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Investigation into malignant transformation of endometriosis. prospective cohort study and molecular biology research

Research Project

Project/Area Number 20249066
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTottori University

Principal Investigator

TERAKAWA Naoki  鳥取大学, 名誉教授 (90163906)

Co-Investigator(Kenkyū-buntansha) HARADA Tasuku  鳥取大学, 医学部, 教授 (40218649)
ITAMOCHI Hiroaki  鳥取大学, 医学部, 講師 (20314601)
TANIGUCHI Fuminori  鳥取大学, 医学部附属病院, 講師 (40322218)
HAYASHI Kunihiko  群馬大学, 医学部, 教授 (80282408)
Co-Investigator(Renkei-kenkyūsha) KOBAYASHI Hiroshi  奈良県立医科大学, 医学部, 教授 (40178330)
MOMOEDA Mikio  聖路加国際病院, 女性総合診療部, 部長 (50221627)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥48,230,000 (Direct Cost: ¥37,100,000、Indirect Cost: ¥11,130,000)
Fiscal Year 2011: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2009: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2008: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
KeywordsJEMS / 子宮内膜症 / がん化 / 疫学研究
Research Abstract

This project is the prospective study "Investigation for malignant transformation of endometriosis in Japan". We have analyzed the personal data collected from approximately 2, 000 patients diagnosed as endometriosis. Of these patients, seven patients who have had ovarian cancer derived from endometrioma until 2011, and this research work will be conducted for next 10 years. In the basic molecular experiments, only the epithelial cells derived from ovarian endometrioma and clear cell carcinoma of ovary were captured, and analyzed gene expression profile by using the comprehensive cDNA microarray. We assessed the expression and function of fibroblast growth factor receptor(FGFR)-2 associated with the malignant transformation of endometrioma.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (82 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (32 results) (of which Peer Reviewed: 29 results) Presentation (45 results) Remarks (5 results)

  • [Journal Article] Apoptosis and endometriosis2011

    • Author(s)
      Taniguchi F, Terakawa N, Harada T, et al.
    • Journal Title

      Front Biosc

      Volume: 3 Pages: 648-662

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel mechanism of reduced proliferation in ovarian clear cell carcinoma cells : Cytoplasmic sequestration of CDK2 by p272011

    • Author(s)
      Itamochi H, Terakawa N, et al.
    • Journal Title

      Gynecol Oncol

      Volume: 122 Pages: 641-647

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibiting the mTOR pathway synergistically enhances cytotoxicity in ovarian cells induced by etoposide through upregulation of c-Jun2011

    • Author(s)
      Itamochi H, Terakawa N, Harada T, et al.
    • Journal Title

      Clin Cancer Res

      Volume: 17 Pages: 742-4750

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apigenin inhibits tumor necrosis factor a-induced cell proliferation and prostaglandin E2 synthesis by inactivating NFkB in endometriotic stromal cells2011

    • Author(s)
      Suou K, Taniguchi F, Harada T, Terakawa N., et al.
    • Journal Title

      Fertility and Sterility

      Volume: 95 Pages: 1518-1521

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Demethylation of a nonpromotor cytosine-phosphate-guanine island in thearomatase gene may cause the aberrant upregulation in endometriotic tissues2011

    • Author(s)
      Izawa M, Taniguchi F, Harada T, et al.
    • Journal Title

      Fertility and Sterility

      Volume: 95 Pages: 33-39

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apigenin inhibits tumor necrosis factor α-induced cell proliferation and prostaglandin E2 synthesis by inactivating NFκB in endometriotic stromal cells2011

    • Author(s)
      Suou K, Terakawa N, et al
    • Journal Title

      Fertility and Sterility

      Volume: 95(4) Issue: 4 Pages: 1518-1521

    • DOI

      10.1016/j.fertnstert.2010.09.046

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis and endometriosis2011

    • Author(s)
      Taniguchi F, Terakawa N, et al
    • Journal Title

      Frontier and Bioscience

      Volume: 1(3) Issue: 1 Pages: 648-662

    • DOI

      10.2741/277

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Demethylation of a nonpromotor cytosine-phosphate-guanine island in the aromatase gene may cause the aberrant upregulation in endometriotic tissues2011

    • Author(s)
      Izawa M, Terakawa N, et al
    • Journal Title

      Fertility and Sterility

      Volume: 95(1) Issue: 1 Pages: 33-39

    • DOI

      10.1016/j.fertnstert.2010.06.024

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel mechanism of reduced proliferation in ovarian clear carcinoma cells : cytoplasmic sequestration of CDK2 by p272011

    • Author(s)
      Itamochi H, Terakawa N, et al
    • Journal Title

      Gynecol Oncol

      Volume: 122(3) Issue: 3 Pages: 641-647

    • DOI

      10.1016/j.ygyno.2011.05.003

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibiting the mTOR pathway synergistically enhances cytotoxicity in ovarian cancer cells induced by etoposide through upregulation of c-Jun2011

    • Author(s)
      Itamochi H, Terakawa N, et al
    • Journal Title

      Clin Cancer Res

      Volume: 17(14) Issue: 14 Pages: 4742-4750

    • DOI

      10.1158/1078-0432.ccr-11-0190

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis and endometriosis.2011

    • Author(s)
      Taniguchi F, Harada T
    • Journal Title

      Frontier and Bioscience 1(3)

      Pages: 648-662

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Demethylation of a nonpromotor cytosine-phosphate-guanine island inthe aromata se gene may cause the aberrant upregul ation in endometriotic tissues.2011

    • Author(s)
      Izawa M, Taniguchi F, Uegaki T, Takai E, Iwabe T, Terakawa N, Harada T
    • Journal Title

      Fertility and Sterility 95(1)

      Pages: 33-39

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Apigenin inhibits tumor necrosis factor α-induced cell proliferation and prostaglan din E2 synthesis by inactivating NFκB in endometriotic stromal cells.2011

    • Author(s)
      Suou K, Taniguchi F, Tagashira Y, Kiyama T, Terakawa N, Harada T
    • Journal Title

      Fertility and Sterility 95(4)

      Pages: 1518-1521

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Demethylation of a nonpromotor cytosine-phosphate-guanine island in the aromatase gene may cause the aberrant upregulation in endometriotic tissues.2011

    • Author(s)
      Izawa, et al
    • Journal Title

      Fertility and Sterility

      Volume: 95(1) Pages: 33-39

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apigenin inhibits tumor necrosis factor α-induced cell proliferation and prostaglandin E2 synthesis by inactivating NFκB in endometriotic stromal cells.2011

    • Author(s)
      Suou, et al
    • Journal Title

      Fertility and Sterility

      Volume: 95(4) Pages: 1518-1521

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipopolysaccharide promoted proliferation and invasion of endometriotic stromal cells via induction of cyclooxygenase-2 expression2010

    • Author(s)
      Takenaka Y, Taniguchi F, Terakawa N, Harada T, et al.
    • Journal Title

      Fertility and Sterility

      Volume: 93(1) Pages: 325-327

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of survivin in the resistance of endometriotic stromal cells to drug-induced apoptosis2009

    • Author(s)
      Watanabe A, Taniguchi F, Terakawa N, Harada T, et al.
    • Journal Title

      Hum Reprod

      Volume: 24(12) Pages: 3172-3179

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] TAK1 activation for cytokine synthesis and proliferation of endometriotic cells2009

    • Author(s)
      Taniguchi F, Harada T, Terakawa N, et al.
    • Journal Title

      Mol Cell Endocrinol

      Volume: 307(1-2) Pages: 196-204

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] TNF alpha gene silencing reduced lipopolysaccharide-promoted proliferation of endometriotic stromal cells2009

    • Author(s)
      Miyamoto A, Taniguchi F, Harada T, Terakawa N., et al.
    • Journal Title

      Am J Reprod Immunol

      Volume: 61(4) Pages: 277-285

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-10 attenuates TNF-alpha-induced interleukin-6 production in endometriotic stromal cells2009

    • Author(s)
      Tagashira Y, Taniguchi F, Harada T, Terakawa N., et al.
    • Journal Title

      Fertil Steril

      Volume: 91 Pages: 2185-2192

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis-a randomized, double-blind, multicenter, controlled trial2009

    • Author(s)
      Harada T, Terakawa N, et al.
    • Journal Title

      Fertil Steril

      Volume: 91(3) Pages: 675-681

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term use of dienogest for the treatment of endometriosis. J. Obstet2009

    • Author(s)
      Momoeda M, Harada T, Terakawa N, et al.
    • Journal Title

      Gynaecol. Res

      Volume: 35(6) Pages: 1069-1076

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] TAK1 activation of cytokine synthesis and proliferation of endometriotic cells.2009

    • Author(s)
      Taniguchi F., et al.
    • Journal Title

      Molecular Cellular Endocrinology 13

      Pages: 196-204

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of survivin in the resistance of endometriotic stromal cells to drug-induced apoptosis.2009

    • Author(s)
      Watanabe A., et al
    • Journal Title

      Human Reproduction 24(12)

      Pages: 3172-3179

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-10 attenuates TNF-alpha-induced interleukin-6 production in endometriotic stromal cells.2009

    • Author(s)
      Tagashira Y., et al.
    • Journal Title

      Fertility and Sterility 91(5Suppl)

      Pages: 2185-2192

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An epigenetic disorder may cause aberrant expression of aromatase gene in endometriotic stromal cells2008

    • Author(s)
      Izawa M, Harada T, Taniguchi F, Terakawa N, et al.
    • Journal Title

      Fertil Steril

      Volume: 89(3) Pages: 1390-1396

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma2008

    • Author(s)
      Itamochi H, Terakawa N, et al.
    • Journal Title

      Cancer Sci

      Volume: 99(4) Pages: 653-658

    • NAID

      10024004412

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression of keratinocyte growth factor receptor in ovarian surface epithelial cells of endometrioma2008

    • Author(s)
      Taniguchi F, Harada T, Terakawa N, et al.
    • Journal Title

      Fertil Steril

      Volume: 89(2) Pages: 478-480

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor-γligand reduced tumor necrosis factor-α-induced interleukin-8 production and growth in endometriotic stromal cells2008

    • Author(s)
      Ohama Y, Harada T, Taniguchi F. Terakawa N, et al.
    • Journal Title

      Fertil Steril

      Volume: 89(2) Pages: 311-317

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] An epigenetic disorder may cause aberrant expression of aromatase gene in endometrlotic stromal cells2008

    • Author(s)
      M. Izawa, et al.
    • Journal Title

      Fertil. Steril. 89

      Pages: 1390-1396

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukln-10 attenuates TNF-α-induced interleukin-6 production in endometriotic stromal cells

    • Author(s)
      Y. Tagashira, et al.
    • Journal Title

      Fertil. Steril (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TNFα gene silencing reduced lipopoly saccharide-promoted proliferation of endoinetriotic stromal cells

    • Author(s)
      A. Miyamoto, et al.
    • Journal Title

      Am J Reprod Immunol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 本邦における子宮内膜症の癌化の頻度と予防に関する疫学研究2012

    • Author(s)
      谷口文紀、原田省、林邦彦、小林浩、百枝幹雄、寺川直樹
    • Organizer
      JEMS中間報告第32回日本エンドメトリオーシス学会
    • Place of Presentation
      長崎市
    • Year and Date
      2012-01-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 「本邦における子宮内膜症の癌化の頻度と予防に関する基礎研究」JEMS中間報告2012

    • Author(s)
      谷口文紀、原田省、林邦彦、小林浩、百枝幹雄、寺川直樹
    • Organizer
      第33回日本エンドメトリオーシス学会
    • Place of Presentation
      ホテルニュー長崎(長崎市)
    • Year and Date
      2012-01-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 薬用ハーブによる子宮内膜症間質細胞の増殖およびPGE2産生抑制2011

    • Author(s)
      高井絵理、谷口文紀、原田省, 他
    • Organizer
      第56回日本生殖医学会学術講演会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 薬用ハーブによる子宮内膜症間質細胞の増殖およびPGE2産生抑制2011

    • Author(s)
      高井絵理、谷口文紀、原田省, 他
    • Organizer
      第56回日本生殖医学会学術講演会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-12-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] ジェノゲストによる子宮内膜症間質細胞の増殖抑制作用とその機序2011

    • Author(s)
      谷口文紀、寺川直樹、原田省, 他
    • Organizer
      第55回日本生殖医学会学術講演会
    • Place of Presentation
      徳島市
    • Year and Date
      2011-11-11
    • Related Report
      2011 Final Research Report
  • [Presentation] ジェノゲストによる子宮内膜症間質細胞の増殖抑制作用とその機序2011

    • Author(s)
      谷口文紀、寺川直樹、原田省, 他
    • Organizer
      第55回日本生殖医学会学術講演会
    • Place of Presentation
      あわぎんホール(徳島市)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 卵巣癌に対するmTOR阻害剤を用いた至適併用化学療法の探索2011

    • Author(s)
      板持広明、寺川直樹、原田省, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 卵巣癌に対するmTOR阻害剤を用いた至適併用化学療法の探索2011

    • Author(s)
      板持広明、寺川直樹、原田省, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子宮内膜症細胞におけるエストロゲン受容体αの発現解析2011

    • Author(s)
      東幸弘、谷口文紀、寺川直樹、原田省, 他
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-08-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 正所性子宮内膜および子宮内膜症組織におけるIAPファミリー発現の差異2011

    • Author(s)
      上垣崇、谷口文紀、寺川直樹、原田省, 他
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-08-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 卵巣癌癌性腹膜炎モデルに対するmTOR阻害剤を用いた至適併用化学療法の探索2011

    • Author(s)
      板持広明、寺川直樹、原田省, 他
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-08-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 子宮内膜症細胞におけるエストロゲン受容体αの発現解析2011

    • Author(s)
      東幸弘、谷口文紀、寺川直樹、原田省, 他
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2011-08-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 正所性子宮内膜および子宮内膜症組織におけるIAPファミリー発現の差異2011

    • Author(s)
      上垣崇、谷口文紀、寺川直樹、原田省, 他
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2011-08-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 卵巣癌癌性腹膜炎モデルに対するmTOR阻害剤を用いた至適併用化学療法の探索2011

    • Author(s)
      板持広明、寺川直樹、原田省, 他
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2011-08-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inhibiting the mTOR pathway synergistically enhances etoposide-induced cytotoxicity by upregulating c-Jun in ovarian cancer cells2011

    • Author(s)
      Itamochi H, Terakawa N, Harada T, et al.
    • Organizer
      102th Annual Meeting of American Association for Cancer Reserach
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2011-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 本邦における子宮内膜症の癌化の頻度と予防に関する疫学研究2011

    • Author(s)
      谷口文紀、原田省、林邦彦、小林浩、百枝幹雄、寺川直樹
    • Organizer
      JEMS中間報告第32回日本エンドメトリオーシス学会
    • Place of Presentation
      東京都
    • Year and Date
      2011-01-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 「本邦における子宮内膜症の癌化の頻度と予防に関する疫学研究」JEMS中間報告2011

    • Author(s)
      谷口文紀、原田省、林邦彦、小林浩、百枝幹雄、寺川直樹
    • Organizer
      第32回日本エンドメトリオーシス学会(東京都)
    • Place of Presentation
      都市センターホテル(東京都)
    • Year and Date
      2011-01-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 「本邦における子宮内膜症の癌化の頻度と予防に関する基礎研究」JEMS中間報告2011

    • Author(s)
      谷口文紀
    • Organizer
      第32回日本エンドメトリオーシス学会
    • Place of Presentation
      都市センターホテル(東京都)
    • Year and Date
      2011-01-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 「本邦における子宮内膜症の癌化の頻度と予防に関する疫学研究」JEMS中間報告2011

    • Author(s)
      谷口文紀
    • Organizer
      第32回日本エンドメトリオーシス学会
    • Place of Presentation
      都市センターホテル(東京都)
    • Year and Date
      2011-01-21
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Aberrant expression of IAP family in endometriotic cells may cause resistance to apoptosis2010

    • Author(s)
      aniguchi F, Terakawa N, Harada T, et al.
    • Organizer
      66th Annual Meeting of American Society for Reproductive Medicine
    • Place of Presentation
      Denver, USA
    • Year and Date
      2010-10-26
    • Related Report
      2011 Final Research Report
  • [Presentation] The mechanism of resistance to apoptosis in endometriosis2010

    • Author(s)
      Taniguchi F, Harada T, et al.
    • Organizer
      The First Asian Conference on Endometriosis
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2010-10-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 卵巣明細胞腺癌に対するERKを標的とした分子標的治療2010

    • Author(s)
      大石徹郎、板持広明、寺川直樹、原田省, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-09-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 子宮内膜症細胞のアポトーシス抵抗性におけるSurvivinの関与2010

    • Author(s)
      谷口文紀、原田省、寺川直樹, 他
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Apigeninによる子宮内膜症間質細胞の増殖およびPGE2産生の抑制2010

    • Author(s)
      周防加奈、谷口文紀、原田省寺川直樹, 他
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Regulation of endometrial function2010

    • Author(s)
      Terakawa N, Fazleabas A
    • Organizer
      14thInternatiomnal Congress of Endocrinology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 本邦における子宮内膜症の癌化の頻度と予防に関する疫学研究2010

    • Author(s)
      谷口文紀、原田省、林邦彦、小林浩、百枝幹雄、寺川直樹
    • Organizer
      JEMS中間報告第31回日本エンドメトリオーシス学会
    • Place of Presentation
      京都市
    • Year and Date
      2010-01-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 「本邦における子宮内膜症の癌化の頻度と予防に関する疫学研究」JEMS中間報告2010

    • Author(s)
      谷口文紀
    • Organizer
      第31回日木エンドメトリオーシス学会ワークショップ
    • Place of Presentation
      京都東急ホテル(京都市)
    • Year and Date
      2010-01-16
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 「本邦における子宮内膜症の癌化の頻度と予防に関する基礎研究」JEMS中間報告2010

    • Author(s)
      谷口文紀
    • Organizer
      第31回日本エンドメトリオーシス学会
    • Place of Presentation
      京都市
    • Year and Date
      2010-01-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Apigenin inhibits TNFα-induced cell proliferation in endometriotic stromal cells2009

    • Author(s)
      Taniguchi F, , Terakawa N, Harada T, et al.
    • Organizer
      65th Annual Meeting of American Societh for Reproductive Medicine
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2009-10-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Possible involvement of survivin in resistance to drug-induced apoptosis of endometriotic stromal cells2009

    • Organizer
      65th Annual Meeting of American Societh for Reproductive Medicine
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2009-10-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 子宮内膜症細胞のアロマターゼ発現にはDNAのメチル化が関与する2009

    • Author(s)
      原田省、谷口文紀, 他
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] パスウェイ特異的アレイを用いた子宮内膜症細胞のアポトーシス抵抗性の解明2009

    • Author(s)
      渡邉彩子、谷口文紀、原田省、寺川直樹, 他
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 子宮内膜症細胞のIL-8産生と細胞増殖に対するGnRHアゴニストおよびアンタゴニストの効果2009

    • Author(s)
      宮本綾子、出浦伊万里、谷口文紀、原田省、寺川直樹, 他
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] LPSによる子宮内膜症細胞のPGE2産生誘導と細胞増殖および浸潤作用2009

    • Author(s)
      竹中泰子、谷口文紀、原田省、寺川直樹, 他
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 子宮内膜症細胞の増殖におけるシグナル分子TAK1の役割2009

    • Author(s)
      谷口文紀、原田省、寺川直樹, 他
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 卵巣明細胞腺癌に対するCDK2活性化によるCDDP耐性克服の試み2009

    • Author(s)
      板持広明、寺川直樹, 他
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] パスウェイ特異的アレイを用いた子宮内膜症細胞のアポトーシス抵抗性の解明2009

    • Author(s)
      谷口 文紀
    • Organizer
      第30回日本エンドメドリオーシス学会
    • Place of Presentation
      仙台市
    • Year and Date
      2009-01-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Exploring mechanisms for regulating growth and survival of ectopic endometriotic cells using comprehensive DNA microarray analysis2008

    • Author(s)
      Taniguchi F, , Terakawa N, Harada T, et al.
    • Organizer
      64th Annual Meeting of American Society for Reproductive Medicine
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2008-11-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Aberrant survivin expression may cause resistance to drug-induced apoptosis in human endometriotic stromal cells2008

    • Author(s)
      Watanabe A, Taniguchi F, , Terakawa N, Harada T, et al.
    • Organizer
      90th Annual Meeting of Endocrine Society for Reproductive Medicine
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2008-06-16
    • Related Report
      2011 Final Research Report
  • [Presentation] TAK1 may play a key role in regulating cytokine synthesis and cell proliferation of human endometriotic stromal cells2008

    • Author(s)
      Taniguchi F, , Terakawa N, Harada T, et al.
    • Organizer
      90th Annual Meeting of Endocrine Society for Reproductive Medicine
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2008-06-16
    • Related Report
      2011 Final Research Report
  • [Presentation] DNAマイクロアレイを用いた子宮内膜症細胞における遺伝子解析-子宮内膜症細胞の増殖におけるシグナル分子TAK1の役割2008

    • Author(s)
      谷口文紀、原田省、寺川直樹, 他
    • Organizer
      第81回日本内分泌学会
    • Place of Presentation
      青森市
    • Year and Date
      2008-05-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 卵巣明細胞腺癌における細胞増殖能と細胞内CDK2局剤の解析2008

    • Author(s)
      板持広明、寺川直樹, 他
    • Organizer
      第60回日本産科婦人科学会学術講演会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 正所性および異所性子宮内膜間質細胞におけるアポトーシス感受性2008

    • Author(s)
      渡邉彩子、谷口文紀、原田省、寺川直樹, 他
    • Organizer
      第60回日本産科婦人科学会学術講演会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-12
    • Related Report
      2011 Final Research Report
  • [Presentation] TNFαに対するsiRNAによる子宮内膜細胞の増殖抑制2008

    • Author(s)
      池田綾子、谷口文紀、原田省、寺川直樹, 他
    • Organizer
      第60回日本産科婦人科学会学術講演会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 子宮内膜症細胞のサイトカイン産生に対するIL-10の影響と細胞内シグナル伝達2008

    • Author(s)
      田頭由紀子、谷口文紀、原田省、寺川直樹, 他
    • Organizer
      第60回日本産科婦人科学会学術講演会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-12
    • Related Report
      2011 Final Research Report
  • [Remarks] jems@ med. Tottori-u. ac. Jp

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://jems.umin.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://jems.umin.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://jems.umin.jp/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://square.umin.ac.jp/JEMS/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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