s): Waak, J., et al
  • Journal Title: J.Bilo.Chem. 284 Pages: 14245-14257
  • Peer Reviewed
• [Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. (2009)
  • Author(s): Iriyama, T., et al.
  • Journal Title: EMBO J. 28 Pages: 843-853
  • Peer Reviewed
• [Journal Article] USP14 inhibits ER-associated degradation via interaction with IRE1 alpha. (2009)
  • Author(s): Nagai, A., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 379 Pages: 995-1000
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Nishitoh, H., et al.
  • Journal Title: Protein Misfolding Disorders : A Trip into the ER (ed Hetz, C.)(Bentham Science Publishers) Pages: 94-102
• [Journal Article] Signaling pathways in invertebrate immune and stress response (2009)
  • Author(s): Hatamaka, R. et al
  • Journal Title: Invertebrate Survival Jourmal 6 Pages: 32-43
  • Peer Reviewed
• [Journal Article] The roles of ASK family proteins in stress responses ond diseases. (2009)
  • Author(s): Hattori, K. er al.
  • Journal Title: Cell Communication and Signaling (In press)
  • Peer Reviewed
• [Journal Article] Stress-Activated MAP Kinass Cascades in Cellular Senescence. (2009)
  • Author(s): Maruyama, J. et al.
  • Journal Title: Curr. Med. Chem. 16
  • Peer Reviewed
• [Journal Article] Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. (2009)
  • Author(s): Galluzzi, L. et al.
  • Journal Title: Cell Death Differ (In press)
  • Peer Reviewed
• [Journal Article] Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1. (2009)
  • Author(s): Waak, J. et al
  • Journal Title: J. Biol. Chem. (In press)
  • Peer Reviewed
• [Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. (2009)
  • Author(s): Iriyama, T. et al.
  • Journal Title: EMBO J., 28 Pages: 843-853
  • Peer Reviewed
• [Journal Article] USP14 inhibits ER-associated degradation via interaction with IEW1alpha (2009)
  • Author(s): Nagai, A. et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 379 Pages: 998-1000
  • Peer Reviewed
• [Journal Article] ALS-linked mutant SOD1 induces ER stress-and ASK1-dependent motor neuron death by targeting Derlin-1 (2008)
  • Author(s): Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K. and Ichijo H.
  • Journal Title: Genes Dev. Volume: 22 Issue: 11 Pages: 1451-1464
  • DOI: 10.1101/gad.1640108
• [Journal Article] Molecular Mechanism of Reactive Oxygen Species-dependent ASK1 Activation in Innate Immunity (2008)
  • Author(s): Yamauchi, S., Noguchi, T. and Ichijo H.
  • Journal Title: Immune Network Volume: 8 Pages: 1-6
• [Journal Article] Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling (2008)
  • Author(s): Matsuzawa, A. and Ichijo H.
  • Journal Title: Biochim. Biophys. Acta. Volume: 1780 Issue: 11 Pages: 1325-1336
  • DOI: 10.1016/j.bbagen.2007.12.011
• [Journal Article] Apoptosis Signal-regulating Kinase 1 (ASK1) in stress and immune response (2008)
  • Author(s): Takeda, K., Noguchi, T., Naguro, I. and Ichijo H.
  • Journal Title: Annu.Rev. Pharmacol.Toxicol. Volume: 48 Issue: 1 Pages: 199-225
  • DOI: 10.1146/annurev.pharmtox.48.113006.094606
• [Journal Article] ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. (2008)
  • Author(s): Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K., Ichijo H.
  • Journal Title: Genes Dev. 22 Pages: 1451-1464
• [Journal Article] Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-jun n-terminal kinase activation. (2008)
  • Author(s): Nakagawa, H. et al.
  • Journal Title: Gastroenterology 135 Pages: 1047-1051
  • Peer Reviewed
• [Journal Article] Olmesartan prevents cardiovascular injury and hepatic steatosis in obesity and diabetes, accompanied by Apoptosis Signal regulating Kinase-1 inhibition. (2008)
  • Author(s): Yamamoto, E. et al.
  • Journal Title: Hypertension 52 Pages: 573-580
  • Peer Reviewed
• [Journal Article] Molecular Mechanism of Reactive Oxygen Species-dependent ASK1 Activation in Innate Immunity. (2008)
  • Author(s): Yamauchi, S. et al.
  • Journal Title: Immune Network 8 Pages: 1-6
  • Peer Reviewed
• [Journal Article] ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1 (2008)
  • Author(s): Nishitoh, H. et al.
  • Journal Title: Genes Dev 22 Pages: 1451-1464
  • Peer Reviewed
• [Journal Article] Requirement of reactive oxygen specis-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macrophage. (2008)
  • Author(s): Noguchi, T. et. al.
  • Journal Title: J. Biol. Chem. 283 Pages: 7657-7665
  • Peer Reviewed
• [Journal Article] Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling. (2008)
  • Author(s): Matsuzawa, A. et al.
  • Journal Title: Biochim. Biophys. Acta. 1780 Pages: 1325-1336
  • Peer Reviewed
• [Journal Article] Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death. (2008)
  • Author(s): WU, Y. et al.
  • Journal Title: Cell Death Differ. 15 Pages: 386-397
  • Peer Reviewed
• [Journal Article] Apoptosis signal-regulationg kinase 1 (ASK1)/p38 signaling pathway negatibely regulates physiological hypertrophy. (2008)
  • Author(s): Taniike, M. et al.
  • Journal Title: Circulation 117 Pages: 54552-54552
  • Peer Reviewed
• [Journal Article] Apoptosis Signal-regulationg Kinase 1 (ASK1) in stress and immune response. (2008)
  • Author(s): Takeda, K. et al.
  • Journal Title: Annu. Rev. Pharmacol. Toxicol. 117 Pages: 545-552
  • Peer Reviewed
• [Presentation] 細胞がストレスを感じる仕組みと疾患 (2013)
  • Author(s): 一條秀憲
  • Organizer: 第37回皮膚科免疫セミナー
  • Place of Presentation: 東京
  • Year and Date: 2013-03-02
• [Presentation] Regulation of cell death signals by ubiquitination and deubiquitination (2013)
  • Author(s): Ichijo, H.
  • Organizer: The 35th Naito Conference The Ubiquitin-proteasome system-
  • Place of Presentation: Sapporo
• [Presentation] Regulation of cell death signals by ubiquitination and deubiquitination (2013)
  • Author(s): Hidenori Ichijo
  • Organizer: The 35th Naito Conference The Ubiquitin-proteasome system-
  • Place of Presentation: 北海道札幌市
• [Presentation] レドックス場としてのASK1シグナル複合体と細胞死 (2013)
  • Author(s): 一條秀憲
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] Stress Signaling in Cell Death and Disease (2013)
  • Author(s): Hidenori Ichijo
  • Organizer: The 8th Japan-Korea conference on cellular signalling for young scientists
  • Place of Presentation: 福岡県福岡市
• [Presentation] ALS発症のメカニズム (2012)
  • Author(s): 一條秀憲
  • Organizer: 第5回東京アンチエイジングアカデミー
  • Place of Presentation: 東京
  • Year and Date: 2012-06-21
• [Presentation] SOD1 as a molecular switch to initiate homeostatic ER stress response under conditions of zinc deficiency (2012)
  • Author(s): Hidenori Ichijo
  • Organizer: The 33rd Naito Conference: Oxygen Biology: Hypoxia, Oxidative Stress and Diseases
  • Place of Presentation: Sapporo
• [Presentation] ストレス応答の破綻と神経変性疾患 (2012)
  • Author(s): 一條秀憲
  • Organizer: 第39回日本脳科学会
  • Place of Presentation: 小倉
• [Presentation] ASK Family Kinases in Stress Response and Disease (2012)
  • Author(s): Hidenori Ichijo
  • Organizer: The 4th Takeda Science Foundation Symposium on Pharma Sciences "On the Frontiers of Chemical Biology"
  • Place of Presentation: Tokyo
• [Presentation] 細胞がストレスを感じるシグナル伝達の仕組みと疾患 (2012)
  • Author(s): 一條秀憲
  • Organizer: 日本分子生物学会第12回春季シンポジウム
  • Place of Presentation: 山梨県笛吹市
  • Invited
• [Presentation] SOD1 as a molecular switch to initiate homeostatic ER stress response under conditions of zinc deficiency (2012)
  • Author(s): Hidenori Ichijo
  • Organizer: 第33回内藤コンファレンス
  • Place of Presentation: 北海道札幌市
  • Invited
• [Presentation] Stress signaling in cell death, inflammation and disease (2012)
  • Author(s): Hidenori Ichijo
  • Organizer: Fifty-third International Symposium on Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues
  • Place of Presentation: Bologna, Italy
  • Invited
• [Presentation] ストレス応答の破綻と神経変性疾患 (2012)
  • Author(s): 一條秀憲
  • Organizer: 第39回日本脳科学会
  • Place of Presentation: 福岡県北九州市
  • Invited
• [Presentation] SOD1 as a molecular switch to initiate the homeostatic ER stress response (2012)
  • Author(s): Hidenori Ichijo
  • Organizer: The 2nd International Symposium by JSPS Core-to-Core Program “Cooperative International Framework in TGF-β Family Signaling”
  • Place of Presentation: 東京都 町田市
  • Invited
• [Presentation] ASK Family Kinases in Stress Response and Disease (2012)
  • Author(s): Hidenori Ichijo
  • Organizer: The 4th Takeda Science Foundation Symposium on PharmaSciences "On the Frontiers of Chemical Biology"
  • Place of Presentation: 東京都港区
  • Invited
• [Presentation] Redox control of cell death (2012)
  • Author(s): Hidenori Ichijo, Yusuke Sekine
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡県福岡市
• [Presentation] SOD1 as a molecular switch to initiate the homeostatic ER stress response under conditions of zinc deficiency (2012)
  • Author(s): Homma, K., et al
  • Organizer: The International Society for Zinc Biology (ISZB) 2012 Conference
  • Place of Presentation: St.Kilda, Australia(招待講演)
• [Presentation] 亜鉛枯渇時に働く小胞体ストレス誘導スイッチとしてのSOD1の新規機能 (2012)
  • Author(s): 一條秀憲、本間謙吾
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌(招待講演)
• [Presentation] ASK-Dependent Stress Signaling in Cell Death, Inflammation and Disease (2011)
  • Author(s): Hidenori Ichijo
  • Organizer: The Uehara Memorial Foundation Symposium.2011
  • Place of Presentation: Tokyo
  • Year and Date: 2011-06-08
• [Presentation] Stress signaling in cell death, infiammation and disease (2011)
  • Author(s): Hidenori Ichijo
  • Organizer: The 23th Annual Meeting of the Korean Society for Molecular and Cellular Biology
  • Place of Presentation: Korea
• [Presentation] 亜鉛枯渇によるSOD1-Derlin-1結合を介した小胞体ストレスの生理的意義 (2011)
  • Author(s): 一條秀憲, 他
  • Organizer: 第22回日本微量元素学会学術集会
  • Place of Presentation: 京都(招待講演)
• [Presentation] Stress signaling in cell death, inflammation and disease (2011)
  • Author(s): Ichijo, H
  • Organizer: The 23th Annual Meeting of the Korean Society for Molecular and Cellular Biology
  • Place of Presentation: Seoul, Korea(招待講演)
• [Presentation] ストレス応答シグナルと疾患 (2010)
  • Author(s): 一條秀憲
  • Organizer: 岩手医科大学「低侵襲医療実現のための患部ターゲティング医療開発研究プロジェクト」キックオフミーティング
  • Place of Presentation: 岩手医科大学
  • Year and Date: 2010-12-11
• [Presentation] ASK family signaling in Cancer and ALS (2010)
  • Author(s): Hidenori Ichijo
  • Organizer: Biomedical Research Seminar LUMC (Liden University Medical Center)
  • Place of Presentation: オランダ
  • Year and Date: 2010-09-08
• [Presentation] ASK family signaling in Cancer and ALS (2010)
  • Author(s): Hidenori Ichijo
  • Organizer: Biomedical Research Seminar LUMC(Liden University Medical Center)
  • Place of Presentation: オランダ
  • Year and Date: 2010-09-08
• [Presentation] ASK family signaling in Cancer and ALS (2010)
  • Author(s): Hidenori Ichijo
  • Organizer: Biomedical Research Seminar LUMC(Liden University Medicl Center)
  • Place of Presentation: ライデン, オランダ
  • Year and Date: 2010-09-08
• [Presentation] ASKファミリーによるストレス応答～細胞がストレスを感じる仕組みと疾患～ (2010)
  • Author(s): 一條秀憲
  • Organizer: 第29回分子病理学研究会
  • Place of Presentation: つくば
  • Year and Date: 2010-07-31
• [Presentation] ASKファミリーによるストレス応答～細胞がストレスを感じる仕組みと疾患～ (2010)
  • Author(s): 一條秀憲
  • Organizer: 第29回分子病理学研究会
  • Place of Presentation: つくば(招待講演)
  • Year and Date: 2010-07-31
• [Presentation] ASKファミリーによるストレス応答～細胞がストレスを感じる仕組みと疾患～ (2010)
  • Author(s): 一條秀憲
  • Organizer: 第29回分子病理学研究会
  • Place of Presentation: 筑波大学
  • Year and Date: 2010-07-31
• [Presentation] ASK family signaling in stress and disease (2010)
  • Author(s): Hidenori Ichijo
  • Organizer: University of Lausanne Seminar
  • Place of Presentation: Zurich, Switzerland
  • Year and Date: 2010-03-31
• [Presentation] ASK family signaling in stress and disease (2010)
  • Author(s): Hidenori Ichijo
  • Organizer: Emory University Seminar
  • Place of Presentation: Atlanta, USA
  • Year and Date: 2010-03-15
• [Presentation] ASK family signaling in stress and disease (2010)
  • Author(s): 一條秀憲
  • Organizer: 第15回愛知県がん国際シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2010-03-06
• [Presentation] ASKファミリーによるストレス応答機構と疾患 (2010)
  • Author(s): 一條秀憲
  • Organizer: 第9回細胞死研究会
  • Place of Presentation: 京都
• [Presentation] ASK-dependent Stress Signaling in Cell Death, Inflammation and Disease (2010)
  • Author(s): Hidenori Ichijo
  • Organizer: ISMC2010
  • Place of Presentation: ベルギー
• [Presentation] ミトコンドリア局在プロテインホスファターゼ PGM5によるストレス応答制御 (2010)
  • Author(s): 武田弘資,一條秀憲
  • Organizer: 第10回日本蛋白質科学会年会ワークショップ
  • Place of Presentation: 札幌
• [Presentation] 細胞がストレスを感じる仕組みと疾患 (2010)
  • Author(s): 一條秀憲
  • Organizer: 第64回日本口腔科学会学術集会シンポジウム
  • Place of Presentation: 札幌
• [Presentation] ASKファミリーを介したストレスシグナルによる発がん制御 (2010)
  • Author(s): 一條秀憲,武田弘資
  • Organizer: 第69回日本癌学会学術総会シンポジウム
  • Place of Presentation: 大阪
• [Presentation] ASK family signaling in ER stress and ALS (2010)
  • Author(s): Hidenori Ichijo
  • Organizer: APRU Research symposium on the Interface between Molecular Biology and Nano-Biology
  • Place of Presentation: Kyoto
• [Presentation] 細胞がストレスを感じる仕組みと疾患 (2010)
  • Author(s): 一條秀憲
  • Organizer: 第64回日本口腔科学会学術集会
  • Place of Presentation: 札幌プリンスホテル国際館
• [Presentation] ASK-dependent Stress Signaling in Cell Death, Inflammation and Disease (2010)
  • Author(s): Hidenori Ichijo
  • Organizer: ISMC2010
  • Place of Presentation: ブリュッセル, ベルギー
• [Presentation] ASKファミリーによるストレス応答機構～浸透圧ストレス応答と血圧制御～ (2009)
  • Author(s): 一條秀憲
  • Organizer: 第8回Vascular and Brain Conference
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-09
• [Presentation] ASK-dependent stress signaling in cell death inflammation, and disease (2009)
  • Author(s): 一條秀憲
  • Organizer: pfizer Seminar
  • Place of Presentation: USA
  • Year and Date: 2009-03-23
• [Presentation] Signaling through ASK1-JNK / p38 pathways (2009)
  • Author(s): Hidenori Ichijo
  • Organizer: 中国 Xiamen Universityセミナー
  • Place of Presentation: 中国
  • Year and Date: 2009-01-17
• [Presentation] ASKファミリーによるストレス応答 (2009)
  • Author(s): 一條秀憲
  • Organizer: 薬理学セミナー
  • Place of Presentation: 熊本
  • Year and Date: 2009-01-06
• [Presentation] Stress Signaling in Cell Death, Inflammation and Disease (2009)
  • Author(s): Hidenori Ichijo
  • Organizer: 日米シンポジウム
  • Place of Presentation: 新潟
• [Presentation] 神経変性の治療標的としてのストレスシグナル (2008)
  • Author(s): 一條秀憲
  • Organizer: CBI学会研究講演会「神経変性疾患の標的と創薬」
  • Place of Presentation: 東京
  • Year and Date: 2008-12-16
• [Presentation] 筋萎縮性側索硬化症における小胞体ストレス (2008)
  • Author(s): 一條秀憲
  • Organizer: BMB2008第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] ストレスシグナルと発がん(モーニングレクチャー) (2008)
  • Author(s): 一條秀憲
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] ストレスシグナルによるアポトーシスの制御機構～細胞がストレスを感じる仕組みと疾患～ (2008)
  • Author(s): 一條秀憲
  • Organizer: 第3回山陰先進医学研究会
  • Place of Presentation: 鳥取
  • Year and Date: 2008-06-12
• [Presentation] ストレス応答の制御機構-細胞がストレスを感じる仕組みと疾病- (2008)
  • Author(s): 一條秀憲
  • Organizer: 第6回幹細胞シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-05-27
• [Presentation] ストレス応答の制御機構～細胞がストレスを感じる仕組みと疾患～ (2008)
  • Author(s): 一條秀憲
  • Organizer: 第6回幹細胞シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-05-16
• [Presentation] 筋萎縮性側索硬化症における小胞体ストレス (2008)
  • Author(s): 一條秀憲
  • Organizer: BMB2008
  • Place of Presentation: 神戸
• [Presentation] ALS発症のメカニズム
  • Author(s): 一條秀憲
  • Organizer: 第５回東京アンチエイジングアカデミー
  • Place of Presentation: 東京都千代田区
  • Invited
• [Presentation] 筋萎縮性側索硬化症(ALS)に共通の分子構造変化と小胞体ストレス
  • Author(s): 一條秀憲
  • Organizer: H24年度戦略的研究展開事業研究会 「生体内劣化・変性・変質タンパク質分子動態イメージング技術の開発」
  • Place of Presentation: 東京都千代田
  • Invited
• [Remarks]
  • URL: http://www.f.u-tokyo.ac.jp/~toxicol/index.html
• [Patent(Industrial Property Rights)] 筋萎縮性側索硬化症.. (ALS)の診断のための抗体 (2010)
  • Inventor(s): 西頭英起、一條秀憲
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 2010-111375
  • Filing Date: 2010-05-13
• [Patent(Industrial Property Rights)] 筋萎縮性側索硬化症(ALS)の診断ための抗体 (2010)
  • Inventor(s): 西頭英起、一條秀憲
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 2010-111375
  • Filing Date: 2010-05-13
• [Patent(Industrial Property Rights)] 筋萎縮性側索硬化症(ALS)の診断のための抗体 (2010)
  • Inventor(s): 西頭英起、一條秀憲
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 2010-111375
  • Filing Date: 2010-05-13