Feeding regulation in a novel Drosophila mutant showing unusual appetite.
| Project/Area Number |
20370029
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Kobe University |
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Principal Investigator |
OZAKI Mamiko Kobe University, 大学院・理学研究科, 教授 (00314302)
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| Co-Investigator(Kenkyū-buntansha) |
TAKANO Toshiyuki 国立遺伝学研究所, 集団遺伝研究系, 准教授 (90202150)
伊藤 雅信 京都工芸繊維大学, 工芸科学研究科, 教授 (60221082)
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| Co-Investigator(Renkei-kenkyūsha) |
ITOH Masanobu 京都工芸繊維大学, 大学院・理工学研究科, 教授 (60221082)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | ショウジョウバエ / 食欲 / 摂食異常 / 味覚 / 糖受容 / 電気生理 / DNAマイクロアレイ / 代謝異常 / ショウジョウバェ |
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| Research Abstract |
Increased and decreased appetites in flies would indicate low and high PER threshold to sucrose, respectively. A mutant TW1 showed hundredfold hyper feeding sensitivity to sucrose under starved condition, partially because of about tenfold increase in sensory sensitivity ; electrophysiological threshold of the sugar receptor cell of a tarsal sensillum decreased to 10% as starvation progressed. In vertebrates, appetite increase caused by starvation has mainly explained by central neuronal alteration via blood sugar and/or hormonal regulation. In Drosophila, however, the present study potentially suggested that increase in peripheral gustatory sensitivity significantly contributes to the appetite increase under starved condition.
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Report
(4 results)
Research Products
(27 results)
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[Presentation] Survival strategies for starvation in a mutant of Drosophila melanogaster, TW12009
Author(s)
Azusa Nishimura, Yuko Ishida, Marina Sakabe, Haruka Okamoto, Kazuyo Fujikawa,Yujiro Umesaki, Aya Takahashi, Toshiyuki Takano, Kenji Tomioka, Mamiko Ozaki
Organizer
The 6th International Symposium on Molecular and Neural Mechanisms ofTaste and Olfactory Perception
Place of Presentation
Fukuoka, Japan
Year and Date
2009-11-03
Related Report
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[Presentation] Survival strategies for starvation in a mutant of Drosophila melanogaster, TW1.2009
Author(s)
Azusa Nishimura, Yuko Ishida, Marina Sakabe, Haruka Okamoto, Kazuyo Fujikawa, Yujiro Umesaki, Aya Takahashi, Toshiyuki Takano, Kenji Tomioka, Mamiko Ozaki
Organizer
TW1. 7^<th> International symposium on molecular and neural mechanisms of taste and olfactory perception
Place of Presentation
九州大学(福岡県)
Year and Date
2009-11-03
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[Book] Insect Taste2009
Author(s)
Mamiko Ozaki, Tadashi Nakamura, 他(共著)
Total Pages
263
Publisher
Taylor and Francis Group, Milton Park Abington, UK
Related Report
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