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PHARMACOKINETICS IN THE PATIENTS WITH METABOLIC SYNDROME AND APPLICATION FOR PHARMACOTHERAPY

Research Project

Project/Area Number 20249036
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionKyoto University

Principal Investigator

INUI Ken-ichi  Kyoto University, 医学研究科, 名誉教授 (70034030)

Co-Investigator(Kenkyū-buntansha) KATSURA Toshiya  京都大学, 医学研究科, 准教授 (10283615)
MASUDA Satoshiro  京都大学, 医学研究科, 講師 (90303825)
TERADA Tomohiro  京都大学, 医学研究科, 薬剤部副薬剤部長 (10324641)
YONEZAWA Atsushi  京都大学, 医学研究科, 助教 (90452341)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000)
Fiscal Year 2010: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2009: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2008: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Keywords薬学 / 薬剤反応 / 薬物トランスポータ / 転写因子 / 核内受容体 / メトホルミン / メタボリックシンドローム / 小腸 / 腎臓 / 肝臓
Research Abstract

Drug response is likely altered in the patient with metabolic syndrome. The present results indicated that the expression levels of drug transporters were varied, and pharmacokinetics was changed in several diseases. Especially, we clearly revealed that an efflux transporter MATE1 could influence the sensitivities of anti-diabetic drug metformin and anti-cancer drug cisplatin. These outcomes can lead to the optimized pharmacotherapy in metabolic syndrome patients.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (111 results)

All 2011 2010 2009 2008 Other

All Journal Article (58 results) (of which Peer Reviewed: 58 results) Presentation (51 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Effects of metabolic acidosis on expression levels of renal drug transporters.2011

    • Author(s)
      Gaowa A, Motohashi H, Katsura T, Inui K.
    • Journal Title

      Pharm Res 28

      Pages: 1023-1030

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Organic cation transporter OCT/SLC22A and H^+/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents.2011

    • Author(s)
      Yonezawa A, Inui K.
    • Journal Title

      Biochem Pharmacol 81

      Pages: 563-568

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Maternal riboflavin deficiency, resulting in transient neonatal-onset glutaric aciduria Type 2, is caused by a microdeletion in the riboflavin transporter gene GPR172B.2011

    • Author(s)
      Ho, G., et al.
    • Journal Title

      Human Mutation

      Volume: 32

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organic cation transporter OCT/SLC22A and H+/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents.[Review]2011

    • Author(s)
      Yonezawa, A., et al.
    • Journal Title

      Biochemical Pharmacology

      Volume: 81 Pages: 563-568

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maternal riboflavin deficiency, resulting in transient neonatal-onset glutaric aciduria Type 2, is caused by a microdeletion in the riboflavin transporter gene GPR172B.2010

    • Author(s)
      Ho G, Yonezawa A, Masuda S, Inui K, 以下7名
    • Journal Title

      Hum Mutat 32

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ABCG2 421C>A polymorphism and high exposure of sunitinib in a patient with renal cell carcinoma.2010

    • Author(s)
      Mizuno T, Terada T, Kamba T, Fukudo M, Katsura T, Nakamura E, Ogawa O, Inui K.
    • Journal Title

      Ann Oncol 21

      Pages: 1382-1383

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss : a prospective clinical trial.2010

    • Author(s)
      Nakagawa T, Sakamoto T, Hiraumi H, Kikkawa YS, Yamamoto N, Hamaguchi K, Ono K, Yamamoto M, Tabata Y, Teramukai S, Tanaka S, Tada H, Onodera R, Yonezawa A, Inui K, Ito J.
    • Journal Title

      BMC Med 8

      Pages: 76-76

    • NAID

      120002661525

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity.2010

    • Author(s)
      Nakamura T, Yonezawa A, Hashimoto S, Katsura T, Inui K.
    • Journal Title

      Biochem Pharmacol 80

      Pages: 1762-1767

    • NAID

      120002619612

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of Cyclin B2 and Cell division cycle 2 on tubular hyperplasia in progressive chronic renal failure rats.2010

    • Author(s)
      Nishihara K, Masuda S, Nakagawa S, Yonezawa A, Ichimura T, Bonventre JV, Inui K.
    • Journal Title

      Am J Physiol Renal Physiol 298

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus-related cirrhosis is a major determinant of the expression levels of hepatic drug transporters.2010

    • Author(s)
      Ogasawara K, Terada T, Katsura T, Hatano E, Ikai I, Yamaoka Y, Inui K.
    • Journal Title

      Drug Metab Pharmacokinet 25

      Pages: 190-199

    • NAID

      10027582589

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.2010

    • Author(s)
      Toyama K, Yonezawa A, Tsuda M, Masuda S, Yano I, Terada T, Osawa R, Katsura T, Hosokawa M, Fujimoto S, Inagaki N, Inui K.
    • Journal Title

      Pharmacogenet Genomics 20

      Pages: 135-138

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice.2010

    • Author(s)
      Watanabe S, Tsuda M, Terada T, Katsura T, Inui K.
    • Journal Title

      J Pharmacol Exp Ther 334

      Pages: 651-656

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain.2010

    • Author(s)
      Yao Y, Yonezawa A, Yoshimatsu H, Masuda S, Katsura T, Inui K.
    • Journal Title

      J Nutr 140

      Pages: 1220-1226

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunosuppressive effects of tacrolimus on macrophages ameliorate experimental colitis.2010

    • Author(s)
      Yoshino T, Nakase H, Honzawa Y, Matsumura K, Yamamoto S, Takeda Y, Ueno S, Uza N, Masuda S, Inui K, Chiba T.
    • Journal Title

      Inflamm Bowel Dis 16

      Pages: 2022-2033

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.2010

    • Author(s)
      Toyama, K., et al.
    • Journal Title

      Pharmacogenetics and Genomics

      Volume: 20 Pages: 135-138

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of Cyclin B2 and Cell division cycle 2 on tubular hyperplasia in progressive chronic renal failure rats2010

    • Author(s)
      Nishihara, K., et al.
    • Journal Title

      American Journal of Physiology-Renal Physiology

      Volume: 298

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus-related cirrhosis is a major determinant of the expression levels of hepatic drug transporters.2010

    • Author(s)
      Ogasawara, K., et al.
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 25 Pages: 190-199

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ABCG2 421C>A polymorphism and high exposure of sunitinib in a patient with renal cell carcinoma2010

    • Author(s)
      Mizuno, T., at al.
    • Journal Title

      Annals of Oncology

      Volume: 21 Pages: 1382-1383

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain.2010

    • Author(s)
      Yao, Y., et al.
    • Journal Title

      Journal of Nutrition

      Volume: 40 Pages: 1220-1226

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced renal clearance of a zwitterionic substrate cephalexin inmatel-deficient mice.2010

    • Author(s)
      Watanabe, S., et al.
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics

      Volume: 334 Pages: 651-656

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity.2010

    • Author(s)
      Nakamura, T., et al.
    • Journal Title

      Biochemical Pharmacology

      Volume: 80 Pages: 1762-1767

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss : a prospective clinical trial.2010

    • Author(s)
      Nakagawa, T., et al.
    • Journal Title

      BMC Medicine

      Volume: 8 Pages: 76-76

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunosuppressive effects of tacrolimus on macrophages ameliorate experimental colitis.2010

    • Author(s)
      Yoshino, T., et al
    • Journal Title

      Inflammatory Bowel Diseases

      Volume: 16 Pages: 2022-2033

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.2010

    • Author(s)
      Toyama K, et al.
    • Journal Title

      Pharmacogent. Gemonics 20

      Pages: 135-138

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus-related cirrhosis is a major determinant of the expression levels of hepatic drug transporters.2010

    • Author(s)
      Ogasawara K, et al.
    • Journal Title

      Drug Metab. Pharmacokinet. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of regulatory polymorphisms in organic anion transporter genes in the human liver.2009

    • Author(s)
      Aoki M, Terada T, Ogasawara K, Katsura T, Hatano E, Ikai I, Inui K.
    • Journal Title

      Pharmacogenet Genomics 19

      Pages: 647-656

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity.2009

    • Author(s)
      Kajiwara M, Terada T, Ogasawara K, Iwano J, Katsura T, Fukatsu A, Doi T, Inui K.
    • Journal Title

      J Hum Genet 54

      Pages: 40-46

    • NAID

      10030728868

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2.2009

    • Author(s)
      Kimura N, Masuda S, Katsura T, Inui K.
    • Journal Title

      Biochem Pharmacol 77

      Pages: 1429-1436

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation.2009

    • Author(s)
      Toyohara T, Suzuki T, Morimoto R, Akiyama Y, Souma T, Shiwaku HO, Takeuchi Y, Mishima E, Abe M, Tanemoto M, Masuda S, Kawano H, Maemura K, Nakayama M, Sato H, Mikkaichi T, Yamaguchi H, Fukui S, Fukumoto Y, Shimokawa H, Inui K, 以下11名
    • Journal Title

      J Am Soc Nephrol 20

      Pages: 2546-2555

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin.2009

    • Author(s)
      Tsuda M, Terada T, Mizuno T, Katsura T, Shimakura J, Inui K.
    • Journal Title

      Mol Pharmacol 75

      Pages: 1280-1286

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells.2009

    • Author(s)
      Tsuda M, Terada T, Ueba M, Sato T, Masuda S, Katsura T, Inui K.
    • Journal Title

      J Pharmacol Exp Ther 329

      Pages: 185-191

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity.2009

    • Author(s)
      Kajiwara M, et al.
    • Journal Title

      J. Hum. Genet. 54

      Pages: 40-46

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2.2009

    • Author(s)
      Kimura N, et al.
    • Journal Title

      Biochem. Pharmacol. 77

      Pages: 1429-1436

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of human multidrug and toxin extrusion 1 (MATE1) in the drug interaction between cimetidine and metformin in renal epithelial cells.2009

    • Author(s)
      Tsuda M, et al.
    • Journal Title

      J. Pharmacol. Exp. Ther. 329

      Pages: 185-191

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeted disruption of the multidrug and toxin extrusion 1 (Matel) gene in mice reduces renal secretion of metformin.2009

    • Author(s)
      Tsuda M, et al.
    • Journal Title

      Mol. Pharmacol. 75

      Pages: 1280-1286

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of regulatory polymorphisms in organic anion transporter genes in the human liver.2009

    • Author(s)
      Aoki M, et al.
    • Journal Title

      Pharmacogent. Gemonics 19

      Pages: 647-656

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SLCO4C1 Transporter Eliminates Uremic Toxins and Attenuates Hypertension and Renal Inflammation.2009

    • Author(s)
      Toyohara T, et al.
    • Journal Title

      J. Am. Soc. Nephrol. 20

      Pages: 2546-2555

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation.2008

    • Author(s)
      Aoki M, Terada T, Kajiwara M, Ogasawara K, Ikai I, Ogawa O, Katsura T, Inui K.
    • Journal Title

      Am J Physiol Renal Physiol 295

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis.2008

    • Author(s)
      Chen J, Terada T, Ogasawara K, Katsura T, Inui K.
    • Journal Title

      Am J Physiol Renal Physiol 295

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of basal core promoter activity of human organic cation transporter 1(OCT1/SLC22A1).2008

    • Author(s)
      Kajiwara M, Terada T, Asaka J, Aoki M, Katsura T, Ikai I, Inui K.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 295

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thyroid hormone regulates the expression and function of P-glycoprotein in Caco-2 cells.2008

    • Author(s)
      Nishio N, Katsura T, Inui K.
    • Journal Title

      Pharm Res 25

      Pages: 1037-1042

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney.2008

    • Author(s)
      Ogasawara K, Terada T, Motohashi H, Asaka J, Aoki M, Katsura T, Kamba T, Ogawa O, Inui K.
    • Journal Title

      J Hum Genet 53

      Pages: 607-614

    • NAID

      10021249665

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of zinc on the absorption of beta-lactam antibiotic ceftibuten via the peptide transporters in rats.2008

    • Author(s)
      Okamura M, Terada T, Katsura T, Inui K.
    • Journal Title

      Drug Metab Pharmacokinet 23

      Pages: 464-468

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory mechanism governing the diurnal rhythm of intestinal H^+/peptide cotransporter 1 (PEPT1).2008

    • Author(s)
      Saito H, Terada T, Shimakura J, Katsura T, Inui K.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 295

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1.2008

    • Author(s)
      Sato T, Masuda S, Yonezawa A, Tanihara Y, Katsura T, Inui K.
    • Journal Title

      Biochem Pharmacol 76

      Pages: 894-903

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of organic cation transporter 3 (SLC22A3) expression for the cytotoxic effect of oxaliplatin in colorectal cancer.2008

    • Author(s)
      Yokoo S, Masuda S, Yonezawa A, Terada T, Katsura T, Inui K.
    • Journal Title

      Drug Metab Dispos 36

      Pages: 2299-2306

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1.2008

    • Author(s)
      Yonezawa A, Masuda S, Katsura T, Inui K.
    • Journal Title

      Am J Physiol Cell Physiol 295

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thyroid hormone regulates the expression and function of P-glycoprotein in Caco-2 cells2008

    • Author(s)
      Nishio N, et al.
    • Journal Title

      Pharm.Res. 25

      Pages: 1037-1042

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analyses of regulatory polymorphisms in organic ion transporter genes(SLC22A)in the kidney2008

    • Author(s)
      Ogasawara K, et al.
    • Journal Title

      J.Hum.Genet. 53

      Pages: 607-614

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kidney-specific expression of human organic cation transporter 2(OCT2/SLC22A2)is regulated by DNA methylation2008

    • Author(s)
      Aoki M, et al.
    • Journal Title

      Am.J.Physiol.Renal Physiol. 295

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adaptive responses of renal organic anion transporter 3(OAT3)during cholestasis2008

    • Author(s)
      Chen J, et al.
    • Journal Title

      Am.J.Physiol.Renal Physiol. 295

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory mechanism governing the diurnal rhythm of intestinal H^+/peptide cotransporter 1(PEPT1)2008

    • Author(s)
      Saito H, et al.
    • Journal Title

      Am.J.Physiol.Gastrointest.Liver Physiol. 295

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and functional characterization of a novel human and rat riboflavin transporter, RFT12008

    • Author(s)
      Yonezawa A, et al.
    • Journal Title

      Am.J.Physiol.Cell Physiol. 295

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE12008

    • Author(s)
      Sato T, et al.
    • Journal Title

      Biochem.Pharmacol. 76

      Pages: 894-903

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of OCT3/SLC22A3, organic cation transporter 3, expression for the cytotoxic effect of oxaliplatin in colorectal cancer2008

    • Author(s)
      Yokoo S, et al.
    • Journal Title

      Drug Metab.Dispos. 36

      Pages: 2299-2306

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of basal core promoter activity of human organic cation transporter 1(OCT1/SLC22A1)2008

    • Author(s)
      Kajiwara M, et al.
    • Journal Title

      Am.J.Physiol.Gastrointest.Liver Physiol. 295

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of zinc on the absorption of □-lactam antibiotic ceftibuten via the peptide transporters in rats2008

    • Author(s)
      Okamura M, et al.
    • Journal Title

      Drug Metab.Pharmacokinet. 23

      Pages: 469-475

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Importance of the Multidrug and Toxin Extrusion MATE/SLC47A Family to Pharmacokinetics, Pharmacodynamics /Toxicodynamics and Pharmacogenomics.

    • Author(s)
      Yonezawa A, Inui K.
    • Journal Title

      Br J Pharmacol (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] H+/有機カチオンアンチポータMATE1ノックアウトマウスにおけるシスプラチン誘発腎毒性の増強2011

    • Author(s)
      中村高規, 他
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山国際会議場、富山市
    • Year and Date
      2011-11-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] H^+/有機カチオンアンチポータMATEの遺伝子多型によるメトホルミンの体内動態変化2010

    • Author(s)
      遠山佳奈
    • Organizer
      第31回臨床薬理学会年会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-12-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 近位尿細管トランスクリプトームに基づく薬剤性尿中バイオマーカーの探索2010

    • Author(s)
      増田智先
    • Organizer
      第31回臨床薬理学会年会
    • Place of Presentation
      国立京都国際会館、京都市
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト腎薬物トランスポータの臨床薬理2010

    • Author(s)
      本橋秀之
    • Organizer
      第31回臨床薬理学会年会
    • Place of Presentation
      国立京都国際会館、京都市
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] H+/有機カチオンアンチポータMATEの遺伝子多型によるメトホルミンの体内動態変化2010

    • Author(s)
      遠山佳奈, 他
    • Organizer
      第31回臨床薬理学会年会
    • Place of Presentation
      国立京都国際会館、京都市
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体肝移植後のタクロリムス関連腎障害の発症におけるCYP3A5遺伝子多型の影響2010

    • Author(s)
      上杉美和, 他
    • Organizer
      第31回臨床薬理学会年会
    • Place of Presentation
      国立京都国際会館、京都市
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 非小細胞肺癌患者におけるエルロチニブの体内動態と副作用に関する母集団解析2010

    • Author(s)
      福土将秀, 他
    • Organizer
      第31回臨床薬理学会年会
    • Place of Presentation
      国立京都国際会館、京都市
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] LC/MS/MSによるTDM対象薬物-斉分析法のバリデーション試験2010

    • Author(s)
      柴田茉衣, 他
    • Organizer
      第31回臨床薬理学会年会
    • Place of Presentation
      国立京都国際会館、京都市
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体肝移植患者の術後経過に及ぼす遺伝的背景の影響2010

    • Author(s)
      河合知喜, 他
    • Organizer
      第31回臨床薬理学会年会
    • Place of Presentation
      国立京都国際会館、京都市
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] H^+/有機カチオンアンチポータMATE1ノックアウトマウスにおけるシスプラチン誘発腎毒性の増強2010

    • Author(s)
      中村高規
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山国際会議場(富山市)
    • Year and Date
      2010-11-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of Metabolic Acidosis on Expression Levels of Renal Drug Transporters2010

    • Author(s)
      Motohashi, M., et al.
    • Organizer
      第4回次世代を担う若手 医療薬科学シンポジウム
    • Place of Presentation
      東京大学、東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Changes of Anion Transporters under The Kidney Development2010

    • Author(s)
      Nomura, M., et al.
    • Organizer
      第4回次世代を担う若手 医療薬科学シンポジウム
    • Place of Presentation
      東京大学、東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Microarray analysis of isolated proximal tubules in rats with cisplatin-induced nephrotoxicity2010

    • Author(s)
      Masuda, S., et al.
    • Organizer
      ASN RENAL WEEK 2010
    • Place of Presentation
      デンバー、アメリカ
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Time-dependent changes of urinary biomarkers in the lung cancer patients after cisplatin-based chemotherapy2010

    • Author(s)
      Sato, T., et al.
    • Organizer
      ASN RENAL WEEK 2010
    • Place of Presentation
      デンバー、アメリカ
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of MATE1 in renal tubular secretion of varenicline.2010

    • Author(s)
      梶原望渡
    • Organizer
      Pharmaceutical Sciences World Congress 2010
    • Place of Presentation
      ニューオーリンズ(アメリカ)
    • Year and Date
      2010-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Flux of platinum agents by MATE2-K rather than MATE1 in the double transfectants with basolateral OCT2 in MDCK monolayers.2010

    • Author(s)
      Sato T
    • Organizer
      Pharmaceutical Sciences World Congress 2010
    • Place of Presentation
      ニューオーリンズ(アメリカ)
    • Year and Date
      2010-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Involvement of MATE1 in renal tubular secretion of varenicline2010

    • Author(s)
      Kajiwara, M., et al.
    • Organizer
      Pharmaceutical Sciences World Congress 2010
    • Place of Presentation
      ニューオーリンズ、アメリカ
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Flux of platinum agents by MATE2-K rather than MATE1 in the double transfectants with basolateral OCT2 in MDCK monolayers2010

    • Author(s)
      Sato, T., et al.
    • Organizer
      Pharmaceutical Sciences World Congress 2010
    • Place of Presentation
      ニューオーリンズ、アメリカ
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 質量分析法を用いた経口チロシンキナーゼ阻害薬6種の一斉定量法の確立2010

    • Author(s)
      水野知行, 他
    • Organizer
      第20回日本医療薬学会年会
    • Place of Presentation
      幕張メッセ、千葉市
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト腎H+/有機カチオンアンチポータhMATE1及びhMATE2-Kとグアニジン化合物との相互作用2010

    • Author(s)
      本山慎也, 他
    • Organizer
      第60回日本薬学会近畿支部総会
    • Place of Presentation
      摂南大学、枚方市
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] シスプラチンの抗腫瘍効果における有機カチオントランスポータの役割2010

    • Author(s)
      濱口隆仁, 他
    • Organizer
      第60回日本薬学会近畿支部総会
    • Place of Presentation
      摂南大学、枚方市
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発達過程における近位尿細管アニオントランスポータの発現変動2010

    • Author(s)
      野村麻貴, 他
    • Organizer
      第60回日本薬学会近畿支部総会
    • Place of Presentation
      摂南大学、枚方市
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Renal Organic Cation Transporter, OCT & MATE : From Drug Discovery to Clinical Applications.2010

    • Author(s)
      Yonezawa, A., et al.
    • Organizer
      International symposium "An Interacted Approach to the Physiology of Organic Cation Transporters"
    • Place of Presentation
      ゲッティンゲン、ドイツ(招待講演)
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Clinical pharmacokinetics of erlotinib and its active metabolite OSI-420 in patients with non-small cell lung cancer2010

    • Author(s)
      Fukudo, M., et al.
    • Organizer
      日本薬物動態学会第25年会
    • Place of Presentation
      大宮ソニックシティ、大宮市
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Multidrug and toxin extrusion 1 mediated tubular secretion of varenicline2010

    • Author(s)
      Kajiwara, M., et al.
    • Organizer
      日本薬物動態学会第25年会
    • Place of Presentation
      大宮ソニックシティ、大宮市
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] INVOLUEMENT OF NOVEL HUMAN RIBOFLAVIN TRANSPORTERS hRFTs IN RIBOFLAVIN UPTAKE BY INTESTINAL T84 CELLS.2010

    • Author(s)
      Yoshimatsu, H., et al.
    • Organizer
      日本薬物動態学会第25年会
    • Place of Presentation
      大宮ソニックシティ、大宮市
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Interaction between guanidino compounds and human multidrug and toxin extrusion(hMATE) 1 AND hMATE2-K2010

    • Author(s)
      Motoyama, S., et al.
    • Organizer
      日本薬物動態学会第25年会
    • Place of Presentation
      大宮ソニックシティ、大宮市
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] OCT2/MATE2-K double transfectant, as an in vitro model of renal handling of cationic drugs in human kidney.2010

    • Author(s)
      Sato T
    • Organizer
      日本薬物動態学会第25年会
    • Place of Presentation
      大宮ソニックシティ(大宮市)
    • Year and Date
      2010-10-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Multidrug and toxin extrusion 1 mediated tubular secretion of varenicline.2010

    • Author(s)
      梶原望渡
    • Organizer
      日本薬物動態学会第25年会
    • Place of Presentation
      大宮ソニックシティ(大宮市)
    • Year and Date
      2010-10-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Interaction between guanidino compounds and human multidrug and toxin extrusion (hMATE)1 and hMATE2-K.2010

    • Author(s)
      Motoyama S
    • Organizer
      日本薬物動態学会第25年会
    • Place of Presentation
      大宮ソニックシティ(大宮市)
    • Year and Date
      2010-10-06
    • Related Report
      2010 Final Research Report
  • [Presentation] OCT2/MATE2-K double transfectant, as an in vitro model of renal handling of cationic drugs in human kidney2010

    • Author(s)
      Sato, T., et al.
    • Organizer
      日本薬物動態学会第25年会
    • Place of Presentation
      大宮ソニックシティ、大宮市
    • Year and Date
      2010-10-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] PREDOMINANT ROLE OF H^+/ORGANIC CATION ANTIPORTER MATE1/SLC47A1 IN THE RENAL TUBULAR SECRETION OF METFORMIN AND CEPHALEXIN.2010

    • Author(s)
      Inui K
    • Organizer
      9th International Meeting of International Society for the Study of Xenobiotics
    • Place of Presentation
      イスタンブール(トルコ)
    • Year and Date
      2010-09-05
    • Related Report
      2010 Final Research Report
  • [Presentation] MOLECULAR CLONING AND COMPARATIVE FUNCTIONAL CHARACTERIZATION OF HUMAN RIBOFLAVIN TRANSPORTERS RFTs.2010

    • Author(s)
      Tsuda, M., et al.
    • Organizer
      9th International Meeting of International Society for the Study of Xenobiotics
    • Place of Presentation
      イスタンブール、トルコ
    • Year and Date
      2010-09-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] PREDOMINANT ROLE OF H+/ORGANIC CATIONANTIPORTER MATE1/SLC47A1 IN THE RENAL TUBULAR SECRETION OF METFORMIN AND CEPHALEXIN2010

    • Author(s)
      Yonezawa, A., et al.
    • Organizer
      9th International Meeting of International Society for the Study of Xenobiotics
    • Place of Presentation
      イスタンブール、トルコ
    • Year and Date
      2010-09-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 有機カチオン排出トランスポーターMatel KOマウスと薬物性腎障害2010

    • Author(s)
      米澤淳, 他
    • Organizer
      FRONT-J第2回学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪、東京
    • Year and Date
      2010-08-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 近位尿細管遺伝子発現解析によるシスプラチン腎症のマーカー探索2010

    • Author(s)
      西原久美子, 他
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸国際会議場、神戸市
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] シスプラチンの腎毒性発現におけるH^+/有機カチオンアンチポータMATE1の役割2010

    • Author(s)
      中村高規
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      あわぎんホール徳島県郷土文化会館(徳島市)
    • Year and Date
      2010-05-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 両性イオン型薬物セファレキシンの腎排泄におけるMATE1の役割2010

    • Author(s)
      渡部辰悟
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      あわぎんホール徳島県郷土文化会館(徳島市)
    • Year and Date
      2010-05-12
    • Related Report
      2010 Final Research Report
  • [Presentation] シスプラチンの腎毒性発現におけるH+/有機カチオンアンチポータMATE1の役割2010

    • Author(s)
      中村高規, 他
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      あわぎんホール徳島県郷土文化会館、徳島市
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 両性イオン型薬物セファレキシンの腎排泄におけるMATE1の役割2010

    • Author(s)
      渡部辰悟, 他
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      あわぎんホール徳島県郷土文化会館、徳島市
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体肝移植術後のタクロリムス体内動態に及ぼす移植部位の影響2010

    • Author(s)
      木村匡宏
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター(岡山県)
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 腎臓の発達過程における有機アニオントランスポータの発現変動2010

    • Author(s)
      関根寛子, 他
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター(岡山県)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性腎不全に対する新規治療標的としてのmTOR経路2009

    • Author(s)
      中川俊作
    • Organizer
      第3回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      九州大学病院地区コラボステーション(福岡県)
    • Year and Date
      2009-11-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 慢性腎有全に対する親規治療標的としてのmTOR経路2009

    • Author(s)
      中川俊作, 他
    • Organizer
      第3回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      九州大学病院地区コラボステーション(福岡県)
    • Year and Date
      2009-11-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roles of the mTOR pathway on progressive tubular dysfunction in chronic renal failure rats.2009

    • Author(s)
      中川俊作
    • Organizer
      BioMedical Transporters 2009
    • Place of Presentation
      シーパークコングレスセンター(トゥーン、スイス連邦)
    • Year and Date
      2009-08-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Roles of the mTOR pathway on progressive tubular dysfunction in chronic renal failure rats2009

    • Author(s)
      Nakagawa S, et al.
    • Organizer
      BioMedical Transporters 2009
    • Place of Presentation
      シーパークコングレスセンター(トゥーン、スイス連邦)
    • Year and Date
      2009-08-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腎尿細管薬物トランスポータの病態生理学的役割2008

    • Author(s)
      増田智先
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館(熊本県)
    • Year and Date
      2008-10-30
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 薬剤業務の科学的基盤の確立と薬物治療への展開2008

    • Author(s)
      乾賢一
    • Organizer
      日本薬剤学会第23年会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2008-05-21
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] ヒト有機カチオントランスポータ(hOCT1)の転写調節機構2008

    • Author(s)
      梶原望渡
    • Organizer
      日本薬剤学会第23年会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2008-05-20
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] プロモーター領域のメチル化によるヒトOCT2の腎特異的な発現制御2008

    • Author(s)
      青木雅世
    • Organizer
      日本薬剤学会第23年会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2008-05-20
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 腎臓の発達過程における有機アニオントランスポータの発現変動2008

    • Author(s)
      関根寛子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター(岡山県)
    • Year and Date
      2008-05-20
    • Related Report
      2010 Final Research Report
  • [Book] 薬物トランスポーター活用ライブラリー2009

    • Author(s)
      乾賢一, 他
    • Total Pages
      246
    • Publisher
      株式会社羊土社
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.kuhp.kyoto-u.ac.jp/?yakuzai/main.htm

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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