| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Research Abstract |
We characterized three Mcm and two PCNA proteins from Thermococcus kodakaraensis. One of the three mcm genes and one of the two pcna genes seemed to be essential for the life of T. kodakaraensis. Furthermore, we detected the functions of Mcm and PCNA proteins in vitro. In addition, we made 3D structure models of PCNA-DNA ligase-DNA, PCNA-DNA polymerase-DNA, and PCNA-UDG-AP-DNA, and discussed their structure-function relationships.
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