| Project/Area Number |
20370029
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Animal physiology/Animal behavior
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
OZAKI Mamiko Kobe University, 大学院・理学研究科, 教授 (00314302)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKANO Toshiyuki 国立遺伝学研究所, 集団遺伝研究系, 准教授 (90202150)
伊藤 雅信 京都工芸繊維大学, 工芸科学研究科, 教授 (60221082)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ITOH Masanobu 京都工芸繊維大学, 大学院・理工学研究科, 教授 (60221082)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|
|---|
| Keywords | ショウジョウバエ / 食欲 / 摂食異常 / 味覚 / 糖受容 / 電気生理 / DNAマイクロアレイ / 代謝異常 / ショウジョウバェ |
|---|
| Research Abstract |
Increased and decreased appetites in flies would indicate low and high PER threshold to sucrose, respectively. A mutant TW1 showed hundredfold hyper feeding sensitivity to sucrose under starved condition, partially because of about tenfold increase in sensory sensitivity ; electrophysiological threshold of the sugar receptor cell of a tarsal sensillum decreased to 10% as starvation progressed. In vertebrates, appetite increase caused by starvation has mainly explained by central neuronal alteration via blood sugar and/or hormonal regulation. In Drosophila, however, the present study potentially suggested that increase in peripheral gustatory sensitivity significantly contributes to the appetite increase under starved condition.
|
