Analysis of the signal transduction mechanism by ER stress sensor IRE1.

• Project/Area Number: 20380062
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied biochemistry
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: KOHNO Kenji Nara Institute of Science and Technology, バイオサイエンス研究科, 教授 (50142005)
• Co-Investigator(Renkei-kenkyūsha): SAITO Michiko 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (40379558)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000); Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
• Keywords: シグナル伝達 / ストレス / 動物 / 細胞・組織 / 蛋白質 / シグナル伝遠

Research Abstract

Mammalian ER stress response pathway, IRE1α-XBP1, and the target molecule of IRE1β have been studied. As the result, the efficient splicing mechanism of precursor XBP1u mRNA, which encodes the precursor of a transcription factor XBP1s, has been precisely studied. Further IRE1β, specifically expressed in goblet cells of colon, plays an important role in the regulation of mRNA stability of secretory and membrane proteins.

Research Products

• [Journal Article] Reconstitution and characterization of the unconventional slicing of XBP1u mRNA in vitro. (2011)
  • Author(s): Shinya, S., Kadokura, H., Imagawa, Y., Inoue, M., Yanagitani K., Kohno, K.
  • Journal Title: Nuc. Acids Res. published online (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Translational pausing ensures membrane-targeting and cytoplasmic splicing of XBP1u mRNA. (2011)
  • Author(s): Yanagitani K., Kimata, Y., Kadokura, H.Kohno, K.
  • Journal Title: Science 331 6017 Pages: 586-589
  • Peer Reviewed
• [Journal Article] XBPlu mRNAが小胞体膜において効率よくスプライシングされるには翻訳停止反応が必要である (2011)
  • Author(s): 柳谷耕太, 河野憲二
  • Journal Title: ライフサイエンス新着論文レビュー
• [Journal Article] Reconstitution and characterization of the unconventional slicing of XBP1u mRNA in vitro. (2011)
  • Author(s): Shinya, S.
  • Journal Title: Nucleic.Acids Res. Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Translational pausing ensures membrane-targeting and cytoplasmic splicing of XBP1u mRNA. (2011)
  • Author(s): Yanagitani, K.
  • Journal Title: Science Volume: 331(6017) Pages: 586-589
  • Peer Reviewed
• [Journal Article] XBP1u mRNAが小胞体膜において効率よくスプライシングされるには翻訳停止反応が必要である (2011)
  • Author(s): 柳谷耕太
  • Journal Title: ライフサイエンス新着論文レビュー
• [Journal Article] 小胞体膜上で起こるスプライシングの洗練されたメカニズム (2011)
  • Author(s): 柳谷耕太
  • Journal Title: 実験医学 Volume: (印刷中)
• [Journal Article] 小胞体膜貫通型センサーIRE1が核に効率よく情報を伝える仕組み (2010)
  • Author(s): 柳谷耕太, 河野憲二
  • Journal Title: 化学と生物 Vol.48 Pages: 226-228
• [Journal Article] Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland. (2010)
  • Author(s): Hosoda, A., Tokuda, M., Akai, R., Kohno, K., Iwawaki, T.
  • Journal Title: Biochem.J. 425 Pages: 117-125
  • Peer Reviewed
• [Journal Article] Stress sensing mechanisms in the unfolded protein response : similarities and differences between yeast and mammals. (2010)
  • Author(s): Kohno, K.
  • Journal Title: J.Biochem. 147 Pages: 27-33
  • Peer Reviewed
• [Journal Article] 小胞体膜貫通型センサーIRE1が核に効率よく情報を伝える仕組み (2010)
  • Author(s): 柳谷耕太
  • Journal Title: 化学と生物 Volume: 48 Pages: 226-228
• [Journal Article] Positive contribution of ERdj5/JPDI to endoplasmic reticulum prote in quality control in the salivary gland. (2010)
  • Author(s): Hosoda, A.
  • Journal Title: Biochem. J. 425 Pages: 117-125
  • Peer Reviewed
• [Journal Article] Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA. (2009)
  • Author(s): Yanagitani K., Imagawa, Y., Iwawaki, T., Hosoda, A., Saito, M., Kimata, Y., Kohno, K.
  • Journal Title: Mol.Cell 34 Pages: 191-200
  • Peer Reviewed
• [Journal Article] Activation of mammalian IRE1 α upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins. (2009)
  • Author(s): Oikawa, D., Kimata Y, Kohno, K., Iwawaki, T.
  • Journal Title: Exp.Cell Res. 315 Pages: 2496-2504
  • Peer Reviewed
• [Journal Article] Function of IRE1alpha in the placenta is essential for placental development and embryonic viability. (2009)
  • Author(s): Iwawaki, T., Akai, R., Yamanaka, S., Kohno, K.
  • Journal Title: Proc Natl Acad Sci USA 106 Pages: 16657-16662
  • Peer Reviewed
• [Journal Article] Pioglitazone reduces ER stress in the liver : Direct monitoring of in vivo ER stress using ER stress-activated indicator transgenic mice. (2009)
  • Author(s): Yoshiuchi, K., Kaneto, H., Matsuoka, TA, Kasami, R., Kohno, K., Iwawaki, T., Nakatani, Y., Yamasaki, Y., Shimomura, I., Matsuhisa, M.
  • Journal Title: Endocr.J. 56 Pages: 1103-1111
  • Peer Reviewed
• [Journal Article] ジフテリア毒素受容体を利用した疾患モデルマウスの作製 (2009)
  • Author(s): 斉藤美知子, 河野憲二
  • Journal Title: 蛋白質核酸酵素 54(5) Pages: 614-620
  • Peer Reviewed
• [Journal Article] 小胞体膜上でのスプライシングに必須なmRNA局在化のメカニズム (2009)
  • Author(s): 柳谷耕太, 河野憲二
  • Journal Title: 細胞工学 28(8) Pages: 826-827
• [Journal Article] 細胞質スプライシングに必須なmRNA局在化のメカニズム (2009)
  • Author(s): 柳谷耕太, 河野憲二
  • Journal Title: 蛋白質核酸酵素 54(16) Pages: 2177-2183
  • Peer Reviewed
• [Journal Article] ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-induced death by inducing aggregation of co-expressed wild-type VAPB. (2009)
  • Author(s): Suzuki, H., Kanekura, K., Levine, T., Kohno, K., Olkkonen, V.M., Aiso, S., Matsuoka M.
  • Journal Title: J.Neurochem. 108 Pages: 973-985
  • Peer Reviewed
• [Journal Article] Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA. (2009)
  • Author(s): Yanagitani, K.
  • Journal Title: Mol.Cell 34 Pages: 191-200
  • Peer Reviewed
• [Journal Article] Activation of mammalinan IREl1a upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins. (2009)
  • Author(s): Oikawa, D.
  • Journal Title: Exp.Cell Res. 315 Pages: 2496-2504
  • Peer Reviewed
• [Journal Article] Function of IRElalpha in the placenta is essential for placental development and embryonic viability. (2009)
  • Author(s): Iwawaki, T.
  • Journal Title: Proc Natl Acad Sci USA 106 Pages: 16657-16662
  • Peer Reviewed
• [Journal Article] Pioglitazone reduces ER stress in the liver : Direct monitoring of in vivo ER stress using ER stress-activated indicator transgenic mice. (2009)
  • Author(s): Yoshiuchi, K.
  • Journal Title: Endocr. J. 56 Pages: 1103-1111
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 斉藤美知子
  • Journal Title: 蛋白質核酸酵素(共立出版) Pages: 614-620
• [Journal Article] (2009)
  • Author(s): 柳谷耕太
  • Journal Title: 細胞工学(学研メディカル秀潤社) Pages: 826-827
• [Journal Article] (2009)
  • Author(s): 柳谷耕太
  • Journal Title: 蛋白質核酸酵素(共立出版) Pages: 2177-2183
• [Journal Article] Cotranslational targeting of XBP1 protein to the membranepromotes cytoplasmic splicing of its own mRNA (2009)
  • Author(s): Kota Yanagitani
  • Journal Title: Mol. Cell 34 Pages: 191-200
  • Peer Reviewed
• [Journal Article] Sacchromyces cerevisiae Rot1 functions as a molecular chaperone in the endoplasmic reticulum. (2008)
  • Author(s): Takeuchi, M., Kimata Y., Kohno, K.
  • Journal Title: Mol.Biol.Cell 19 Pages: 3514-3525
  • Peer Reviewed
• [Journal Article] Saccharomyces cerevisiae Rotl is an essential molecularchaperone in the endoplasmic reticulum. (2008)
  • Author(s): Masato. Takeuchi
  • Journal Title: Mol. Biol. Cell 19 Pages: 3514-3525
  • Peer Reviewed
• [Journal Article] ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB. (2008)
  • Author(s): Suzuki, H.
  • Journal Title: J. Neurochem. 108 Pages: 973-985
  • Peer Reviewed
• [Presentation] XBP1uタンパク質の小胞体膜局在化メカニズムの解析 (2010)
  • Author(s): 江崎悠太
  • Organizer: BMB2010
  • Place of Presentation: 兵庫県
  • Year and Date: 2010-12-10
• [Presentation] Functional Difference Between IRE1 α and IRE1β (2010)
  • Author(s): 杉村瞳
  • Organizer: BMB2010
  • Place of Presentation: 兵庫県
  • Year and Date: 2010-12-10
• [Presentation] XBP1uタンパク質の小胞体膜局在化メカニズムの解析 (2010)
  • Author(s): 江崎悠太
  • Organizer: BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会・合同大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-10
• [Presentation] Functional Difference Between IRE1a and IRE1b (2010)
  • Author(s): 杉村瞳
  • Organizer: BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会・合同大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-10
• [Presentation] The ER stress sensor IRE1β down-regulates MUC2 mRNA to optimize mucin production (2010)
  • Author(s): 都留秋雄
  • Organizer: BMB2010
  • Place of Presentation: 兵庫県
  • Year and Date: 2010-12-07
• [Presentation] The ER stress sensor IRE1β down-regulates MUC2 mRNA to optimize mucin production (2010)
  • Author(s): 都留秋雄
  • Organizer: BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会・合同大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-07
• [Presentation] Unfolded-protein interaction with stress sensor Ire1 (2010)
  • Author(s): 柳谷耕太
  • Organizer: The 3rd InternationalSymposium on Protein Community
  • Place of Presentation: 奈良県
  • Year and Date: 2010-09-13
• [Presentation] The role of IRE1β in LS174T human colon carcinoma cells (2010)
  • Author(s): 中村大祐
  • Organizer: The 3rd InternationalSymposium on Protein Community
  • Place of Presentation: 奈良県
  • Year and Date: 2010-09-13
• [Presentation] Exploring factors involved in the splicing of XBP1 Mrna (2010)
  • Author(s): 新谷紗代子
  • Organizer: The 3rd InternationalSymposium on Protein Community
  • Place of Presentation: 奈良県
  • Year and Date: 2010-09-13
• [Presentation] Unfolded-protein interaction with stress sensor Ire1 (2010)
  • Author(s): Kota Yanagitani
  • Organizer: The 3rd InternationalSymposium on Protein Community
  • Place of Presentation: ホテル日航奈良
  • Year and Date: 2010-09-13
• [Presentation] The role of IRE1β in LS174T human colon carcinoma cells (2010)
  • Author(s): Daisuke Nakamura
  • Organizer: The 3rd InternationalSymposium on Protein Community
  • Place of Presentation: ホテル日航奈良
  • Year and Date: 2010-09-13
• [Presentation] Exploring factors involved in the splicing of XBP1 mRNA. (2010)
  • Author(s): Sayoko Shinya
  • Organizer: The 3rd InternationalSymposium on Protein Community
  • Place of Presentation: ホテル日航奈良
  • Year and Date: 2010-09-13
• [Presentation] The ER stress sensor IRE1β down-regulates MUC2 mRNA to optimize mucin production (2010)
  • Author(s): Akio Tsuru
  • Organizer: The 3rd InternationalSymposium on Protein Community
  • Place of Presentation: ホテル日航奈良
  • Year and Date: 2010-09-13
• [Presentation] Analysis of XBP1 mRNA splicing reaction in unfolded protein response (2010)
  • Author(s): 新谷紗代子
  • Organizer: 15th Annual meeting of the RNA society
  • Place of Presentation: Washington(USA)
  • Year and Date: 2010-06-23
• [Presentation] Analysis of XBP1 mRNA splicing reaction in unfolded protein response (2010)
  • Author(s): Sayoko Shinya
  • Organizer: 15th Annual meeting of the RNA society
  • Place of Presentation: Washington (USA)
  • Year and Date: 2010-06-23
• [Presentation] 新生鎖を介したXBP1u mRNAの膜局在化に必須な分子機構 (2010)
  • Author(s): 柳谷耕太
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪府
  • Year and Date: 2010-05-21
• [Presentation] 新生鎖を介したXBP1u mRNAの膜局在化に必須な分子機構 (2010)
  • Author(s): 柳谷耕太
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-05-21
• [Presentation] The ER stress-sensory mechanism by transmembrane protein Ire1 .Dimerization of Ire1 is not sufficient for its activation,CSHL Meeting (2010)
  • Author(s): 河野憲二
  • Organizer: Molecular Chaperones & Stress Responses
  • Place of Presentation: NewYork(USA)
  • Year and Date: 2010-05-05
• [Presentation] Molecular mechanism for nascent chain-mediated XBP1u mRNA targeting onto membrane, CSHL Meeting (2010)
  • Author(s): 柳谷耕太
  • Organizer: Molecular Chaperones & Stress Responses
  • Place of Presentation: NewYork(USA)
  • Year and Date: 2010-05-05
• [Presentation] The ER stress-sensory mechanism by transmembrane protein Ire1-Dimerization of Ire1 is not sufficient for its activation (2010)
  • Author(s): Kenji Kohno
  • Organizer: Cold Spring Harbor Laboratory Meeting "Molecular Chaperones & Stress Responses"
  • Place of Presentation: Cold Spring Harbor, NewYork (USA)
  • Year and Date: 2010-05-05
• [Presentation] Molecular mechanism for nascent chain-mediated XBP1u mRNA targeting onto membrane (2010)
  • Author(s): Kota Yanagitani
  • Organizer: Cold Spring Harbor Laboratory Meeting "Molecular Chaperones & Stress Responses"
  • Place of Presentation: Cold Spring Harbor, NewYork (USA)
  • Year and Date: 2010-05-05
• [Presentation] ATF4 induces IRE1α under stressed conditions (2009)
  • Author(s): 今井安隆
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川県
  • Year and Date: 2009-12-12
• [Presentation] Analysis of XBP1 mRNA splicing reaction in ER stress response (2009)
  • Author(s): 新谷紗代子
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川県
  • Year and Date: 2009-12-12
• [Presentation] A novel ER-localized DnaJprotein, DNAJB12, particpates in ER quality control (2009)
  • Author(s): 山本洋平
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川県
  • Year and Date: 2009-12-12
• [Presentation] Molecular phylogenetic and evolutionary trace analysis for stress response sensor protein IRE1 (2009)
  • Author(s): 神園栄夫
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川県
  • Year and Date: 2009-12-12
• [Presentation] HSP70 plays an important role in the recovery of IRE1β knockout goblet cells from ER distension (2009)
  • Author(s): 松崎永英
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川県
  • Year and Date: 2009-12-12
• [Presentation] The life of XBP1u protein : From birth to death (2009)
  • Author(s): 横田有希子
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川県
  • Year and Date: 2009-12-12
• [Presentation] ATF4 induces IRE1a under stressed conditions (2009)
  • Author(s): 今井安隆
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-12-12
• [Presentation] Analysis of XBP1 mRNA splicing reaction in ER stress response (2009)
  • Author(s): 新谷紗代子
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-12-12
• [Presentation] A novel ER-localized DnaJ protein, DNAJB12, particpates in ER quality control (2009)
  • Author(s): 山本洋平
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-12-12
• [Presentation] Molecular phylogenetic and evolutionary trace analysis for stress response sensor protein IRE1 (2009)
  • Author(s): 神園栄夫
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-12-12
• [Presentation] HSP70 plays an important role in the recovery of IRE1b knockout goblet cells from ER distension (2009)
  • Author(s): 松崎永英
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-12-12
• [Presentation] The life of XBP1u protein : From birth to death (2009)
  • Author(s): 横田有希子
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-12-12
• [Presentation] IRE1β is a key molecule for ER quality control in goblet cells (2009)
  • Author(s): 河野憲二
  • Organizer: The 4th Cell Stress Society International(CSSI)Congress on Stress Responses in Biology and Medicine
  • Place of Presentation: 北海道
  • Year and Date: 2009-10-07
• [Presentation] IRE1B is a key molecule for ER quality control in goblet cells (2009)
  • Author(s): 河野憲二
  • Organizer: The 4th Cell Stress Society International(CSSI)Congress on Stress Responses in Biology and Medicine
  • Place of Presentation: 北海道 招待講演
  • Year and Date: 2009-10-07
• [Presentation] 小胞体ストレスセンサーIRE1のクラスタリングと細胞質スプライシング (2009)
  • Author(s): 河野憲二
  • Organizer: 第69回酵母研究会
  • Place of Presentation: 京都
  • Year and Date: 2009-09-09
• [Presentation] 小胞体ストレスセンサーIRE1のクラスタリングと細胞質スプライシング (2009)
  • Author(s): 河野憲二
  • Organizer: 第69回酵母研究会
  • Place of Presentation: 京都 招待講演
  • Year and Date: 2009-09-09
• [Presentation] The role of IRE1 in unfolded protein response (2009)
  • Author(s): 河野憲二
  • Organizer: IV International Conference on Moleular Mechanisms of Fungal Cell Wall Biogenesis
  • Place of Presentation: Warsaw(Poland)
  • Year and Date: 2009-08-31
• [Presentation] The role of IRE1 in unfolded protein response (2009)
  • Author(s): 河野憲二
  • Organizer: IV Interantional Conference on Moleular Mechanisms of Fungal Cell Wall Biogenesis
  • Place of Presentation: Warsaw(Poland)招待講演
  • Year and Date: 2009-08-31
• [Presentation] Dynamic regulation of XBP1 mRNA distribution in ER stress response (2009)
  • Author(s): 河野憲二
  • Organizer: Gordon Research Conferences "Stress Protein In Growth, Development & Disease"
  • Place of Presentation: Andover(U.S.A)
  • Year and Date: 2009-07-01
• [Presentation] Dynamic regulation of XBP1 mRNA distribution in ER stress response (2009)
  • Author(s): 河野憲二
  • Organizer: Gordon Research Conferences "Stress Protein In Growth, Development & Disease"
  • Place of Presentation: Andover(U.S.A)招待講演
  • Year and Date: 2009-07-01
• [Presentation] A novel ER-localized DnaJ protein, DNAJB12, participates in ER quality control (2009)
  • Author(s): 山本洋平
  • Organizer: FASEB SUMMER RESEARCH CONFERENCES "From Unfolded Protein in the Endoplasmic Reticulum to Disease"
  • Place of Presentation: Vermont (U.S.A.)
  • Year and Date: 2009-06-09
• [Presentation] A novel ER-localized DnaJ protein, DNAJB12, participates in ER quality control. (2009)
  • Author(s): 山本洋平
  • Organizer: FASEB SUMMER RESEARCH CONFERENCES "From Unfolded Protein in the Endoplasmic Reticulum to Disease"
  • Place of Presentation: Vermont(U.S.A.)
  • Year and Date: 2009-06-09
• [Presentation] Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA (2009)
  • Author(s): 柳谷耕太
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 愛知県
  • Year and Date: 2009-06-04
• [Presentation] Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own Mrna (2009)
  • Author(s): 柳谷耕太
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 愛知 招待講演
  • Year and Date: 2009-06-04
• [Presentation] 小胞体ストレス応答におけるXBP1 mRNA細胞内局在のダイナミックな制御 (2009)
  • Author(s): 河野憲二
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 愛知県
  • Year and Date: 2009-06-03
• [Presentation] 小胞体ストレスセンサーIRE1βの翻訳抑制機構 (2009)
  • Author(s): 中村大祐
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 愛知県
  • Year and Date: 2009-06-03
• [Presentation] Dynamic regulation of XBP1 mRNA distribution in the ER stress response (2009)
  • Author(s): 河野憲二
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 愛知 招待講演
  • Year and Date: 2009-06-03
• [Presentation] 小胞体ストレスセンサーIRE1bの翻訳抑制機構 (2009)
  • Author(s): 田村大祐
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 愛知
  • Year and Date: 2009-06-03
• [Presentation] IRE1beta is a key molecule for ER quality control in goblet cells (2008)
  • Author(s): 河野憲二
  • Organizer: BMB2008
  • Place of Presentation: 兵庫県
  • Year and Date: 2008-12-10
• [Presentation] 膵β細胞のインスリン分泌におけるIRE1αの役割 (2008)
  • Author(s): 斉藤美知子
  • Organizer: BMB2008
  • Place of Presentation: 兵庫県
  • Year and Date: 2008-12-10
• [Presentation] 酵母小胞体分子シャペロンRot1による蛋白質折り畳み機構の解析 (2008)
  • Author(s): 竹内雅人
  • Organizer: BMB2008
  • Place of Presentation: 兵庫県
  • Year and Date: 2008-12-10
• [Presentation] 小胞体ストレス下におけるIRE1α誘導機構の解析 (2008)
  • Author(s): 今井安隆
  • Organizer: BMB2008
  • Place of Presentation: 兵庫県
  • Year and Date: 2008-12-10
• [Presentation] Ire1は構造異常蛋白質の蓄積以外の小胞体ストレスも感知する (2008)
  • Author(s): 紫藤昌宏
  • Organizer: BMB2008
  • Place of Presentation: 兵庫県
  • Year and Date: 2008-12-10
• [Presentation] 小胞体ストレスセンサーIre1ファミリーのN末配列の役割 (2008)
  • Author(s): 竹内あすみ
  • Organizer: BMB2008
  • Place of Presentation: 兵庫県
  • Year and Date: 2008-12-10
• [Presentation] 膵島における小胞体ストレス応答経路活性化機構の解析 (2008)
  • Author(s): 中村優作
  • Organizer: BMB2008
  • Place of Presentation: 兵庫県
  • Year and Date: 2008-12-10
• [Presentation] 新規Hsp40 familyタンパク質DNAJB12及びDNAJB14の機能解析 (2008)
  • Author(s): 山本洋平
  • Organizer: BMB2008
  • Place of Presentation: 兵庫県
  • Year and Date: 2008-12-10
• [Presentation] IRE 1beta is a key molecule for ER quality control in goblet cells (2008)
  • Author(s): 河野 憲二
  • Organizer: BMB2008 (第31回日本分子生物学会年会第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド(兵庫)
  • Year and Date: 2008-12-10
• [Presentation] 膵b細胞のインスリン分泌におけるIRElaの役割 (2008)
  • Author(s): 斉藤 美知子
  • Organizer: BMB2008(第31回日本分子生物学会年会第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド(兵庫)
  • Year and Date: 2008-12-10
• [Presentation] 酵母小胞体分子シャペロンRot1による蛋白質折り畳み機構の解析 (2008)
  • Author(s): 竹内 雅人
  • Organizer: BMB2008(第31回日本分子生物学会年会第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド(兵庫)
  • Year and Date: 2008-12-10
• [Presentation] 小胞体ストレス下におけるIRE1a誘導機構の解析 (2008)
  • Author(s): 今井 安隆
  • Organizer: BMB2008(第31回日本分子生物学会年会第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド(兵庫)
  • Year and Date: 2008-12-10
• [Presentation] Ire1は構造異常蛋白質の蓄積以外の小胞体ストレスも感知する (2008)
  • Author(s): 紫藤 昌宏
  • Organizer: BMB2008(第31回日本分子生物学会年会第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド(兵庫)
  • Year and Date: 2008-12-10
• [Presentation] 小胞体ストレスセンサーIre1ファミリーのN末配列の役割 (2008)
  • Author(s): 竹内 あすみ
  • Organizer: BMB2008(第31回日本分子生物学会年会第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド(兵庫)
  • Year and Date: 2008-12-10
• [Presentation] 洋島における小胞体ストレス応答経路活性化機構の解析 (2008)
  • Author(s): 中村 優作
  • Organizer: BMB2008(第31回日本分子生物学会年会第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド(兵庫)
  • Year and Date: 2008-12-10
• [Presentation] 新規Hsp40 familyタンパク質DNAJB12及びDNAJB14の機能解析 (2008)
  • Author(s): 山本 洋平
  • Organizer: BMB2008(第31回日本分子生物学会年会第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド(兵庫)
  • Year and Date: 2008-12-10
• [Presentation] タンパク質ジスルフィド結合形成反応中間体の検出とその解析 (2008)
  • Author(s): 門倉広
  • Organizer: BMB2008
  • Place of Presentation: 兵庫県
  • Year and Date: 2008-12-09
• [Presentation] タンパク質ジスルフィド結合形成反応中間体の検出とその解析 (2008)
  • Author(s): 門倉 広
  • Organizer: BMB2008(第31回日本分子生物学会年会第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド(兵庫)
  • Year and Date: 2008-12-09
• [Presentation] XBP1 mRNAの小胞体ストレス時における局在変化 (2008)
  • Author(s): 河野憲二
  • Organizer: 第3回小胞体ストレス研究会
  • Place of Presentation: 岐阜県
  • Year and Date: 2008-10-04
• [Presentation] XBP1 mRNAの小胞体ストレス時における局在変化 (2008)
  • Author(s): 河野 憲二
  • Organizer: 第3回小胞体ストレス研究会
  • Place of Presentation: じゅうろくプラザ(岐阜)
  • Year and Date: 2008-10-04
• [Presentation] XBP1 mRNAはER膜上に局在することでIRE1αlphaによって効率的にスプライシングされる (2008)
  • Author(s): 柳谷耕太
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: 神奈川県
  • Year and Date: 2008-06-30
• [Presentation] IRE1βによる分泌タンパク質選択的な翻訳抑制 (2008)
  • Author(s): 中村大祐
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: 神奈川県
  • Year and Date: 2008-06-30
• [Presentation] Ire1は構造異常蛋白質の蓄積とは別種の小胞体ストレスとして膜の異常を感知しているのかもしれない (2008)
  • Author(s): 紫藤昌宏
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: 神奈川県
  • Year and Date: 2008-06-30
• [Presentation] IRE1βは杯細胞の小胞体品質管理における重要な分子である (2008)
  • Author(s): 藤本直子
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: 神奈川県
  • Year and Date: 2008-06-30
• [Presentation] XBP1 mRNAはER膜上に局在することでIRE1alphaによって効率的にスプライシングされる (2008)
  • Author(s): 柳谷 耕太
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2008-06-30
• [Presentation] IRE1bによる分泌タンパク質選択的な翻訳抑制 (2008)
  • Author(s): 中村 大祐
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2008-06-30
• [Presentation] Ire1は構造異常蛋白質の蓄積とは別種の小胞体ストレスとして膜の異常を感知しているのかもしれない (2008)
  • Author(s): 紫藤 昌宏
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: パシフイコ横浜(神奈川)
  • Year and Date: 2008-06-30
• [Presentation] IRE1bは杯細胞の小胞体品質管理における重要な分子である (2008)
  • Author(s): 藤本 直子
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: パシフイコ横浜(神奈川)
  • Year and Date: 2008-06-30
• [Presentation] Membrane localization of XBP1 mRNA contributes the efficiency of IRE1 αlpha-dependent cytoplasmic splicing. (2008)
  • Author(s): 柳谷耕太
  • Organizer: Cold Spring Harbor Laboratory Meeting "Molecular Chaperones and Stress Response"
  • Place of Presentation: Cold Spring Harbor(U.S.A)
  • Year and Date: 2008-05-03
• [Presentation] Membrane localization of XBP1 mRNA contributes theefficiency of IRE1alpha-dependent cytoplasmic splicing. (2008)
  • Author(s): 柳谷 耕太
  • Organizer: Cold Spring Harbor Laboratory Meeting「Molecular Chaperones and Stress Response」
  • Place of Presentation: Cold Spring Harbor (U.S.A.)
  • Year and Date: 2008-05-03
• [Presentation] IRE1beta specifically attenuates the translation of ER proteins (2008)
  • Author(s): 中村大祐
  • Organizer: Cold Spring Harbor Laboratory Meeting "Molecular Chaperones and Stress Response"
  • Place of Presentation: Cold Spring Harbor
  • Year and Date: 2008-05-02
• [Presentation] IRE1beta specifically attenuates the translation of ER proteins. (2008)
  • Author(s): 中村 大祐
  • Organizer: Cold Spring Harbor Laboratory Meeting「Molecular Chaperones and Stress Response」
  • Place of Presentation: Cold Spring Harbor (U.S.A.)
  • Year and Date: 2008-05-02
• [Book] 蛋白質核酸酵素増刊「キーワード : タンパク質の一生」 (2008)
  • Author(s): 河野憲二
  • Total Pages: 3
  • Publisher: 共立出版
• [Remarks] ホームページアドレス
  • URL: http://bsw3.naist.jp/kouno/kouno.html
• [Remarks] HP
  • URL: http://bsw3.naist.jp/kouno/kouno.html
• [Remarks]
  • URL: http://bsw3.naist.jp/kouno/kouno.html
• [Remarks]
  • URL: http://bsw3.naist.jp/kouno/kouno.html
• [Patent(Industrial Property Rights)] 形質転換動物及び形質転換幹細胞並びにそれらの利用 (2010)
  • Inventor(s): 河野憲二、斉藤美知子、中島欽一、古川智久
  • Industrial Property Rights Holder: 国立大学法人奈良先端科学技術大学院大学
  • Industrial Property Number: 2010-181449
  • Filing Date: 2010-08-13
• [Patent(Industrial Property Rights)] Diabetes model animal. United States Patent (2010)
  • Inventor(s): 河野憲二
  • Industrial Property Rights Holder: 奈良先端科学技術大学院大学
  • Acquisition Date: 2010-01-05
  • Overseas