Research on transcriptional mediators regulated by signals
| Project/Area Number |
20370074
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ISHII Shunsuke The Institute of Physical and Chemical Research, 石井分子遺伝学研究室, 主任研究員 (00124785)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | コリプレッサー / コアクティベーター / アダプター / Ski / Shn-2 / ヒストンアセチル化 / 複合体 / ヒストンメチル化 / 転写抑制 / Sno |
|---|
| Research Abstract |
We found that the Ski corepressor complex contained Smad2/3/4, histone deacetylase HDAC3, and protein arginine N-methyltransferase PRMT5. This suggests that Ski binds to the TGF-β/BMP target genes to keep their low basal transcription levels via HDAC3 and PRMT5. We also showed that Shn-2 adaptor protein has a role to maintain cellular proliferation via suppressing apoptosis during T cell development.
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Report
(4 results)
Research Products
(67 results)
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[Journal Article] Schnurri-2 deficiency counteracts against bone loss induced by ovariectomy2011
Author(s)
Nagao M, Saita Y, Hanyu R, Hemmi H, Notomi T, Hayata T, Nakamoto T, Kaneko K, Kurosawa H, Ishii S, Ezura Y, Noda M
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Journal Title
J Cell Physiol. 226
Pages: 573-578
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Peer Reviewed
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[Journal Article] SKI knockdown inhibits human melanoma tumor growth in vivo2009
Author(s)
Chen D, Lin Q, Box N, Roop D, Ishii S, Matsuzaki K, Fan T, Hornyak TJ, Reed JA, Stavnezer E, Timchenko NA, Medrano EE
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Journal Title
Pigment Cell Melanoma Res. 22
Pages: 761-772
Related Report
Peer Reviewed
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[Presentation] Role of ATF-2 in epigenetic regulation2009
Author(s)
Shunsuke Ishii,Ki-Hyeon Seong, Toshio Maekawa, Hideyuki Shimizu, Seungjoon Kim, Daisuke Nakai
Organizer
The 24th Naito Conference on Nuclear Dynamics and RNA [II]
Place of Presentation
Sapporo, Japan
Year and Date
2009-06-06
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