| Project/Area Number |
20300144
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Shinshu University |
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Principal Investigator |
HIGUCHI Keiichi Shinshu University, 医学系研究科, 教授 (20173156)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Masayuki 信州大学, 医学系研究科, 准教授 (60273190)
SAWASHITA Jinko 信州大学, 医学系研究科, 助教 (40359732)
KAMETANI Fuyuki (財)東京都医学研究機構, 東京都精神医学総合研究所, 主任研究員 (70186013)
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| Co-Investigator(Renkei-kenkyūsha) |
NAIKI Hironobu 福井大学, 医学部, 教授 (10227704)
MAEDA Shuichiro 山梨大学, 医学工学総合研究部, 教授 (10117244)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | アミロイドーシス / マウス / アミロイド線維 / 伝播 / apoA-II,ノックアウトマウス / 熱ショック蛋白質 / リポ蛋白質 / 疾患モデル / HDL / apoA-II / apoA-I / モデル動物 / ノックアウトマウス / SAA |
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| Research Abstract |
Amyloidoses are protein structural disorders characterized by the extracellular deposition of insoluble amyloid fibrils resulting from abnormal conformational changes. We have developed a new analytical system for amyloid fibril formation from synthetic peptides in test tubes and several new mouse strains for studying various kinds of amyloidoses. Using these in vitro and in vivo systems, systemic analysis of amyloidosis was performed to elucidate the pathogenesis of transmission of amyloidosis. We found 1) new transmission routes through feces and skeletal muscle, 2) new therapeutic targets including peptides inhibiting fibril formation, heat shock transcription factor 1 (HSF1) and apolipoprotein A-I, and 3) several newly developed mouse strains variable for amyloidosis researches.
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