| Budget Amount *help |
¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2011: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2009: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Research Abstract |
Bacteria have evolved two-component signal transduction systems (TCS), which are comprisedof sensor histidine kinases(HK) and theircognate response regulators(RR, transcriptional factor). Bacterial cells have a number of TCSs to respond to various environmental stresses. Comprehensive transcriptome studies of these TCSs suggest that they interact with each other by means of a signal transduction network. In Escherichia colicells, we haveclarified the molecular mechanism of how EvgS/EvgA TCS connects to PhoQ/PhoP TCS via a connector SafA.
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