| Project/Area Number |
20380173
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Kagoshima University |
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Principal Investigator |
YAMATO Osamu 鹿児島大学, 農学部, 教授 (80261337)
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| Co-Investigator(Renkei-kenkyūsha) |
ENDOH Daiji 酪農学園大学, 獣医学部, 教授 (40168828)
KUNIEDA Tetsuo 岡山大学, 自然科学研究科, 教授 (80178011)
TAKEHANA Kazushige 酪農学園大学, 獣医学部, 教授 (80137413)
YAMANAKA Shoji 横浜市立大学, 大学病院, 准教授 (80264604)
OCHIAI Kenji 北海道大学, 獣医学研究科, 教授 (80214162)
UCHIDA Kazuyuki 東京大学, 農学生命科学研究科, 准教授 (10223554)
HASEGAWA Daisuke 日本獣医生命科学大学, 獣医学部, 講師 (20366793)
MATSUKI Naoaki 東京大学, 農学生命科学研究科, 教授 (40251417)
NAKAICHI Munekazu 山口大学, 農学部, 教授 (60243630)
ITAMOTO Kazuhiro 山口大学, 農学部, 准教授 (50379921)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | ライソゾーム蓄積病 / 動物モデル / ガングリオシドーシス / サンドホフ病 / セロイドリポフスチン症 / 遺伝病 / スクリーニング |
|---|
| Research Abstract |
Diagnostic and screening methods for a number of novel and known animal inherited diseases especially lysosomal storage disorders were developed in this study. For canine diseases such as GM1 gangliosidosis and neuronal ceroid lipofuscinosis, preventive strategies were planed and carried out. The preventive measures resulted in a decrease of carrier frequency without the occurrence of affected animals in Japan at the end of study period. Furthermore, anti-inflammatory therapy was carried out in a cat affected with GM2 gangliosidosis suggesting that this treatment might have a survival advantage. In addition, some novel inherited diseases were indentified in dogs and cats, which will be investigated in the next study.
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