| Project/Area Number |
20249030
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
HIRANO Toshio Osaka University, 生命機能研究科, 教授 (40136718)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Masaaki 大阪大学, 生命機能研究科, 准教授 (00250514)
KAMIMURA Daisuke 大阪大学, 生命機能研究科, 助教 (20391922)
FUKUSHIMA Toru 大阪大学, 医学系研究科, 助教 (60447977)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKADA Toshiyuki 理化学研究所, 免疫アレルギー総合科学研究センター, 上級研究員 (70373363)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥50,700,000 (Direct Cost: ¥39,000,000、Indirect Cost: ¥11,700,000)
Fiscal Year 2010: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2009: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2008: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
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| Keywords | 亜鉛 / 亜鉛トランスポーター / Zip13 / STAT3 / 免疫反応 |
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| Research Abstract |
We here attempt to investigate intracellular Zn signaling, which is important for cell fate and/or cell activation status determination followed by various diseases and disorders. We mainly have three results, which are obtained by this grant. (I) Investigation of intracellular Zn signals, (II) Molecular basis of Zn signal to analyze Zn-binding sites in the target molecules and their mechanism, and (III) in vivo significances of Zn signal using various Zn-related molecule deficient mice and several disease/disorder models.
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