Construction of the standard chiroptical analysis method by vibrational circular dichroism
Project/Area Number |
20310127
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Living organism molecular science
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Research Institution | Hokkaido University |
Principal Investigator |
MONDE Kenji Hokkaido University, 大学院・先端生命科学研究院, 教授 (40210207)
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Co-Investigator(Kenkyū-buntansha) |
MIURA Nobuaki 北海道大学, 大学院・先端生命科学研究院, 特任准教授 (80372267)
TANIGUCHI Tohru 北海道大学, 大学院・先端生命科学研究院, 助教 (00587123)
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Co-Investigator(Renkei-kenkyūsha) |
MIURA Nobuaki 北海道大学, 大学院・先端生命科学研究院, 特任准教授 (80372267)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
|
Keywords | 生体機能関連物質 / トランス脂肪酸 / キラル / VCD / 脂質 / ジアシルグリセロール / グリセロール / 糖脂質 / グリセロ糖脂質 / グリコシル化 |
Research Abstract |
Glycerolipids are essential substances for sustaining our life. Although the number of their chiral carbon is only one like most of amino acids, their stereochemistry has not been assigned with ease. In order to establish a new analytical method for determination of their absolute configurations, optically pure glycerolipids and related compounds were prepared by chemical synthesis, and subjected to the "Vibrational Circular Dichromism" measurement. The precise analysis of their spectral data resulted in a discovery of an empirical rule on the stereochemistry of diacylglycerolipids including glycolipids for the first time.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] Salvileucalin C, a novel rearranged neoclerodane diterpene from Salvia leucantha2011
Author(s)
Aoyagi Y., Yamazaki A., Kato R., Tobe F., Fukaya H., Nishikawa T., Nakahashi A., Miura N., Monde K., Takeya K.
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Journal Title
Tetrahedron Lett. 52
Pages: 1851-1853
Related Report
Peer Reviewed
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[Journal Article] Salvileucalin C, a novel rearranged neoclerodane diterpene from Salvia leucantha2011
Author(s)
Aoyagi Y., Yamazaki A., Kato R., Tobe F., Fukaya H., Nishikawa T., Nakahashi A., Miura N., Monde K., Takeya K.
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Journal Title
Tetrahedron Lett.
Volume: 52
Pages: 1851-1853
Related Report
Peer Reviewed
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[Journal Article] Super Water- and Highly Oil-Repellent Films Made of Fluorinated Poly(alkylpyrroles)2010
Author(s)
Chiba, K., Kurogi, K., Monde, K., Hashimoto, M., Yoshida, M., Mayama, H., Tsujii, K.
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Journal Title
Colloids Surf., A 354
Pages: 234-239
Related Report
Peer Reviewed
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[Journal Article] Stereochemical Studies of Flavorous 2-Substituted-3(2H)-furanones by Vibrational Circular Dichroism2009
Author(s)
Emura, M., Yaguchi, Y., Nakahashi, A., Sugimoto, D., Miura, N., Monde, K.
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Journal Title
J.Agric.Food Chem. 57
Pages: 9909-9915
Related Report
Peer Reviewed
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[Journal Article] Stereochemical Study of a Novel Tautomeric Furanone, Homofuraneol2009
Author(s)
Monde, K., Nakahashi, A., Miura, N., Yaguchi, Y., Sugimoto, D., Emura, M.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Alterations in the glycoform of cisplatin-resistant human carcinoma cells are caused by defects in the endoplasmic reticulum-associated degradation system2008
Author(s)
Nakagawa H., Ohira M., Hayashi S., Abe S., Saito S., Nagahori N., Monde K., Shinohara Y., Fujitani N., Kondo H., Akiyama S.-I., Nakagawara A., Nishimura S.-I.
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Journal Title
Cancer Lett. 270
Pages: 295-301
Related Report
Peer Reviewed
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[Presentation] ENVIRONMENT-FRIENDLY SYNTHESIS OF CHIRAL FLUOROUS SPHINGOLIPIDS FOR METABOLIC ANALYSIS2010
Author(s)
Shota Saito, Masafumi Yoshida, Atsufumi Nakahashi, Mostafa A.S.Hammam, Tohru Taniguchi, Susumu Mitsutake, Yasuyuki Igarashi, Kenji Monde
Organizer
21st International Symposium on Chirality, Chirality 2010
Place of Presentation
Sapporo Convention Center, Sapporo, Japan(Poster)
Year and Date
2010-07-14
Related Report
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[Presentation] Chirality of Lipids2009
Author(s)
Monde K.; Shibata M.; Nakahashi A.; Fukuzawa M.; Taniguchi T.; Miura N.
Organizer
CD 2009-12th International Conference on Circular Dichroism, ISBC-5th Interdisciplinary Symposium on Biological Chirality
Place of Presentation
University of Brescia, Italy(Oral)
Year and Date
2009-09-03
Related Report
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[Presentation] Chirality of Lipids2009
Author(s)
Monde, K.; Shibata, M.; Nakahashi, A.; Fukuzawa, M.; Taniguchi, T.; Miura, N.
Organizer
CD 2009-12th International Conference on Circular Dichroism, ISBC-5th Interdisciplinary Symposium on Biological Chirality
Place of Presentation
University of Brescia, Italy
Year and Date
2009-09-03
Related Report
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[Presentation] Chiroptical Analysis of Lipids & Glycolipids by Vibrational Circular Dichroism2009
Author(s)
Monde, K.; Shibata, M.; Nakahashi, A.; Fukuzawa, M.; Taniguchi, T.; Miura, N.; Nishimura, S.-I.
Organizer
21st International Symposium on Chirality, Chirality 2009
Place of Presentation
Breckenridge, Colorado, USA
Year and Date
2009-07-13
Related Report
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[Presentation] Stereochemical Study of Chiral Tautomeric Flavorous Furanones by Vibrational Circular Dichroism2009
Author(s)
Nakahashi, A., Miura, N., Monde, K., Emura, M., Yaguchi, Y., Sugimoto, D.
Organizer
21st International Symposium on Chirality, Chirality 2009
Place of Presentation
Breckenridge, Colorado, USA
Related Report
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[Presentation] Theoretical Calculation of Optical Activity2008
Author(s)
Taniguchi Tohru ; Monde Kenji ; Gerhard Schlingmann ; Nakanishi Koji ; Berova Nina
Organizer
Absolute Configurations of Phytoalexins and Other Natural Products.(50th 281-284)
Place of Presentation
Tennen Yuki Kagobutsu Toronkai Koen Yoshishu
Related Report
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