| Budget Amount *help |
¥40,820,000 (Direct Cost: ¥31,400,000、Indirect Cost: ¥9,420,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
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| Research Abstract |
We have succeeded in the development of 2, 4, 6-triethyl-1, 3, 5-di(alkylamino) benzene dynamic combinatorial library having affinity to hemin by utilizing aldehyde/amine-imine equilibrium reaction between 2, 4, 6-triethyl-1, 3, 5-benzenetricarbaldehyde(1) scaffold and amines. Increased products in the presence of hemin had higher affinity with hemin than not increased products. Porphyrin having four aldehyde precursors as a scaffold was synthesized. Equilibrium reaction between scaffold 1 and boomerang-form diamines converged to a cage-type supramolecule mainly.
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