| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Research Abstract |
Rafts are dynamic clusters composed largely of cholesterol and sphingolipids. Microdomains are expected to function as platforms of endocytic carriers. Along these lines, giant multicomponent liposomes, raft-exhibiting model membranes, are efficient tools for studying the physicochemical properties of microdomains. We have shown that some simple stimuli (osmosis or detergents) may induce bud formation of raft domains in model membranes. We also showed interaction between amyloid beta (Aβ) and model membranes. Moreover, morphological changes might be related to the neurotoxicity in the pathology of Alzheimer's disease (AD). We used both liposomes and actual living cells for studies of dynamic movement of membrane structure.
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