|Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Arcadlin is an activity-regulated membrane protein that reduces excitatory synpatic number by activating the TAO2-MEK3-p38 MAPK signaling and inducing N-cadherin endocytosis. We have analyzed the physiological and pathological roles, regulatory mechanism, and knockout mice of arcadlin. As a result, we found 1) the arcadlin-N-cadherin complex associates with GluR2 and accelerates its endocytosis, 2) the internalization of arcadlin is mediated by endophilin-3 and arc, 3) arcadlin expression is regulated by COX-2, 4) arcadlin knockout mice show abnormal behavior, and 5) TAO2 mutation may cause developmental disorder.