Involvement of dopamine system and orbito frontal cortex in update and memory of value signals
| Project/Area Number |
20240040
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Tamagawa University (2010)
Kyoto Prefectural University of Medicine (2008-2009) |
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Principal Investigator |
KIMURA Minoru Kyoto Prefectural University of Medicine, 脳科学研究所, 教授 (40118451)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Naoyuki 京都府立医科大学, 医学研究科, 講師 (00252726)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥50,180,000 (Direct Cost: ¥38,600,000、Indirect Cost: ¥11,580,000)
Fiscal Year 2010: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2009: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2008: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
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| Keywords | ドーパミンニューロン / 線条体 / 価値判断 / 報酬予測 / 報酬予測誤差 / 試行錯誤 / 目標・ゴール / 教科学習 / 強化学習 / システム神経生理 / ニューロインフォマティクス |
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| Research Abstract |
We examined whether the midbrain dopamine neurons encode signals of long-term reward prediction and its error. Three Japanese monkeys performed multi-step choices for 3 rewards. Anticipatory licking during the task performance showed that monkey's expectation did not reflect reward probability of individual trials but precisely reflected reward value (probability x volume) of expected total rewards with future rewards discounted, value function of reinforcement learning. Remarkably, dopamine neuron activity encoded the long-term reward prediction rather than reward value of individual trials. The results suggested that the dopamine signals of long-term reward prediction may play critical roles in update of value signals for directing future goals in the target structures such as the striatum.
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Report
(4 results)
Research Products
(40 results)
