Study on functionalization of biomaterials by controlling the high order structure
Project/Area Number |
20350108
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Polymer/Textile materials
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Research Institution | National Institute for Materials Science |
Principal Investigator |
KOBAYASHI Hisatoshi National Institute for Materials Science, 生体材料センター, グループリーダー (90354266)
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Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Chiaki 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 (10447930)
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Research Collaborator |
HATTORI Shinya 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, ポスドク研究員 (30469762)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2008: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
|
Keywords | 高分子機能材料 / ナノ材料 / 生体材料 / ナノバイオ / 構造・機能材料 / 高分子合成 |
Research Abstract |
The size of the receptor on the cellular membrane and the recognition of the adhesion molecules are regulated in nanometer order. Therefore it is necessary to design and to control the 3D structure of the materials. In this consequence, we try to understand the real cell recognition mechanism on the functionalized biomaterials by controlling the material nano-micro-macro structure. In this research, we aimed (1) "control of the second/three-dimensional array structure of the fiber" and (2) "three-dimensional structural control of the concentrated polymer brush", and the bodily function characteristic was examined in detail. From the results, the concept of the new type of the tissue engineering scaffolds was developed.
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Report
(4 results)
Research Products
(113 results)
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[Journal Article] Tissue engineering with natural tissue matrices(5th Forum on New Materials, 2010, Part E, Stafa-Zuerich, Switzerland).2010
Author(s)
Kishida A, Funamoto S, Negishi J, Hashimoto Y, Nam K, Kimura T, Fujisato T, Kobayashi H
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Journal Title
Advances in Science and Technology 76
Pages: 125-132
Related Report
Peer Reviewed
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[Journal Article] Preparation and characterization of decellularized cornea using high-hydrostatic pressurization for corneal tissue engineering.2010
Author(s)
Hashimoto Y, Funamoto S, Sasaki S, Honda T, Hattori S, Nam K, Kimura T, Mochizuki M, Fujisato T, Kobayashi H, et al
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Journal Title
Biomaterials 31(14)
Pages: 3941-3948
Related Report
Peer Reviewed
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[Presentation] 新水性濃厚ポリマーブラシの生体適合性2009
Author(s)
吉川千晶, 橋本良秀, 服部晋也, 辻井敬亘, 岸田晶夫, 小林尚俊
Organizer
特別推進研究「濃厚ポリマーブラシの科学と技術」公開シンポジウム
Place of Presentation
ホテルセントノーム京都,京都,日本
Year and Date
2009-03-27
Related Report
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[Presentation] 濃厚ポリマーブラシの生体適合性2009
Author(s)
吉川千晶, 橋本良秀, 服部晋也, 辻井敬亘, 岸田晶夫, 小林尚俊
Organizer
第13回高分子表面研究討論会
Place of Presentation
東京工業大学 百年記念館フェライト会議室,東京,日本
Year and Date
2009-01-30
Related Report
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[Presentation] 脱細胞化角膜を用いたがん化用足場材料の研究2008
Author(s)
舩本誠一, 橋本良秀, 佐々木秀次, 本田貴子, 服部晋也, 望月学, 藤里俊哉, 木村剛, 小林尚俊, 岸田晶夫
Organizer
第37回医用高分子シンポジウム
Place of Presentation
上智大学,東京
Related Report
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[Presentation] Structure evaluation of Porcine Cornea Decellularized by Ultra High Hydrostatical Pressurization2008
Author(s)
小林尚俊, 木村剛, 舩本誠一, 橋本良秀, 佐々木秀次, 服部晋也, 望月学, 本田貴子, 藤里俊哉, 岸田晶夫
Organizer
E-MRS、Polish Materials Science Society
Place of Presentation
Warsaw University of Technology, warsaw, Poland
Related Report
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[Presentation] 脱細胞化処理による角膜実質の微細線維構造の変化に関する研究2008
Author(s)
服部晋也, 木村剛, 吉川千晶, 舩本誠一, 橋本良秀, 佐々木秀次, 望月學, 南広祐, 藤里俊哉, 北村総一郎, 岸田晶夫, 本田貴子, 小林尚俊
Organizer
第57回高分子討論会
Place of Presentation
大阪市立大学杉本キャンパス,大阪市
Related Report
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[Presentation] STRUCTURAL FEATURES OF DECELLULARIZED CORNEA USING ULTRA HIGH HYDROSTATIC PRESSURIZATION METHOD2008
Author(s)
服部晋也, 木村剛, 吉川千晶, 舩本誠一, 橋本良秀, 佐々木秀次, 藤里俊哉, 本田貴子, 岸田晶夫, 小林尚俊
Organizer
2008 TERMIS-AP
Place of Presentation
Chien-Tan Overseas Youth Activity Center Taipei, Taiwan
Related Report
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[Presentation] EVALUATION OF DECELLULARIZED CORNEA MADE BY ULTRA HIGH HYDROSTATIC PRESSURIZATION METHOD AS A SCAFFOLD FOR CORNEAL STROMA2008
Author(s)
本田貴子, 木村剛, 吉川千晶, 舩本誠一, 橋本良秀, 佐々木秀次, 藤里俊哉, 服部晋也, 岸田晶夫, 小林尚俊
Organizer
2008 TERMIS-AP
Place of Presentation
Chien-Tan Overseas Youth Activity Center Taipei, Taiwan
Related Report
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[Presentation] 高圧印加処理を用いた脱細胞化による人工角膜開発の試み2008
Author(s)
服部晋也, 木村剛, 吉川千晶, 舩本誠一, 橋本良秀, 佐々木秀次, 望月學, 南広祐, 藤里俊哉, 北村総一郎, 岸田晶夫, 本田貴子, 小林尚俊
Organizer
日本バイオマテリアル学会シンポジウム2008
Place of Presentation
東京大学本郷キャンパス,東京
Related Report
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