Basic research on the integrated regulation of locomotive function

• Project/Area Number: 20249064
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: TANAKA Sakae 東京大学, 医学部・附属病院, 教授 (50282661)
• Co-Investigator(Kenkyū-buntansha): HIKAWA Takeshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20263824) ; OGATA Toru 国立身体障害者リハビリテーションセンター研究所, 運動機能系障害研究部, 室長 (00392192) ; HAGA Nobuhiko 東京大学, 医学部附属病院, 教授 (80251263)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥46,540,000 (Direct Cost: ¥35,800,000、Indirect Cost: ¥10,740,000); Fiscal Year 2011: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000); Fiscal Year 2010: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000); Fiscal Year 2009: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2008: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
• Keywords: 骨 / 軟骨 / 筋 / 神経 / Bcl-2ファミリー / Bcl-xL / 破骨細胞 / TGF-beta / Cbl-b / RANTES / VICOM / Oligodendrocyte / 運動器 / 筋細胞 / アポトーシス / c-Src / Bc1-2 / RFN10 / apoptosis

Research Abstract

"Locomotive organs "regulates the important function of animals, motor function, and include various tissues such as bone, cartilage, muscle and neuron. We here investigated the regulatory mechanism of locomotive organs by focusing on the role of Bcl-2 family proteins, which regulate the apoptosis of the cells.

Research Products

• [Journal Article] Unloading stress disturbs muscle regeneration through perturbed recruitment and function of macrophages (2012)
  • Author(s): Kohno S, Nikawa T, et al.
  • Journal Title: J Appl Physiol Volume: (Online first)
  • Peer Reviewed
• [Journal Article] Phosphorylated neurofilament subunit NF-H as a biomarker for evaluating the severity of spinal cord injury patients, a pilot study (2012)
  • Author(s): Hayakawa K, Ogata T, et al.
  • Journal Title: Spinal Cord Volume: (Online first)
  • Peer Reviewed
• [Journal Article] Intra-articular injection of hyaluronan restores the aberrant expression of matrix metalloproteinase-13 in osteoarthritic subchondral bone (2011)
  • Author(s): Hiraoka N, Takahashi KA, Arai Y, Sakao K, Mazda O, Kishida T, Honjo K, Tanaka S, Kubo T
  • Journal Title: J Orthop Res Volume: 29(3) Pages: 354-360
• [Journal Article] Hyperphosphorylated neurofilament NF-H as a biomarker of the efficacy of minocycline therapy for spinal cord injury (2011)
  • Author(s): Ueno T, Ohori Y, Ito J, Hoshikawa S, Yamamoto S, Nakamura K, Tanaka S, Akai M, Tobimatsu Y, Ogata T.
  • Journal Title: Spinal Cord Volume: 49(3) Pages: 333-336
• [Journal Article] Regulation of RANKL-induced osteoclastogenesis by TGF-b through molecular interaction between Smad3 and Traf6 (2011)
  • Author(s): Yasui T, Kadono Y, Nakamura M, Oshima Y, Matsumoto T, Masuda H, Hirose J, Omata Y, Yasuda H, Imumara T, Nakamura K, Tanaka S.
  • Journal Title: J Bone Miner Res Volume: 26(7) Issue: 7 Pages: 1447-1456
  • DOI: 10.1002/jbmr.357
• [Journal Article] Hes1 functions downstream of growth factors to maintain oligodendeocyte lineage cells in the early progenitor stage (2011)
  • Author(s): Ogata T, Ueno T, Hoshikawa S, Ito J, Okazaki R, Hayakawa K, Morioka K, Yamamoto S, Nakamura K, Tanaka S, Akai M.
  • Journal Title: Neuroscience Volume: 176 Pages: 132-141
• [Journal Article] Epigenetic Regulation of Osteoclast Differentiation : Possible Involvement of Jmjd3 in the Histone Demethylation of Nfatc1 (2011)
  • Author(s): Yasui T, Hirose J, Tsutsumi S, Nakamura K, Aburatani H, Tanaka S.
  • Journal Title: J Bone Miner Res Volume: 26(11) Pages: 2665-2671
• [Journal Article] Distinguishing the pro-apoptotic and anti-resorptive functions of risedronate in osteoclasts : Role of the Akt pathway and the Erk/Bim axis (2011)
  • Author(s): Matsumoto T, Nagase Y, Iwasawa M, Yasui T, Masuda H, Kadono Y, Nakamura K, Tanaka S.
  • Journal Title: Arthritis Rheum Volume: 63(12) Pages: 3908-3917
• [Journal Article] Increased bone mass in mice after a single injection of an anti-RANKL neutralizing antibody : evidence for a bone anabolic effect of PTH in mice with few osteoclasts (2011)
  • Author(s): Furuya Y, Mori K, Ninomiya T, Tomimori Y, Tanaka S, Takahashi N, Udagawa N, Uchida K, Yasuda H.
  • Journal Title: J Biol Chem Volume: 286(42) Pages: 31-37023
• [Journal Article] Risk factors of pulmonary embolism and the effects of fondaparinux after total hip and knee arthroplasty : a retrospective observational study using a national database in Japan (2011)
  • Author(s): Nagase Y, Yasunaga H, Horiguchi H, Hashimoto H, Shoda N, Kadono Y, Matsuda S, Nakamura K, Tanaka S.
  • Journal Title: J Bone Joint Surg(Am) Volume: 93(24)
• [Journal Article] Are bone and serum cefazolin concentrations adequate for antimicrobial prophylaxis (2011)
  • Author(s): Yamada K, Matsumoto K, Tokumura F, Okazaki H, Tanaka S.
  • Journal Title: Clin Orthop Relat Res Volume: 469(12) Pages: 3486-3494
• [Journal Article] Identification of a redox-modulatory interaction between uncoupling protein 3 and thioredoxin 2 in the mitochondrial intermembrane space (2011)
  • Author(s): Hirasaka K, Lago CU, Kenaston MA, Fathe K, Nowinski SM, Nikawa T, Mills EM.
  • Journal Title: Antioxid Redox Signal Volume: 15(10) Pages: 61-2645
• [Journal Article] Rantes secreted from macrophages disturbs skeletal muscle regeneration after cardiotoxin injection in Cbl-b-deficient mice (2011)
  • Author(s): Kohno S, Ueji T, Abe T, Nakao R, Hirasaka K, Oarada M, Harada-Sukeno A, Ohno A, Higashibata A, Mukai R, Terao J, Okumura Y, Nikawa T.
  • Journal Title: Muscle Nerve Volume: 43(2) Pages: 9-223
• [Journal Article] A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H. (2011)
  • Author(s): Ohte S, Shin M, Sasanuma H, Yoneyama K, Akita M, Ikebuchi K, Jimi E, Maruki Y, Matsuoka M, Namba A, Tomoda H, Okazaki Y, Ohtake A, Oda H, Owan I, Yoda T, Furuya H, Kamizono J, Kitoh H, Nakashima Y, Susami T, Haga N, Komori T, Katagiri T.
  • Journal Title: Biochem Biophys Res Commun Volume: 407(1) Pages: 8-213
• [Journal Article] Epigenetic regulation of osteoclast differentiation : possible involvement of Jmjd3 in the histone demethylation of Nfatc1 (2011)
  • Author(s): Yasui T, Tanaka S, et al.
  • Journal Title: Journal of Bone and Mineral Research Volume: 26 Pages: 2655-2671
  • Peer Reviewed
• [Journal Article] Rantes secreted from macrophages disturbs skeletal muscle regeneration after cardiotoxin inj ection in Cbl-b-deficient mice. (2011)
  • Author(s): Kohono S, Nikawa T, et al.
  • Journal Title: Muscle Nerve. Volume: 43 Pages: 223-229
  • Peer Reviewed
• [Journal Article] Choong PF. PEDF regulates osteoclasts via osteoprotegerin and RANKL (2010)
  • Author(s): Akiyama T, Dass CR, Shinoda Y, Kawano H, Tanaka S
  • Journal Title: Biochem Biophys Res Commun Volume: 391(1) Pages: 789-794
• [Journal Article] Statistics in orthopaedic surgery in 2006-2007 : data from the Japanese diagnosis procedure combination(DPC) database (2010)
  • Author(s): Kadono Y, Yasunaga H, Horiguchi H, Hashimoto H, Matsuda M, Tanaka S, Nakamura S.
  • Journal Title: J Orthop Sci Volume: 15(2) Pages: 162-170
• [Journal Article] Impact of Biologics on the Prevalence of Orthopaedic Surgery in the National Database of Rheumatic Diseases in Japan (2010)
  • Author(s): Yasui T, Nishino J, Kadono Y, Matui T, Nakamura K, Tanaka S, Tohma S.
  • Journal Title: Mod Rheumatol Volume: 20(3) Pages: 233-237
• [Journal Article] The usefulness of neutrophil CD64 expression in diagnosis of local infection in patients with rheumatoid arthritis in daily practice (2010)
  • Author(s): Nishino J, Tanaka S, Kadono Y, Matsui A, Komiya K, Nishimura K, Tohma S.
  • Journal Title: J Orthop Sci Volume: 15(4) Pages: 547-552
  • NAID: 10026704845
• [Journal Article] Neutrophil CD64 expression as a diagnostic marker for local infection and crystal-induced arthritis (2010)
  • Author(s): Doi T, Miyazaki T, Nishino J, Tanaka S, Matsui T, Komiya A, Yamamoto S, Tokimura F, Mori T, Nishimura K, Katho N, Hasegawa J, Omata Y, Matsushita T, Thoma S.
  • Journal Title: Mod Rheumatol Volume: 20(6) Pages: 573-579
  • NAID: 10027647433
• [Journal Article] Antiapoptotic molecule Bcl-2 is essential for the anabolic activity of parathyroid hormone in bone (2010)
  • Author(s): Nagase Y, Iwasawa M, Akiyama T, Ogata N, Kadono Y, Nakamura M, Oshima Y, Yasui T, Matsumoto T, Masuda H, Bouillet P, Nakamura K, Tanaka S.
  • Journal Title: Ann N Y Acad Sci Volume: 1192(1) Pages: 330-337
• [Journal Article] tPA activates LDL receptor-related protein 1-mediated mitogenic signaling involving the p90RSK and GSK3beta pathway (2010)
  • Author(s): Lin L, Bu G, Mars WM, Reeves WB, Tanaka S, Hu K.
  • Journal Title: Am J Pathol Volume: 177(4) Pages: 1687-1696
• [Journal Article] Evaluation of nonnociceptive sensation in patients with congenital insensitivity to pain with anhidrosis. (2010)
  • Author(s): Iijima, M., Haga, N.
  • Journal Title: Childs Nerv Syst 26 Pages: 1085-1089
• [Journal Article] Antiapoptotic molecule Bcl-2 is essential for the anabolic activity of Parathyroid hormone in bone. (2010)
  • Author(s): Nagase Y, Tanaka S, et al.
  • Journal Title: Ann N Y Acad Sci. Volume: 1192 Pages: 330-337
  • Peer Reviewed
• [Journal Article] Hes 1 FUNCTIONS DOWNSTREAM OF GROWTH FACTORS TOMA-NTA-N OLIGODENDROCYTE L-NEAGE CELLS IN THE EARLY PROGENITOR STAGE (2010)
  • Author(s): Ogata T, et al.
  • Journal Title: Neuroscience Volume: (On line first)
  • Peer Reviewed
• [Journal Article] Negative regulation of bone-resorbing activity of osteoclasts by anti-apoptotic Bcl-xL protein (2009)
  • Author(s): Iwasawa M, Miyazaki T, Nagase Y, Akiyama T, Kadono Y, Nakamura M, Oshima Y, Yasui T, Nakamura T, Kato S, Henninghausen L, Nakamura K, Tanaka S.
  • Journal Title: J Clin Invest Volume: 119 Pages: 3149-3159
• [Journal Article] Rheumatoid arthritis associated with osteopetrosis (2009)
  • Author(s): Kadono Y, Tanaka S, Nishino J, Nishimura K, Nakamura I, Miyazaki T, Takayanagi H, Nakamura K.
  • Journal Title: Mod Rheumatol Volume: 19(6) Pages: 687-690
  • NAID: 10027168048
• [Journal Article] Over-expression of integrin beta3 can partially overcome the defect of integrin beta3 signaling in transglutaminase 2 null macrophages (2009)
  • Author(s): Toth B, Sarang Z, Vereb G, Zhang A, Tanaka S, Melino G, Fesus L, Szondy Z.
  • Journal Title: Immunol Lett Volume: 126(1-2) Pages: 22-28
• [Journal Article] Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-alpha (2009)
  • Author(s): Hikita A, Tanaka N, Yamane S, Ikeda Y, Furukawa H, Tohma S, Suzuki R, Tanaka S, Mitomi H, Fukui N.
  • Journal Title: Biochem Cell Biol Volume: 87(4) Pages: 581-593
• [Journal Article] The anti-apoptotic molecule Bcl-2 regulates the differentiation, activation and survival of both osteoblasts and osteoclasts (2009)
  • Author(s): Nagase Y, Iwasawa M, Akiyama T, Kadono Y, Nakamura M, Oshima Y, Yasui T, Matsumoto T, Hirose J, Nakamura H, Miyamoto T, Bouillet P, Nakamura K, Tanaka S.
  • Journal Title: J Biol Chem Volume: 284(52) Pages: 36659-36669
• [Journal Article] Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading (2009)
  • Author(s): Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T.
  • Journal Title: Mol Cell Biol Volume: 29(17) Pages: 811-4798
• [Journal Article] Anti-apoptotic molecule Bcl-2 regulates the differentiation, activation, and survival of both osteoblasts and osteoclasts. (2009)
  • Author(s): Nagase, Y., Iwasawa, M., Akiyama, T., Kadono, Y., Nakamura, M., Oshima, Y., Yasui, T., Matsumoto, T., Hirose, J., Nakamura, H., Tanaka, S., et al.
  • Journal Title: J Biol Chem 284 Pages: 36659-36669
• [Journal Article] The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice. (2009)
  • Author(s): Iwasawa, M., Miyazaki, T., Nagase, Y., Akiyama, T., Kadono, Y., Nakamura, M., Oshima, Y., Yasui, T., Matsumoto, T., Nakamura, T., Tanaka, S., et al.
  • Journal Title: J Clin Invest 119 Pages: 3149-3159
• [Journal Article] Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading. (2009)
  • Author(s): Nakao, R., Hirasaka, K., Goto, J., Ishidoh, K., Yamada, C., Ohno, A., Okumura, Y., Nonaka, I., Yasutomo, K., Baldwin, K.M., Nikawa, T., et al.
  • Journal Title: Mol Cell Biol 29 Pages: 4798-4811
• [Journal Article] Negative regulation of bone-resorbing activity of osteoclasts by anti-apoptotic Bcl-xL protein. (2009)
  • Author(s): Iwasawa M, Tanaka S, et al.
  • Journal Title: Journal of Clinical Investigation 119 Pages: 3149-3159
  • Peer Reviewed
• [Journal Article] Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading. (2009)
  • Author(s): Nakao R, Nikawa T, et al.
  • Journal Title: Molecular and cellular Biology 29 Pages: 4798-811
  • Peer Reviewed
• [Journal Article] Successful ambulation by surgical conversion in a complex form of epigastric heteropagus. (2009)
  • Author(s): Haga N, et al.
  • Journal Title: Journal of Pediatric Orthopaedics Part B
  • Peer Reviewed
• [Journal Article] A novel function of RING finger protein 10 in transcriptional protein 10 in transcriptional regulation of the myelin-associated glycoprotein gene and myelin formation in Schwann cells. (2008)
  • Author(s): Hoshikawa, S., Ogata, T., Fujiwara, S., Nakamura, K., Tanaka, S.
  • Journal Title: PLoS One 3 Pages: 3464-3464
• [Journal Article] Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis. (2008)
  • Author(s): Oshima Y, Tanaka S他
  • Journal Title: J Biol Chem. 283 Pages: 26499-26508
  • Peer Reviewed
• [Journal Article] A novel function of RING finger protein 10 in transcriptional regulation of the myelin-associated glycoprotein gene and myelin formation in Schwann cells. (2008)
  • Author(s): Hoshikawa S, Ogata T, Fujiwara S, Nakamura K, Tanaka S.
  • Journal Title: PLoS ONE 3
  • Peer Reviewed
• [Journal Article] Evaluation of postural control in quiet standing using center of mass acceler ation: comparison among the young, the elderly and people with stroke (2008)
  • Author(s): Haga N他
  • Journal Title: Arch Phys Med Rehabil 89 Pages: 1133-1139
  • Peer Reviewed
• [Presentation] 教育講演2関節リウマチに於ける核医学の現状と将来「関節リウマチの最近の分子病態解明の進歩および分子標的薬」 (2011)
  • Author(s): 田中栄
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: さいたま
  • Year and Date: 2011-11-11
• [Presentation] 長州セミナー6「関節リウマチにおける大関節破壊予防戦略」 (2011)
  • Author(s): 田中栄
  • Organizer: 第117回中部日本整形外科災害外科学会学術集会
  • Place of Presentation: 宇部
  • Year and Date: 2011-10-29
• [Presentation] シンポジウム3炎症と関節破壊「関節リウマチにおける骨脆弱性と骨破壊」 (2011)
  • Author(s): 田中栄
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-10-20
• [Presentation] Epigenetic Regulation of the Osteoclast (2011)
  • Author(s): 田中栄
  • Organizer: 2nd Asia-Pacific Osteoporosis and Bone Meeting (2011.9.4-7)
  • Place of Presentation: ゴールドコースト(オーストラリア)(招待講演)
  • Year and Date: 2011-09-07
• [Presentation] シンポジウム1リウマチ性疾患の新たな治療「骨粗鬆症治療の新展開」 (2011)
  • Author(s): 田中栄
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-07-18
• [Presentation] シンポジウム8骨代謝調節研究の進展と臨床展開「骨吸収抑制薬による骨粗鬆症治療」 (2011)
  • Author(s): 田中栄
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2011-04-22
• [Presentation] 岡豊セミナー1「新しい作用機序を有する骨粗鬆症治療薬」 (2011)
  • Author(s): 田中栄
  • Organizer: 第116回中部日本整形外科災害外科学会・学術集会
  • Place of Presentation: 高知
  • Year and Date: 2011-04-07
• [Presentation] グラバーセミナーLS 11「整形外科領域におけるSSI対策と新しい感染症診断マーカー」 (2011)
  • Author(s): 田中栄
  • Organizer: 第40回日本人工関節学会
  • Place of Presentation: 沖縄
  • Year and Date: 2011-02-27
• [Presentation] シンポジウム1TKAフィルムレス術前計画について「立体骨モデルを用いた3次元術前計画」 (2011)
  • Author(s): 田中栄
  • Organizer: 第41回日本人工関節学会
  • Place of Presentation: 東京
  • Year and Date: 2011-02-25
• [Presentation] シンポジウム3リウマチと炎症、破壊、修復「関節リウマチにおける骨脆弱性と骨破壊」 (2011)
  • Author(s): 田中栄
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] ランチョンセミナー9「エストロゲンの骨作用とSERMによる骨粗鬆症治療」 (2011)
  • Author(s): 田中栄
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] シンポジウム1骨粗鬆症治療薬の新たな展開「カテプシンK阻害薬」 (2011)
  • Author(s): 田中栄
  • Organizer: 第13回日本骨粗鬆症学会
  • Place of Presentation: 大阪
• [Presentation] イブニングセミナー2「新しい活性型ビタミンD3誘導体による骨粗鬆症治療」 (2011)
  • Author(s): 田中栄
  • Organizer: 第13回日本骨粗鬆症学会
  • Place of Presentation: 大阪
• [Presentation] カレントトピックス基礎から臨床への架け橋「骨粗鬆症治療From bench to bedside」 (2011)
  • Author(s): 田中栄
  • Organizer: 第13回日本骨粗鬆症学会
  • Place of Presentation: 大阪
• [Presentation] ベイサイドセミナー12「骨吸収抑制薬による骨粗鬆症治療とその作用機序」 (2011)
  • Author(s): 田中栄
  • Organizer: 第39回日本関節病学会
  • Place of Presentation: 横浜
• [Presentation] Active vitamin D3 therapy for osteoporosis in Japan (2010)
  • Organizer: IOF Regionals, 1st Asia-Pacific Osteoporosis Meeting Singapore
  • Place of Presentation: Singapore
  • Year and Date: 2010-12-10
• [Presentation] 関節病セミナー2「関節破壊を標的にした関節リウマチ治療戦略」 (2010)
  • Author(s): 田中栄
  • Organizer: 第38回日本関節病学会
  • Place of Presentation: 京都
  • Year and Date: 2010-11-18
• [Presentation] 関節リウマチにおける骨脆弱性と関節破壊のメカニズム (2010)
  • Author(s): 田中栄
  • Organizer: 第21回日本リウマチ学会中国・四国支部学術集会
  • Place of Presentation: 高松
  • Year and Date: 2010-10-23
• [Presentation] Lunchtime Lecture 5-2 "Regulation of Apoptosis and Function of Osteoclasts by Bcl-2 Family Proteins" (2010)
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-27
• [Presentation] Regulation of Apoptosis and Function of Osteoclasts by Bcl-2 Family Proteins (2010)
  • Author(s): 田中栄
  • Organizer: 14^<th>International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-27
• [Presentation] シンポジウム4関節リウマチと骨代謝「RANKLを標的にした関節リウマチ治療」 (2010)
  • Author(s): 田中栄
  • Organizer: 第28回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-21
• [Presentation] 薬物による骨粗鬆症脆弱性骨折の予防 (2010)
  • Author(s): 田中栄
  • Organizer: 第36回日本骨折治療学会ランチョンセミナー
  • Place of Presentation: 幕張
  • Year and Date: 2010-07-03
• [Presentation] Session V Basic concepts into osteoimmunology : Osteoclasts "Molecular understanding of differentiation, activity and survival of osteoclasts" (2010)
  • Organizer: 3rd International Conference on Osteoimmunology : Interactions of the Immune and Skeletal Systems
  • Year and Date: 2010-06-23
• [Presentation] 関節リウマチにおける骨粗鬆症と骨破壊 (2010)
  • Author(s): 田中栄
  • Organizer: 第83回日本整形外科学会学術集会ランチョンセミナー20
  • Place of Presentation: 東京
  • Year and Date: 2010-05-29
• [Presentation] シンポジウム4人工膝関節の術前計画:近未来を科学する「立体骨モデルを用いた3次元術前計画」 (2010)
  • Author(s): 田中栄
  • Organizer: 第403回日本人工関節学会
  • Place of Presentation: 沖縄
  • Year and Date: 2010-02-27
• [Presentation] シンポジウム2生物学的製剤時代における手術の変遷-画像診断と外科的治療-関節リウマチ骨破壊の画像評価法-Modified Sharp Scoreを中心に- (2010)
  • Author(s): 田中栄
  • Organizer: 日本リウマチ学会
  • Place of Presentation: 神戸
• [Presentation] ランチョンセミナーLS24関節疾患の病態・治療と今後の展望 (2010)
  • Author(s): 田中栄
  • Organizer: 日本リウマチ学会
  • Place of Presentation: 神戸
• [Presentation] シンポジウム1骨粗鬆症治療薬の今後「Denosumab」 (2010)
  • Author(s): 田中栄
  • Organizer: 第12回日本骨粗鬆症学会
  • Place of Presentation: 大阪
• [Presentation] シンポジウム3関節リウマチ患者の骨の健康を守るために「関節リウマチにみられる細胞レベルでの骨の異常」 (2010)
  • Author(s): 田中栄
  • Organizer: 第12回日本骨粗鬆症学会
  • Place of Presentation: 大阪
• [Presentation] ランチョンセミナー2「RANKL/RANK pathwayを標的にした骨代謝疾患治療戦略」 (2010)
  • Author(s): 田中栄
  • Organizer: 第12回日本骨粗鬆症学会
  • Place of Presentation: 大阪
• [Presentation] 関節リウマチ手術の適応・成績・合併症-いつどのようなときに整形外科に依頼するか? (2009)
  • Author(s): 田中栄
  • Organizer: JCR2009全国中央教育研修会大阪大会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-13
• [Presentation] Regulation of Apoptosis and Function of Osteoclasts (2009)
  • Author(s): 田中栄
  • Organizer: The 26th NAITO CONFERENCE
  • Place of Presentation: Awaji, Hyogo, Japan
  • Year and Date: 2009-11-05
• [Presentation] シンポジウム4骨を舞台にした基礎と臨床のクロストーク「破骨細胞分化・活性化メカニズムと骨吸収を標的にした骨軟骨疾患治療」 (2009)
  • Author(s): 田中栄
  • Organizer: 第50回記念日本組織細胞化学会総会・学術総会
  • Place of Presentation: 大津
  • Year and Date: 2009-09-27
• [Presentation] 関節リウマチ手術の適応・成績・合併症-いつどのようなときに整形外科に依頼するか? (2009)
  • Author(s): 田中栄
  • Organizer: JCR2009全国中央教育研修会東京大会
  • Place of Presentation: 東京
  • Year and Date: 2009-08-23
• [Presentation] 整形外科領域における静脈血栓塞栓症の診断と予防 (2009)
  • Author(s): 田中栄
  • Organizer: 第1回日本関節鏡・膝・スポーツ整形外科学会(JOSKAS 2009)すずらんセミナーLS10
  • Place of Presentation: 札幌
  • Year and Date: 2009-06-27
• [Presentation] 関節リウマチにおける骨破壊機序 (2009)
  • Author(s): 田中栄
  • Organizer: 第82回日本整形外科学会学術総会教育研修講演29
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-16
• [Presentation] Regulation of osteoclast apoptosis and function (2009)
  • Organizer: 3rd NEW YORK SKELETAL BIOLOGY AND MEDICINE
  • Place of Presentation: New York
  • Year and Date: 2009-05-01
• [Presentation] アニュアルコースレクチャー6「関節リウマチ」 (2009)
  • Author(s): 田中栄
  • Organizer: 第53回日本リウマチ学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-26
• [Presentation] サテライトシンポジウム骨破壊の要因「関節リウマチと骨破壊」 (2009)
  • Author(s): 田中栄
  • Organizer: 第53回日本リウマチ学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-23
• [Presentation] ランチョンセミナー2「窒素含有型ビスフォスフォネートによる破骨細胞アポトーシスと骨吸収能の制御メカニズム」 (2009)
  • Author(s): 田中栄
  • Organizer: 第27回日本骨代謝学会
  • Place of Presentation: 大阪
• [Presentation] ミニシンポジウム6骨粗鬆症治療薬の新展開「カテプシンK阻害薬」 (2009)
  • Author(s): 田中栄
  • Organizer: 第27回日本骨代謝学会
  • Place of Presentation: 大阪
• [Presentation] Session V Basic Concepts into osteoimmunology : Osteoclasts "Regulation of Skeletal Homeostasis by Bcl-2 family" (2008)
  • Organizer: 2nd International Conference on Osteoimmunology : Interactions of the Immune and Skeletal Systems
  • Place of Presentation: Rhodes, Greek
  • Year and Date: 2008-07-11
• [Presentation] Regulation of Skeletal Homeostasis by Bcl-2 family (2008)
  • Author(s): Arch Phys Med Rehabil
  • Organizer: 2nd International Conference on Osteoimmunology
  • Place of Presentation: ギリシャ
  • Year and Date: 2008-07-11
• [Presentation] シンポジウム4生物製剤「骨関節感染症診断におけるCD64の臨床的有用性」 (2008)
  • Author(s): 田中栄
  • Organizer: 第39回日本人工関節学会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-13