Effectiveness of intensive rTMS for post stroke patients with aphasia based on functional MRI and NIRS findings

• Project/Area Number: 20300188
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Jikei University School of Medicine
• Principal Investigator: ABO Masahiro Jikei University School of Medicine, 医学部, 教授 (00266587)
• Co-Investigator(Kenkyū-buntansha): KAKUDA Wataru 東京慈恵会医科大学, 医学部, 講師 (00453788)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
• Keywords: 失語症 / rTMS / 右半球 / 左半球 / 回復 / 脳梗塞 / 脳出血 / FMRI

Research Abstract

Our study demonstrated that application of low-frequency rTMS to an area homologous to the most activated area on pretreatment fMRI with a language task resulted in improvement of language function in aphasic stroke patients without any adverse effects. Therefore, our fMRI-based therapeutic rTMS strategy for chronic stroke patients with aphasia seems feasible and potentially useful neurorehabilitative approach with low-risk symptomatic deterioration.

Research Products

• [Journal Article] 言語障害 (2010)
  • Author(s): 小林健太郎、安保雅博
  • Journal Title: Medical Practices 27(10) Pages: 1688-1690
• [Journal Article] Low-frequency rTMS with language therapy over a 3-month period for sensory-dominant aphasia : case series of two post-stroke Japanese patients. (2010)
  • Author(s): Kakuda W, Abo M, Uruma G, Kaito N, Watanabe M
  • Journal Title: Brain Inj 24(3) Pages: 1113-1117
  • Peer Reviewed
• [Journal Article] Neuroimaging and neurorehabilitation for aphasia. (2010)
  • Author(s): 安保雅博, 角田亘
  • Journal Title: Brain Nerve 62 Pages: 141-149
  • NAID: 40016987763
• [Journal Article] Functional MRI-Based Therapeutic rTMS Strategy for Aphasic Stroke Patients : A Case Series Pilot Study (2010)
  • Author(s): Kakuda W, Abo M, Kaito N, Watanabe M, Senoo A
  • Journal Title: Int J Neurosci 120 Pages: 60-66
  • Peer Reviewed
• [Journal Article] Low-frequency rTMS with language therapy over a 3-month period for sensory-dominant aphasia : case series of two post-stroke Japanese patients. (2010)
  • Author(s): Kakuda W, Abo M, Uruma G, Kaito N, Watanabe M
  • Journal Title: Brain Inj Volume: 24(3) Pages: 1113-1117
  • Peer Reviewed
• [Journal Article] 言語障害 (2010)
  • Author(s): 小林健太郎、安保雅博
  • Journal Title: Medical Practices Volume: 27(10) Pages: 1688-1690
• [Journal Article] Functional MRI-Based Therapeutic rTMS Strategy for Aphasic Stroke Patients : A Case Series Pilot Study. (2010)
  • Author(s): Kakuda W, Abo M, Kaito N, Watanabe M, Senoo A.
  • Journal Title: Int J Neurosci 120 Pages: 60-66
  • Peer Reviewed
• [Journal Article] Neuroimaging and neurorehabilitation for aphasia. (2010)
  • Author(s): Abo M, Kakuda W
  • Journal Title: Brain Nerve 62 Pages: 141-149
  • NAID: 40016987763
• [Journal Article] 失語症の回復と機能再編 (2009)
  • Author(s): 安保雅博
  • Journal Title: Jpn J Rehabil Med 46 Pages: 32-34
  • NAID: 110007028616
• [Journal Article] 先進的医療技術を駆使した治療戦略 (2009)
  • Author(s): 角田亘、安保雅博
  • Journal Title: 総合リハビリテーション 37 Pages: 11-16
• [Journal Article] Repetitive Low-Frequency Transcranial Magnetic Stimulation Pluse Speech Therapy over a Six-Month Period Improved Naming and Writing. (2009)
  • Author(s): Kakuda W, Abo M, kaito N, Senoo A, Watanabe M
  • Journal Title: Jikeikai Med J 56 Pages: 31-36
  • Peer Reviewed
• [Journal Article] Repetitive Low-Frequency Transcranial Magnetic Stimulation Pluse Speech Therapy over a Six-Month Period Improved Naming and Writing. (2009)
  • Author(s): Kakuda W, Abo M, kaito N, Senoo A, Watanabe M.
  • Journal Title: Jikeikai Med J 56 Pages: 31-36
  • Peer Reviewed
• [Journal Article] 先進的医療技術を駆使した治療戦略 (2009)
  • Author(s): 角田亘, 安保雅博
  • Journal Title: 総合リハビリテーション 37 Pages: 11-16
• [Presentation] 失語症における脳機能画像とニューロリハビリテーション (2011)
  • Author(s): 安保雅博
  • Organizer: 第31回日本脳神経外科コングレス総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-05-06
• [Presentation] 反復経頭蓋磁気刺激による失語症治療-言語訓練との併用、FMRIをベースとして- (2011)
  • Author(s): 安保雅博
  • Organizer: 日本ニューロリハビリテーション学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-02-12
• [Presentation] 反復経頭蓋磁気刺激による失語症治療-言語訓練との併用、FMRIをベースとして- (2011)
  • Author(s): 安保雅博
  • Organizer: 日本ニューロリハビリテーション学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-02-12
• [Presentation] 脳梗塞後の感覚性失語に対する経頭蓋磁気刺激の治療的適用 (2009)
  • Author(s): 角田亘,安保雅博,渡邉基
  • Organizer: 第33回日本高次脳機能障害学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-30
• [Presentation] 脳卒中後失語症に対する低頻度反復性経頭蓋磁気刺激の外来通院下における長期的導入 (2009)
  • Author(s): 角田亘,安保雅博,海渡信義,妹尾淳史,渡邉基
  • Organizer: Stroke2009
  • Place of Presentation: 島根
  • Year and Date: 2009-03-20
• [Presentation] A Novel Approach Stroke Patients : Functional MRI-based Therapeutic rTMS Strategy (2009)
  • Author(s): Kakuda W, Abo M, Kaito N, Watanabe M
  • Organizer: INTERNATIONAL STROKE conference
  • Place of Presentation: San Diego
  • Year and Date: 2009-02-19
• [Remarks] ホームページ等
  • URL: http://jikei-reha.com/