Developmental neurotoxicity of environmental chemicals : Development of an evaluation method through toxicogenomic approach
| Project/Area Number |
20310037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Aoyama Gakuin University |
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Principal Investigator |
TASHIRO Tomoko Aoyama Gakuin University, 理工学部, 教授 (50114541)
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| Co-Investigator(Kenkyū-buntansha) |
NEGISHI Takayuki 青山学院大学, 理工学部, 助教 (80453489)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2008: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 環境 / 神経科学 / 発生・分化 / マイクロアレイ / 発達神経毒性 / 環境化学物質 / トキシコゲノミクス |
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| Research Abstract |
In order to develop an efficient method to evaluate developmental neurotoxicity of chemicals, we analyzed gene expression changes in the brain of rats fetally exposed to tributyl tin (TBT) or thalidomide using original oligonucleotide microarrays. About 450 developmentally regulated genes were selected experimentally, and gene-specific 45-mer oligonucletide probes were spotted onto microarrays. The results showed that sensitivity of brain regions and gene groups were significantly different between the 2 chemicals, indicating that neurotoxicity arising from 2 different mechanisms could be effectively detected and distinguished by this method.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Enhanced inhibitory effects of TBT chloride on the development of F1 rats.2010
Author(s)
Asakawa H, Tsunoda M, Kaido T, Hosokawa M, Sugaya C, Inoue Y, Kudo Y, Satoh T, Katagiri H, Akita H, Saji M, Wakasa M, Negishi T, Tashiro T, Aizawa Y.
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Journal Title
Arch.Environ.Contam.Toxicol. 58(4)
Pages: 1065-1073
Related Report
Peer Reviewed
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