| Project/Area Number |
20310129
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KIGOSHI Hideo University of Tsukuba, 大学院・数理物質科学研究科, 教授 (90169839)
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| Co-Investigator(Kenkyū-buntansha) |
KITA Masaki 筑波大学, 大学院・数理物質科学研究科, 講師 (30335012)
HAYAKAWA Ichiro 筑波大学, 大学院・数理物質科学研究科, 助教 (20375413)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | 海洋天然物 / 抗腫瘍性物質 / アクチン脱重合 / 腫瘍細胞増殖阻害 / アプリロニンA / 海洋天延物 / プローブ分子 / 細胞毒性物質 / アクチン脱重合物質 / ハテルマライドNA / オーリライド / 抗腫瘍性 / 細胞毒性 / オーリピロンB / ハテルマライドB |
|---|
| Research Abstract |
Bioorganic studies on novel modes of antitumor/cytototic activities of aplyronine A, aurilide, and haterumalides are effected. A hybrid analog between aplyronine A and mycalolide B was synthesized, and its bioactivities were evaluated. Target biomolecule of aurilide was identified to be prohibitin, a mitochondrial protein, which stabilized the tubular structure of mitochondria. Aurilide binds to probititin, which resulted in the fragmentation of mitochondoria. Analogs of haterumalides were synthesized, and their cytotoxicity was evaluated.
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