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Can higher brain activity modify exercise pressor reflex? -application of awake-sleep cycle to changing brain activity

Research Project

Project/Area Number 20300202
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical education
Research InstitutionHiroshima University

Principal Investigator

MATSUKAWA Kanji  Hiroshima University, 大学院・保健学研究科, 教授 (90165788)

Co-Investigator(Kenkyū-buntansha) SADAMOTO Tomoko  日本女子体育大学, 体育学部, 教授 (30201528)
Research Collaborator LIANG Nang  広島大学, 大学院・保健学研究科, 助教 (70512515)
NAKAMOTO Tomoko  広島大学, 大学院・保健学研究科, 大学院生
KASHIMA Eri  広島大学, 大学院・保健学研究科, 大学院生
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Keywords筋受容器反射 / 心循環調節 / 筋機械受容器 / 筋代謝受容器 / セントラルコマンド / 覚醒状態 / 睡眠状態 / 覚醒睡眠サイクル
Research Abstract

The present study has revealed that central command, originating from higher brain centers, plays an important role in controlling the cardiovascular system during voluntary exercise in daily life. In particular, the cardiovascular control by central command is prominent during flexion than extension movement. On the other hand, exercise pressor reflex originating from contacting skeletal muscles are suppressed in the conscious condition. However, muscle mechano- and metaboreflex become evident during sleep or anesthesia, suggesting that an inhibition of higher brain activity facilitates exercise pressor reflex. The brain serotonergic receptor system (especially, 5-HT_<1A> receptors) may be involved in the facilitation of the exercise pressor reflex.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (62 results)

All 2011 2010 2009 2008 Other

All Journal Article (28 results) (of which Peer Reviewed: 28 results) Presentation (28 results) Book (2 results) Remarks (4 results)

  • [Journal Article] Electrical stimulation of the mesencephalic ventral tegmental area evokes skeletal muscle vasodilation in the cat and rat.2011

    • Author(s)
      Matsukawa K, Nakamoto T, Liang N.
    • Journal Title

      J Physiol Sci in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coactivation of renal sympathetic neurons and somatic motor neurons by chemical stimulation of the midbrain ventral tegmental area.2011

    • Author(s)
      Nakamoto T, Matsukawa K, Liang N, Wakasugi R, Wilson LB, Horiuchi J.
    • Journal Title

      J Appl Physiol 110

      Pages: 1342-1353

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Central command does not decrease cardiac parasympathetic efferent nerve activity during spontaneous fictive motor activity in decerebrate cats.2011

    • Author(s)
      Kadowaki A, Matsukawa K, Wakasugi R, Nakamoto T, Liang N.
    • Journal Title

      Am J Physiol Heart Circ Physiol 300

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential contribution of central command to the cardiovascular responses during static exercise of ankle dorsal and plantar flexion in humans.2011

    • Author(s)
      Liang N, Nakamoto T, Mochizuki S, Matsukawa K.
    • Journal Title

      J Appl Physiol 110

      Pages: 670-680

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of unilateral voluntary movement on motor imagery of the contralateral limb.2011

    • Author(s)
      Liang N, Funase K, Narita T, Takahashi M, Matsukawa K, Kasai T.
    • Journal Title

      Clin Neurophysiol 122

      Pages: 550-557

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The distribution of blood flow in the carotid and vertebral arteies during dynamic exercise in humans.2011

    • Author(s)
      Sato K, Ogoh S, Hirasawa A, Oue A, Sadamoto T.
    • Journal Title

      J Physiol in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coactivation of renal sympathetic neurons and somatic motor neurons by chemical stimulation of the midbrain ventral tegmental area.2011

    • Author(s)
      Nakamoto Tomoko
    • Journal Title

      J Appl Physiol

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central command does not decrease cardiac parasympathetic efferent nerve activity during spontaneous fictive motor activity in decerebrate cats.2011

    • Author(s)
      Kadowaki Akito
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 300

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of unilateral voluntary movement on motor imagery of the contralateral limb.2011

    • Author(s)
      Liang Nan
    • Journal Title

      Clin Neurophysiol

      Volume: 122 Pages: 550-557

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased cardiac parasympathetic nerve activity during footbath in pregnant women.2010

    • Author(s)
      Miyazato K, Matsukawa K.
    • Journal Title

      Jpn J Nurs Sci 7

      Pages: 65-75

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of adrenalectomy and autonomic blockades on the exercise tachycardia in conscious rats.2010

    • Author(s)
      Wakasugi R, Nakamoto T, Matsukawa K.
    • Journal Title

      Auton Neurosci 155

      Pages: 59-67

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The centrally-evoked increase in preganglionic adrenal sympathetic nerve activity during hypothalamic stimulation elicits immediate adrenaline secretion from the adrenal medulla.2010

    • Author(s)
      Tsuchimochi H, Nakamoto T, Matsukawa K.
    • Journal Title

      Exp Physiol 95

      Pages: 93-106

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different blood flow responses to dynamic exercise between internal carotid and vertebral arteries in women.2010

    • Author(s)
      Sato K, Sadamoto T.
    • Journal Title

      J Appl Physiol 109

      Pages: 864-869

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic cerebral autoregulation during and after handgrip exercise in humans.2010

    • Author(s)
      Ogoh S, Sato K, Akimoto T, Oue A, Hirasawa A, Sadamoto T.
    • Journal Title

      J Appl Physiol 108

      Pages: 1701-1705

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential contribution of central command to the cardiovascular responses during static exercise of ankle dorsal and plantar flexion in humans.2010

    • Author(s)
      Liang Nan
    • Journal Title

      J Appl Physiol

      Volume: 110 Pages: 670-680

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased cardiac parasympathetic nerve activity of pregnant women during foot bathes.2010

    • Author(s)
      Miyazato Kuniko
    • Journal Title

      Jpn J Nurs Sci

      Volume: 7 Pages: 65-75

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of adrenalectomy and autonomic blockades on the exercise tachycardia in conscious rats2010

    • Author(s)
      Wakasugi Rie
    • Journal Title

      Autonomic Neuroscience 12(印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Centrally evoked increase in adrenal sympathetic outflow elicits immediate secretion of adrenaline in anaesthetized rats2010

    • Author(s)
      Tsuchimochi Hirotsugu
    • Journal Title

      Experimental Physiology 95

      Pages: 93-106

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The enhancing effect of propofol anesthesia on skeletal muscle mechanoreflex in conscious cats.2009

    • Author(s)
      Matsukawa K, Nakamoto T, Kadowaki A, Shimizu M, Liang N, Endo K.
    • Journal Title

      Auton Neurosci 151

      Pages: 111-116

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Central command and the increase in middle cerebral artery blood flow velocity during static arm exercsie in women.2009

    • Author(s)
      Sato K, Sadamoto T, Ueda-Sasahara C, Shibuya K, Shimizu-Okuyama S, Osada T, Kamo M, Saito M, Kagaya A.
    • Journal Title

      Exp Physiol 94

      Pages: 1132-1138

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of central command on cerebral blood flow at the onset of exercsie in women.2009

    • Author(s)
      Sato K, Moriyama M, Sadamoto T.
    • Journal Title

      Exp Physiol 94

      Pages: 1139-1146

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The enhancing effect of propofol anesthesia on skeletal muscle mechanoreflex in conscious cats2009

    • Author(s)
      Matsukawa Kanji
    • Journal Title

      Autonomic Neuroscience 151

      Pages: 111-116

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sympathetic cholinergic nerve contributes to increased muscle blood flow at the onset of voluntary static exercise in conscious cats.2008

    • Author(s)
      Komine H, Matsukawa K, Tsuchimochi H, Nakamoto T, Murata J.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol 295

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Muscle receptors close to the myotendinous junction play a role in eliciting exercise pressor reflex during contraction.2008

    • Author(s)
      Nakamoto T, Matsukawa K.
    • Journal Title

      Auton Neurosci 138

      Pages: 99-107

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Muscle mechanosensitive reflex is suppressed in the conscious condition : effect of anesthesia.2008

    • Author(s)
      Matsukawa K, Nakamoto T.
    • Journal Title

      J Appl Physiol 104

      Pages: 82-87

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sympathetic cholinergic nerve contributes to increased muscle blood flow at the onset of voluntary static exercise in consciouscats.2008

    • Author(s)
      Komine Hidehiko
    • Journal Title

      Am J physiol Regul Integr Comp Physiol 295

      Pages: 1251-1262

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muscle receptors close to the myotendinous junction play a role in eliciting exercise pressor reflex during contraction.2008

    • Author(s)
      Nakamoto Tomoko
    • Journal Title

      Auton Neurosci 138

      Pages: 99-107

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muscle mechanosensitive reflex is suppressed in the conscious condition : effect of anesthesia.2008

    • Author(s)
      Matsukawa Kanji
    • Journal Title

      J Appl Physiol 104

      Pages: 82-87

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] The differential effects of central command on the aortic and carotid sinus baroreflex at the onset of fictive motor activity.2011

    • Author(s)
      Matsukawa K, Kadowaki A, Ishii K, Myoi S, Takakuwa T, Inoue A, Liang N
    • Organizer
      第88回日本生理学会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Increased cerebral blood flow in the prefrontal cortex preceding the onset of voluntary arm cranking and leg cycling exercise in humans.2011

    • Author(s)
      Ishii K, Matsukawa K, Liang N
    • Organizer
      第88回日本生理学会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Motor imagery, but not action observation, modulates the corticospinal excitability in a phase-dependent manner.2011

    • Author(s)
      Liang N, Takahashi M, Matsukawa K
    • Organizer
      第88回日本生理学会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 自発運動開始時にみられるセントラルコマンドが及ぼす大動脈血圧受容器反射そして頸動脈洞血圧受容器反射への異なる影響2011

    • Author(s)
      松川寛二
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      横浜市(招待講演)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 体位変化試験2010

    • Author(s)
      松川寛二
    • Organizer
      第63回日本自律神経学会総会,教育セミナー"ゼロからわかる自律神経機能検査"
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Cardiac vagal efferent discharge does not decrease during spontaneous fictive motor activity in decerebrate cats.2010

    • Author(s)
      Kadowaki A, Matsukawa K, Wakasugi R, Nakamoto T, Liang N
    • Organizer
      ACSM Conference on Integrative Physiology of Exercise.
    • Place of Presentation
      Miami, Florida, USA
    • Year and Date
      2010-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Increased blood flow in the cerebral prefrontal cortex preceding the onset of voluntary exercise.2010

    • Author(s)
      Matsukawa K, Ohtani R, Ishii K.
    • Organizer
      第87回日本生理学会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Central command contributes to increasing blood flow to non-exercising muscle at onset of voluntary exercise.2010

    • Author(s)
      Ishii K, Ohtani R, Matsukawa K
    • Organizer
      第87回日本生理学会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of ischemic heart failure on the muscle mechanosensitive reflex in conscious cats.2010

    • Author(s)
      Kadowaki A, Wakasugi R, Asahi R, Myoi S, Matsukawa K
    • Organizer
      第87回日本生理学会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Short- and longterm effects of exercise on the arterial baroreflexes.2010

    • Author(s)
      Komine H, Matsukawa K
    • Organizer
      第87回日本生理学会Symposium "Recent insight into cardiovascular regulation during exercise : central command and baroreflex"
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of ischemic heart failure on the muscle mechanosensitive reflex in conscious cats.2010

    • Author(s)
      Matsukawa K, Wakasugi R, Kadowaki A, Asahi R, Myoi S.
    • Organizer
      Experimental Biology
    • Place of Presentation
      Anaheim, California, USA
    • Year and Date
      2010-04-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 循環調節によるFeedforward制御2009

    • Author(s)
      松川寛二
    • Organizer
      第32回日本生体医工学会中国四国支部大会,特別講演
    • Place of Presentation
      広島市
    • Year and Date
      2009-11-28
    • Related Report
      2010 Final Research Report
  • [Presentation] A hypothesis for generation of central command signal during exercise.2009

    • Author(s)
      松川寛二
    • Organizer
      International Sports Science Network Forum in Nagano
    • Place of Presentation
      軽井沢町
    • Year and Date
      2009-08-03
    • Related Report
      2010 Final Research Report
  • [Presentation] The differential cardiovascular responses to voluntary and electrically-evoked involuntary static contraction between ankle extensor and flexor muscles in humans.2009

    • Author(s)
      Liang N, Matsukawa K, Nakamoto T, Mochizuki S, Oda K.
    • Organizer
      International Sports Science Network Forum in Nagano
    • Place of Presentation
      軽井沢町
    • Year and Date
      2009-08-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Activation of cardiac sympathetic outflow, but not vagal withdrawal, during spontaneous motor activity in decerebrate cats.2009

    • Author(s)
      Kadowaki A, Matsukawa K, Nakamoto N, Liang N, Wakasugi R
    • Organizer
      International Sports Science Network Forum in Nagano
    • Place of Presentation
      軽井沢町
    • Year and Date
      2009-08-03
    • Related Report
      2010 Final Research Report
  • [Presentation] The effects of adrenalectomy and autonomic blockades on the tachycardia at the beginning of dynamic exercise in conscious rats.2009

    • Author(s)
      Wakasugi R, Nakamoto N, Matsukawa K
    • Organizer
      International Sports Science Network Forum in Nagano
    • Place of Presentation
      軽井沢町
    • Year and Date
      2009-08-03
    • Related Report
      2010 Final Research Report
  • [Presentation] The effects of adrenalectomy and autonomic blockadeson the exercise induced tachycardia in conscious rats.2009

    • Author(s)
      若杉理恵, 中本智子, 松川寛二
    • Organizer
      36^<th> Congress of the lnternational Union of Physiological Sciences
    • Place of Presentation
      京都市
    • Year and Date
      2009-07-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Autonomic and cardiovascular responses to stimulation of midbrain dopaminergic neurons in anesthetized rats.2009

    • Author(s)
      Nakamoto N, Matsukawa K, Wakasugi R, Liang N, Wilson LB, Horiuchi J.
    • Organizer
      36^<th> Congress of the International Union of Physiological Sciences
    • Place of Presentation
      京都市
    • Year and Date
      2009-07-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Endogenous activation of 5-HT_<1A> receptors suppresses muscle mechanosensitive reflex in the conscious condition.2009

    • Author(s)
      Matsukawa K, Shimizu M, Kadowaki A, Nakamoto T, Liang N, Wakasugi R
    • Organizer
      36^<th> Congress of the International Union of Physiological Sciences
    • Place of Presentation
      京都市
    • Year and Date
      2009-07-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Activation of cardiac sympathetic outflow, but not vagal withdrawal, during spontaneous motor activity in decerebrate cats.2009

    • Author(s)
      Kadowaki A, Matsukawa K, Nakamoto N, Liang N, Wakasugi R, Shimizu M.
    • Organizer
      36^<th> Congress of the International Union of Physiological Sciences
    • Place of Presentation
      京都市
    • Year and Date
      2009-07-30
    • Related Report
      2010 Final Research Report
  • [Presentation] The Cardiovascular responses to voluntary and electrically-evoked involuntary static exercise of ankle plantar and dorsal flexion in humans.2009

    • Author(s)
      Liang N, Mochizuki S, Oda K, Nakamoto T, Matsukawa K
    • Organizer
      36^<th> Congress of the International Union of Physiological Sciences
    • Place of Presentation
      京都市
    • Year and Date
      2009-07-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Endogenous activation of 5-HT receptors suppresses muscle mechanosensitive reflex in the conscious condition2009

    • Author(s)
      松川寛二
    • Organizer
      Proceedings of the XXXVI International Congress of Physiological Sciences (IUPS2009)
    • Place of Presentation
      京都市
    • Year and Date
      2009-07-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心拍変動と自律神経活動2008

    • Author(s)
      松川寛二, 中本智子, 梁楠
    • Organizer
      第47回日本生気象学会大会「自律神経の基礎と最前線」シンポジウム
    • Place of Presentation
      奈良市
    • Year and Date
      2008-11-23
    • Related Report
      2010 Final Research Report
  • [Presentation] ラツト運動時の心拍数調節のメカニズム : 副腎摘出ならびに自律神経系遮断薬の効果2008

    • Author(s)
      若 杉 理 恵
    • Organizer
      第60回 日本生理学会中国四国地方会
    • Place of Presentation
      愛媛大学城北キャンパス
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 慢性覚醒動物を用いた循環調節研究:運動時に働くセントラルコマンドと筋機械受容器反射について2008

    • Author(s)
      松川寛二, 中本智子, 加島絵理, 土持裕胤, 遠藤加菜, 若杉理恵, 梁楠
    • Organizer
      第9回Neurocardiology Workshop
    • Place of Presentation
      東京都
    • Year and Date
      2008-07-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Muscle mechanosensitive reflex is suppressed in the conscious condition : effect of anesthesia.2008

    • Author(s)
      Nakamoto T, Matsukawa K, Tsuchimochi H.
    • Organizer
      Experimental Biology
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2008-04-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Does acute dynamic exercise improve brain cognitive function in humans?2008

    • Author(s)
      Endo K, Tsuchimochi H, Nakamoto T, Kashima E, Matsukawa K, Okamura H, Hamaoka T.
    • Organizer
      Experimental Biology
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2008-04-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Modulation of muscle mechanosensitive reflex in humans : comparison of the cardiovascular response to passive cycling between the awake and sleep conditions.2008

    • Author(s)
      Matsukawa K, Kashima E, Tsuchimochi H, Nakamoto T, Endo K, Sadamoto T.
    • Organizer
      Experimental Biology
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2008-04-06
    • Related Report
      2010 Final Research Report
  • [Book] 「運動生理学からみた身体機能の維持・向上」(第10章.トレーニングと循環1.心拍応答)2009

    • Author(s)
      松川寛二
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2010 Final Research Report
  • [Book] 身体トレーニング : 運動生理学からみた身体機能の維持・向上第10章 : トレーニングと循環, 1. 心拍応答2009

    • Author(s)
      松 川 寛 二
    • Publisher
      真興交易(株) 医書出版部
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://home.hiroshima-u.ac.jp/matsulab/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/hsc/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/hsc/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/hsc/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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