Preventive effects of marine carotenoids on life-style-related diseases based on anti-inflammatory effects as molecular targets
| Project/Area Number |
20380117
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Fisheries chemistry
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
HOSOKAWA Masashi Hokkaido University, 大学院・水産科学研究院, 准教授 (10241374)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YASUI Yumiko 酪農学園大学, 獣医学部, 講師 (90434472)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
|
|---|
| Keywords | 食品化学 / 分子栄養学 / カロテノイド / 抗炎症 / サイトカイン / 肥満 / 大腸癌 / マクロファージ / 脂肪組織 / 大腸組織 / 大腸 / 脂肪細胞 / 炎症性腸疾患 / アスタキサンチン |
|---|
| Research Abstract |
Astaxanthin exhibited inhibitory effects on dextran sodium sulfate-induced colitis and inflammatory-related colon carcinogenesis in mice. In colon of the mice fed astaxanthin, mRNA expression levels of inflammatory cytokines such as TNF-α and IL-1β were suppressed through inhibition of NF-κB activation. After feeding for 20 weeks, colonic mucosal ulcers, dysplastic crypts and colonic adenocarcinoma were inhibited by 200 ppm astaxanthin-containing diet. In addition, astaxanthin, pectenolone, alloxanthin and diatoxanthin isolated from marine organisms attenuated excessive mRNA expression of inflammatory cytokines and COX-2 and iNOS in macrophages activated by LPS. On the other hand, dietary 0.2% fucoxanthin markedly suppressed mRNA expression of inflammatory cytokines such as TNF-α and IL-6 to induce insulin resistance and inhibited macrophage infiltration in white adipose tissue through suppression of MCP-1 mRNA expression after 4 weeks feeding. Further, fucoxanthinol, which is one of fucoxanthin metabolites, also regulated cross talk of adipocytes and macrophages via palmitic acid and TNF-α. These results suggest that anti-inflammatory effects are molecular mechanism for anti-obesity and anti-diabetic effects of fucoxanthin.
|
Report
(4 results)
Research Products
(53 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article]2009
Author(s)
K.Miyashita, M.Hosokawa.
-
Journal Title
Chapter 11, Antiobesity effect of allenic carotenoid, fucoxanthin. in"Nutrigenomics and proteomics in health and disease"(Wiley-Blackwell, USA)
Pages: 145-160
Related Report
-
[Journal Article]2009
Author(s)
前多隼人, 細川雅史
-
Journal Title
第12章 アレンカロテノイドの機能性.in「カロテノイドの科学と最新応用技術」(シーエムシー出版、東京)
Pages: 201-210
Related Report
-
[Journal Article]2009
Author(s)
安井由美子, 田中卓二
-
Journal Title
第7章 予防医学とカロテノイド. in「カロテノイドの科学と最新応用技術」(シーエムシー出版、東京)
Pages: 153-160
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Chemopreventive Efiects of Silymarin, a Plant Constituent, against the Carcingenicity of Dimethylhydrazine Plus Dextran Sodium Sulfate in the Colon of gpt delta Transgenic Rats2010
Author(s)
N.Toyoda-Hokaiwado, Y.Yasui, M.Muramatsu, K.Masumura, M.Takamune, M.Yamada, T.Ohta, T.Tanaka, T.Nohmi
Organizer
10th International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis
Place of Presentation
Brazil・Hotel Sofitel Jequitimar
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
