Development of nano-particles with tumor retention by single molecular DDS imaging

• Project/Area Number: 20310067
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: Tohoku University
• Principal Investigator: OHUCHI Noriaki Tohoku University, 大学院・医学系研究科, 教授 (90203710)
• Co-Investigator(Kenkyū-buntansha): KASUYA Atsuo 東北大学, 国際高等研究教育機構, 客員教授 (10005986) ; TAKEDA Motohiro 東北大学, 大学院・医学系研究科, 准教授 (10333808) ; AMARI Masakazu 東北大学, 病院, 講師 (50400312) ; KAWAI Masaaki 東北大学, 大学院・医学系研究科, 客員准教授 (80513530) ; 櫻井 遊 東北大学, 大学院・医学系研究科, 助教 (80451574)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2008: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
• Keywords: 生体内イメージング / 転移 / ナノ粒子 / 腫瘍滞留性ナノ粒子 / 高分子ミセル / ドラッグデリバリーシステム / ブロック共重合体 / パクリタキセル / 微小管 / 1粒子 / 蛍光イメージング / DDS / 一粒子イメージング / EPR / 量子ドット / 1粒子イメージング / シリカコーティング蛍光ナノ粒子

Research Abstract

To develop an effective anticancer drug, the understanding of cancer mechanisms and drug delivery system (DDS) is very important. Here, we have developed a method for in vivo imaging with very high spatial accuracy and succeeded in tracking the membrane protein PAR1 during metastasis in living mice. To investigate drug movement in association to its size in tumor, fluorescent nano-particles were injected into the tumor-bearing mice and visualized by in vivo imaging. Additionally, we developed a novel method to evaluate the structural stability and anti-cancer effect of drug-incorporating polymeric micelles.

Research Products

• [Journal Article] Control of shell thickness in silica-coating of Au nanoparticles and their X-ray imaging properties. (2011)
  • Author(s): Kobayashi Y, Inose H, Nakagawa T, Gonda K, Takeda M, Ohuchi N, Kasuya A.
  • Journal Title: J Colloid Interface Sci 358 Pages: 329-333
  • Peer Reviewed
• [Journal Article] Single-particle tracking confirms that multivalent Tat-protein transduction domain induced Heparan-sulfate Proteoglycan (HSPG) cross-linkage activates Racl for internalization. (2011)
  • Author(s): Imamura J, Suzuki Y, Gonda K, Nath Roy C, Gatanaga H, Ohuchi N, Higuchi H.
  • Journal Title: J Biol Chem 286 Pages: 10581-10592
  • Peer Reviewed
• [Journal Article] がん転移の生体ナノイメージング (2011)
  • Author(s): 権田幸祐、渡邉朋信、大内憲明、樋口秀男
  • Journal Title: 生物物理 51 Pages: 82-83
  • NAID: 10028105819
• [Journal Article] Control of shell thickness in silica-coating of Au nanoparticles and their X-ray imaging properties. (2011)
  • Author(s): Kobayashi Y, Inose H, Nakagawa T, Gonda K, Takeda M, Ohuchi N, Kasuya A.
  • Journal Title: J.Colloid Interface Sci. Volume: 未定(in press)
  • Peer Reviewed
• [Journal Article] Single-particle tracking confirms that multivalent Tat-protein transducti on domain induced Heparan-sulfate Proteoglycan (HSPG) cross-linkage a ctivates Racl for internalization. (2011)
  • Author(s): Imamura J, Suzuki Y, Gonda K, Nath Roy C, Gatanaga H, Ohuchi N, Higuchi H.
  • Journal Title: J Biol Chemist Volume: 未定(in press)
  • Peer Reviewed
• [Journal Article] Size-selective growth and stabilization of small CdSe nanoparticles in aqueous solution. (2010)
  • Author(s): Park YS, Dmytruk A, Dmitruk I, Kasuya A, Takeda M, Ohuchi N, Okamoto Y, Kaji N, Tokeshi M, Baba Y.
  • Journal Title: ACS Nano 26 Pages: 121-128
  • Peer Reviewed
• [Journal Article] In vivo nano-imaging of membrane dynamics in metastatic tumor cells using quantum dots. (2010)
  • Author(s): Gonda K, Watanabe TM, Ohuchi N, Higuchi H.
  • Journal Title: J Biol Chem 285 Pages: 2750-2757
  • Peer Reviewed
• [Journal Article] Nano-imaging of the lymph network structure with quantum dots. (2010)
  • Author(s): Hikage M, Gonda K, Takeda M, Kamei T, Kobayashi M, Kumasaka M, Watanabe M, Satomi S, Ohuchi N.
  • Journal Title: Nanotechnology 21 Pages: 185103-185103
  • Peer Reviewed
• [Journal Article] Direct coating of quantum dots with silica shell. (2010)
  • Author(s): Kobayashi Y, Nozawa T, Nakagawa T, Gonda K, Takeda M, Ohuchi N.
  • Journal Title: J Sol-Gel Sci Techn 55 Pages: 79-85
  • Peer Reviewed
• [Journal Article] Synthesis of silica-coated AgI nanoparticles and immobilization of proteins on them. (2010)
  • Author(s): Kobayashi Y, Minato M, Ihara K, Sato M, Suzuki N, Takeda M, Ohuchi N, Kasuya A.
  • Journal Title: J Nanosci Nanotechnol 10 Pages: 7758-7761
  • Peer Reviewed
• [Journal Article] Uniform silica coated fluorescent nanoparticles : synthetic method, improved light stability and application to visualize lymph network tracer. (2010)
  • Author(s): Cong L, Takeda M, Hamanaka Y, Gonda K, Watanabe M, Kumasaka M, Kobayashi Y, Kobayashi M, Ohuchi N.
  • Journal Title: PLoS One 18
  • Peer Reviewed
• [Journal Article] Direct coating of quantum dots with silica shell. (2010)
  • Author(s): Kobayashi Y, Nozawa T, Nakaga wa T, Gonda K, Takeda M, Ohuchi N.
  • Journal Title: J Sol-Gel Sci Techn Volume: 55 Pages: 79-85
  • Peer Reviewed
• [Journal Article] Synthesis of silica-coated AgI nanoparticles and immobilization of protei ns on them. (2010)
  • Author(s): Kobayashi Y, Minato M, Ihara K, Sato M, Suzuki N, Takeda M , Ohuchi N, Kasuya A.
  • Journal Title: J Nanosci Nanotechnol. Volume: 10 Pages: 7758-7761
  • Peer Reviewed
• [Journal Article] Uniform silica coated fluorescent nanoparticles : synthetic method, impro ved light stability and application to visualize lymph network tracer. (2010)
  • Author(s): Cong L, Takeda M, Hamanaka Y, Gonda K, Watanabe M, Kum asaka M, Kobayashi Y, Kobayas hi M, Ohuchi N.
  • Journal Title: PLoS One Volume: 118
  • Peer Reviewed
• [Journal Article] in vivo nano-imaging of membrane dynamics in metastatic tumor cells using quantum dots. (2010)
  • Author(s): Gonda K, Watanabe TM, Ohuchi N, Higuchi H
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 2750-2757
  • Peer Reviewed
• [Journal Article] Nano-imaging of the lymph network structure with quantum dots. (2010)
  • Author(s): Hikage M, Gonda K, Takeda M, Kamei T, Kobayashi M, Kumasaka M, Watanabe M, Satomi S, Ohuchi N.
  • Journal Title: Nanotechnology Volume: 21
  • Peer Reviewed
• [Journal Article] Size-selective growth and stabilization of small CdSe nanoparticles in a queous solution. (2010)
  • Author(s): Park YS, Dmytruk A, Dmitruk I, Kasuya A, Takeda M, Ohuchi N, Okamoto Y, Kaji N, Tokeshi M, Baba Y
  • Journal Title: ACS Nano 26 Pages: 121-128
  • Peer Reviewed
• [Journal Article] In vivo nano-imaging of membrane dynamics in metastatic tumor cells using quantum dots. (2010)
  • Author(s): Gonda K, Watanabe TM, Ohuchi N, Higuchi H.
  • Journal Title: J Biol Chem. 285 Pages: 2750-2757
  • Peer Reviewed
• [Journal Article] Dynamics of different sized solid state nanocrystals as tracers for a drug delivery system in the interstitium of a human tumor xenograft. (2009)
  • Author(s): Kawai M, Higuchi H, Takeda M, Kobayashi Y, Ohuchi N.
  • Journal Title: Breast Cancer Research 11
  • Peer Reviewed
• [Journal Article] Dynamics of different sized solid state nanocrystals as tracers for a drug delivery system in the interstitium of a human tumor xenograft. (2009)
  • Author(s): Kawai M, Higuchi H, Takeda M, Kobayashi Y, Ohuchi N
  • Journal Title: Breast Cancer Research 11
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 武田元博, 権田幸祐, 大内憲明
  • Journal Title: 医学のあゆみ「【ナノ粒子メディスン】ナノテクノロジーと乳腺外科」(医歯薬出版(株)) Pages: 507-511
• [Journal Article] (2009)
  • Author(s): 武田元博, 権田幸祐, 大内憲明
  • Journal Title: 乳癌 テーラーメード治療の理論と実践「ナノDDSと乳癌標的治療」(金原出版) Pages: 83-90
• [Journal Article] (2009)
  • Author(s): 権田幸祐, 武田元博, 大内憲明
  • Journal Title: ナノ医療のためのin vivoナノイメージング。現代化学11月号(東京化学同人) Pages: 49-54
• [Journal Article] In vivo single molecular imaging and sentinel node navigation by nano-technology for molecular targeting drug delivery system and tailor made medicine. (2008)
  • Author(s): Takeda M, Tada H, Higuchi H, Kobayashi Y, Kobayashi M, Sakurai Y, Ishida T, Ohuchi N.
  • Journal Title: Breast Cancer 15 Pages: 145-152
  • NAID: 10025371809
  • Peer Reviewed
• [Journal Article] Preparation of amine free silica coated AgI nanoparticles with modified Stober method. (2008)
  • Author(s): Kobayashi Y, Shimizu N, Misawa K, Takeda M, Ohuchi N, Kasuya A, Konno M.
  • Journal Title: Surfaces Engineering 24 Pages: 248-252
  • Peer Reviewed
• [Journal Article] In vivo single molecular imaging and sentinel node navigation by nano-technology for molecular targeting drug delivery system and tailor made medicine (2008)
  • Author(s): Takeda M, Tada H, Higuchi H, Kobayashi Y, Kobayashi M, Sakurai Y, Ishida T, Ohuchi N
  • Journal Title: Breast Cancer 15 Pages: 145-152
  • NAID: 10025371809
  • Peer Reviewed
• [Journal Article] Preparation of amine free silica coated AgI nanoparticles with modified Stober method (2008)
  • Author(s): Kobayashi Y, Shimizu N, Misawa K, Takeda M, Ohuchi N, Kasuya A. Konno M
  • Journal Title: Surfaces Engineering 24 Pages: 248-252
  • Peer Reviewed
• [Journal Article] Phase II study of capecitabine and trastuzumab combination chemotherapy in patients with HER2 overexpressing metastatic breast cancers resistant to both anthracyclines and taxanes (2008)
  • Author(s): Ishida T, Kiba T, Takeda M, Matsuyama K, Teramukai S, Ishiwata R, Masuda N, Takatsuka Y, Noguchi S, Ishioka C, FukushimaM, Ohuchi N.
  • Journal Title: Cancer Chemother Pharmacol (Published on line : 12 December 2008.)
  • Peer Reviewed
• [Presentation] 高精度蛍光ナノ計測による新世代がん診断法の開発 (2011)
  • Author(s): 大内憲明
  • Organizer: 第7回ナノバイオ国際シンポジウム、基調講演
  • Place of Presentation: 東京
  • Year and Date: 2011-02-16
• [Presentation] 高精度蛍光ナノ計測による新世代がん診断法の開発 (2011)
  • Author(s): 大内憲明
  • Organizer: 第7回ナノバイオ国際シンポジウム,基調講演
  • Place of Presentation: 東京
  • Year and Date: 2011-02-16
• [Presentation] In vivo nano-imaging of cancer metastasis in tumor-bearing mice and.a ngiogenesis in ischemic model mice. (2011)
  • Author(s): Gonda K
  • Organizer: Network Medicine Global COE International Mini symposium
  • Place of Presentation: Sendai
  • Year and Date: 2011-02-04
• [Presentation] Quantitative analysis of mechanism of cancer metastasis using in vivo nano-imagine with quantum dots. (2011)
  • Author(s): Gonda K, Hikage M, Hamada Y, Takeda M, Higuchi H, Ohuchi N
  • Organizer: 4th International Symposium on Nanomedicine
  • Place of Presentation: Okazaki
• [Presentation] In vivOイメージングによる血管新生メカニズムの定量的解析 (2011)
  • Author(s): 濱田庸, 権田幸祐, 武田元博, 大内憲明
  • Organizer: 2011年生体運動研究合同班会議
  • Place of Presentation: 大阪
• [Presentation] ナノイメージングを用いたがん転移のメカニズム解析と診断法開発 (2010)
  • Author(s): 権田幸祐, 日景允, 武田元博, 大内憲明
  • Organizer: 実験動物中央研究所組織連携シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2010-12-21
• [Presentation] ナノイメージングを用いたがん転移のメカニズム解析と診断法開発 (2010)
  • Author(s): 権田幸祐, 日景允, 武田元博, 大内憲明
  • Organizer: 実騒動物中央研究所織連携シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2010-12-21
• [Presentation] In vivo real-time tracking of polymeric micelles for DDS visualization. (2010)
  • Author(s): Hamanaka Y, Gonda K, Takeda M, Shiraishi K, Yokoyama M, Ohuchi N.
  • Organizer: 4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
  • Place of Presentation: Singapore, Singapore
• [Presentation] Research for Cancer Cell Imaging and Therapy based on Nano-biotechnology. (2010)
  • Author(s): 大内憲明, 権田幸祐, 武田元博
  • Organizer: Tohoku GCOE - MIT SMART Program Workshop
  • Place of Presentation: Singapore
• [Presentation] Precise sentinel node imaging by fluorescent nanoparticles in laparoscopic surgery. (2010)
  • Author(s): Takeda M, Hikage M, Gonda K, Ohuchi N.
  • Organizer: 6th World Congress of Biomechanics and 14th International Conference on Biomedical Engineering
  • Place of Presentation: Singapore, Singapore
• [Presentation] in vivoナノイメージングによる乳癌研究:1分子可視化で判ってきたこと (2010)
  • Author(s): 大内憲明、権田幸祐、河合賢朗、多田寛、武田元博
  • Organizer: 第18回日本乳癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 転移性がん細胞の膜ダイナミックスのin vivoナノイメージング (2010)
  • Author(s): 権田幸祐、渡邉朋信、武田元博、大内憲明、樋口秀男
  • Organizer: ナノ学会第8回大会
  • Place of Presentation: 岡崎
• [Presentation] 転移性がん細胞の膜ダイナミックスのin vivOナノイメージング (2010)
  • Author(s): 権田幸祐, 渡邉朋信, 武田元博, 大内憲明, 樋言秀男
  • Organizer: ナノ学会第8回大会
  • Place of Presentation: 岡崎
• [Presentation] Precise sentinel node imaging by fluorescent nanoparticles in laparoscop is surgery. (2010)
  • Author(s): Takeda M, Hikage M, Gonda K, Ohuchi N
  • Organizer: 6th World Congress of Biomechanics and 14th Int ernational Conference on Biomedical Engineering
  • Place of Presentation: Singapore, Singapore
• [Presentation] Biodistribution of novel silica-coated nano-particles for fluorescence and CT imaging in tumor-bearing mice. (2010)
  • Author(s): Nakagawa T, Gonda K, Takeda M, Kamei T, Kobayashi Y, Inose H, Morimoto H, Nozawa T, Ohuchi N
  • Organizer: 4th East Asian Pacific Student Workshop on Nan o-Biomedical Engineering
  • Place of Presentation: Singapore, Singapore
• [Presentation] In vivo molecular imaging of vasculature in ischemic model mice. (2010)
  • Author(s): Hamada Y, Gonda K, Takeda M, Yambe T, Ohuchi N
  • Organizer: 4th East Asian Pacific Student Workshop on Nan o-Biomedical Engineering
  • Place of Presentation: Singapore, Singapore
• [Presentation] In vivo real-time tracking of polymeric micelles for DDS visualization. (2010)
  • Author(s): Hamanaka Y, Gonda K, Takeda M, Shiraishi K, Yokoyama M, Ohuchi N
  • Organizer: 4th East Asian Pacific Student Workshop on Nan o-Biomedical Engineering
  • Place of Presentation: Singapore, Singapore
• [Presentation] In vivo molecular imaging of the distribution of VEGF receptor in ische mic model mice. (2010)
  • Author(s): Hamada Y, Gonda K, Takeda M, Ohuchi N
  • Organizer: 4th International Symposium on Nanomedicine
  • Place of Presentation: Okazaki
• [Presentation] Nano-imaging of sentinel lymph node with endoscopicallyinjected quantum dots. (2010)
  • Author(s): Hikage M, Gonda K, Takeda M, Kamei T, Kobayashi M, Kumasaka M, Niizuma N, Miyata G, Ohuchi N
  • Organizer: The 7th International Sentinel Node Society Meeting
  • Place of Presentation: Yokohama
• [Presentation] Fluorescence and CT imaging of thmor-bearing mice with novel silica-coated nano-nartielas (2010)
  • Author(s): Nakagawa T, Gonda K, Takeda M, Kobayashi Y, Ohuchi N
  • Organizer: KIST-Tohoku Joint Symposium on Nanobiomedical Engineering
  • Place of Presentation: Seoul, Korea
• [Presentation] In vivo real-time tracking of polymeric micelles for DDS visualization. (2010)
  • Author(s): Hamanaka Y, Gonda K, Takeda M, Shiraishi K, Yokoyama M, Ohuchi N
  • Organizer: KIST-Tohoku Joint Symposium on Nanobiomedical Engineering
  • Place of Presentation: Seoul, Korea
• [Presentation] Novel Live cell imaging revealed the involvement of intracellular organe lies transporting systems in viral envelop induced cell fusion. (2010)
  • Author(s): 鈴木康弘, Chandora Nath Roy, 権田幸祐, 大内憲明
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
• [Presentation] 動物モデルにおけるシリカコーティング蛍光性ナノ粒子を用いたセンチネルリンパ節のイメージング (2010)
  • Author(s): 叢莉蔓, 武田元博, 権田幸祐, 渡辺みか, 濱中洋平, 小林芳男, 熊坂増高, 小林正樹, 大内憲明
  • Organizer: 陣・回日本癌学会学術総会
  • Place of Presentation: 大阪
• [Presentation] 抗がん剤内包高分子ミセルの腫瘍組織内in vivoイメージング (2010)
  • Author(s): 濱中洋平, 権田幸祐, 武田元博, 白石貢一, 横山昌幸, 大内憲明
  • Organizer: 第18回日本乳癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 2次元高分解能分光による癌検出法の開発 (2010)
  • Author(s): 根城均, 武田元博, 大内憲明
  • Organizer: ナノ学会第8回大会
  • Place of Presentation: 岡崎
• [Presentation] 量子ドットを用いたリンパネットワークの微細構造イメージング (2010)
  • Author(s): 日景允, 権田幸祐, 武田元博, 亀井尚, 小林正樹, 熊坂増高, 濱中洋平, 濱田庸, 中川智彦, 宮田剛, 大内憲明
  • Organizer: ナノ学会第8回大会
  • Place of Presentation: 岡崎
• [Presentation] in vivo イメージングによる蛍光標識高分子ミセルの鵬内動態解析 (2010)
  • Author(s): 濱中洋平, 権田幸祐, 武田元博, 白石貢一, 横山昌幸, 大内憲明
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
• [Presentation] ナノスケール蛍光粒子を用いた革新的センチネルリンパ節イメージング (2010)
  • Author(s): 日景允, 武田元博, 亀井尚, 権田幸祐, 小林正樹, 熊坂増高, 渡辺みか, 里見進, 大内憲明
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
• [Presentation] Precise sentinel node imaging by fluorescent nanoparticles in laparoscopic surgery. (2010)
  • Author(s): Takeda M, Hikage M, Gonda K, Ohuchi N
  • Organizer: 6th World Congress of Biomechanics and 14th Int ernational Conference on Biomedical Engineering
  • Place of Presentation: Singapore, Singapore
• [Presentation] Quantitative analysis of mechanism of cancer metastasis using in vivo nano-imaeing with quantum dots. (2010)
  • Author(s): Gonda K, Hikage M, Hamada Y, Takeda M. Higuchi H, Ohuchi N
  • Organizer: 4th International Symposium on Nanomedicine
  • Place of Presentation: Okazaki
• [Presentation] Research for Cancer Cell Imaging and Therapy based on Nano-biotechnology. (2010)
  • Author(s): Ohuchi N, Gonda K, Takeda M.
  • Organizer: Tohoku GCOE-MIT SMART Program Workshop
  • Place of Presentation: Singapore
• [Presentation] Nano-imaging of Cancer Metastasis with a Novel Antibody-based Therapeutic Agent. (2010)
  • Author(s): Gonda K, Miyashita M, Ohuchi N, Takeda M.
  • Organizer: Tohoku GCOE-MIT SMART Program Workshop
  • Place of Presentation: Singapore
• [Presentation] ナノ・バイオテクノロジーによる乳がんの1分子イメージング・DDSと大規模臨床試験 (2009)
  • Author(s): 大内憲明
  • Organizer: 第4回低侵襲医療機器実現化フォーラム、主催:(財)医療機器センター研究開発部
  • Place of Presentation: 東京慈恵医大、東京
  • Year and Date: 2009-11-24
• [Presentation] ナノ・バイオテクノロジーによる乳がんの1分子イメージング・DDSと大規模臨床試験 (2009)
  • Author(s): 大内憲明
  • Organizer: 第4回低侵襲医療機器実現化フォーラム主催:(財)医療機器センター研究開発部
  • Place of Presentation: 東京慈恵医大
  • Year and Date: 2009-11-24
• [Presentation] 乳がんのナノ標的イメージングと薬物動態・腫瘍機能解析 (2009)
  • Author(s): 武田元博、権田幸祐、樋口秀男、大内憲明
  • Organizer: 第31回日本バイオマテリアル学会シンポジウム6「生体イメージングとターゲティング」
  • Place of Presentation: 京都府民総合交流プラザ、京都
  • Year and Date: 2009-11-17
• [Presentation] 乳がんのナノ標的イメージングと薬物動態・腫瘍機能解析 (2009)
  • Author(s): 武田元博, 権田幸祐, 樋口秀男, 大内憲明
  • Organizer: 第31回日本バイオマテリアル学会シンポジウム6「生体イメージングとターゲティング」
  • Place of Presentation: 京都府民総合交流プラザ
  • Year and Date: 2009-11-17
• [Presentation] In vivo imaging of membrane dynamics in metastatic tumor cells using quantum dots. (2009)
  • Author(s): 権田幸祐, 武田元博, 樋口秀男,大内憲明
  • Organizer: The 68th annual meeting of Japan Cancer Society
  • Place of Presentation: Pacifico Yokohama
  • Year and Date: 2009-10-03
• [Presentation] Diagnosis of cancer by detecting the chemiluminescence of hematoporphyrins in peripheral blood lymphocytes. (2009)
  • Author(s): Takeda M, Kohno M, Amari M, Nakajima M, Ishida T, Ohuchi N.
  • Organizer: The 68th annual meeting of Japan Cancer Society
  • Place of Presentation: Pacifico Yokohama
  • Year and Date: 2009-10-02
• [Presentation] Diagnosis of cancer by detecting the chemiluminescence of hematoporphyrins in peripheral blood lymphocyes (2009)
  • Author(s): Takeda M, Kohno M, Amari M, Nakajima M, Ishida T, Ohuchi N.
  • Organizer: The 68th annual meeting of Japan Cancer Society
  • Place of Presentation: Pacifico Yokohama
  • Year and Date: 2009-10-02
• [Presentation] In vivo real-time tracking of single polymeric micelle for DDS dynamics (2009)
  • Author(s): Hamanaka Y, Gonda K, Takeda M, Shiraishi K, Yokoyama M, Ohuchi N.
  • Organizer: The 68th annual meeting of Japan Cancer Society
  • Place of Presentation: Pacifico Yokohama
  • Year and Date: 2009-10-01
• [Presentation] In vivo imaging of cancer metastasis with quantum dots. (2009)
  • Author(s): Gonda K, Watanabe T.M, Takeda M, Ohuchi N, Higuchi H.
  • Organizer: International Symposium organized by JST & IFReC "Frontier Immuno-Imaging
  • Place of Presentation: Osaka University.
  • Year and Date: 2009-05-11
• [Presentation] 生体ナノ計測で解き明かすがん転移メカニズム (2009)
  • Author(s): 権田幸祐、渡邉朋信、武田元博、樋口秀男、大内憲明
  • Organizer: ナノ学会第7回大会
  • Place of Presentation: 東京大学 本郷キャンパス(浅野地区)武田ホール
  • Year and Date: 2009-05-10
• [Presentation] 生体ナノ計測で解き明かすがん転移メカニズム (2009)
  • Author(s): 権田幸祐、渡邉朋信、武田元博、樋口秀男、大内憲明
  • Organizer: ナノ学会第7回大会
  • Place of Presentation: 東京大学 本郷キャンパス(浅野地区) 武田ホール
  • Year and Date: 2009-05-10
• [Presentation] Novel bio-imaging by functional nano-particle (2009)
  • Author(s): Ohuchi N, Takada M, Gonda K, Kawai M, Cong L, Sakurai Y
  • Organizer: 9^<th> International Symposium of Tohoku University Global COE Program
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2009-03-24
• [Presentation] Silica-coated fluorescent nano-particle for sentinel lymph node mapping (2009)
  • Author(s): Cong L, Takada M, Watanabe M, Kobayashi Y, Kobayashi M, Ohuchi N,
  • Organizer: 9^<th> International Symposium of Tohoku University Global COE Program
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2009-03-24
• [Presentation] In vivo real-time traching of single polymneric micelle. (2009)
  • Author(s): Hamanaka Y, Gonda K, Takeda M. Ohuchi N
  • Organizer: 9^<th> International Symposium of Tohoku University Global COE Program
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2009-03-24
• [Presentation] In vivo imaging of membrane dynamics in metastatic tumor cells. (2009)
  • Author(s): 権田幸祐, 渡邉朋信, 武田元博, 樋口秀男, 大内憲明
  • Organizer: The 2nd International Symposium on Nanomedicine, Asian Core Symposium-Nano and Biomedical Molecular Science-
  • Place of Presentation: Okazaki, Japan
  • Year and Date: 2009-02-04
• [Presentation] Bioimaging and dynamics of functional nano-particles. (2009)
  • Author(s): Takeda M, Gonda K, Kawai M, Sakurai Y, Cong L, Higuchi H, Ohuchi N.
  • Organizer: The 2nd International Symposium on Nanomedicine, Asian Core Symposium-Nano and Biomedical Molecular Science-
  • Place of Presentation: Okazaki, Japan
  • Year and Date: 2009-02-04
• [Presentation] In vivo imaging of membrane dynamics in metastatic tumor cells (2009)
  • Author(s): Gonda K, Watanabe TM, Takeda M, Higuchi H and Ohuchi N.
  • Organizer: The 2^<nd> International Symposium on Nanomedicine, Asian Core Symposium-Nano and Biomedical Molecular Science-
  • Place of Presentation: Okazaki, Japan
  • Year and Date: 2009-02-04
• [Presentation] Bioimaging and dynamics of functional nano-particles (2009)
  • Author(s): Takeda M, Gonda K, Kawai M, Sakurai Y, Cong L, Higuchi H, Ohuchi N
  • Organizer: The 2^<nd> International Symposium on Nanomedicine, Asian Core Symposium-Nano and Biomedical Molecular Science-
  • Place of Presentation: Okazaki, Japan
  • Year and Date: 2009-02-04
• [Presentation] Basic examination of the fluorescent endoscopic surgery using nanoparticle tracer (2009)
  • Author(s): Hikage M, Takeda M, Kamei T, Kobayashi M, Gonda K, Nakano T, Sakurai Y, Kawai M, Liman C, Hamanaka Y, Kumasaka M, Satomi S, Ohuchi N
  • Organizer: The 2^<nd> International Symposium on Nanomedicine, Asian Core Symposium-Nano and Biomedical Molecular Science-
  • Place of Presentation: Okazaki, Japan
  • Year and Date: 2009-02-04
• [Presentation] がん細胞の膜のダイナミックスは転移の進行にともない劇的に変化する (2009)
  • Author(s): 権田幸祐、渡邉朋信、武田元博、大内憲明、樋口秀男
  • Organizer: 2009年生体運動合同班会議
  • Place of Presentation: 東京大学
  • Year and Date: 2009-01-09
• [Presentation] 分子イメージングIn vivoナノイメージングで解き明かすがん転移とDDSの仕組み (2009)
  • Author(s): 権田幸祐、渡邉朋信、河合賢朗、武田元博、樋口秀男、大内憲明
  • Organizer: 第25回日本DDS学会学術集会、ワークショップ「分子イメージング」
  • Place of Presentation: 東京ドームホテル
• [Presentation] がん治療に向けたナノバイオ研究最前線 (2009)
  • Author(s): 大内憲明
  • Organizer: 第8回国際バイオEXPO、特別講演
  • Place of Presentation: 東京ビッグサイト、東京
• [Presentation] 蛍光1分子計測による薬物動態イメージング (2009)
  • Author(s): 武田元博、権田幸祐、樋口秀男、大内憲明
  • Organizer: 第48回日本生体医工学会オーガナイズドセッション「ナノキャリアーと物理エネルギーを融合したハイブリッド標的化・診断」
  • Place of Presentation: タワーホール船堀、東京
• [Presentation] 分子イメージングIn vivoナノイメージングで解き明かすがん転移とDDSの仕組み (2009)
  • Author(s): 権田幸祐、渡邉朋信、河合賢朗、武田元博、樋口秀男、大内憲明
  • Organizer: 第25回日本DDS学会学術集会 ワークショップ「分子イメージング」
  • Place of Presentation: 東京ドームホテル
• [Presentation] In vivo real-time tracking of single polymeric micelle for DDS Visualization (2009)
  • Author(s): Hamanaka Y, Gonda K, Takeda M, Shiraishi K, Yokoyama M, Ohuchi N.
  • Organizer: 3^<rd> EAST Asian Pacific Student Workshop on Nano-Biomedical Engineering
  • Place of Presentation: National University of Singapore, Singapore
• [Presentation] 蛍光1分子計測による薬物動態イメージング (2009)
  • Author(s): 武田元博, 権田幸祐, 樋口秀男, 大内憲明
  • Organizer: 第48回日本生体医工学会オーガナィズドセッション「ナノキャリアーと物理エネルギーを融合したハイブリッド標的化・診断」
  • Place of Presentation: 東京都江戸川区(タワーホール船堀)
• [Presentation] Development of novel antibody-based therapeutic agents targeting cancer metastasis. (2009)
  • Author(s): Gonda K, Miyashita M, Watanabe T.M., Takeda M, Higuchi K, Ohuchi N.
  • Organizer: 3rd International Symposium on Nanomedicine.
  • Place of Presentation: Okazaki.
• [Presentation] Imaging of single motor molecules in living cells and mice with nanometer precision. (2009)
  • Author(s): Higuchi H, Ohuchi N.
  • Organizer: 3rd International Symposium on Nanomedicine.
  • Place of Presentation: Okazaki.
• [Presentation] Interdisciplinaly research for nano-biomedicine in Tohoku University. 3rd Intemational Symposium on Nanomedicine. (2009)
  • Author(s): Takeda M, Yamaguchi T, Ohuchi N.
  • Organizer: 3rd International Symposium on Nanomedicine.
  • Place of Presentation: Okazaki.
• [Presentation] In vivo real-time tracking of polymeric micelles for DDS visualization. (2009)
  • Author(s): Hamanaka Y, Gonda K, Takeda M, Shiraishi K, Yokoyama M, Ohuchi N.
  • Organizer: 3rd International Symposium on Nanomedicine.
  • Place of Presentation: Okazaki.
• [Presentation] がん治療に向けたナノバイオ研究最前線 (2009)
  • Author(s): 大内憲明
  • Organizer: 第8回国際バイオEXPO特別講演
  • Place of Presentation: 東京ビッグサイト
• [Presentation] In vivoイメージングで観えてきた癌転移の仕組み (2008)
  • Author(s): 権田幸祐, 渡邉朋信, 武田元博, 樋口秀男, 大内憲明
  • Organizer: 第31回日本分子生物学会・第81回日本生化学会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] The feature of the interstitial nano drug delivery system with fluorescent nanocrystals of different sizes in the human tumor xenograft in mice. (2008)
  • Author(s): 河合賢朗, 武田元博, 大内憲明
  • Organizer: The 13^<th> International Conference on Biomedical Engineering
  • Place of Presentation: National University of Singapore, Singapore
  • Year and Date: 2008-12-04
• [Presentation] Bio-imaging by functional nano-particles of nano to macro scale (2008)
  • Author(s): Takeda M, Tada H, Kawai M, Sakurai Y, Cong L, Gonda K, Higuchi H, Ohuchi N.
  • Organizer: The 13th Internatonal Conferencenon Biomedical Engineering
  • Place of Presentation: National University of Singapore, Singapore
  • Year and Date: 2008-12-04
• [Presentation] The feature of the interstitial nano drug delivery system with fluorescent nanocrystals of different sizes in the human tumor xenograft in mice (2008)
  • Author(s): Kawai, M, Takeda M, Ohuchi N
  • Organizer: The 13th Internatonal Conferencenon Biomedical Engineering
  • Place of Presentation: National University of Singapore, Singapore
  • Year and Date: 2008-12-04
• [Presentation] Silica-coated fuorescent nano-Particles for sentinel lymph node biopsy and mapping (2008)
  • Author(s): Cong L, Takeda M, Watanabe M, Kobayashi Y, Kobayashi M, Ohuchi N.
  • Organizer: Tohoku-NUS student joint symposium
  • Place of Presentation: National University of Singapore, Singapore
  • Year and Date: 2008-12-04
• [Presentation] 機能性ナノ粒子による生体イメージングの臨床検査・外科への応用 (2008)
  • Author(s): 武田元博、権田幸祐、桜井遊、河合賢朗、石田孝宣、大内憲明
  • Organizer: 第55回日本臨床検査医学会学術集会、シンポジウム10 : 医学領域におけるナノ粒子展開をめぐる話題「機能性ナノ粒子による生体イメージングの臨床検査への応用」
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-27
• [Presentation] In vivoナノイメージングで観えてきた癌転移の仕組み (2008)
  • Author(s): 権田幸祐、武田元博、樋口秀男、大内憲明
  • Organizer: 第125回バィオメカニクス研究会(日本生体医工学会専門別研究会)
  • Place of Presentation: 仙台
  • Year and Date: 2008-10-28
• [Presentation] Imaging of cancer metastasis in living tumor with quantum dots (2008)
  • Author(s): Gonda K, Takeda M, Kawai M Sakurai Y, Higuchi H, Ohuchi, N.
  • Organizer: The 7th International Symposium on Nano-Biomedical Engineering
  • Place of Presentation: National Cheng Kung University, Tainan
  • Year and Date: 2008-10-24
• [Presentation] Plenary lecture : Drug resistance as a target for cancer chemotherapy. (2008)
  • Author(s): 大内憲明
  • Organizer: The 26th Congress of the International Association for Breast Cancer Research
  • Place of Presentation: 岡山県倉敷市
  • Year and Date: 2008-09-24
• [Presentation] Interstitial Nano-particle Tracking and Analysis of the Movements in the Human Tumor Xenografts in Mice (2008)
  • Author(s): Kawai M, Takeda M, Ishida T, Suzuki A. Amari M. Ohuchi N.
  • Organizer: The 26^<th> Congress of the International Association for Breast Cancer Research
  • Place of Presentation: 岡山県倉敷市
  • Year and Date: 2008-09-24
• [Presentation] Nanosized Silver-Iodide Beads as Novel X-ray Contrast Media for Cancer Detection (2008)
  • Author(s): Takeda M, Sakurai Y, Kobayashi Y, Cong L, Hikage M, Amari M, Ishida T. Gonda K. Ohuchi N.
  • Organizer: The 26^<th> Congress of the International Association for Breast Cancer Research
  • Place of Presentation: 岡山県倉敷市
  • Year and Date: 2008-09-24
• [Presentation] Plenary lecture : Drug resistance as a target for cancer chemotherapy (2008)
  • Author(s): Ohuchi N
  • Organizer: The 26^<th> Congress of the International Association for Breast Cancer Research
  • Place of Presentation: 岡山県倉敷市
  • Year and Date: 2008-09-24
• [Presentation] 粒径の異なるナノ粒子による腫瘍間質ドラッグデリバリーシステムの解析 (2008)
  • Author(s): 河合賢朗、武田元博、石田孝宣、大内憲明
  • Organizer: 第18回乳癌基礎研究会
  • Place of Presentation: 福島
  • Year and Date: 2008-07-15
• [Presentation] 量子ドットを用いた腫瘍細胞のin vivoイメージング (2008)
  • Author(s): 権田幸祐, 渡邊朋信, 武田元博, 大内憲明, 樋口秀男
  • Organizer: 第60回日本細胞生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-07-15
• [Presentation] 腫瘍間質におけるナノスケールでの分子挙動解析によるDDSの解明 (2008)
  • Author(s): 河合賢朗、樋口秀男、武田元博、石田孝宣、鈴木昭彦、甘利正和、宇佐美伸、桜井遊、渡部剛、大内憲明
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2008-05-15
• [Presentation] 蛍光ナノ粒子を用いた担がんマウスにおける腫瘍間質ナノドラッグデリバリーシステムの解析 (2008)
  • Author(s): 河合賢朗、武田元博、石田孝宣、大内憲明
  • Organizer: ナノ学会第6回大会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-07
• [Presentation] 量子ドットを用いた腫瘍細胞の膜伸縮運動のin vivoイメージング (2008)
  • Author(s): 権田幸祐, 渡邉朋信, 武田元博, 大内憲明, 樋口秀男
  • Organizer: ナノ学会第6回大会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-07
• [Presentation] シリカコーティング蛍光ナノビーズによるセンチネルリンパ節生検と分子画像診断 (2008)
  • Author(s): 叢莉蔓、小林芳男、武田元博、櫻井遊、甘利正和、大内憲明
  • Organizer: ナノ学会第6回大会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-07
• [Presentation] ナノヨウ化銀ビーズによるCT造影法の外科応用に関する基礎的検討 (2008)
  • Author(s): 武田元博、小林芳男、小林正樹、桜井遊、権田幸祐、樋口秀男、大内憲明
  • Organizer: ナノ学会第6回大会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-07
• [Presentation] 規ナノ粒子をトレーサーとした鏡視下手術の基礎的検討 (2008)
  • Author(s): 日景充、亀井尚、武田元博、小林正樹、大内憲明
  • Organizer: ナノ学会第6回大会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-07
• [Book] SURGERY FRONTIER (2010)
  • Author(s): 武田元博, 日景允, 権田幸祐, 叢莉蔓, 大内憲明
  • Publisher: メディカルレビュー社
• [Book] 乳癌 テーラーメード治療の理論と実践「ナノDDSと乳癌標的治療」 (2009)
  • Author(s): 武田元博、権田幸祐、大内憲明
  • Publisher: 金原出版
• [Book] 外科医に必要ながん化学療法の知識B.がん化学療法の実際7.乳癌「乳癌の集学的治療と化学療法」 (2008)
  • Author(s): 河合賢朗、武田元博、大内憲明
  • Publisher: 外科治療
• [Book] がん分子イメージングの新展開 (2008)
  • Author(s): 武田元博、大内憲明
  • Publisher: 癌と化学療法
• [Book] 新規開発ナノサイズヨウ化銀ビーズを用いたX線CT造影効果および体内動態の検討 (2008)
  • Author(s): 武田元博、桜井遊、小林芳男、大内憲明
  • Publisher: 乳癌基礎研究
• [Book] 機能性ナノ粒子による生体イメージング-がん診療への応用-。ナノメディシンナノテクの医療応用 (2008)
  • Author(s): 武田元博、小林芳男、小林正樹、櫻井遊、大内憲明
  • Publisher: オーム社
• [Book] 機能性ナノ粒子の医学領域における展開。有機分散系の分散・凝集技術、川口春馬編 (2008)
  • Author(s): 武田元博、大内憲明
  • Publisher: シーエムシー出版
• [Remarks] 腫瘍外科分野
  • URL: http://www.med.tohoku.ac.jp/org/medica1/36/index.html
• [Remarks] ナノ医科学講座
  • URL: http://ww.med.tohoku.ac.jp/org/contribute/107/index.html
• [Patent(Industrial Property Rights)] 免疫組織染色法、およびこれを用いた抗体医薬の有効性を判定する方法 (2011)
  • Inventor(s): 岡田尚大、中野寧、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Filing Date: 2011-03-25
• [Patent(Industrial Property Rights)] 組織の自家蛍光と蛍光物質内包ナノ粒子の蛍光を利用した免疫組織化学法 (2011)
  • Inventor(s): 岡田尚大、郷田秀樹、中野寧、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Filing Date: 2011-03-17
• [Patent(Industrial Property Rights)] 免疫組織化学染色方法及び反応試薬 (2011)
  • Inventor(s): 高野敬三、星野秀樹、岡田尚大、中野寧、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Filing Date: 2011-03-16
• [Patent(Industrial Property Rights)] 半導体ナノ粒子集積体及び半導体ナノ粒子集積体の製造方法 (2011)
  • Inventor(s): 星野秀樹、高橋優、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Filing Date: 2011-03-15
• [Patent(Industrial Property Rights)] 組織染色方法、組織評価方法および生体物質検出方法 (2011)
  • Inventor(s): 相宮拓司、郷田秀樹、岡田尚大、中野寧、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Filing Date: 2011-03-15
• [Patent(Industrial Property Rights)] 半導体ナノ粒子集積体 (2011)
  • Inventor(s): 高橋優、高梨健作、星野秀樹、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Filing Date: 2011-03-15
  • Overseas
• [Patent(Industrial Property Rights)] 半導体ナノ粒子集積体及び半導体ナノ粒子集積体の製造方法 (2011)
  • Inventor(s): 星野秀樹、高橋優、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Filing Date: 2011-03-15
  • Overseas
• [Patent(Industrial Property Rights)] 組織染色方法、組織評価方法および生体物質検出方法 (2011)
  • Inventor(s): 相宮拓司、郷田秀樹、岡田尚大、中野寧、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Filing Date: 2011-03-15
  • Overseas
• [Patent(Industrial Property Rights)] 免疫組織化学染色方法及び反応試薬 (2011)
  • Inventor(s): 高野敬三、星野秀樹、岡田尚大、中野寧、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Industrial Property Number: 2011-057345
  • Filing Date: 2011-03-16
• [Patent(Industrial Property Rights)] 組織評価方法 (2011)
  • Inventor(s): 岡田尚大、郷田秀樹、高梨健作、相宮拓司、中野寧、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Industrial Property Number: 2011-057343
  • Filing Date: 2011-03-16
• [Patent(Industrial Property Rights)] 組織の自家蛍光と蛍光物質内包ナノ粒子の蛍光を利用した免疫組織化学法 (2011)
  • Inventor(s): 岡田尚大、郷田秀樹、中野寧、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Industrial Property Number: 2011-059172
  • Filing Date: 2011-03-17
• [Patent(Industrial Property Rights)] 免疫組織染色法、およびこれを用いた抗体医薬の有効性を判定する方法 (2011)
  • Inventor(s): 郷田秀樹、岡田尚大、中野寧、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Industrial Property Number: 2011-067448
  • Filing Date: 2011-03-25
• [Patent(Industrial Property Rights)] がん発症又はがん発症リスクの判定方法 (2010)
  • Inventor(s): 権田幸祐、宮下穣、武田元博、大内憲明
  • Industrial Property Rights Holder: 東北大学
  • Filing Date: 2010-09-02
• [Patent(Industrial Property Rights)] 半導体ナノ粒子集積体 (2010)
  • Inventor(s): 高橋優、高梨健作、星野秀樹、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Industrial Property Number: 2010-190352
  • Filing Date: 2010-08-27
• [Patent(Industrial Property Rights)] 半導体ナノ粒子集積体及び半導体ナノ粒子集積体の製造方法 (2010)
  • Inventor(s): 星野秀樹、高橋優、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学.
  • Industrial Property Number: 2010-190354
  • Filing Date: 2010-08-27
• [Patent(Industrial Property Rights)] 生体物質検出方法 (2010)
  • Inventor(s): 相宮拓司、郷田秀樹、岡田尚大、中野寧、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Industrial Property Number: 2010-161921
  • Filing Date: 2010-08-31
• [Patent(Industrial Property Rights)] 生体物質検出方法 (2010)
  • Inventor(s): 高梨健作、郷田秀樹、岡田尚大、中野寧、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Industrial Property Number: 2010-193154
  • Filing Date: 2010-08-31
• [Patent(Industrial Property Rights)] 組織評価方法 (2010)
  • Inventor(s): 郷田秀樹、相宮拓司、岡田尚大、中野寧、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Industrial Property Number: 2010-193153
  • Filing Date: 2010-08-31
• [Patent(Industrial Property Rights)] 組織評価方法及び組織評価方法 (2010)
  • Inventor(s): 郷田秀樹、相宮拓司、岡田尚大、中野寧、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: コニカミノルタエムジー(株)、東北大学
  • Industrial Property Number: 2010-193155
  • Filing Date: 2010-08-31
• [Patent(Industrial Property Rights)] がん発症又はがん発症リスクの判定方法 (2010)
  • Inventor(s): 権田幸祐、宮下穣、武田元博、大内憲明
  • Industrial Property Rights Holder: 東北大学
  • Industrial Property Number: 2010-196442
  • Filing Date: 2010-09-02
• [Patent(Industrial Property Rights)] 抗体を成分として含む医薬品の有効性の判定方法 (2010)
  • Inventor(s): 宮下穣、権田幸祐、武田元博、大内憲明
  • Industrial Property Rights Holder: 東北大学
  • Industrial Property Number: 2010-209322
  • Filing Date: 2010-09-17
• [Patent(Industrial Property Rights)] がん細胞運動およびがん細胞浸潤抑制剤 (2009)
  • Inventor(s): 権田幸祐, 樋口秀男, 大内憲明、武田元博
  • Industrial Property Rights Holder: 権田幸祐, 樋口秀男, 大内憲明、武田元博
  • Filing Date: 2009-03-19
• [Patent(Industrial Property Rights)] 輸入リンパ管流入部検出方法及び特定細胞同定方法 (2009)
  • Inventor(s): 日景允
  • Industrial Property Rights Holder: 日景允、権田幸祐、武田元博、亀井尚、大内憲明、郷田秀樹、中野寧
  • Industrial Property Number: 2009-152781
  • Filing Date: 2009-06-26
• [Patent(Industrial Property Rights)] がん細胞運動およびがん細胞浸潤抑制剤 (2009)
  • Inventor(s): 権田幸祐
  • Industrial Property Rights Holder: 権田幸祐, 樋口秀男, 大内憲明, 武田元博
  • Filing Date: 2009-03-19
  • Overseas
• [Patent(Industrial Property Rights)] がん細胞運動およびがん細胞浸潤抑制剤 (2009)
  • Inventor(s): 権田幸祐, 樋口秀男, 大内憲明、武田元博
  • Industrial Property Rights Holder: 権田幸祐, 樋口秀男, 大内憲明、武田元博
  • Filing Date: 2009-03-19
  • Overseas