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Development ofnew nanogel-based drug delivery systems

Research Project

Project/Area Number 20240047
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKyoto University (2010-2012)
Tokyo Medical and Dental University (2008-2009)

Principal Investigator

AKIYOSHI Kazunari  京都大学, 工学研究科, 教授 (90201285)

Co-Investigator(Kenkyū-buntansha) SASAKI Yoshihiro  京都大学, 工学研究科, 准教授 (90314541)
SAWADA Shinichi  京都大学, 工学研究科, 助教 (50444104)
MORITA Ikuo  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (60100129)
MORIMOTO Nobuyuki  東北大学, 工学研究科, 准教授 (00313263)
Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥50,830,000 (Direct Cost: ¥39,100,000、Indirect Cost: ¥11,730,000)
Fiscal Year 2012: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥22,490,000 (Direct Cost: ¥17,300,000、Indirect Cost: ¥5,190,000)
Keywordsナノゲル / ヒドロゲル / タンパク質 / ドラッグデリバリー / 細胞機能 / 多糖 / タンパク質デリバリー / 核酸デリバリー / 反応性ナノゲル / 骨形成 / ビタミンB6 / リポソーム / Schiff塩基 / ドラッグデリバリーシステム / 再生医療用足場材料 / ナノゲル架橋微粒子 / プロスタグランジンE1 / 骨再生 / アパタイト / 有機-無機ハイブリッド
Research Abstract

We first reported new method of preparation of physically cross-linked nanogels by self-assembly of hydrophobized polysaccharides. In this project, we develop new polysaccharide nanogels by functional associating polymers and bottom-up nanogel engineering, in which nanogels are used as building blocks to control the nanostructure of macrogels, particles, sheets. Nanogel-based materials with functions of molecular chaperon are useful as protein delivery system and as scaffolds in regenerative medicine such as bone formation.

Report

(7 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (88 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (44 results) (of which Peer Reviewed: 42 results) Presentation (29 results) (of which Invited: 3 results) Book (15 results)

  • [Journal Article] Self-Assembled pH-Sensitive Cholesteryl Pullulan Nanogel As a Protein Delivery Vehicle2013

    • Author(s)
      Nobuyuki Morimoto, Sayaka Hirano, Haruko Takahashi, Scott Loethen, David H. Thompson, Kazunari Akiyoshi
    • Journal Title

      Biomacromolecules

      Volume: 14 Issue: 1 Pages: 56-63

    • DOI

      10.1021/bm301286h

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cholesteryl group- and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 fo bone tissue engineering2012

    • Author(s)
      Fujioka-Kobayashi Masako, et al.
    • Journal Title

      Biomaterials.

      Volume: 33 Issue: 30 Pages: 7613-7620

    • DOI

      10.1016/j.biomaterials.2012.06.075

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biodegradable Nanoge-integrated Hydrogels for Sustained Protein Delivery2012

    • Author(s)
      Asako Shimoda, et al.
    • Journal Title

      Macromolecular Research

      Volume: 20 Issue: 3 Pages: 266-270

    • DOI

      10.1007/s13233-012-0054-x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups2012

    • Author(s)
      Y. Sasaki, et al
    • Journal Title

      Polymers

      Volume: 4 Issue: 2 Pages: 1056-1064

    • DOI

      10.3390/polym4021056

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual crosslinked hydrogel nanoparticles by nanogel bottom-up method for sustained-release delivery2011

    • Author(s)
      Asako Shimoda, et al
    • Journal Title

      Colloids Surf B Biointerfaces

      Volume: (in press) Pages: 38-44

    • DOI

      10.1016/j.colsurfb.2011.09.025

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polysaccharide nanogel gene delivery system with endosome-escaping function: Co-delivery of plasmid DNA and phospholipase A22011

    • Author(s)
      Toita S, Sawada S, Akiyoshi K
    • Journal Title

      J Controlled Release

      Volume: 155 Issue: 1 Pages: 54-59

    • DOI

      10.1016/j.jconrel.2010.12.008

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell specific peptide-conjugated polysaccharide nanogels for protein delivery2011

    • Author(s)
      Asako Shimoda, et al
    • Journal Title

      Macromol Biosci

      Volume: Vol.11 Issue: 7 Pages: 882-888

    • DOI

      10.1002/mabi.201000491

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of protein-crosslinked nanogels with vitamin B6 bearing polysaccharide2011

    • Author(s)
      Sasaki Y, Tsuchido Y, Sawada S, Akiyoshi K
    • Journal Title

      Polym Chem

      Volume: 2 Issue: 6 Pages: 1267-1270

    • DOI

      10.1039/c1py00100k

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amphiphilic Polysaccharide Nanogels as Artificial Chaperones in Cell-Free Protein Synthesis2011

    • Author(s)
      Sasaki, Y, Asayama, W., Niwa, T., Sawada, S., Ueda, T., Taguchi, H., Akiyoshi, K.*
    • Journal Title

      Macromol. Biosci.

      Volume: 11 Issue: 6 Pages: 814-820

    • DOI

      10.1002/mabi.201000457

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclodextrin-responsive nanogel as an artificial chaperone for horseradish peroxidase2011

    • Author(s)
      Sawada S, Sasaki Y, Nomura Y, Akiyoshi K
    • Journal Title

      Colloid Polym Sci

      Volume: 289 Issue: 5-6 Pages: 685-691

    • DOI

      10.1007/s00396-010-2361-0

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amphiphilic Polysaccharide Nanoballs: A New Building Block for Nanogel Biomedical Engineering and Artificial Chaperones2011

    • Author(s)
      Takahashi H, Sawada S, Akiyoshi K
    • Journal Title

      ACS Nano

      Volume: 5 Issue: 1 Pages: 337-345

    • DOI

      10.1021/nn101447m

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amphiphilic Polysaccharide Nanogels as an Artificial Chaperone in Cell-Free Protein Synthesis2011

    • Author(s)
      Y.Sasaki, et al
    • Journal Title

      Macromolecular Bioscience

      Volume: 11 Pages: 814-820

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of protein-crosslinked nanogels with vitamin B6 bearing polysaccharide2011

    • Author(s)
      Y.Sasaki, et al
    • Journal Title

      Polymer Chemistry

      Volume: 2 Pages: 1267-1270

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amphiphilic Polysaccharide Nanoballs : A New Building Block for Nanogel Biomedical Engineering and Artificial Chaperones2011

    • Author(s)
      Takahashi H, Sawada S, Akiyoshi K
    • Journal Title

      ACS Nano 5

      Pages: 337-345

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Amphiphilic polysaccharide nanoballs : a new building block for nanogel biomedical engineering and artificial chaperone2011

    • Author(s)
      H.Takahashi, et al
    • Journal Title

      ACS Nano

      Volume: 5 Pages: 337-345

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nano-encapsulation of lipase by self-assembled nanogels: induction of high enzyme activity and thermal stabilization2010

    • Author(s)
      Sawada S, Akiyoshi K
    • Journal Title

      Macromol Biosci

      Volume: 10 Issue: 4 Pages: 353-358

    • DOI

      10.1002/mabi.200900304

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional cycloamylose-based biomaterial: application in a gene delivery system2010

    • Author(s)
      Toita S, Morimoto N, Akiyoshi K
    • Journal Title

      Biomacromolecules

      Volume: 11 Issue: 2 Pages: 397-401

    • DOI

      10.1021/bm901109z

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nano-encapsulation of lipase by self-assembled nanogels2010

    • Author(s)
      Sawada S, Akiyoshi K
    • Journal Title

      : induction of high enzyme activity and thermal stabilization, Macromol Biosci 10

      Pages: 353-358

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Nano-encapsulation of lipase by self-assembled nanogels : induction of high enzyme activity and thermal stabilization2010

    • Author(s)
      S.Sawada, et al
    • Journal Title

      Macromolecular Bioscience

      Volume: 10 Pages: 353-358

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an Artificial Chaperone System Based on Cyclodextrin2010

    • Author(s)
      Y.Sasaki, et al
    • Journal Title

      Current Pharmaceutical Biotechnology

      Volume: 11 Pages: 300-305

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA separation by cholesterol-bearing pullulan nanogels2010

    • Author(s)
      K.Kondo, et al
    • Journal Title

      Biomicrofluidics

      Volume: 4 Pages: 32210-33218

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polysaccharide nanogel-cyclodextrin system as artificial chaperone for in vitro protein synthesis of green fluorescent protein2010

    • Author(s)
      Y.Sasaki, et al
    • Journal Title

      Polymer Journal

      Volume: 42 Pages: 823-828

    • NAID

      10026687316

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanogel engineering for new nanobiomaterials : From chaperoning engineering to biomedical applications2010

    • Author(s)
      Y.Sasaki, et al
    • Journal Title

      The Chemical Record

      Volume: 10 Pages: 366-376

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metal coordinative-crosslinked polysaccharide nanogels with redox sensitivity2010

    • Author(s)
      Y.Sasaki, et al
    • Journal Title

      Chemistry Letters

      Volume: 40 Pages: 182-183

    • NAID

      10027814881

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional cycloamylose-based biomaterial : application in a gene delivery system2010

    • Author(s)
      S.Toita, et al
    • Journal Title

      Biomacromolecules 11

      Pages: 397-401

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nano-encapsulation of lipase by self-assembled nanogels : induction of high enzyme activity and thermal stabilization2010

    • Author(s)
      S.Sawada, et al
    • Journal Title

      Macromol Biosci (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cycloamylose-based biomaterial: nanogel of cholesterol-bearing cationic cycloamylose for siRNA delivery2009

    • Author(s)
      Toita S, Soma Y, Morimoto N, Akiyoshi K
    • Journal Title

      Chem Lett

      Volume: 38 Issue: 11 Pages: 1114-1115

    • DOI

      10.1246/cl.2009.1114

    • NAID

      10025548461

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cycloamylose-based biomaterial : nanogel of cholesterol-bearing cationic cycloamylose for siRNA delivery2009

    • Author(s)
      Toita S, Soma Y, Morimoto N, Akiyoshi K
    • Journal Title

      Chem Lett 38

      Pages: 1114-1115

    • NAID

      10025548461

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Composite Nanomaterials by Self-assembly and Controlled Crystallization of Poly(2-isopropyl-2-oxazoline)-Grafted Polysaccharide2009

    • Author(s)
      N.Morimoto, et al
    • Journal Title

      Soft Matter 5

      Pages: 1597-1600

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ANA deficiency enhances BMP-induced ectopic bone formation via trans criptional events2009

    • Author(s)
      K.Miyai, et al
    • Journal Title

      J Biol Chem 284

      Pages: 10593-10600

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polysaccharide nanogel delivery of a TNF-a and RANKL antagonist peptide allows systemic prevention of bone loss2009

    • Author(s)
      N.Alles, et al
    • Journal Title

      Eur J Pharm Sci 37

      Pages: 83-88

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoblastic bone formation is induced by using nanogel-crosslinking hydrogel as novel scaffold for bone growth factor2009

    • Author(s)
      C.Hayashi, et al
    • Journal Title

      J Cell Physiol 220

      Pages: 1-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of cholesterol-bearing pullulan (CHP)-nanogels in combination with prostaglandin El on wound healing2009

    • Author(s)
      H.Kobayashi, et al
    • Journal Title

      J Biomed Mater Res B 91

      Pages: 55-60

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cycloamylose-based Biomaterial : Nanogels of Cholesterol-bearing Cationic Cycloamylose for siRNA Delivery2009

    • Author(s)
      S.Toita, et al
    • Journal Title

      Chem Lett 38

      Pages: 1114-1115

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Raspberry-Like Assembly of Cross-Linked Nanogels for Protein Delivery2009

    • Author(s)
      U.Hasegawa, et al
    • Journal Title

      J Control Release 140

      Pages: 312-317

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      高橋治子, 秋吉一成, 三林浩二監修
    • Journal Title

      DDSナノデバイス,バイオ利用&健康デバイス(シーエムシー出版)

      Pages: 158-167

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      秋吉一成, 国武豊喜監修
    • Journal Title

      分子シャペロン機能工学,超分子サイエンス&テクノロジー(NTS)

      Pages: 158-167

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Hybrid Nanoapatitby Polysaccharide Nanogel -Templated Mineralization2009

    • Author(s)
      S. Yamane, et al
    • Journal Title

      J. Bioactive and Compatible Polymer 24

      Pages: 129-150

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-assembled cationic nanogels for intracellular protein delivery system2008

    • Author(s)
      Ayame H, Morimoto N, Akiyoshi K
    • Journal Title

      Bioconjugate Chem

      Volume: 19 Issue: 4 Pages: 882-890

    • DOI

      10.1021/bc700422s

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-assembled cationic nanogels for intracellular protein delivery system2008

    • Author(s)
      Ayame H, Morimoto N, Akiyoshi K
    • Journal Title

      Bioconjugate Chem 19

      Pages: 882-890

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Self-assembled cationic nanogels for intracellular protein delivery system2008

    • Author(s)
      H. Ayame, et al
    • Journal Title

      Bioconjugate Chem 19

      Pages: 882-890

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermo-responsive hydrogels with nanodomains : rapid shrinking of nanogel -crosslinking hydrogel of poly (N -isopropyl acrylamide)2008

    • Author(s)
      N. Morimoto, et al
    • Journal Title

      Macromolecular Rapid Communication s 29

      Pages: 672-676

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual stimuli-responsive nanogels by self-assembly of polysaccharides lightly grafted with thiol-terminated poly(N-isopropylacrylamide) chains.2008

    • Author(s)
      N. Morimoto, et al
    • Journal Title

      Macromolecules 41

      Pages: 5985-5987

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-assembeld nanogel of hydrophobized dendritic dextrin for protein delivery

    • Author(s)
      Y. Ozawa, et al
    • Journal Title

      Macromol. Bioscience 印刷中

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 多糖ナノゲル工学によるタンパク質 DDS の開発2013

    • Author(s)
      秋吉一成
    • Organizer
      第4回ナノバイオ創薬研究シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2013-03-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 多糖ナノゲルによるタンパク質,核酸バイオ医薬 DDS の開発2013

    • Author(s)
      秋吉一成
    • Organizer
      第6回 硬組織疾患ゲノムセンターシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2013-03-05
    • Related Report
      2012 Final Research Report
  • [Presentation] ナノゲル基盤有機-無機ハイブリッド材料の創製とバイオ応用2012

    • Author(s)
      秋吉一成
    • Organizer
      公益社団法人日本セラミック協会 第25回秋季シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] ナノゲル工学による新規タンパク質 DDS の開発2012

    • Author(s)
      秋吉一成
    • Organizer
      ファーマテックジャパンセミナー
    • Place of Presentation
      東京
    • Year and Date
      2012-03-22
    • Related Report
      2012 Final Research Report
  • [Presentation] ナノゲル工学による新規タンパク質DDSの開発2012

    • Author(s)
      秋吉一成
    • Organizer
      ファーマテックジャパンセミナー
    • Place of Presentation
      東京ビッグサイト(東京都)(招待講演)
    • Year and Date
      2012-03-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Amphiphilic enzymatically synthesized glycogen : new building block for nanogel engineering2012

    • Author(s)
      K.Akiyoshi, et al
    • Organizer
      5th KIFEE International Symposium on Environment, Energy, and Materials
    • Place of Presentation
      Kyoto, Japan(招待講演)
    • Year and Date
      2012-03-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nanogel engineering by associating polymers2011

    • Author(s)
      K. Akiyoshi
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2011-11-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Nanogel engineering by associating polymers2011

    • Author(s)
      K.Akiyoshi
    • Organizer
      KIPS-ESPCI Workshop on Polymer Science 2011
    • Place of Presentation
      京都大学(招待講演)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Polysaccharide nanogel engineering for antigen delivery system2011

    • Author(s)
      K. Akiyoshi
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2011-11-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Polysaccharide nanogel engineering for antigen delivery system2011

    • Author(s)
      K.Akiyoshi
    • Organizer
      3rd International Congress on Biohydrogels
    • Place of Presentation
      Florence, Italy(招待講演)
    • Year and Date
      2011-11-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] ナノゲル工学による新規材料設計2011

    • Author(s)
      秋吉一成
    • Organizer
      第63回コロイドおよび界面化学討論会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-08
    • Related Report
      2012 Final Research Report
  • [Presentation] ナノゲル工学による新規材料設計2011

    • Author(s)
      秋吉一成
    • Organizer
      第63回コロイドおよび界面化学討論会
    • Place of Presentation
      京都大学(招待講演)
    • Year and Date
      2011-09-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多糖ナノゲルと細胞との相互作用2011

    • Author(s)
      澤田晋一、秋吉一成
    • Organizer
      財団法人日本化学繊維研究所 第10回「高分子材料研究会」
    • Place of Presentation
      京都
    • Year and Date
      2011-06-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 多糖ナノゲルと細胞との相互作用2011

    • Author(s)
      澤田晋一, 秋吉一成
    • Organizer
      財団法人日本化学繊維研究所第10回「高分子材料研究会」
    • Place of Presentation
      京都タワーホテル(京都府)(招待講演)
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] ナノゲル工学のバイオマテリアルへの応用2010

    • Author(s)
      秋吉一成
    • Organizer
      第19回ポリマー材料フォーラム
    • Place of Presentation
      名古屋
    • Year and Date
      2010-12-02
    • Related Report
      2012 Final Research Report 2010 Self-evaluation Report
  • [Presentation] 新規バイオ材料設計のためのシャペロン機能工学2010

    • Author(s)
      秋吉一成
    • Organizer
      第59回高分子学会年次大会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nanogel Engineering for Protein Drug Delivery System2010

    • Author(s)
      K. Akiyoshi
    • Organizer
      6th Sweden-Japan Workshop on BioNano Technology
    • Place of Presentation
      shizuoka, Japan
    • Year and Date
      2010-05-11
    • Related Report
      2012 Final Research Report 2010 Self-evaluation Report
  • [Presentation] 多糖ナノゲル工学による新規バイオマテリアルの創製2009

    • Author(s)
      秋吉一成
    • Organizer
      第3回多糖の未来フォーラム-多糖の資源活用と機能探求に向けて-
    • Place of Presentation
      仙台
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Design of New Hydrogel Biomaterials by Nanogel Engineering2009

    • Author(s)
      秋吉一成
    • Organizer
      The 4th International Symposium on Integrated Molecular/Materials Engineering(ISIMME2009)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Polysaccharide nanogel engineering for protein delivery system2009

    • Author(s)
      K. Akiyoshi
    • Organizer
      KIFEE workshop on environment, Energy and Materials
    • Place of Presentation
      Trondheim, Norway
    • Year and Date
      2009-09-08
    • Related Report
      2012 Final Research Report 2010 Self-evaluation Report 2009 Annual Research Report
  • [Presentation] ナノゲル工学による新規DDSの設計2009

    • Author(s)
      秋吉一成
    • Organizer
      第27回物性物理化学研究会「DDSと製剤基材の物性」
    • Place of Presentation
      京都
    • Year and Date
      2009-06-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] ナノゲル工学による新規バイオマテリアルの設計と応用2009

    • Author(s)
      秋吉一成
    • Organizer
      第58回高分子学会年次大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-05-29
    • Related Report
      2012 Final Research Report 2009 Annual Research Report
  • [Presentation] Nanogel Engineering for Protein Delivery2009

    • Author(s)
      秋吉一成
    • Organizer
      8th International Symposium on Frontiers in Biomedical Polymers
    • Place of Presentation
      Mishima, Japan
    • Year and Date
      2009-05-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] ナノゲルを用いたDDS2008

    • Author(s)
      秋吉一成
    • Organizer
      第19回高分子ゲル研究会講座
    • Place of Presentation
      東京
    • Year and Date
      2008-12-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 分子シャペロン機能工学によるタンパク質の集積,機能制御2008

    • Author(s)
      秋吉一成
    • Organizer
      第24回日本DDS学会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-30
    • Related Report
      2012 Final Research Report 2010 Self-evaluation Report
  • [Presentation] 分子シャペロン機能工学によるタンパク質の集積, 機能制御2008

    • Author(s)
      秋吉一成
    • Organizer
      第24回日本DDS学会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ナノゲル基盤有機-無機ハイブリッド材料の創製とバイオ応用

    • Author(s)
      秋吉一成
    • Organizer
      公益社団法人日本セラミック協会 第25回秋季シンポジウム
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 多糖ナノゲルによるタンパク質,核酸バイオ医薬DDSの開発

    • Author(s)
      秋吉一成
    • Organizer
      第6回 硬組織疾患ゲノムセンターシンポジウム
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 多糖ナノゲル工学によるタンパク質DDSの開発

    • Author(s)
      秋吉一成
    • Organizer
      第4回ナノバイオ創薬研究シンポジウム
    • Place of Presentation
      京都大学(京都府)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 自己組織化と機能材料,最先端材料システムOne Point 32012

    • Author(s)
      佐々木善浩,秋吉一成
    • Publisher
      共立出版
    • Related Report
      2012 Final Research Report
  • [Book] 自己組織化と機能材料,最先端材料システムOne Point 32012

    • Author(s)
      佐々木善浩,秋吉一成
    • Publisher
      共立出版
    • Related Report
      2012 Annual Research Report
  • [Book] 量子ドットデリバリーシステム, 蛍光イメージング/MRI プローブの開発2011

    • Author(s)
      戸井田さやか,秋吉一成,西成勝好 監修
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Final Research Report
  • [Book] 量子ドットデリバリーシステム,蛍光イメージング/MRIプローブの開発2011

    • Author(s)
      戸井田さやか, 秋吉一成
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Annual Research Report
  • [Book] ナノゲル工学によるDDSキャリアの開発と応用,食品・化粧品・医療分野へのゲルの利用2010

    • Author(s)
      戸井田さやか,秋吉一成,西成勝好 監修
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Final Research Report
  • [Book] 人工分子シャペロンシステム,酵素利用技術体系-基礎・解析から改変・高機能化・産業利用まで-2010

    • Author(s)
      高橋治子,秋吉一成,小宮山眞 監修
    • Publisher
      NTS
    • Related Report
      2012 Final Research Report
  • [Book] 食品・化粧品・医療分野へのゲルの利用(ナノゲル工学によるDDSキャリアの開発と応用)2010

    • Author(s)
      戸井田さやか, 秋吉一成, 西成勝好 監修
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Self-evaluation Report
  • [Book] 人工シャペロンシステム,酵素利用技術大系-基礎・解析から改変・高機能化・産業利用まで-2010

    • Author(s)
      高橋治子, 秋吉一成
    • Publisher
      NTS
    • Related Report
      2010 Annual Research Report
  • [Book] 先端医療に活きるコロイド界面化学と技術,リポソーム,現代界面コロイド科学の事典2010

    • Author(s)
      秋吉一成
    • Publisher
      日本化学会
    • Related Report
      2010 Annual Research Report
  • [Book] DDSナノデバイス,バイオ利用&健康デバイス2009

    • Author(s)
      高橋治子,秋吉一成,三林浩二 監修
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Final Research Report
  • [Book] 分子シャペロン機能工学,超分子 サイエンス& テクノロジー2009

    • Author(s)
      秋吉一成,国武豊喜 監修
    • Publisher
      NTS
    • Related Report
      2012 Final Research Report
  • [Book] 超分子 サイエンス & テクノロジー(分子シャペロン機能工学)2009

    • Author(s)
      秋吉一成, 国武豊喜 監修
    • Publisher
      NTS
    • Related Report
      2010 Self-evaluation Report
  • [Book] 次世代医療のための高分子材料工学2008

    • Author(s)
      秋吉一成,岸田晶夫 監修
    • Total Pages
      238
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Final Research Report
  • [Book] 次世代医療のための高分子材料工学2008

    • Author(s)
      秋吉一成, 岸田晶夫 監修
    • Total Pages
      238
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Self-evaluation Report
  • [Book] 次世代医療のための高分子材料工学2008

    • Author(s)
      秋吉一成, 岸田晶夫監修
    • Total Pages
      286
    • Publisher
      シーエムシー出版
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2019-07-29  

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